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31 results on '"Jang, Mi Ok"'

6. Predictive Value of Procalcitonin for Bacterial Infection after Transarterial Chemoembolization or Radiofrequency Ablation for Hepatocellular Carcinoma

Author

Kang, Seung Ji, primary, Kim, Uh Jin, additional, Kim, Seong Eun, additional, An, Joon Hwan, additional, Jang, Mi Ok, additional, Myung, Dae-Seong, additional, Park, Kyung-Hwa, additional, Jung, Sook-In, additional, Cho, Sung Bum, additional, Jang, Hee-Chang, additional, and Joo, Young Eun, additional

Published
2018
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8. Treatment of BK virus-associated hemorrhagic cystitis with low-dose intravenous cidofovir in patients undergoing allogeneic hematopoietic cell transplantation

Author

Lee, Seung-Shin, primary, Ahn, Jae-Sook, additional, Jung, Sung-Hoon, additional, Ahn, Seo-Yeon, additional, Kim, Jae-Yong, additional, Jang, Hee-Chang, additional, Kang, Seung-Ji, additional, Jang, Mi-Ok, additional, Yang, Deok-Hwan, additional, Kim, Yeo-Kyeoung, additional, Lee, Je-Jung, additional, and Kim, Hyeoung-Joon, additional

Published
2015
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10. Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction

Author

Kim, Jong-Sun, primary, Lee, Wan-Sik, additional, Chung, Cho-Yun, additional, Park, Hyung-Chul, additional, Myung, Dae-Seong, additional, Oak, Chan-Young, additional, Kim, Mi-Young, additional, Jang, Mi-Ok, additional, Kang, Seung-Ji, additional, Jang, Hee-Chang, additional, Cho, Sung-Bum, additional, Kim, Hyun-Soo, additional, and Joo, Young-Eun, additional

Published
2015
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27. The Clinical Characteristics, Carbapenem Resistance, and Outcome of Acinetobacter Bacteremia According to Genospecies.

Author

Park, Kyung-Hwa, Shin, Jong-Hee, Lee, Seung Yeop, Kim, Soo Hyun, Jang, Mi Ok, Kang, Seung-Ji, Jung, Sook-In, Chung, Eun-Kyung, Ko, Kwan Soo, and Jang, Hee-Chang

Subjects
CARBAPENEMS, BACTEREMIA, MEDICAL microbiology, ACINETOBACTER baumannii, BACTERIAL diseases, COMMUNICABLE diseases, CLINICAL epidemiology, RETROSPECTIVE studies
Abstract

Background: Few clinical data are available on the relationship between genospecies and outcome of Acinetobacter bacteremia, and the results are inconsistent. We performed this study to evaluate the relationship between genospecies and the outcome of Acinetobacter bacteremia. Methods: Clinical data from 180 patients who had Acinetobacter bacteremia from 2003 to 2010 were reviewed retrospectively. The genospecies were identified by rpoB gene sequence analysis. The clinical features and outcomes of 90 patients with A. baumannii bacteremia were compared to those of 90 patients with non-baumannii Acinetobacter bacteremia (60 with A. nosocomialis, 17 with Acinetobacter species “close to 13 TU”, 11 with A. pittii, and two with A. calcoaceticus). Results: A. baumannii bacteremia was associated with intensive care unit-onset, mechanical ventilation, pneumonia, carbapenem resistance, and higher APACHE II scores, compared to non-baumannii Acinetobacter bacteremia (P<0.05). In univariate analyses, age, pneumonia, multidrug resistance, carbapenem resistance, inappropriate empirical antibiotics, higher APACHE II scores, and A. baumannii genospecies were risk factors for mortality (P<0.05). Multivariate analysis revealed A. baumannii genospecies (OR, 3.60; 95% CI, 1.56–8.33), age, pneumonia, and higher APACHE II scores to be independent risk factors for mortality (P<0.05). Conclusion: A. baumannii genospecies was an independent risk factor for mortality in patients with Acinetobacter bacteremia. Our results emphasize the importance of correct species identification of Acinetobacter blood isolates. [ABSTRACT FROM AUTHOR]

Published
2013
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28. Expression of the B Subunit of E. coliHeat-labile Enterotoxin in the Chloroplasts of Plants and its Characterization

Author

Kang, Tae-Jin, Loc, Nguyen-Hoang, Jang, Mi-Ok, Jang, Yong-Suk, Kim, Young-Sook, Seo, Jo-Eun, and Yang, Moon-Sik

Abstract

Transgenic chloroplasts have become attractive systems for heterologous gene expressions because of unique advantages. Here, we report a feasibility study for producing the nontoxic B subunit of Escherichia coliheat-labile enterotoxin (LTB) viachloroplast transformation of tobacco. Stable site-specific integration of the LTB gene into chloroplast genome was confirmed by PCR and genomic Southern blot analysis in transformed plants. Immunoblot analysis indicated that plant-derived LTB protein was oligomeric, and dissociated after boiling. Pentameric LTB molecules were the dominant molecular species in LTB isolated from transgenic tobacco leaf tissues. The amount of LTB protein detected in transplastomic tobacco leaf was approximately 2.5% of the total soluble plant protein, approximately 250-fold higher than in plants generated via nuclear transformation. The GM1–ELISA binding assay indicated that chloroplast-synthesized LTB protein bound to GM1-ganglioside receptors. LTB protein with biochemical properties identical to native LTB protein in the chloroplast of edible plants opens the way for inexpensive, safe, and effective plant-based edible vaccines for humans and animals.

Published
2003
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29. Refractory Clostridium difficile Infection Cured With Fecal Microbiota Transplantation in Vancomycin-Resistant Enterococcus Colonized Patient.

Author

Jang MO, An JH, Jung SI, and Park KH

Abstract

The rates and severity of Clostridium difficile infections, including pseudomembranous colitis, have increased markedly. However, there are few effective treatments for refractory or recurrent C. difficile infections and the outcomes are poor. Fecal microbiota transplantation is becoming increasingly accepted as an effective and safe intervention in patients with recurrent disease, likely due to the restoration of a disrupted microbiome. Cure rates of >90% are being consistently reported from multiple centers. We cured a case of severe refractory C. difficile infection with fecal microbiota transplantation in a patient colonized by vancomycin-resistant enterococcus.

Published
2015
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30. Inappropriateness of quinolone in scrub typhus treatment due to gyrA mutation in Orientia tsutsugamushi Boryong strain.

Author

Jang HC, Choi SM, Jang MO, Ahn JH, Kim UJ, Kang SJ, Shin JH, Choy HE, Jung SI, and Park KH

Subjects
Aged, Aged, 80 and over, Amino Acid Sequence, Doxycycline therapeutic use, Drug Resistance, Bacterial, Female, Genotype, Humans, Male, Middle Aged, Molecular Sequence Data, Mutation, Orientia tsutsugamushi classification, Orientia tsutsugamushi enzymology, Phylogeny, Prospective Studies, Sequence Alignment, Sequence Analysis, DNA, Anti-Bacterial Agents therapeutic use, Bacterial Proteins genetics, Ciprofloxacin therapeutic use, DNA Gyrase genetics, Orientia tsutsugamushi genetics, Scrub Typhus drug therapy
Abstract

The use of quinolone for treatment of rickettsial diseases remains controversial. Recent clinical studies suggest that quinolone is not as effective as others in patients with rickettsial diseases including scrub typhus, although the mechanism is not well understood. In this study, we evaluated the mutation in gyrA associated with quinolone resistance. We prospectively enrolled scrub typhus patients, collected blood samples and clinical data from October, 2010 to November, 2011. Among the 21 patients enrolled, one initially received ciprofloxacin for 3 days but was switched to doxycycline due to clinical deterioration. We obtained the gyrA gene of Orientia tsutsugamushi from 21 samples (20 Boryong strain, 1 Kato strain) and sequenced the quinolone resistance-determining region. All of 21 samples had the Ser83Leu mutation in the gyrA gene, which is known to be associated with quinolone resistance. This suggests that quinolones may be avoided for the treatment of serious scrub typhus.

Published
2013
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31. Lemierre Syndrome Caused by Arcanobacterium haemolyticum Alone in a Healthy Man.

Author

Lee KJ, Kim EJ, Kang SJ, Jang MO, Jang HC, Jung SI, Shin JH, and Park KH

Abstract

Arcanobacterium haemolyticum was isolated from the blood cultures of a previously healthy 37-year-old man who met all the criteria of Lemierre syndrome, including a primary oropharyngeal infection, evidence of thrombophlebitis of the internal jugular vein, and metastatic infections. To the best of our knowledge, this is the first case of Lemierre syndrome caused by A. haemolyticum in Korea and shows that A. haemolyticum alone can cause Lemierre syndrome.

Published
2012
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