3 results on '"James Papin"'
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2. Contributors
- Author
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Tawfik Aboellail, Jônatas Santos Abrahão, Talita Adelino, Ramesh Akkina, Ayman Alboudi, Luiz Carlos Junior Alcantara, Henning Andersen, Teresinha De Jesus Aguiar Dos Santos Andrade, Masashi Arakawa, Josélio Maria Galvão de Araújo, Pamella Nunes Azevedo, Omar Bagasra, Mark J. Bailey, Serdar Baraklı, Alison Jane Basile, Luis Federico Bátiz, Benan Bayrakci, Aline Almeida Bentes, Jean A. Bernatchez, A.B. Blázquez, Viola Borchardt-Lohölter, Ana Luiza Vilela Borges, Maria Sole Burali, Felipe A. Bustamante-Barrientos, Paulo E. Cabral Filho, Steven Vargas Cañas, Talita Castro, Gwong-Jen J. Chang, Day-Yu Chao, Ameya Chaudhari, Duverney Chaverra-Rodriguez, Raissa R. Christoff, Luiz Felipe Leomil Coelho, Diogo Goulart Corrêa, Michael Coste, Raquel Zanatta Coutinho, Joaquim Soares da Costa Júnior, Anna Carolina Toledo da Cunha Pereira, Paulo Marcos da Matta Guedes, Guilherme Liberato da Silva, Jaderson Costa DaCosta, Prajakta Dandekar, Amos Danielli, Maria das Dores Alves de Oliveira, Orhan Deniz, Philippe Desprès, Betânia Paiva Drumond, Jonny Duque, Patrícia e Silva Alves, Chaker El Kalamouni, José Veríssimo Fernandes, Gustavo Portela Ferreira, T. Foiadelli, Vagner Fonseca, Adriana Fontes, Lawrence Frenkel, Gilles Gadea, Patricia P. Garcez, Marta Giovanetti, Fernando Gomez, Bonnie E. Gulas-Wroblewski, Şadiye Gümüşyayla, Sunam Gurung, Juliano G. Haddad, Thomas Harbo, Cecília Hedin-Pereira, Roberto Henzi, Holly R. Hughes, Luiz Celso Hygino da Cruz Júnior, Andrew Jameson, Rachel Jordan, Rebecca B. Kairis, Taruna Kaura, Selman Kesici, Ahmad Suhail Khazali, Julia Maria Klemens, Erna Geessien Kroon, Walter Sze Tung Lam, Erik Lattwein, Vladimir V. Lazarev, Túlio César Rodrigues Leite, Cui Li, Nerilson Marques Lima, Maria Elizabeth Lopes Moreira, Karina Carrillo Loza, Denise Cantarelli Machado, Fernanda Majolo, Luiz Cosme Cotta Malaquias, Giuseppe Manfroni, Daniel Rodrigo Marinowic, Dimitri Marques Abramov, G.L. Marseglia, Ewen McLean, Breno de Mello Silva, Stelia Mendez-Sanchez, Abhishek Mewara, Eiji Morita, Kristy O. Murray, Dean Myers, Manuela Sales Lima Nascimento, Osvaldo J.M. Nascimento, Marciano Viana Paes, James Papin, Giovannia A.L. Pereira, Goreti Pereira, Maria I.A. Pereira, Naveed Pervaiz, Byron W. Purse, Kíssila Rabelo, Jéssika F.F. Ribeiro, Shannon E. Ronca, Shira Roth, Tania Regina Saad Salles, Lívia Sacchetto, J.C. Saiz, Natália Gedeão Salomão, Beate S. Santos, Sandra Saschenbrecker, S. Savasta, Wolfgang Schlumberger, Kimberly Schmitt, Jair L. Siqueira-Neto, Derek Tuck Loong Soon, José Luis Soto-Hernández, Gabriel Augusto Pires de Souza, Katja Steinhagen, Konstanze Stiba, Paul Ananth Tambyah, Gene S. Tan, Stephane Tosta, C. Trabatti, Gönül Vural, Heron Werner, Joilson Xavier, Zhiheng Xu, Tay Wei Xuan, and Rohana Yusof
- Published
- 2022
3. Distinct Renal Pathology and a Chemotactic Phenotype after Enterohemorrhagic Escherichia coli Shiga Toxins in Non-Human Primate Models of Hemolytic Uremic Syndrome
- Author
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Rama P. Cherla, Sun-Young Oh, James Papin, Joel M. Henderson, Deborah J. Stearns-Kurosawa, Shinichiro Kurosawa, Moo-Seung Lee, and Vernon L. Tesh
- Subjects
Hemolytic anemia ,Thrombotic microangiopathy ,Inflammation ,Biology ,Kidney ,Shiga Toxin 1 ,Shiga Toxins ,Shiga Toxin 2 ,Pathology and Forensic Medicine ,medicine ,Animals ,Humans ,RNA, Messenger ,Macrophage inflammatory protein ,Chemotaxis ,Acute kidney injury ,Kidney metabolism ,Endothelial Cells ,Regular Article ,medicine.disease ,Eosinophils ,Disease Models, Animal ,medicine.anatomical_structure ,Phenotype ,Renal pathology ,Gene Expression Regulation ,Enterohemorrhagic Escherichia coli ,Immunology ,Hemolytic-Uremic Syndrome ,Mesangial Cells ,medicine.symptom ,Chemokines ,Papio - Abstract
Enterohemorrhagic Escherichia coli cause approximately 1.5 million infections globally with 176,000 cases occurring in the United States annually from ingesting contaminated food, most frequently E. coli O157:H7 in ground beef or fresh produce. In severe cases, the painful prodromal hemorrhagic colitis is complicated by potentially lethal hemolytic uremic syndrome (HUS), particularly in children. Bacterial Shiga-like toxins (Stx1, Stx2) are primarily responsible for HUS and the kidney and neurologic damage that ensue. Small animal models are hampered by the inability to reproduce HUS with thrombotic microangiopathy, hemolytic anemia, and acute kidney injury. Earlier, we showed that nonhuman primates (Papio) recapitulated clinical HUS after Stx challenge and that novel therapeutic intervention rescued the animals. Here, we present detailed light and electron microscopic pathology examination of the kidneys from these Stx studies. Stx1 challenge resulted in more severe glomerular endothelial injury, whereas the glomerular injury after Stx2 also included prominent mesangiolysis and an eosinophilic inflammatory infiltration. Both toxins induced glomerular platelet-rich thrombi, interstitial hemorrhage, and tubular injury. Analysis of kidney and other organs for inflammation biomarkers showed a striking chemotactic profile, with extremely high mRNA levels for IL-8, monocyte chemoattractant protein 1, and macrophage inflammatory protein 1α and elevated urine chemokines at 48 hours after challenge. These observations give unique insight into the pathologic consequences of each toxin in a near human setting and present potential pathways for therapeutic intervention.
- Published
- 2013
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