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1. Isotope Effects

Author

Jancsó, G., Vértes, Attila, editor, Nagy, Sándor, editor, Klencsár, Zoltán, editor, Lovas, Rezső G., editor, and Rösch, Frank, editor

Published
2011
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24. The effect of laparoscopic pre- and postconditioning on pneumoperitoneum induced injury of the peritoneum.

Author

Veres, T.Gy., Petrovics, L., Sárvári, K., Vereczkei, A., Jancsó, G., Farkas, K. Borbásné, and Takács, I.

Subjects
INTRA-abdominal pressure, PERITONEUM, LAPAROSCOPIC surgery, PNEUMOPERITONEUM, OXIDATIVE stress, ISCHEMIC preconditioning
Abstract

INTRODUCTION: Pneumoperitoneum, widely used in laparoscopic surgery increases the intraabdominal pressure, leading to hypoperfusion of the abdominal organs, and promoting the buildup of reactive oxygen species(ROS) and inflammatory cytokines which in turn impairs the body postoperatively. Aim of our investigation was to evaluate the potential protective effects of short ischemic episodes on ischemic damages. METHODS: 70 Wistar rats were used, divided into 7 groups: 1st group sham, 2nd group pneumoperitoneum with 5 mmHg, 3rd group preconditioning with 5 mmHg, 4th group: postconditioning with 5 mmHg, 5th group pneumoperitoneum with 10 mmHg, 6th group: preconditioning with 10 mmHg, 7th group postconditioning with 10 mmHg. Pneumoperitoneum was created by Veres needle. Oxidative stress parameters: malondialdehyde (MDA) concentration, reduced glutathione (GSH), sulfhydril (SH-), myeloperoxidase (MPO) levels and superoxide-dismutase (SOD) activity were measured. We measured TNF-α and IL-6 concentrations. We monitored the activation of anti- and proapoptotic common signaling pathways (bax, bcl-2, p53) during the early phase of reperfusion. Histology was made from kidney samples. RESULTS: GSH concentrations were significantly reduced, MDA concentrations were significantly higher in each group compared to the Sham. SOD enzyme: a pressure of 10 mmHg elicited significantly greater damage than 5 mmHg. There was a significantly higher SOD activity in group 10 mmHg IPC compared to 10 mmHg. We found that the expression of bax was considerably higher in the none conditioned groups. Noticeably higher expression of anti-apoptotic bcl-2 level was measured in 10 mmHg IPC and 10 mmHg IPoC groups. In case of p53 expression: significant decrease could be seen in groups 10 mmHg IPC and 10 mmHg IPoC compared to the 10 mmHg group. CONCLUSION: Based on our results, the elevated intraabdominal pressure due to pneumoperitoneum induces oxidative stress, which is dependent on the applied pressure. Mostly precondiotioning – but also postconditioning – reduces surgical stress following laparoscopic procedures. In order to explore its mechanism it requires further investigations. [ABSTRACT FROM AUTHOR]

Published
2019
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25. The excess thermodynamic properties of liquid (CH4+CD4).

Author

Calado, J. C. G., Jancsó, G., Lopes, J. N. C., Markó, L., da Ponte, M. Nunes, Rebelo, L. P. N., and Staveley, L. A. K.

Subjects
*VAPOR pressure, *THERMODYNAMICS, *GIBBS' free energy
Abstract

The vapor pressure differences between a mixture of (CH4+CD4) and CH4 and between CD4 and CH4 were measured simultaneously with the CH4 vapor pressure. This was done at 29 temperatures between 97 and 122 K, and for six different mixtures, of compositions 0.150, 0.250, 0.375, 0.500, 0.625, and 0.750 mole fraction in CD4. These mixtures exhibit very small positive deviations from Raoult’s law. Calculated excess Gibbs energies for equimolar mixtures were 0.60 J mol-1 at 100 K and 0.42 J mol-1 at 120 K. These values of GE are 2 to 3 orders of magnitude smaller than those typically found in binary mixtures of simple nonisotopic species. The molar excess enthalpy, calculated from the temperature dependence of GE, is HE(x=0.5)=(1.5±0.2) J mol-1. The experimental results were used to test three theoretical models: the vdW-1 fluid theory, 1cLJ perturbation theory, and the theory of isotope effects in mixtures. While the first two proved to be inadequate, the isotope effect theory agrees well with experiment. [ABSTRACT FROM AUTHOR]

Published
1994
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32. Comparison of multiplicity distributions to the negative binomial distribution in muon-proton scattering

Author

Arneodo, M., Arvidson, A., Aubert, J. J., Badełek, B., Beaufays, J., Bee, C. P., Benchouk, C., Berghoff, G., Bird, I., Blum, D., Böhm, E., de Bouard, X., Brasse, F. W., Braun, H., Broll, C., Brown, S., Brück, H., Calen, H., Chima, J. S., Ciborowski, J., Clifft, R., Coignet, G., Combley, F., Coughlan, J., D'Agostini, G., Dahlgren, S., Dengler, F., Derado, I., Dreyer, T., Drees, J., Düren, M., Eckardt, V., Edwards, A., Edwards, M., Ernst, T., Eszes, G., Favier, J., Ferrero, M. I., Figiel, J., Flauger, W., Foster, J., Ftáčnik, J., Gabathuler, E., Gajewski, J., Gamet, R., Gayler, J., Geddes, N., Grafström, P., Grard, F., Haas, J., Hagberg, E., Hasert, F. J., Hayman, P., Heusse, P., Jaffré, M., Jachołkowska, A., Janata, F., Jancsó, G., Johnson, A. S., Kabuss, E. M., Kellner, G., Korbel, V., Krüger, J., Kullander, S., Landgraf, U., Lanske, D., Loken, J., Long, K., Maire, M., Malecki, P., Manz, A., Maselli, S., Mohr, W., Montanet, F., Montgomery, H. E., Nagy, E., Nassalski, J., Norton, P. R., Oakham, F. G., Osborne, A. M., Pascaud, C., Pawlik, B., Payre, P., Peroni, C., Peschel, H., Pessard, H., Pettinghale, J., Pietrzyk, B., Pietrzyk, U., Pönsgen, B., Pötsch, M., Renton, P., Ribarics, P., Rith, K., Rondio, E., Sandacz, A., Scheer, M., Schlagböhmer, A., Schiemann, H., Schmitz, N., Schneegans, M., Schneider, A., Scholz, M., Schröder, T., Schultze, K., Sloan, T., Stier, H. E., Studt, M., Taylor, G. N., Thénard, J. M., Thompson, J. C., de la Torre, A., Toth, J., Urban, L., Urban, L., Wallucks, W., Whalley, M., Wheeler, S., Williams, W. S. C., Wimpenny, S. J., Windmolders, R., Wolf, G., and The European Muon Collaboration

Published
1987
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34. Charge structure of the hadronic final state in deep-inelastic muon-nucleon scattering

Author

Arneodo, M., Arvidson, A., Aubert, J. J., Bedełek, J., Beaufays, J., Bee, C. P., Benchouk, C., Berghoff, G., Bird, I., Blum, D., Böhm, E., de Bouard, X., Brasse, F. W., Braun, H., Broll, C., Brown, S., Brück, H., Calen, H., Chima, J. S., Ciborowski, J., Clifft, R., Coignet, G., Combley, F., Coughlan, J., D'Agostini, G., Dahlgren, S., Dengler, F., Derado, I., Dreyer, T., Drees, J., Düren, M., Eckardt, V., Edwards, A., Edwards, M., Ernst, T., Eszes, G., Favier, J., Ferrero, M. I., Figiel, J., Flauger, W., Foster, J., Ftáčnik, J., Gabathuler, E., Gajewski, J., Gamet, R., Gayler, J., Geddes, N., Grafström, P., Grard, F., Haas, J., Hagberg, E., Hasert, F. J., Hayman, P., Heusse, P., Jaffré, M., Jachołkowska, A., Janata, F., Jancsó, G., Johnson, A. S., Kabuss, E. M., Kellner, G., Korbel, V., Krüger, J., Kullander, S., Landgraf, U., Lanske, D., Loken, J., Long, K., Maire, M., Malecki, P., Manz, A., Maselli, S., Mohr, W., Montanet, F., Montgomery, H. E., Nagy, E., Nassalski, J., Norton, P. R., Oakham, F. G., Osborne, A. M., Pascaud, C., Pawlik, B., Payre, P., Peroni, C., Peschel, H., Pessard, H., Pettinghale, J., Pietrzyk, B., Pietrzyk, U., Pönsgen, B., Pötsch, M., Renton, P., Ribarics, P., Rith, K., Rondio, E., Sandacz, A., Scheer, M., Schlagböhmer, A., Schiemann, H., Schmitz, N., Schneegans, M., Schneider, A., Scholz, M., Schröder, T., Schultze, K., Sloan, T., Stier, H. E., Studt, M., Taylor, G. N., Thénard, J. M., Thompson, J. C., de la Torre, A., Toth, J., Urban, L., Wallucks, W., Whalley, M., Wheeler, S., Williams, W. S. C., Wimpenny, S. J., Windmolders, R., Wolf, G., and European Muon Collaboration

Published
1988
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37. Abstracts

Author

Abdullah, Lubna H., Buchanan, K. D., Akopyan, T. N., Arzumanyan, A. M., Arutunyan, A. A., Berger, H., Oehme, P., Atkinson, M. E., Chaggar, J. S., Bailey, S. J., Featherstone, R. L., Jordan, C. C., Morton, I. K. M., Balfe, A., Skrabanek, P., Powell, D., Barja, F., Mathison, R., Huggel, H., Bittiger, H., Heid, J., Björkroth, Ulla, Rosell, Sune, Boyd, N. D., Anthony, M. P., Leeman, S. E., Briggs, I., Growcott, J. W., Jamieson, A., Tarpey, Ann V., Brodin, E., Meyerson, B. A., Brown, J. R., Hayes, A. G., Meecham, K. G., Tyers, M. B., Burcher, E., Bynke, G., Håkanson, R., Hörig, J., Cann, John R., Rahim, Iffat, Vatter, Albert, Stewart, John M., Cascieri, Margaret A., Liang, Tehming, Cheeseman, H. J., Pinnock, R. O., Henderson, G., Constantinidis, J., Bouras, C., Taban, C. H., Guntern, R., Couture, R., Cuello, A. C., Dalsgaard, C. -J., Jonsson, C. -E., Arvidsson, J., Risling, M., Hökfelt, T., Schultzberg, M., Vincent, S. R., Elfvin, L. -G., de Beaurepaire, R., Iversen, S. D., Delbro, D., Lisander, B., Fändriks, L., Andersson, S. A., Del Fiacco, M., Dessi, M. L., Levarvti, M. C., Del Rio, J., Naranjo, J. R., Domschke, S., Bloom, S. R., Adrian, T. E., Lux, G., Bryant, M. G., McGregor, G. P., Domschke, W., Donnerer, J., Barthó, L., Holzer, P., Lembeck, F., Skofitsch, G., Elliott, P. J., Bannon, M. J., Alpert, J. E., Ferri, G. -L, McGregor, G., Vezzadini, P., Labo, G., Polak, J. M., Fontaine-Perus, J. C., Chanconie, M., Foreman, J. C., Piotrowski, W., Fox, J. E. T., Daniel, E. E., Jury, J., Domoto, T., Berezin, I., Gaudino, G., Mondardini, L., Fasolo, A., Gazelius, B., Kahan, T., Panopoulos, P., Olgart, L., Gintzler, Alan R., Jaffe, Bernard M., Baron, Sheri A., GrÖnstad, K. O., Ahlman, H., Zinner, M. J., Jaffe, B. M., Yeo, C., Gu, J., Huang, W. M., lslam, K. N., Terenghi, G., Morrison, J., Güllner, H. -G., Haeusler, Guenther, Handelmann, Gail E., Selsky, Joyce H., Helme, R. D., White, D. M., Höfler, H., Heitzt, Ph. U., Auböck, L., Petsche, Ulrike, Lippe, Irmgard, Hylden, Janice L. K., Wilcox, George L., Inoue, Atsuko, Nakata, Yoshihiro, Segawa, Tomio, Jakubowska-Naziemblo, B., Potargowicz, E., Traczyk, W. Z., Cannon, D., Rohde, W., JancsÓ, G., Király, E., Karcsú, S., Szebeni, A., Bácsy, E., Jones, R. S. G., Olpe, H. -R., Wrightt, D. M., Jurna, I., Kerdelhué, B., Lenoir, V., Pasqualini, C., El Abed, A., Morel, G., Dubois, P., Hublot, P., Tartar, A., Klingmúller, D., Waltz, C., Kramer, H. J., Koop, H., Luster, W., Gropp, C., Havemenn, K., Arnold, R., Krause, James E., McKelvy, Jeffrey F., Krivoy, W., Couch, J., Strand, F., Leander, S., Folkers, K., Lee, C. M., Snyder, S. H., Lindberg, P., Dahlström, A., Lundberg, J. M., Lindefors, N., Ungerstedt, U., Liu-Chen, L. -Y., Liszczak, T., Mayberg, M. R., Moskowitz, M. A., Lundberg, Jan M., Saria, Alois, Brodin, Ernst, Martling, Claes-Roland, Hökfelt, Tomas, Lundblad, Lars, Änggård, Anders, McGeeney, K. F., O'Donnell, M. D., Blank, M. A., Manolas, K., Linger, W. G., Allen, J. M., Maggio, J. E., Sandberg, B. E. B., Bradley, C. V., Iversen, L. L., Santikarn, S., Williams, D. H., Hunter, J. C., Hanley, M. R., Magnusson, I., Thulin, L., Mandahl, Agneta, Bill, Anders, Manning, Maurice, Martensson, H., Akande, B., Stofer, P., Chappuis, G., Immer, H., Groog, P., Matthews, Margaret R., Connaughton, M., Moratalla, R., Nobin, Anders, Emson, Piers, Sundler, Frank, O'Donohue, T. L., Shults, C. W., Quirion, R., Moody, T. W., Chase, T. N., Otsuka, M., Konishi, S., Yanagisawa, M., Akagi, H., Otten, U., Rüegg, U. T., Pawlik, W., Konturek, S. J., Kania, J., Gustaw, P., Cosgrove, Patricia G., Pazoles, Christopher J., Priestley, J. V., Jensen, R. T., Pert, C. B., Regoli, D., Mizrahi, J., D'Orléans-Juste, P., Caranikas, S., Escher, E., Folkers, Karl, Rüegg, Urs T., Bishai, W. R., Saria, A., Rama Sastry, B. V., Jaiswal, Neelam, Tayeb, Osama S., Schultheiss, Hartmut, Hörig, Joachim, Scott, T. M., Shanahan, F., Befus, A. D., Fox, J., Denburg, J. A., Bienenstock, J., Sheppard, M. N., Kurian, S. S., Siegel, R. A., Weidenfeld, J., Globus, M., Melamed, E., Sjödin, L., Srivastava, G., Hall, Michael E., Suhar, A., Turk, V., Marks, N., Szkudlarek, U., Tarkkanen, A., Tervo, T., Tervo, K., Eränkö, L., Eränkö, O., Huang, W. -M., Morrison, J. F. B., Unger, W. G., Tessler, A., Himes, B. T., Murray, M., Goldberger, M. E., Torrens, Y., Beaujouan, J. C., Viger, A., Glowinski, J., Casanueva, F. F., Knuth, E., Havlicek, V., Friesen, H. G., Triepel, J., Weindl, A., Reinecke, M., Mader, J., Forssmann, W. G., Unger, Thomas, Becker, Hans, König, Manfred, Ganten, Detlev, Lang, Rudolf E., Vacca, L. L., Naftchi, N. E., Guan, X. -M., Ai, M. -K., Vijayan, E., Wang, Y. M., Mashford, M. L., Watson, Stephen P., Sandberg, Bengt E. B., Iversen, Leslie L., Weihe, E., Hartschuh, W., Kuchling, G., Winter, E. A., Keen, P., Yeo, C. J., Ylikoski, Jukka, Tervo, Timo, Tervo, Kaarina, Eränko, Liisa, and Cuello, Claudio

Published
1983
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41. Cardiac capsaicin-sensitive sensory nerves regulate myocardial relaxation via S-nitrosylation of SERCA: role of peroxynitrite

Author

Bencsik, P, Kupai, K, Giricz, Z, Görbe, A, Huliák, I, Fürst, S, Dux, L, Csont, T, Jancsó, G, and Ferdinandy, P

Subjects
Male, Nitric Oxide Synthase Type III, Superoxide Dismutase, Myocardium, Nitric Oxide, Research Papers, Ventricular Function, Left, Rats, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Peroxynitrous Acid, Animals, Calcium, Neurons, Afferent, RNA, Messenger, Capsaicin, Nitric Oxide Synthase, Rats, Wistar
Abstract

Sensory neuropathy develops in the presence of cardiovascular risk factors (e.g. diabetes, dyslipidemia), but its pathological consequences in the heart are unclear. We have previously shown that systemic sensory chemodenervation by capsaicin leads to impaired myocardial relaxation and diminished cardiac nitric oxide (NO) content. Here we examined the mechanism of diminished NO formation and if it may lead to a reduction of peroxynitrite (ONOO(-))-induced S-nitrosylation of sarcoendoplasmic reticulum Ca(2+)-ATPase (SERCA2a).Male Wistar rats were treated with capsaicin for 3 days to induce sensory chemodenervation. Seven days later, myocardial function and biochemical parameters were measured.Capsaicin pretreatment significantly increased left ventricular end-diastolic pressure (LVEDP) decreased cardiac NO level, Ca(2+)-dependent NO synthase (NOS) activity, and NOS-3 mRNA. Myocardial superoxide content, xanthine oxidoreductase and NADPH oxidase activities did not change, although superoxide dismutase (SOD) activity increased. Myocardial and serum ONOO(-) concentration and S-nitrosylation of SERCA2a were significantly decreased.Our results show that sensory chemodenervation decreases cardiac NO via decreased expression and activity of Ca(2+)-dependent NOS and increases SOD activity, thereby leading to decreased basal ONOO(-) formation and reduction of S-nitrosylation of SERCA2a, which causes impaired myocardial relaxation characterized by increased left ventricular end-diastolic pressure (LVEDP). This suggests that capsaicin sensitive sensory neurons regulate myocardial relaxation via maintaining basal ONOO(-) formation and SERCA S-nitrosylation.

Published
2007

44. Ischaemic postconditioning reduces serum and tubular TNF-α expression in ischaemic-reperfused kidney in healthy rats

Author

Miklós, Z., primary, Kürthy, M., additional, Degrell, P., additional, Ranczinger, E., additional, Vida, M., additional, Lantos, J., additional, Arató, E., additional, Sínay, L., additional, Hardi, P., additional, Balatonyi, B., additional, Ferencz, S., additional, Jávor, Sz., additional, Kovács, V., additional, Borsiczky, B., additional, Wéber, Gy., additional, Rőth, E., additional, and Jancsó, G., additional

Published
2012
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46. Effect of vitamin E on reperfusion injuries during reconstructive vascular operations on lower limbs

Author

Arató, E., primary, Kürthy, M., additional, Sínay, L., additional, Kasza, G., additional, Menyhei, G., additional, Hardi, P., additional, Masoud, S., additional, Ripp, K., additional, Szilágyi, K., additional, Takács, I., additional, Miklós, Z., additional, Bátor, A., additional, Lantos, J., additional, Kollár, L., additional, Rőth, E., additional, and Jancsó, G., additional

Published
2010
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49. Ischaemic postconditioning reduces peroxide formation, cytokine expression and leukocyte activation in reperfusion injury after abdominal aortic surgery in rat model

Author

Sínay, L., primary, Kürthy, M., additional, Horváth, Sz., additional, Arató, E., additional, Shafiei, M., additional, Lantos, J., additional, Ferencz, S., additional, Bátor, A., additional, Balatonyi, B., additional, Verzár, Zs., additional, Sütő, B., additional, Kollár, L., additional, Wéber, Gy., additional, Rőth, E., additional, and Jancsó, G., additional

Published
2008
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