229 results on '"Jann, Johann-Christoph"'
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2. Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells
3. Treatment with the apoptosis inhibitor Asunercept reduces clone sizes in patients with lower risk Myelodysplastic Neoplasms
4. Instructive interaction between myelodysplastic hematopoiesis and the bone marrow microenvironment at the single-cell level
5. Functional analysis of structural variants in single cells using Strand-seq
6. Inhibition of lysyl oxidases synergizes with 5-azacytidine to restore erythropoiesis in myelodysplastic and myeloid malignancies
7. Humanized three-dimensional scaffold xenotransplantation models for myelodysplastic syndromes
8. Preclinical evaluation of eltrombopag in a PDX model of myelodysplastic syndromes
9. Cohesin mutations in myeloid malignancies
10. Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states
11. Instructive interaction between myelodysplastic hematopoiesis and the bone marrow microenvironment at single cell level
12. Genome-wide DNA methylation analysis pre- and post-lenalidomide treatment in patients with myelodysplastic syndrome with isolated deletion (5q)
13. Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo
14. Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
15. Safety and efficacy of the CD95-ligand inhibitor asunercept in transfusion-dependent patients with low and intermediate risk MDS
16. 2. Diagnose und WHO-Klassifikation myeloischer Neoplasien
17. Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure
18. Functional analysis of structural variants in single cells using Strand-seq
19. Significant improvement of bone marrow-derived MSC expansion from MDS patients by defined xeno-free medium
20. Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit
21. Functional analysis of structural variants in single cells using Strand-seq
22. Inter-Modality Variance of Blast Quantification in Patients with Myelodysplastic Syndrome (MDS) and Its Impact on Risk Stratification and Overall Survival
23. Splicing Modulators Impair DNA Damage Response and Induce Killing of Cohesin-Mutant MDS/AML
24. Inhibition of Lysyl Oxidases Synergizes with 5-Azacytidine to Restore Erythropoiesis in Myeloid Neoplasms
25. ASXL1 Mutations Are Associated with a Response to the Combination of Alvocidib and 5-Azacytidine in Higher-Risk Myelodysplastic Syndromes
26. Accurate quantification of chromosomal lesions via short tandem repeat analysis using minimal amounts of DNA
27. Abstract 6257: Mutations in the ASXL1 and ZRSR2 genes are associated with the response to the combination of alvocidib and 5-azacytidine in higher-risk myelodysplastic syndromes
28. Concomitant MDS with isolated 5q deletion and MGUS: case report and review of molecular aspects
29. 3019 – SINGLE-CELL PROTEO-GENOMIC REFERENCE MAPS OF THE HEMATOPOIETIC SYSTEM ENABLE THE PURIFICATION AND MASSIVE PROFILING OF PRECISELY DEFINED CELL STATES
30. Haplotype-aware single-cell multiomics uncovers functional effects of somatic structural variation
31. Preclinical Assessment of Alvocidib in Combination with 5-Azacytidine in High-Risk Myelodysplastic Syndromes
32. Mesenchymal Stromal Cells (MSCs) from Myelodysplastic Syndromes (MDS) Are Not Clonally Mutated I n Vivo
33. Effects of the environmental contaminants DEHP and TCDD on estradiol synthesis and aryl hydrocarbon receptor and peroxisome proliferator-activated receptor signalling in the human granulosa cell line KGN
34. Instructive Interaction between Myelodysplastic Hematopoiesis and the Bone Marrow Microenvironment at Single Cell Level
35. STAG2 loss Induces HSC Programs By Modulating Accessibility of AP-1 Bound Enhancers
36. Subunit-Specific Analysis of Cohesin-Mutant Myeloid Malignancies Reveals Distinct Ontogeny and Outcomes
37. Preclinical evaluation of eltrombopag in a PDX model of myelodysplastic syndromes
38. Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states
39. High erythroferrone expression in CD71+ erythroid progenitors predicts superior survival in myelodysplastic syndromes
40. Comparative analysis of clonal hematopoiesis of multipotent stem cells in healthy elderly in blood and bone marrow
41. Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations
42. RNA-sequencing of acute promyelocytic leukemia primary blasts reveals novel molecular biomarkers of early death events
43. Characterization of Stem-like Circulating Tumor Cells in Pancreatic Cancer
44. MutaSeq reveals the transcriptomic consequences of clonal evolution in acute myeloid leukemia
45. R-Loops-Induced ATR Signaling As a Potential Therapeutic Target in Myelodysplastic Syndrome
46. Comparison of Four Different Humanized Hematopoietic Niche Xenotransplantation Methods to Engraft Myelodysplastic Syndromes (MDS)
47. Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T-cell clusters as a response pattern to lenalidomide
48. High erythroferrone expression in CD71+ erythroid progenitors predicts superior survival in myelodysplastic syndromes.
49. Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
50. Placebo Controlled Functional Analysis of Eltrombopag in a Preclinical Xenograft Model of Myelodysplastic Syndromes (MDS)
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