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Your search keyword '"Jang, Eun-Hae"' showing total 17 results
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17 results on '"Jang, Eun-Hae"'

1. Integrated proteogenomic characterization of glioblastoma evolution

Author

Kim, Kyung-Hee, Migliozzi, Simona, Koo, Harim, Hong, Jun-Hee, Park, Seung Min, Kim, Sooheon, Kwon, Hyung Joon, Ha, Seokjun, Garofano, Luciano, Oh, Young Taek, D'Angelo, Fulvio, Kim, Chan Il, Kim, Seongsoo, Lee, Ji Yoon, Kim, Jiwon, Hong, Jisoo, Jang, Eun-Hae, Mathon, Bertrand, Di Stefano, Anna-Luisa, Bielle, Franck, Laurenge, Alice, Nesvizhskii, Alexey I., Hur, Eun-Mi, Yin, Jinlong, Shi, Bingyang, Kim, Youngwook, Moon, Kyung-Sub, Kwon, Jeong Taik, Lee, Shin Heon, Lee, Seung Hoon, Gwak, Ho Shin, Lasorella, Anna, Yoo, Heon, Sanson, Marc, Sa, Jason K., Park, Chul-Kee, Nam, Do-Hyun, Iavarone, Antonio, and Park, Jong Bae

Published
2024
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6. Neur1andNeur2are required for hippocampus‐dependent spatial memory and synaptic plasticity

Author

Lee, Jaehyun, primary, Yoon, Ki‐Jun, additional, Park, Pojeong, additional, Lee, Chaery, additional, Kim, Min Jung, additional, Han, Dae Hee, additional, Kim, Ji‐il, additional, Kim, Somi, additional, Lee, Hye‐Ryeon, additional, Lee, Yeseul, additional, Jang, Eun‐Hae, additional, Ko, Hyoung‐Gon, additional, Kong, Young‐Yun, additional, and Kaang, Bong‐Kiun, additional

Published
2020
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9. Neur1 and Neur2 are required for hippocampus‐dependent spatial memory and synaptic plasticity.

Author

Lee, Jaehyun, Yoon, Ki‐Jun, Park, Pojeong, Lee, Chaery, Kim, Min Jung, Han, Dae Hee, Kim, Ji‐il, Kim, Somi, Lee, Hye‐Ryeon, Lee, Yeseul, Jang, Eun‐Hae, Ko, Hyoung‐Gon, Kong, Young‐Yun, and Kaang, Bong‐Kiun

Subjects
SPATIAL memory, NEUROPLASTICITY, NOTCH signaling pathway, LONG-term synaptic depression, UBIQUITIN ligases, LONG-term potentiation
Abstract

Neur1 and Neur2, mouse homologs of the Drosophila neur gene, consist of two neuralized homology repeat domains and a RING domain. Both Neur1 and Neur2 are expressed in the whole adult brain and encode E3 ubiquitin ligases, which play a crucial role in the Notch signaling pathways. A previous study reported that overexpression of Neur1 enhances hippocampus‐dependent memory, whereas the role of Neur2 remains largely unknown. Here, we aimed to elucidate the respective roles of Neur1 and Neur2 in hippocampus‐dependent memory using three lines of genetically modified mice: Neur1 knock‐out, Neur2 knock‐out, and Neur1 and Neur2 double knock‐out (D‐KO). Our results showed that spatial memory was impaired when both Neur1 and Neur2 were deleted, but not in the individual knock‐out of either Neur1 or Neur2. In addition, basal synaptic properties estimated by input–output relationships and paired‐pulse facilitation did not change, but a form of long‐term potentiation that requires protein synthesis was specifically impaired in the D‐KO mice. These results collectively suggest that Neur1 and Neur2 are crucially involved in hippocampus‐dependent spatial memory and synaptic plasticity. [ABSTRACT FROM AUTHOR]

Published
2020
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11. Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

Author

Jeong, Ga Ram, primary, Jang, Eun-Hae, additional, Bae, Jae Ryul, additional, Jun, Soyoung, additional, Kang, Ho Chul, additional, Park, Chi-Hu, additional, Shin, Joo-Ho, additional, Yamamoto, Yukio, additional, Tanaka-Yamamoto, Keiko, additional, Dawson, Valina L., additional, Dawson, Ted M., additional, Hur, Eun-Mi, additional, and Lee, Byoung Dae, additional

Published
2018
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12. PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory

Author

Lim, Chae-Seok, primary, Nam, Hye Jin, additional, Lee, Jaehyun, additional, Kim, Dongha, additional, Choi, Ja Eun, additional, Kang, SukJae Joshua, additional, Kim, Somi, additional, Kim, Hyopil, additional, Kwak, Chuljung, additional, Shim, Kyu-Won, additional, Kim, Siyong, additional, Ko, Hyoung-Gon, additional, Lee, Ro Un, additional, Jang, Eun-Hae, additional, Yoo, Juyoun, additional, Shim, Jaehoon, additional, Islam, Md Ariful, additional, Lee, Yong-Seok, additional, Lee, Jae-Hyung, additional, Baek, Sung Hee, additional, and Kaang, Bong-Kiun, additional

Published
2017
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13. The Brain-Enriched MicroRNA miR-9-3p Regulates Synaptic Plasticity and Memory

Author

Sim, Su-Eon, primary, Lim, Chae-Seok, additional, Kim, Jae-Ick, additional, Seo, Daekwan, additional, Chun, Heejung, additional, Yu, Nam-Kyung, additional, Lee, Jaehyun, additional, Kang, SukJae Joshua, additional, Ko, Hyoung-Gon, additional, Choi, Jun-Hyeok, additional, Kim, TaeHyun, additional, Jang, Eun-Hae, additional, Han, Joohyun, additional, Bak, Myeong Seong, additional, Park, Jong-Eun, additional, Jang, Deok-Jin, additional, Baek, Daehyun, additional, Lee, Yong-Seok, additional, and Kaang, Bong-Kiun, additional

Published
2016
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17. In situ silver nanoparticle development for molecular-specific biological imaging via highly accessible microscopies.

Author

Song DH, Song CW, Chung J, Jang EH, Kim H, Hur Y, Hur EM, Kim D, and Chang JB

Abstract

In biological studies and diagnoses, brightfield (BF), fluorescence, and electron microscopy (EM) are used to image biomolecules inside cells. When compared, their relative advantages and disadvantages are obvious. BF microscopy is the most accessible of the three, but its resolution is limited to a few microns. EM provides a nanoscale resolution, but sample preparation is time-consuming. In this study, we present a new imaging technique, which we termed decoration microscopy (DecoM), and quantitative investigations to address the aforementioned issues in EM and BF microscopy. For molecular-specific EM imaging, DecoM labels proteins inside cells using antibodies bearing 1.4 nm gold nanoparticles (AuNPs) and grows silver layers on the AuNPs' surfaces. The cells are then dried without buffer exchange and imaged using scanning electron microscopy (SEM). Structures labeled with silver-grown AuNPs are clearly visible on SEM, even they are covered with lipid membranes. Using stochastic optical reconstruction microscopy, we show that the drying process causes negligible distortion of structures and that less structural deformation could be achieved through simple buffer exchange to hexamethyldisilazane. Using DecoM, we visualize the nanoscale alterations in microtubules by microtubule-severing proteins that cannot be observed with diffraction-limited fluorescence microscopy. We then combine DecoM with expansion microscopy to enable sub-micron resolution BF microscopy imaging. We first show that silver-grown AuNPs strongly absorb white light, and the structures labeled with them are clearly visible on BF microscopy. We then show that the application of AuNPs and silver development must follow expansion to visualize the labeled proteins clearly with sub-micron resolution., Competing Interests: The authors declare no competing financial interest., (This journal is © The Royal Society of Chemistry.)

Published
2022
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