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20 results on '"Janouskova, Hana"'

1. Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer

Author

Bernasocchi, Tiziano, El Tekle, Geniver, Bolis, Marco, Mutti, Azzurra, Vallerga, Arianna, Brandt, Laura P., Spriano, Filippo, Svinkina, Tanya, Zoma, Marita, Ceserani, Valentina, Rinaldi, Anna, Janouskova, Hana, Bossi, Daniela, Cavalli, Manuela, Mosole, Simone, Geiger, Roger, Dong, Ze, Yang, Cai-Guang, Albino, Domenico, Rinaldi, Andrea, Schraml, Peter, Linder, Simon, Carbone, Giuseppina M., Alimonti, Andrea, Bertoni, Francesco, Moch, Holger, Carr, Steven A., Zwart, Wilbert, Kruithof-de Julio, Marianna, Rubin, Mark A., Udeshi, Namrata D., and Theurillat, Jean-Philippe P.

Published
2021
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2. TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer

Author

Groner, Anna C., Cato, Laura, de Tribolet-Hardy, Jonas, Bernasocchi, Tiziano, Janouskova, Hana, Melchers, Diana, Houtman, René, Cato, Andrew C.B., Tschopp, Patrick, Gu, Lei, Corsinotti, Andrea, Zhong, Qing, Fankhauser, Christian, Fritz, Christine, Poyet, Cédric, Wagner, Ulrich, Guo, Tiannan, Aebersold, Ruedi, Garraway, Levi A., Wild, Peter J., Theurillat, Jean-Philippe, and Brown, Myles

Published
2016
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3. Data from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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4. Supplementary Figure 2 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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5. Supplementary Table 2 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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6. Supplementary Table 3 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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7. Supplementary Table 1 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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8. Supplementary Figure 1 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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9. Supplementary Figure 3 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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10. Supplementary Figure Legends 1-3 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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11. Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors

Author

Janouskova, Hana, El Tekle, Geniver, Bellini, Elisa, Udeshi, Namrata D, Rinaldi, Anna, Ulbricht, Anna, Bernasocchi, Tiziano, Civenni, Gianluca, Losa, Marco, Svinkina, Tanya, Bielski, Craig M, Kryukov, Gregory V, Cascione, Luciano, Napoli, Sara, Enchev, Radoslav I, Mutch, David G, Carney, Michael E, Berchuck, Andrew, Winterhoff, Boris J N, Broaddus, Russell R, Schraml, Peter, Moch, Holger, Bertoni, Francesco, Catapano, Carlo V, Peter, Matthias, Carr, Steven A, Garraway, Levi A, Wild, Peter J, and Theurillat, Jean-Philippe P

Subjects
Cancer -- Genetic aspects -- Care and treatment -- Research, Gene mutation -- Physiological aspects -- Research, Proteolysis -- Genetic aspects -- Research, Biological sciences, Health
Abstract

It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses. Cancer genome studies have identified recurrent but divergent missense mutations affecting the substrate-recognition domain of the ubiquitin ligase adaptor SPOP in endometrial and prostate cancers. The therapeutic implications of these mutations remain incompletely understood. Here we analyzed changes in the ubiquitin landscape induced by endometrial cancer-associated SPOP mutations and identified BRD2, BRD3 and BRD4 proteins (BETs) as SPOP-CUL3 substrates that are preferentially degraded by endometrial cancer-associated SPOP mutants. The resulting reduction of BET protein levels sensitized cancer cells to BET inhibitors. Conversely, prostate cancer-specific SPOP mutations resulted in impaired degradation of BETs, promoting their resistance to pharmacologic inhibition. These results uncover an oncogenomics paradox, whereby mutations mapping to the same domain evoke opposing drug susceptibilities. Specifically, we provide a molecular rationale for the use of BET inhibitors to treat patients with endometrial but not prostate cancer who harbor SPOP mutations., Author(s): Hana Janouskova [1, 2]; Geniver El Tekle [1, 2, 3]; Elisa Bellini [4]; Namrata D Udeshi [5]; Anna Rinaldi [1, 2]; Anna Ulbricht [6]; Tiziano Bernasocchi [1, 2, 3]; [...]

Published
2017
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15. Dual Functions of SPOP and ERG Dictate Androgen Therapy Responses in Prostate Cancer

Author

Bernasocchi, Tiziano, primary, El Tekle, Geniver, additional, Bolis, Marco, additional, Mutti, Azzurra, additional, Vallerga, Arianna, additional, Brandt, Laura P., additional, Spriano, Filippo, additional, Svinkina, Tanya, additional, Zoma, Marita, additional, Ceserani, Valentina, additional, Rinaldi, Anna, additional, Janouskova, Hana, additional, Bossi, Daniela, additional, Cavalli, Manuela, additional, Mosole, Simone, additional, Geiger, Roger, additional, Dong, Ze, additional, Yang, Cai-Guang, additional, Albino, Domenico, additional, Rinaldi, Andrea, additional, Schraml, Peter, additional, Linder, Simon, additional, Carbone, Giuseppina M., additional, Alimonti, Andrea, additional, Bertoni, Francesco, additional, Moch, Holger, additional, Carr, Steven A., additional, Zwart, Wilbert, additional, Kruithof-de Julio, Marianna, additional, Rubin, Mark A., additional, Udeshi, Namrata D., additional, and Theurillat, Jean-Philippe P., additional

Published
2020
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16. Is nutlin-3A a new therapeutic option for a subset of high grade glioma expressing a wild type P53 and high α5β1 integrin?

Author

Janouskova, Hana, Maglott, Anne, Leger, David Y, Bossert, Catherine, Noulet, Fanny, Guérin, Eric, Guenot, Dominique, Pinel, Sophie, Chastagner, Pascal, Plénat, François, Entz-Werlé, Natacha, Godet, Julien, Martin, Sophie, Dotenwill, Monique, Maquin, Didier, Laboratoire de Biophotonique et Pharmacologie - UMR 7213 (LBP), Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Développement et physiopathologie de l'intestin et du pancréas, Institut National de la Santé et de la Recherche Médicale (INSERM), Signalisation, Génomique et Recherche Translationnelle en Oncologie (SIGRETO), and Université Henri Poincaré - Nancy 1 (UHP)

Subjects
[SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.CAN]Life Sciences [q-bio]/Cancer
Abstract

published in Oncologie 13(9)S4; National audience

Published
2011

19. Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, additional, Leger, David Y., additional, Bossert, Catherine, additional, Noulet, Fanny, additional, Guerin, Eric, additional, Guenot, Dominique, additional, Pinel, Sophie, additional, Chastagner, Pascal, additional, Plenat, François, additional, Entz-Werle, Natacha, additional, Lehmann-Che, Jacqueline, additional, Godet, Julien, additional, Martin, Sophie, additional, Teisinger, Jan, additional, and Dontenwill, Monique, additional

Published
2012
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