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165 results on '"Jan, Ren-Long"'

19. A Taiwan Nationwide Population-Based Study of Socio-Demographic Factors and Comorbid Conditions Associated with Non-Arteritic Anterior Ischaemic Optic Neuropathy.

Author

Jan, Ren-Long, Ho, Chung-Han, Wang, Jhi-Joung, and Chang, Yuh-Shin

Subjects
SOCIODEMOGRAPHIC factors, NOSOLOGY, NEUROPATHY, CHRONIC kidney failure, COMORBIDITY, GIANT cell arteritis, TAKAYASU arteritis
Abstract

Aims: The aim of the study was to investigate the socio-demographic factors and systemic conditions associated with non-arteritic anterior ischaemic optic neuropathy (NAION). Methods: This was a nationwide population-based retrospective case-controlled study that recruited 9,261 NAION patients selected from the Taiwan National Health Insurance Research Database. The control group consisted of 9,261 age-, sex-, and index date-matched non-NAION patients recruited from the Taiwan Longitudinal Health Insurance Database, 2000. NAION was designated in the database by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) as "code 377.41: ischaemic optic neuropathy without ICD-9-CM code 446.5: giant cell arteritis." Associated socio-demographic factors and systemic medical conditions were analysed using the McNemar's test, and continuous variables were analysed using the paired t test. The odds ratio (OR) and adjusted OR of developing NAION were compared using univariate logistic regression and multivariable logistic regression analyses, respectively. Results: Patients with systemic conditions such as diabetes mellitus, hypertension, hyperlipidaemia, chronic kidney disease, and hypotension were more likely to develop NAION than controls (adjusted OR = 1.81, 95% confidence interval [CI] = 1.67–1.97, p < 0.0001; adjusted OR = 1.46, 95% CI = 1.36–1.57, p < 0.0001; adjusted OR = 1.44, 95% CI = 1.33–1.57, p < 0.0001; adjusted OR = 3.26, 95% CI = 2.65–4.01, p < 0.0001; adjusted OR = 2.32, 95% CI = 1.31–4.10, p = 0.0039, respectively). Conclusions: NAION is strongly associated with diabetes mellitus, hypertension, hyperlipidaemia, chronic kidney disease, and hypotension. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Association between atopic keratoconjunctivitis and the risk of keratoconus.

Author

Weng, Shih‐Feng, Jan, Ren‐Long, Wang, Jhi‐Joung, Tseng, Sung‐Huei, and Chang, Yuh‐Shin

Subjects
*KERATOCONJUNCTIVITIS, *NOSOLOGY, *KERATOCONUS, *HEALTH insurance, *REGRESSION analysis
Abstract

Purpose: To investigate the risk of keratoconus (KCN) in patients with atopic keratoconjunctivitis (AKC). Methods: This nationwide, retrospective, matched cohort study included 186 202 newly diagnosed AKC patients who were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM), code 372.05, and selected from the Taiwan National Health Insurance Research Database. The age‐ and sex‐matched control group included 186 202 non‐AKC patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Patient information was collected between 1 January 2004 and 31 December 2011, and both groups of patients were tracked from the index date until December 2013. The incidence and risk of KCN (ICD‐9‐CM, code 371.6) were compared between the groups. A Cox proportional hazard regression analysis was performed to obtain the adjusted hazard ratio (HR) for KCN. The cumulative KCN incidence rate was calculated with the Kaplan‐Meier analysis. Results: In total, 62 AKC patients and 26 controls developed KCN during the follow‐up period. The incidence rate of KCN was 2.49 times (95% confidence interval [CI] = 1.57–3.93; p < 0.0001) higher in AKC patients than in controls. After adjusting for potential confounders, AKC patients were 2.25 times more likely to develop KCN than controls (adjusted HR, 2.25; 95% CI = 1.41–3.58; p < 0.05). Conclusion: Atopic keratoconjunctivitis (AKC) patients had an increased risk of developing KCN. Therefore, AKC patients should be advised of this risk. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Risk of Retinal Artery Occlusion in Patients With End-Stage Renal Disease

Author

Chang, Yuh-Shin, Weng, Shih-Feng, Chang, Chun, Wang, Jhi-Joung, Tseng, Sung-Huei, Ko, Shun-Yao, Su, Shih-Bin, Huang, Chien-Cheng, Wang, Jiu-Yao, and Jan, Ren-Long

Subjects
Male, Retinal Artery Occlusion, Observational Study, Middle Aged, urologic and male genital diseases, Risk Assessment, Cohort Studies, Humans, Kidney Failure, Chronic, Female, Research Article, Aged, Retrospective Studies
Abstract

There is globally increasing prevalence and incidence in end-stage renal disease (ESRD). These patients are frequently reported to have retinal abnormalities and both diseases share some systemic risk factors. Hence, it is clinically relevant to determine whether ESRD is a predictor of retinal artery occlusion (RAO). To investigate the risk of RAO in ESRD patients. A retrospective, nationwide, matched cohort study. The study included 93,766 ESRD patients recruited between 2000 and 2009 from the Taiwan National Health Insurance Research Database. The same number control group included age- and sex-matched patients without ESRD selected from the Taiwan Longitudinal Health Insurance Database, 2000. Data for each patient were collected from the index date until December 2011. The incidence and risk of RAO were compared between the 2 groups. The hazard ratio (HR) for RAO after adjustment for potential confounders was calculated using Cox proportional hazards regression. Kaplan–Meier analysis was used to calculate the cumulative RAO incidence rate. In total, 237 ESRD patients and 73 controls exhibited RAO during follow-up; thus, the RAO incidence rate in ESRD patients was 4.49 times (95% confidence interval (CI), 3.45–5.83) that in the control patients. After adjustment for potential confounders, including diabetes mellitus, hypertension, hyperlipidemia, congestive heart failure, and coronary artery disease, ESRD patients were 2.78 times (95% CI, 2.02–3.84) more likely to develop RAO in cohort for the total sample. Among patients with hypertension, the RAO incidence rate was significantly higher in the ESRD group, and hypertension significantly increased RAO risk even after adjustment for other confounders in the cohort. ESRD increases the risk of RAO, particularly in ESRD patients with hypertension. Therefore, clinicians should educate ESRD patients about RAO and ensure appropriate blood pressure control.

Published
2016

37. Association between atopic keratoconjunctivitis and the risk of corneal ulcer

Author

Jan, Ren-Long, Weng, Shih-Feng, Wang, Jhi-Joung, Tseng, Sung-Huei, and Chang, Yuh-Shin

Abstract

AimsTo investigate the risk of corneal ulcer in patients with atopic keratoconjunctivitis (AKC).MethodsThe nationwide, population-based, retrospective, matched cohort study included 171 019 newly diagnosed patients with AKC who were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), code 372.05, and selected from the Taiwan National Health Insurance Research Database. The age-, sex- and potential comorbidities-matched control group included 171 019 patients with non-AKC selected from the Taiwan Longitudinal Health Insurance Database 2000. Patient information was collected between 1 January 2004 and 31 December 2011, and both groups of patients were tracked from the index date until December 2013. The incidence and risk of corneal ulcer (ICD-9-CM code 370.0 except for 370.07) was compared between the groups. A Cox proportional hazard regression analysis was performed to obtain the adjusted HR for corneal ulcer. The cumulative corneal ulcer incidence rate was calculated with the Kaplan-Meier analysis.ResultsIn total, 2018 patients with AKC and 1481 controls developed a corneal ulcer during the follow-up period. The incidence rate of corneal ulcer was 1.42 times (95% CI1.33 to 1.52; p<0.0001) higher in patients with AKC than in controls. After adjusting for potential confounders, including diabetes mellitus, chronic renal disease, topical steroid ophthalmic agent use, lid margin disease, keratoconjunctivitis sicca, ocular blunt trauma and post-corneal transplantation, patients with AKC were 1.26 times more likely to develop a corneal ulcer than controls (adjusted HR, 1.26; 95% CI 1.14 to 1.39; p<0.05).ConclusionsPatients with AKC had an increased risk of developing a corneal ulcer and should be advised of this risk.

Published
2021
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41. Vasculoprotective effects of Centella asiatica, Justicia gendarussaand Imperata cylindricadecoction via the NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats

Author

Sulistyowati, Erna, Jan, Ren-Long, Liou, Shu-Fen, Chen, Ying-Fu, Wu, Bin-Nan, Hsu, Jong-Hau, and Yeh, Jwu-Lai

Abstract

Centella asiatica, Justicia gendarussaand Imperata cylindricadecoction (CJID) is efficacious for hypertension. NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX)-induced reactive oxygen species (ROS) generation modulates nuclear factor kappa B (NF-κB) activation and thus mediates hypertension-induced vascular remodeling. This research aims to investigate the anti-remodeling effect of CJID through the mechanism of NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats (SHRs).

Published
2020
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50. Risk of corneal ulcer in patients with end-stage renal disease: a retrospective large-scale cohort study

Author

Jan, Ren-Long, Tai, Ming-Cheng, Weng, Shih-Feng, Chang, Chun, Wang, Jhi-Joung, and Chang, Yuh-Shin

Abstract

Background/AimsTo investigate the risk of corneal ulcer in patients with end-stage renal disease (ESRD).MethodsThis retrospective, nationwide, matched cohort study included 92 967 patients with ESRD recruited between 2000 and 2009 from the Taiwan National Health Insurance Research Database. The same number of age-matched and sex-matched patients without ESRD were selected from the Taiwan Longitudinal Health Insurance Database, 2000 as the control group. Data for each patient were collected from the index date until December 2011. Corneal ulcer incidence rate and risk were compared between the groups. A Cox proportional hazards regression was used to calculate the HR for a corneal ulcer after adjustment for potential confounders. The cumulative corneal ulcer incidence rate was calculated using Kaplan-Meier analysis.ResultsIn total, 660 patients with ESRD and 591 controls showed a corneal ulcer during follow-up; thus, the corneal ulcer incidence rate in patients with ESRD was 1.54 times (95% CI 1.38–1.72) that in the control patients. After adjustment for potential confounders, including diabetes mellitus and HIV disease, patients with ESRD were 1.17 times (95% CI 1.03 to 1.33) more likely to develop a corneal ulcer in the cohort for the total sample. Among patients with diabetes mellitus, the corneal ulcer incidence rate was significantly higher in the ESRD group, and diabetes mellitus significantly increased corneal ulcer risk even after adjustment for other confounders in the cohort.ConclusionESRD increases the risk of a corneal ulcer, particularly in patients with ESRD with diabetes mellitus. Regular ocular examinations are suggested for patients with ESRD.

Published
2018
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