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Introduction. Scientific evidence indicates the anti-caries benefits of using the 1000-1500 ppm fluoride toothpastes compared to ≤ 600 ppm in permanent dentition, while there is a small number of studies regarding effectiveness of fluoride toothpastes in children with primary dentition. Aim. The purpose of this study was to present the results of a systematic review of the literature on the effectiveness of early childhood caries (ECC) prophylaxis using low and standard toothpastes, in the age group of 1-6 years. Material and methods. The methodology was in line with the guidelines from PRISMA. Article search was performed independently by two reviewers, in six electronic databases. Narrative analysis of the mean caries increment was performed to assess the effect of fluoride toothpaste on dmft and dmfs indices. Results. Nine studies out of 136 originally identified articles were included in the systematic review. The results of the analysis comparing effect of 1000-1500 versus ≤ 600 ppm fluoride toothpastes for tooth (dmft) and surface level (dmfs) confirmed the evidence of association between level of fluoride content and ECC increment. Conclusions. This systematic review, despite some limitations, indicate a greater efficacy of toothpastes containing 1000-1500 ppm F compared to those with low fluorine content in the prevention of ECC.

Osteonecrosis of the jaw is an uncommon side effect of bisphosphonates that are used in patients with bone metastases. The paper presents a case of a patient with breast cancer and numerous bone metastases, who received an intravenous infusion of zoledronic acid every 28 days for 4.5 years. The indication for the administration of bisphosphonates was the prevention of bone complications. The patient was diagnosed with osteonecrosis of the jaw associated with the administration of zoledronic acid and underwent surgical treatment. In this article, we pointed out the necessity of sanitation of the oral cavity before administration of oncological doses of bisphosphonates, repeated dentist control, and self-examination of teeth condition during the bisphosphonate treatment, as well as reduction of risk factors, in order to prevent osteonecrosis of the jaw.