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4. Preoperative 11C-Methionine PET-MRI in Pediatric Infratentorial Tumors

Author

Beuriat, Pierre-Aurélien, Flaus, Anthime, Portefaix, Aurélie, Szathmari, Alexandru, Janier, Marc, Hermier, Marc, Lorthois-Ninou, Sylvie, Scheiber, Christian, Isal, Sibel, Costes, Nicolas, Merida, Ines, Lancelot, Sophie, Vasiljevic, Alexandre, Leblond, Pierre, Faure Conter, Cécile, Saunier, Clarisse, Kassai, Behrouz, Vinchon, Matthieu, Di Rocco, Federico, and Mottolese, Carmine

Published
2024
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6. AGuIX® from bench to bedside—Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Author

Lux, François, Tran, Vu Long, Thomas, Eloïse, Dufort, Sandrine, Rossetti, Fabien, Martini, Matteo, Truillet, Charles, Doussineau, Tristan, Bort, Guillaume, Denat, Franck, Boschetti, Frédéric, Angelovski, Goran, Detappe, Alexandre, Crémillieux, Yannick, Mignet, Nathalie, Doan, Bich-Thuy, Larrat, Benoit, Meriaux, Sébastien, Barbier, Emmanuel, Roux, Stéphane, Fries, Peter, Müller, Andreas, Abadjian, Marie-Caline, Anderson, Carolyn, Canet-Soulas, Emmanuelle, Bouziotis, Penelope, Barberi-Heyob, Muriel, Frochot, Céline, Verry, Camille, Balosso, Jacques, Evans, Michael, Sidi-Boumedine, Jacqueline, Janier, Marc, Butterworth, Karl, McMahon, Stephen, Prise, Kevin, Aloy, Marie-Thérèse, Ardail, Dominique, Rodriguez-Lafrasse, Claire, Porcel, Erika, Lacombe, Sandrine, Berbeco, Ross, Allouch, Awatef, Perfettini, Jean-Luc, Chargari, Cyrus, Deutsch, Eric, Le Duc, Géraldine, and Tillement, Olivier

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Nanotechnology, Cancer, Bioengineering, Rare Diseases, Animals, Brain Neoplasms, Forecasting, Gadolinium, Head and Neck Neoplasms, Humans, Melanoma, Mice, Nanoparticles, Radiation-Sensitizing Agents, Theranostic Nanomedicine, Clinical Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences, Oncology and carcinogenesis
Abstract

AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been observed with different types of irradiations in vitro and in vivo on a large number of cancer types (brain, lung, melanoma, head and neck…). The review concludes with the second generation of AGuIX nanoparticles and the first preliminary results on human.

Published
2019

7. Clinical features and outcome in patients with functional head and neck paragangliomas: French national cohort and literature review

Author

Pinigina, Iuliia, primary, Ceruse, Philippe, additional, Herman, Philippe, additional, Catherine, Cardot, additional, Haissaguerre, Magalie, additional, Cornu, Erika, additional, Amar, Laurence, additional, Batisse-Lignier, Marie, additional, Chardon, Laurence, additional, Barraud, Sara, additional, Feuvret, Loic, additional, Janier, Marc, additional, Helene, Lasolle, additional, Borson-Chazot, Francoise, additional, and Juliette, Abeillon, additional

Published
2024
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11. Outcome on Mesenteric Mass Response of Small-Intestinal Neuroendocrine Tumors Treated by177Lu-DOTATATE Peptide Receptor Radionuclide Therapy: The MesenLuth Study, a National Study from the French Group of Endocrine Tumors and Endocan-RENATEN Network

Author

Al Mansour, Laure, primary, De Mestier, Louis, additional, Haissaguerre, Magalie, additional, Afchain, Pauline, additional, Hadoux, Julien, additional, Lecomte, Thierry, additional, Morland, David, additional, Cottereau, Anne Segolene, additional, De Rycke, Ophelie, additional, Tlili, Ghoufrane, additional, Tordo, Jérémie, additional, Janier, Marc, additional, Deville, Agathe, additional, and Walter, Thomas, additional

Published
2024
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12. Preoperative 11 C-Methionine PET-MRI in Pediatric Infratentorial Tumors.

Author

Beuriat, Pierre-Aurélien, Flaus, Anthime, Portefaix, Aurélie, Szathmari, Alexandru, Janier, Marc, Hermier, Marc, Lorthois-Ninou, Sylvie, Scheiber, Christian, Isal, Sibel, Costes, Nicolas, Merida, Ines, Lancelot, Sophie, Vasiljevic, Alexandre, Leblond, Pierre, Faure Conter, Cécile, Saunier, Clarisse, Kassai, Behrouz, Vinchon, Matthieu, Di Rocco, Federico, and Mottolese, Carmine

Published
2024
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15. Deep‐learning predicted PET can be subtracted from the true clinical fluorodeoxyglucose PET co‐registered to MRI to identify the epileptogenic zone in focal epilepsy

Author

Flaus, Anthime, primary, Jung, Julien, additional, Ostrowky‐Coste, Karine, additional, Rheims, Sylvain, additional, Guénot, Marc, additional, Bouvard, Sandrine, additional, Janier, Marc, additional, Yaakub, Siti N, additional, Lartizien, Carole, additional, Costes, Nicolas, additional, and Hammers, Alexander, additional

Published
2023
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17. Outcome on Mesenteric Mass Response of Small-Intestinal Neuroendocrine Tumors Treated by 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy: The MesenLuth Study, a National Study from the French Group of Endocrine Tumors and Endocan-RENATEN Network.

Author

Al Mansour, Laure, De Mestier, Louis, Haissaguerre, Magalie, Afchain, Pauline, Hadoux, Julien, Lecomte, Thierry, Morland, David, Cottereau, Anne Segolene, De Rycke, Ophelie, Tlili, Ghoufrane, Tordo, Jérémie, Janier, Marc, Deville, Agathe, and Walter, Thomas

Published
2024
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25. PET image enhancement using artificial intelligence for better characterization of epilepsy lesions

Author

Flaus, Anthime, Deddah, Tahya, Reilhac, Anthonin, Leiris, Nicolas De, Janier, Marc, Merida, Ines, Grenier, Thomas, McGinnity, Colm J., Hammers, Alexander, Lartizien, Carole, and Costes, Nicolas

Subjects
General Medicine
Abstract

Introduction[18F]fluorodeoxyglucose ([18F]FDG) brain PET is used clinically to detect small areas of decreased uptake associated with epileptogenic lesions, e.g., Focal Cortical Dysplasias (FCD) but its performance is limited due to spatial resolution and low contrast. We aimed to develop a deep learning-based PET image enhancement method using simulated PET to improve lesion visualization.MethodsWe created 210 numerical brain phantoms (MRI segmented into 9 regions) and assigned 10 different plausible activity values (e.g., GM/WM ratios) resulting in 2100 ground truth high quality (GT-HQ) PET phantoms. With a validated Monte-Carlo PET simulator, we then created 2100 simulated standard quality (S-SQ) [18F]FDG scans. We trained a ResNet on 80% of this dataset (10% used for validation) to learn the mapping between S-SQ and GT-HQ PET, outputting a predicted HQ (P-HQ) PET. For the remaining 10%, we assessed Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index Measure (SSIM), and Root Mean Squared Error (RMSE) against GT-HQ PET. For GM and WM, we computed recovery coefficients (RC) and coefficient of variation (COV). We also created lesioned GT-HQ phantoms, S-SQ PET and P-HQ PET with simulated small hypometabolic lesions characteristic of FCDs. We evaluated lesion detectability on S-SQ and P-HQ PET both visually and measuring the Relative Lesion Activity (RLA, measured activity in the reduced-activity ROI over the standard-activity ROI). Lastly, we applied our previously trained ResNet on 10 clinical epilepsy PETs to predict the corresponding HQ-PET and assessed image quality and confidence metrics.ResultsCompared to S-SQ PET, P-HQ PET improved PNSR, SSIM and RMSE; significatively improved GM RCs (from 0.29 ± 0.03 to 0.79 ± 0.04) and WM RCs (from 0.49 ± 0.03 to 1 ± 0.05); mean COVs were not statistically different. Visual lesion detection improved from 38 to 75%, with average RLA decreasing from 0.83 ± 0.08 to 0.67 ± 0.14. Visual quality of P-HQ clinical PET improved as well as reader confidence.ConclusionP-HQ PET showed improved image quality compared to S-SQ PET across several objective quantitative metrics and increased detectability of simulated lesions. In addition, the model generalized to clinical data. Further evaluation is required to study generalization of our method and to assess clinical performance in larger cohorts.

Published
2022
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26. Proof of Concept of the Radiosensitizing Effect of Gadolinium Oxide Nanoparticles in Cell Spheroids and a Tumor-Implanted Murine Model of Chondrosarcoma

Author

Aloy, Marie-Thérèse, primary, Sidi Boumedine, Jacqueline, additional, Deville, Agathe, additional, Kryza, David, additional, Gauthier, Arnaud, additional, Brichart-Vernos, Delphine, additional, Ollier, Grégoire, additional, La Padula, Veronica, additional, Lux, François, additional, Tillement, Olivier, additional, Rodriguez-Lafrasse, Claire, additional, and Janier, Marc, additional

Published
2022
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29. A Strategy to Quantitatively Evaluate MRI/PET Cardiac Rigid Registration Methods Using a Monte Carlo Simulator

Author

Pauna, Nicoleta, Croisille, Pierre, Costes, Nicolas, Reilhac, Anthonin, Mäkelä, Timo, Cozar, Onuc, Janier, Marc, Clarysse, Patrick, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Magnin, Isabelle E., editor, Montagnat, Johan, editor, Clarysse, Patrick, editor, Nenonen, Jukka, editor, and Katila, Toivo, editor

Published
2003
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30. Disappearance of FDG uptake on PET scan after antimicrobial therapy could help for the diagnosis of Coxiella burnetii spondylodiscitis

Author

Gaudé, Marine, Julien, Saison, Laurent, Frédéric, Ferry, Tristan, Perpoint, Thomas, Boibieux, André, Biron, François, Ader, Florence, Valour, Florent, Roux, Sandrine, Daoud, Fatiha, Lippman, Johanna, Braun, Evelyne, Vallat, Marie-Paule, Miailhes, Patrick, Chidiac, Christian, Gillet, Yves, Hees, Laure, Lustig, Sébastien, Neyret, Philippe, Reynaud, Olivier, Peltier, Adrien, Viste, Anthony, Bérard, Jean-Baptiste, Dalat, Frédéric, Cantin, Olivier, Desmarchelier, Romain, Vermersch, Thibault, Fessy, Michel-Henry, Barrey, Cédric, Signorelli, Francesco, Jouanneau, Emmanuel, Jacquesson, Timothée, Mojallal, Ali, Boucher, Fabien, Shipkov, Hristo, Ismail, Mehdi, Chateau, Joseph, Vandenesch, François, Rasigade, Jean-Philippe, Dupieux, Céline, Trouillet-Assant, Sophie, Morelec, Isabelle, Janier, Marc, Giammarile, Francesco, Tod, Michel, Gagnieu, Marie-Claude, Goutelle, Sylvain, and Mabrut, Eugénie

Published
2016
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32. Proof of Concept of the Radiosensitizing Effect of Gadolinium Oxide Nanoparticles in Cell Spheroids and a Tumor-Implanted Murine Model of Chondrosarcoma

Author

Aloy,Marie-Thérèse, Sidi Boumedine,Jacqueline, Deville,Agathe, Kryza,David, Gauthier,Arnaud, Brichart-Vernos,Delphine, Ollier,Grégoire, La Padula,Veronica, Lux,François, Tillement,Olivier, Rodriguez-Lafrasse,Claire, Janier,Marc, Aloy,Marie-Thérèse, Sidi Boumedine,Jacqueline, Deville,Agathe, Kryza,David, Gauthier,Arnaud, Brichart-Vernos,Delphine, Ollier,Grégoire, La Padula,Veronica, Lux,François, Tillement,Olivier, Rodriguez-Lafrasse,Claire, and Janier,Marc

Abstract

Marie-Thérèse Aloy,1,* Jacqueline Sidi Boumedine,2,* Agathe Deville,2,3 David Kryza,2 Arnaud Gauthier,1,4 Delphine Brichart-Vernos,1,5 Grégoire Ollier,1 Veronica La Padula,5 François Lux,5 Olivier Tillement,5 Claire Rodriguez-Lafrasse,1,4,* Marc Janier2,3,* 1Laboratory of Cellular and Molecular Radiobiology, UMR CNRS5822/IP2I, Lyon-Sud Medical School, Univ Lyon, Lyon 1 University, Oullins, France; 2CNRS, LAGEPP, UMR5007, IMTHERNAT, Lyon 1 University, Hospital Edouard Herriot, Lyon, France; 3Department of Nuclear Medicine, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France; 4Department of Biochemistry and Molecular Biology, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France; 5Light Matter Institut UMR CNRS 5306, Lyon 1 University, Villeurbanne, France*These authors contributed equally to this workCorrespondence: Marc Janier, Department of Nuclear Medicine, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, 69634, France, Tel +33472356999, Fax +33472357345, Email marc.janier@univ-lyon1.frPurpose: Chondrosarcomas (CHSs), which represent 20% of primary bone tumors in adults, are mostly resistant to radio- and chemotherapy. It is therefore essential that new therapeutic approaches, targeted to the tumour, be developed to improve the prognosis of patients. The effectiveness, as a radiosensitizing agent, of gadolinium oxide nanoparticles (GdoNP, AGuIX®) nanoparticles in CHS was evaluated in vitro, in spheroid CHS models allowing to reproduce cell-cell extracellular matrix interactions, and, in vivo, in a nude mouse model with heterotopic tumour xenograft.Methods: Spheroids from SW1353 and HEMC-SS cells were characterized by confocal microscopy with or without GdoNP treatment. Real-time microscopy enabled quantification of cell viability, cell migration and invasion. In vivo, the efficacy of the association of GdoNP combined with a single (4Gy) or fractionated (4x1Gy) irradiation wa

Published
2022

34. Semi-quantitative analysis of visually normal 123I-FP-CIT across three large databases revealed no difference between control and patients.

Author

Flaus, Anthime, Philippe, Remi, Thobois, Stephane, Janier, Marc, and Scheiber, Christian

Subjects
DATABASES, DATA harmonization, SINGLE-photon emission computed tomography, INDEPENDENT variables, DEPENDENT variables
Abstract

Background: To show the equivalence between the specific binding ratios (SBR) of visually normal 123I-FP-CIT SPECT scans from patients to those from healthy volunteers (Hv) or patients without dopaminergic degeneration to allow their use as a reference database. Methods: The SBR values of visually normal SPECT scans from 3 groups were studied: (1) suspected Parkinsonism and no diagnostic follow-up (ScanOnlyDB: n = 764, NM/CT 670 CZT, GE Healthcare), (2) no degenerative dopaminergic pathology after a 5-year follow-up (NoDG5YearsDB: n = 237, Symbia T2, Siemens Medical Solutions), and 3) Hv (HvDB: n = 118, commercial GE database). A general linear model (GLM) was constructed with caudate, putamen, and striatum SBR as the dependent variables, and age and gender as the independent variables. Following post-reconstruction harmonization of the data, DB were combined in pairs, ScanOnlyDB&NoDG5yearsDG and ScanOnlyDB&HvDB before performing GLM analysis. Additionally, ScanOnlyDB GLM estimates were compared to those published from Siemens commercial DB (SiemensDB) and ENC-DAT. Results: The dispersion parameters, R2 and the SBR coefficients of variation, did not differ between databases. For all volumes of interest and all databases, SBR decreased significantly with age (e.g., decrease per decade for the striatum: − 4.94% for ScanOnlyDB, − 4.65% for NoDG5YearsDB, − 5.69% for HvDB). There was a significant covariance between SBR and gender for ScanOnlyDB (P < 10–5) and NoDG5YearsDB (P < 10–2). The age-gender interaction was significant only for ScanOnlyDB (P < 10–2), and the p-value decreased to 10–6 after combining ScanOnlyDB with NoDG5YearsDB. ScanOnlyDB GLM estimates were not significantly different from those from SiemensDB or ENC-DAT except for age-gender interaction. Conclusion: SBR values distribution from visually normal scans were not different from the existing reference database, enabling this method to create a reference database by expert nuclear physicians. In addition, it showed a rarely described age-gender interaction related to its size. The proposed post-reconstruction harmonization method can also facilitate the use of semi-quantitative analysis. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Reactivation of Clostridium tertium bone infection 30 years after the Iran–Iraq war

Author

Virot, Emilie, Servien, Elvire, Laurent, Frederic, Ferry, Tristan, Perpoint, Thomas, Boibieux, André, Biron, François, Ader, Florence, Saison, Julien, Valour, Florent, Daoud, Fatiha, Lippman, Johanna, Braun, Evelyne, Vallat, Marie-Paule, Miailhes, Patrick, Chidiac, Christian, Peyramond, Dominique, Lustig, Sébastien, Neyret, Philippe, Reynaud, Olivier, Debette, Caroline, Peltier, Adrien, Viste, Anthony, Bérard, Jean-Baptiste, Dalat, Frédéric, Cantin, Olivier, Desmarchelier, Romain, Fessy, Michel-Henry, Barrey, Cédric, Signorelli, Francesco, Jouanneau, Emmanuel, Jacquesson, Timothée, Breton, Pierre, Mojallal, Ali, Boucher, Fabien, Shipkov, Hristo, Vandenesch, François, Rasigade, Jean-Philippe, Dupieux, Céline, Boussel, Loïc, Pialat, Jean-Baptiste, Morelec, Isabelle, Janier, Marc, Giammarile, Francesco, Tod, Michel, Gagnieu, Marie-Claude, Goutelle, Sylvain, and Mabrut, Eugénie

Published
2015
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36. A 22-year-old woman with right lumpy jaw syndrome and fistula

Author

Valour, F, Chidiac, C, Ferry, T, Ferry, Tristan, Perpoint, Thomas, Boibieux, André, Biron, François, Ader, Florence, Saison, Julien, Valour, Florent, Daoud, Fatiha, Lippman, Johanna, Braun, Evelyne, Vallat, Marie-Paule, Miailhes, Patrick, Chidiac, Christian, Peyramond, Dominique, Lustig, Sébastien, Neyret, Philippe, Reynaud, Olivier, Debette, Caroline, Peltier, Adrien, Viste, Anthony, Bérard, Jean-Baptiste, Dalat, Frédéric, Cantin, Olivier, Desmarchelier, Romain, Vermersch, Thibault, Fessy, Michel-Henry, Barrey, Cédric, Signorelli, Francesco, Jouanneau, Emmanuel, Jacquesson, Timothée, Breton, Pierre, Mojallal, Ali, Boucher, Fabien, Shipkov, Hristo, Laurent, Frederic, Vandenesch, François, Rasigade, Jean-Philippe, Dupieux, Céline, Morelec, Isabelle, Janier, Marc, Giammarile, Francesco, Tod, Michel, Gagnieu, Marie-Claude, Goutelle, Sylvain, and Mabrut, Eugénie

Published
2015
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37. Pristinamycin in the treatment of MSSA bone and joint infection

Author

Valour, Florent, Boibieux, André, Karsenty, Judith, Vallat, Marie-Paule, Braun, Evelyne, Perpoint, Thomas, Biron, François, Laurent, Frédéric, Lustig, Sébastien, Chidiac, Christian, Ferry, Tristan, Ader, Florence, Biron, François, Boibieux, André, Braun, Evelyne, Chidiac, Christian, Daoud, Fatiha, Ferry, Tristan, Gillet, Yves, Hees, Laure, Lippmann, Johanna, Miailhes, Patrick, Perpoint, Thomas, Roux, Sandrine, Saison, Julien, Vallat, Marie-Paule, Valour, Florent, Barrey, Cédric, Bérard, Jean-Baptiste, Boucher, Fabien, Breton, Pierre, Cantin, Olivier, Dalat, Frédéric, Desmarchelier, Romain, Fessy, Michel-Henry, Jacquesson, Timothée, Jouanneau, Emmanuel, Lustig, Sébastien, Mojallal, Ali, Neyret, Philippe, Peltier, Adrien, Reynaud, Olivier, Shipkov, Hristo, Signorelli, Francesco, Vermersch, Thibault, Viste, Anthony, Dupieux, Céline, Laurent, Frederic, Rasigade, Jean-Philippe, Vandenesch, François, Giammarile, Francesco, Janier, Marc, Morelec, Isabelle, Gagnieu, Marie-Claude, Goutelle, Sylvain, Tod, Michel, and Mabrut, Eugénie

Published
2016
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39. Chronic Propionibacterium acnes prosthesis joint infection manifesting as a large abscess with gas, without prosthesis loosening

Author

Lorillou, Marjolie, Martha, Benoit, Chidiac, Christian, Ferry, Tristan, Ferry, Tristan, Perpoint, Thomas, Boibieux, André, Biron, François, Ader, Florence, Karsenty, Judith, Valour, Florent, Daoud, Fatiha, Lippman, Johanna, Braun, Evelyne, Vallat, Marie-Paule, Miailhes, Patrick, Chidiac, Christian, Peyramond, Dominique, Lustig, Sébastien, Neyret, Philippe, Guyen, Olivier, Bérard, Jean-Baptiste, Desmarchelier, Romain, Fessy, Michel-Henry, Barrey, Cédric, Signorelli, Francesco, Breton, Pierre, Mojallal, Ali, Boucher, Fabien, Laurent, Frederic, Vandenesch, François, Rasigade, Jean-Philippe, Morelec, Isabelle, Janier, Marc, Giammarile, Francesco, Tod, Michel, Gagnieu, Marie-Claude, Goutelle, Sylvain, and Mabrut, Eugénie

Published
2013
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42. Prognostic Impact of 18F-FDG PET/CT in Patients With Aggressive B-Cell Lymphoma Treated With Anti-CD19 Chimeric Antigen Receptor T Cells

Author

Sesques, Pierre, primary, Tordo, Jérémie, additional, Ferrant, Emmanuelle, additional, Safar, Violaine, additional, Wallet, Florent, additional, Dhomps, Anthony, additional, Brisou, Gabriel, additional, Bouafia, Fadhela, additional, Karlin, Lionel, additional, Ghergus, Dana, additional, Golfier, Camille, additional, Lequeu, Helène, additional, Lazareth, Anne, additional, Vercasson, Marlène, additional, Hospital-Gustem, Carole, additional, Schwiertz, Vérane, additional, Choquet, Marion, additional, Sujobert, Pierre, additional, Novelli, Silvana, additional, Mialou, Valérie, additional, Hequet, Olivier, additional, Carras, Sylvain, additional, Fouillet, Ludovic, additional, Lebras, Laure, additional, Guillermin, Yann, additional, Leyronnas, Cécile, additional, Cavalieri, Doriane, additional, Janier, Marc, additional, Ghesquières, Hervé, additional, Salles, Gilles, additional, and Bachy, Emmanuel, additional

Published
2021
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44. Hybrid gadolinium oxide nanoparticles: Multimodal contrast agents for in vivo imaging

Author

Bridol, Jean-Luc, Faure, Anne-Charlotte, Laurent, Sophie, Riviere, Charlotte, Billotey, Claire, Hiba, Bassem, Tillement, Olivier, Janier, Marc, Josserand, Veronique, Coll, Jean-Luc, Elst, Luce Vander, Muller, Robert, Roux, Stephane, and Perriat, Pascal

Subjects
Gadolinium -- Chemical properties, Gadolinium -- Magnetic properties, Nanoparticles -- Magnetic properties, Nanoparticles -- Chemical properties, Contrast media -- Chemical properties, Contrast media -- Magnetic properties, Chemistry
Abstract

Various luminescent hybrid nanoparticles with a paramagnetic gadolinium oxide core, which are encapsulated within a polysiloxane shell, are applied and used as multimodal contrast agents for in vivo fluorescence, as well as magnetic resonance imaging. The analysis reveals that all these particles are suited for dual modality imaging and hence can be freely circulated in the blood vessels without being accumulated in the lungs and liver.

Published
2007

45. Mechanisms leading to reversible mechanical dysfunction in severe CAD: alternatives to myocardial stunning

Author

Mazzadi, Alejandro N., Andre-Fouet, Xavier, Costes, Nicolas, Croisille, Pierre, Revel, Didier, and Janier, Marc F.

Subjects
Coronary heart disease -- Research, Coronary heart disease -- Risk factors, Imaging systems -- Usage, Heart muscle -- Research, Biological sciences
Abstract

Patients with severe chronic coronary artery disease (CAD) exhibit a highly altered myocardial pattern of perfusion, metabolism, and mechanical performance. In this context, the diagnosis of stunning remains elusive not only because of methodological and logistic considerations, but also because of the pathophysiological characteristics of the myocardium of these patients. In addition, a number of alternative pathophysiological mechanisms may act by mimicking the functional manifestations usually attributed to stunning. The present review describes three mechanisms that could theoretically lead to reversible mechanical dysfunction in these patients: myocardial wall stress, the tethering effect, and myocardial expression and release of auto- and paracrine agents. Attention is focused on the role of these mechanisms in scintigraphically 'normal' regions (i.e., regions usually showing normal perfusion, glucose metabolism, and cellular integrity as assessed by nuclear imaging techniques), in which stunning is usually considered, but these mechanisms could also operate throughout the viable myocardium. We hypothesize that reversion of these three mechanisms could partially explain the unexpected functional benefit after reperfusion recently high-lighted by high-spatial-resolution imaging techniques. stunned myocardium; hibernating myocardium; inotropic reserve; cardiac imaging; myocardial wall stress; ventricular remodeling

Published
2006

46. Automated seeds location for whole body NaF PET segmentation

Author

Grenier, Thomas, Revol-Muller, Chantal, Costes, Nicolas, Janier, Marc, and Gimenez, Gerard

Subjects
PET imaging -- Analysis, Image processing -- Methods, Image processing -- Analysis, Business, Electronics, Electronics and electrical industries
Abstract

[sup.18]F-labeled NaF, also called [[sup.18]F] fluoride ion, Positron Emission Tomography (NaF PET) is a specific imaging modality of bone activity and allows bone tumor detection. In this paper, we propose a fast-automated method for the location of anatomical structures by special planes and seeds in whole body NaF PET images. This step is crucial in registration and segmentation processes such as region growing. Our method proceeds in two steps: first, it delineates anatomical objects such as bladder, skull, spine and legs with two horizontal planes (bottom and top); secondly, it determines labeled seeds in these objects. Processes are based on the analysis of the Slice Energy (SE) and the computation of the Center of Gravity (CG) of all transverse slices. This method was applied to seeds initialization in order to segment the whole skeleton. This segmentation could be helpful for bone tumors detection and bone uptake quantification. Fast and satisfying results are obtained. Robustness of our method was positively tested on a set of seven NaF PET images. Index Terms--Image segmentation, PET image analysis, region growing.

Published
2005

49. Tagged MRI and PET in severe CAD: discrepancy between preoperative inotropic reserve and intramyocardial functional outcome after revascularization

Author

Mazzadi, Alejandro N., Janier, Marc F., Brossier, Benjamin, Andre-Fouet, Xavier, Revel, Didier, and Croisille, Pierre

Subjects
PET imaging -- Research, Magnetic resonance imaging -- Research, Cardiology -- Research, Biological sciences
Abstract

Tagged MRI and PET in severe CAD: discrepancy between preoperative inotropic reserve and intramyocardial functional outcome after revascularization. Am J Physiol Heart Circ Physiol 287: H2226-H2233, 2004. First published July 1, 2004; doi:10.1152/ajpheart.00263. 2004.--In severe coronary artery disease (CAD), it has been shown that intramyocardial inotropic reserve as assessed with tagged magnetic resonance imaging (MRI) is uniformly distributed among positron emission tomography (PET) patterns reflecting normal or concomitant reductions in perfusion and glucose metabolism. This preliminary study aimed to delineate the relationship between preoperative values of intramyocardial inotropic reserve (in different PET patterns of perfusion and glucose uptake) and intramyocardial functional outcome after surgical revascularization in severe CAD. Twelve patients underwent preoperative tagged MRI (baseline, 10 [micro]g*[kg.sup.-1]*[min.sup.-1] of dobutamine), [H.sub.2][sup.15]O/[[sup.18]F]fluorodeoxyglucose PET imaging, and postoperative resting tagged MRI. Regional midmyocardial circumferential shortening ([E.sub.cc], in %) and PET patterns (normal, match viable, mismatch viable, and infarcted) were assessed in three tagged MRI/PET short-axis slices. [E.sub.cc] at baseline ranged from 12 [+ or -] 6 to 8 [+ or -] 5 and 4 [+ or -] 4% in normal, match-viable, and infarcted regions, respectively (P < 0.05) and was 8 [+ or -] 5% in mismatch-viable regions. Of the 429 regions studied, 187 showed preoperative inotropic reserve with dobutamine, but 238 showed postoperative functional improvement. Postoperative functional improvement was less common in infarcted regions (41 vs. ~60% in the other PET patterns), but the extent of improvement was similar among PET patterns (~6%). Postoperative functional improvement occurred in 53% of all (normal, match viable, and mismatch viable) regions without inotropic reserve. In severe CAD, revascularization affords greater intramyocardial functional benefit than expected from the evaluation of intramyocardial inotropic reserve with low-dose dobutamine. Postoperative functional improvement in PET-viable regions without inotropic reserve suggests that factors other than regionally enhanced perfusion contribute to such functional improvement. magnetic resonance imaging; positron emission tomography; dobutamine; myocardial viability

Published
2004

50. Thyroid hormone receptor [alpha] is a molecular switch of cardiac function between fetal and postnatal life

Author

Mai, Wilfried, Janier, Marc F., Allioli, Nathalie, Quignodon, Laure, Chuzel, Thomas, Flamant, Frederic, and Samarut, Jacques

Subjects
Thyroid hormones -- Research, Thyroid hormones -- Genetic aspects, Science and technology, National Academy of Sciences -- Research
Abstract

Thyroid hormones are involved in the regulation of many physiological processes and regulate gene transcription by binding to their nuclear receptors TR[alpha] and TR[beta]. In the absence of triiodothyronine (T3), the unliganded receptors (aporeceptors) do bind DNA and repress the transcription of target genes. The role of thyroid hormone aporeceptors as repressors was observed in hypothyroid adult mice, but its physiological relevance in nonpathological hypothyroid conditions remained to be determined. Here we show that, in the normal mouse fetus, TR[alpha] aporeceptors repress heart rate as well as the expression of TR[beta] and several genes encoding ion channels involved in cardiac contractile activity. Right after birth, when T3 concentration sharply increases, liganded TR[alpha] (holoreceptors) turn on the expression of some of these same genes concomitantly with heart rate increase. These data describe a physiological situation under which conversion of TR[alpha] from apo-receptors into holo-receptors, upon changes in T3 availability, plays a determinant role in a developmental process.

Published
2004

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