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The article informs that the U.S. Court of Appeals for the Federal Circuit has issued a series of decisions rejecting Retroactive Cost Disallowance (RCD) arguments raised by contractors based on their failure to show affirmative misconduct by the government. It further argues that did the Federal Circuit commit error by failing to recognize relevant Supreme Court precedent when it decided "Rumsfeld v. UTC."

The article discusses the study that determines the formation of smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder. According to the author, former studies reveal several structural brain abnormalities observed in men having schizotypal personality disorder. The authors aim to determine if same condition can be observed with women.

The expression of endogenous retrotransposable elements, including long interspersed nuclear element 1 (LINE-1 or L1) and human endogenous retrovirus, accompanies neoplastic transformation and infection with viruses such as HIV. The ability to engender immunity safely against such self-antigens would facilitate the development of novel vaccines and immunotherapies. In this article, we address the safety and immunogenicity of vaccination with these elements. We used immunohistochemical analysis and literature precedent to identify potential off-target tissues in humans and establish their translatability in preclinical species to guide safety assessments. Immunization of mice with murine L1 open reading frame 2 induced strong CD8 T cell responses without detectable tissue damage. Similarly, immunization of rhesus macaques with human LINE-1 open reading frame 2 (96% identity with macaque), as well as simian endogenous retrovirus-K Gag and Env, induced polyfunctional T cell responses to all Ags, and Ab responses to simian endogenous retrovirus-K Env. There were no adverse safety or pathological findings related to vaccination. These studies provide the first evidence, to our knowledge, that immune responses can be induced safely against this class of self-antigens and pave the way for investigation of them as HIV- or tumor-associated targets.