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10 results on '"Jansen, Manon A.A."'

3. Oral prednisolone suppresses skin inflammation in a healthy volunteer imiquimod challenge model

Author

Assil, Salma, Buters, Thomas P., Hameeteman, Pieter W., Hallard, Charlie, Treijtel, Nicoline, Niemeyer – Van der Kolk, Tessa, de Kam, Marieke L., Florencia, Edwin F.I.I.I., Prens, Errol P., van Doorn, Martijn B.A., Rissmann, Robert, Klarenbeek, Naomi B., Jansen, Manon A.A., Moerland, Matthijs, Assil, Salma, Buters, Thomas P., Hameeteman, Pieter W., Hallard, Charlie, Treijtel, Nicoline, Niemeyer – Van der Kolk, Tessa, de Kam, Marieke L., Florencia, Edwin F.I.I.I., Prens, Errol P., van Doorn, Martijn B.A., Rissmann, Robert, Klarenbeek, Naomi B., Jansen, Manon A.A., and Moerland, Matthijs

Abstract

Imiquimod (IMQ) is a topical agent that induces local inflammation via the Toll-like receptor 7 pathway. Recently, an IMQ-driven skin inflammation model was developed in healthy volunteers for proof-of-pharmacology trials. The aim of this study was to profile the cellular, biochemical, and clinical effects of the marketed anti-inflammatory compound prednisolone in an IMQ model. This randomized, double-blind, placebo-controlled study was conducted in 24 healthy volunteers. Oral prednisolone (0.25 mg/kg/dose) or placebo (1:1) was administered twice daily for 6 consecutive days. Two days after treatment initiation with prednisolone or placebo, 5 mg imiquimod (IMQ) once daily for two following days was applied under occlusion on the tape-stripped skin of the back for 48 h in healthy volunteers. Non-invasive (imaging and biophysical) and invasive (skin punch biopsies and blister induction) assessments were performed, as well as IMQ ex vivo stimulation of whole blood. Prednisolone reduced blood perfusion and skin erythema following 48 h of IMQ application (95% CI [−26.4%, −4.3%], p = 0.0111 and 95% CI [−7.96, −2.13], p = 0.0016). Oral prednisolone suppressed the IMQ-elevated total cell count (95% CI [−79.7%, −16.3%], p = 0.0165), NK and dendritic cells (95% CI [−68.7%, −5.2%], p = 0.0333, 95% CI [−76.9%, −13.9%], p = 0.0184), and classical monocytes (95% CI [−76.7%, −26.6%], p = 0.0043) in blister fluid. Notably, TNF, IL-6, IL-8, and Mx-A responses in blister exudate were also reduced by prednisolone compared to placebo. Oral prednisolone suppresses IMQ-induced skin inflammation, which underlines the value of this cutaneous challenge model in clinical pharmacology studies of novel anti-inflammatory compounds. In these studies, prednisolone can be used as a benchmark.

Published
2023

4. Effect of hydroxychloroquine on the cardiac ventricular repolarization:A randomized clinical trial

Author

Eveleens Maarse, Boukje C., Graff, Claus, Kanters, Jørgen K., van Esdonk, Michiel J., Kemme, Michiel J.B., in 't Veld, Aliede E., Jansen, Manon A.A., Moerland, Matthijs, Gal, Pim, Eveleens Maarse, Boukje C., Graff, Claus, Kanters, Jørgen K., van Esdonk, Michiel J., Kemme, Michiel J.B., in 't Veld, Aliede E., Jansen, Manon A.A., Moerland, Matthijs, and Gal, Pim

Published
2022

5. Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers

Author

Buters, Thomas P., Hameeteman, Pieter W., Jansen, Iris M.E., van Hindevoort, Floris C., ten Voorde, Wouter, Florencia, Edwin, Osse, Michelle, de Kam, Marieke L., Grievink, Hendrika W., Schoonakker, Mascha, Patel, Amit A., Yona, Simon, Gilroy, Derek W., Lubberts, Erik, Damman, Jeffrey, Feiss, Gary, Rissmann, Robert, Jansen, Manon A.A., Burggraaf, Jacobus, Moerland, Matthijs, Buters, Thomas P., Hameeteman, Pieter W., Jansen, Iris M.E., van Hindevoort, Floris C., ten Voorde, Wouter, Florencia, Edwin, Osse, Michelle, de Kam, Marieke L., Grievink, Hendrika W., Schoonakker, Mascha, Patel, Amit A., Yona, Simon, Gilroy, Derek W., Lubberts, Erik, Damman, Jeffrey, Feiss, Gary, Rissmann, Robert, Jansen, Manon A.A., Burggraaf, Jacobus, and Moerland, Matthijs

Published
2022

6. Clinical, Cellular, and Molecular Effects of Corticosteroids on the Response to Intradermal Lipopolysaccharide Administration in Healthy Volunteers

Author

Buters, Thomas P., primary, Hameeteman, Pieter W., additional, Jansen, Iris M.E., additional, van Hindevoort, Floris C., additional, ten Voorde, Wouter, additional, Grievink, Hendrika W., additional, Schoonakker, Mascha, additional, de Kam, Marieke L., additional, Gilroy, Derek W., additional, Feiss, Gary, additional, Rissmann, Robert, additional, Jansen, Manon A.A., additional, Burggraaf, Jacobus, additional, and Moerland, Matthijs, additional

Published
2022
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7. Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis

Author

Spiering, Rachel, Jansen, Manon A.A., Wood, Matthew J., Fath, Anshorulloh A., Eltherington, Oliver, Anderson, Amy E., Pratt, Arthur G., Van Eden, Willem, Isaacs, John D., Broere, Femke, Hilkens, Catharien M.U., Spiering, Rachel, Jansen, Manon A.A., Wood, Matthew J., Fath, Anshorulloh A., Eltherington, Oliver, Anderson, Amy E., Pratt, Arthur G., Van Eden, Willem, Isaacs, John D., Broere, Femke, and Hilkens, Catharien M.U.

Published
2019

8. Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis

Author

LS Immunologie, dI&I RA-I&I I&I, Spiering, Rachel, Jansen, Manon A.A., Wood, Matthew J., Fath, Anshorulloh A., Eltherington, Oliver, Anderson, Amy E., Pratt, Arthur G., Van Eden, Willem, Isaacs, John D., Broere, Femke, Hilkens, Catharien M.U., LS Immunologie, dI&I RA-I&I I&I, Spiering, Rachel, Jansen, Manon A.A., Wood, Matthew J., Fath, Anshorulloh A., Eltherington, Oliver, Anderson, Amy E., Pratt, Arthur G., Van Eden, Willem, Isaacs, John D., Broere, Femke, and Hilkens, Catharien M.U.

Published
2019

9. Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model

Author

LS Immunologie, dI&I RA-I&I I&I, Geneeskunde van gezelschapsdieren, Jansen, Manon A.A., Klausen, Lasse H., Thanki, Kaushik, Lyngsø, Jeppe, Skov Pedersen, Jan, Franzyk, Henrik, Nielsen, Hanne M., van Eden, Willem, Dong, Mingdong, Broere, Femke, Foged, Camilla, Zeng, Xianghui, LS Immunologie, dI&I RA-I&I I&I, Geneeskunde van gezelschapsdieren, Jansen, Manon A.A., Klausen, Lasse H., Thanki, Kaushik, Lyngsø, Jeppe, Skov Pedersen, Jan, Franzyk, Henrik, Nielsen, Hanne M., van Eden, Willem, Dong, Mingdong, Broere, Femke, Foged, Camilla, and Zeng, Xianghui

Published
2019

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