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1. Digitalisierung im Krankenhaus

Author

Janssen, Maike

Subjects
Artefakt, Digitalisierung, Gesundheit, Gesundheitswesen, Krankenhaus, Krankenhaussoziologie, Krankheit, Medizin, Nachsorge, Organisation, Soziologie, Überwachung, Wissenssoziologie, thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBC Social research and statistics, thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBF Medical and health informatics
Abstract

Die Digitalisierung des Gesundheitswesens und seiner wichtigsten Subinstitution, dem Krankenhaus, steht im Zentrum fachlicher, politischer und alltagspraktischer Debatten. Maike Janssen entfaltet einen analytischen Zusammenhang zwischen diesen Diskursen und den Prozess- und Strukturlogiken, die in Situationen der Digitalisierung zusammenwirken. Im Mittelpunkt stehen jene Bedeutungen, die Akteure digitalen Artefakten zuschreiben und sie entsprechend gestalten. Janssens empirisch fundierte »Krankenhaussoziologie des Digitalen« erlaubt einen auflösungsstarken Zugriff auf das Zusammenspiel von Sinn, Artefakt und Organisation.

Published
2024

2. The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia

Author

Weidenauer, Katharina, Schmidt, Christina, Rohde, Christian, Pauli, Cornelius, Blank, Maximilian F., Heid, Daniel, Waclawiczek, Alexander, Corbacioglu, Anika, Göllner, Stefanie, Lotze, Michelle, Vierbaum, Lisa, Renders, Simon, Krijgsveld, Jeroen, Raffel, Simon, Sauer, Tim, Trumpp, Andreas, Pabst, Caroline, Müller-Tidow, Carsten, and Janssen, Maike

Published
2023
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3. Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial

Author

Denkinger, Claudia M., Janssen, Maike, Schäkel, Ulrike, Gall, Julia, Leo, Albrecht, Stelmach, Patrick, Weber, Stefan F., Krisam, Johannes, Baumann, Lukas, Stermann, Jacek, Merle, Uta, Weigand, Markus A., Nusshag, Christian, Bullinger, Lars, Schrezenmeier, Jens-Florian, Bornhäuser, Martin, Alakel, Nael, Witzke, Oliver, Wolf, Timo, Vehreschild, Maria J. G. T., Schmiedel, Stefan, Addo, Marylyn M., Herth, Felix, Kreuter, Michael, Tepasse, Phil-Robin, Hertenstein, Bernd, Hänel, Mathias, Morgner, Anke, Kiehl, Michael, Hopfer, Olaf, Wattad, Mohammad-Amen, Schimanski, Carl C., Celik, Cihan, Pohle, Thorsten, Ruhe, Matthias, Kern, Winfried V., Schmitt, Anita, Lorenz, Hanns-Martin, Souto-Carneiro, Margarida, Gaeddert, Mary, Halama, Niels, Meuer, Stefan, Kräusslich, Hans-Georg, Müller, Barbara, Schnitzler, Paul, Parthé, Sylvia, Bartenschlager, Ralf, Gronkowski, Martina, Klemmer, Jennifer, Schmitt, Michael, Dreger, Peter, Kriegsmann, Katharina, Schlenk, Richard F., and Müller-Tidow, Carsten

Published
2023
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4. Protein tyrosine kinase 2b inhibition reverts niche-associated resistance to tyrosine kinase inhibitors in AML

Author

Allert, Catana, Waclawiczek, Alexander, Zimmermann, Sarah Miriam Naomi, Göllner, Stefanie, Heid, Daniel, Janssen, Maike, Renders, Simon, Rohde, Christian, Bauer, Marcus, Bruckmann, Margarita, Zinz, Rafael, Pauli, Cornelius, Besenbeck, Birgit, Wickenhauser, Claudia, Trumpp, Andreas, Krijgsveld, Jeroen, Müller-Tidow, Carsten, and Blank, Maximilian Felix

Published
2022
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5. Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

Author

Beneyto-Calabuig, Sergi, Merbach, Anne Kathrin, Kniffka, Jonas-Alexander, Antes, Magdalena, Szu-Tu, Chelsea, Rohde, Christian, Waclawiczek, Alexander, Stelmach, Patrick, Gräßle, Sarah, Pervan, Philip, Janssen, Maike, Landry, Jonathan J.M., Benes, Vladimir, Jauch, Anna, Brough, Michaela, Bauer, Marcus, Besenbeck, Birgit, Felden, Julia, Bäumer, Sebastian, Hundemer, Michael, Sauer, Tim, Pabst, Caroline, Wickenhauser, Claudia, Angenendt, Linus, Schliemann, Christoph, Trumpp, Andreas, Haas, Simon, Scherer, Michael, Raffel, Simon, Müller-Tidow, Carsten, and Velten, Lars

Published
2023
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7. Treatment of chronic COVID‐19 with convalescent/postvaccination plasma in patients with hematologic malignancies

Author

Janssen, Maike, primary, Leo, Albrecht, additional, Wolf, Cornelia, additional, Stenzinger, Miriam, additional, Bartenschlager, Marie, additional, Brandt, Juliane, additional, Sauer, Sandra, additional, Schmitt, Michael, additional, Dreger, Peter, additional, Schlenk, Richard F., additional, Denkinger, Claudia M., additional, and Müller‐Tidow, Carsten, additional

Published
2024
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8. Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1

Author

Janssen, Maike, Schmidt, Christina, Bruch, Peter-Martin, Blank, Maximilian F., Rohde, Christian, Waclawiczek, Alexander, Heid, Daniel, Renders, Simon, Göllner, Stefanie, Vierbaum, Lisa, Besenbeck, Birgit, Herbst, Sophie A., Knoll, Mareike, Kolb, Carolin, Przybylla, Adriana, Weidenauer, Katharina, Ludwig, Anne Kathrin, Fabre, Margarete, Gu, Muxin, Schlenk, Richard F., Stölzel, Friedrich, Bornhäuser, Martin, Röllig, Christoph, Platzbecker, Uwe, Baldus, Claudia, Serve, Hubert, Sauer, Tim, Raffel, Simon, Pabst, Caroline, Vassiliou, George, Vick, Binje, Jeremias, Irmela, Trumpp, Andreas, Krijgsveld, Jeroen, Müller-Tidow, Carsten, and Dietrich, Sascha

Published
2022
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9. Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response

Author

Scheller, Marina, Ludwig, Anne Kathrin, Göllner, Stefanie, Rohde, Christian, Krämer, Stephen, Stäble, Sina, Janssen, Maike, Müller, James-Arne, He, Lixiazi, Bäumer, Nicole, Arnold, Christian, Gerß, Joachim, Schönung, Maximilian, Thiede, Christian, Niederwieser, Christian, Niederwieser, Dietger, Serve, Hubert, Berdel, Wolfgang E., Thiem, Ulrich, Hemmerling, Inga, Leuschner, Florian, Plass, Christoph, Schlesner, Matthias, Zaugg, Judith, Milsom, Michael D., Trumpp, Andreas, Pabst, Caroline, Lipka, Daniel B., and Müller-Tidow, Carsten

Published
2021
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10. Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials

Author

Axfors, Cathrine, Janiaud, Perrine, Schmitt, Andreas M., van’t Hooft, Janneke, Smith, Emily R., Haber, Noah A., Abayomi, Akin, Abduljalil, Manal, Abdulrahman, Abdulkarim, Acosta-Ampudia, Yeny, Aguilar-Guisado, Manuela, Al-Beidh, Farah, Alejandria, Marissa M., Alfonso, Rachelle N., Ali, Mohammad, AlQahtani, Manaf, AlZamrooni, Alaa, Anaya, Juan-Manuel, Ang, Mark Angelo C., Aomar, Ismael F., Argumanis, Luis E., Averyanov, Alexander, Baklaushev, Vladimir P., Balionis, Olga, Benfield, Thomas, Berry, Scott, Birocco, Nadia, Bonifacio, Lynn B., Bowen, Asha C., Bown, Abbie, Cabello-Gutierrez, Carlos, Camacho, Bernardo, Camacho-Ortiz, Adrian, Campbell-Lee, Sally, Cao, Damon H., Cardesa, Ana, Carnate, Jose M., Castillo, German Jr. J., Cavallo, Rossana, Chowdhury, Fazle R., Chowdhury, Forhad U. H., Ciccone, Giovannino, Cingolani, Antonella, Climacosa, Fresthel Monica M., Compernolle, Veerle, Cortez, Carlo Francisco N., Costa Neto, Abel, D’Antico, Sergio, Daly, James, Danielle, Franca, Davis, Joshua S., De Rosa, Francesco Giuseppe, Denholm, Justin T., Denkinger, Claudia M., Desmecht, Daniel, Díaz-Coronado, Juan C., Díaz Ponce-Medrano, Juan A., Donneau, Anne-Françoise, Dumagay, Teresita E., Dunachie, Susanna, Dungog, Cecile C., Erinoso, Olufemi, Escasa, Ivy Mae S., Estcourt, Lise J., Evans, Amy, Evasan, Agnes L. M., Fareli, Christian J., Fernandez-Sanchez, Veronica, Galassi, Claudia, Gallo, Juan E., Garcia, Patricia J., Garcia, Patricia L., Garcia, Jesus A., Garigliany, Mutien, Garza-Gonzalez, Elvira, Gauiran, Deonne Thaddeus V., Gaviria García, Paula A., Giron-Gonzalez, Jose-Antonio, Gómez-Almaguer, David, Gordon, Anthony C., Gothot, André, Grass Guaqueta, Jeser Santiago, Green, Cameron, Grimaldi, David, Hammond, Naomi E., Harvala, Heli, Heralde, Francisco M., Herrick, Jesica, Higgins, Alisa M., Hills, Thomas E., Hines, Jennifer, Holm, Karin, Hoque, Ashraful, Hoste, Eric, Ignacio, Jose M., Ivanov, Alexander V., Janssen, Maike, Jennings, Jeffrey H., Jha, Vivekanand, King, Ruby Anne N., Kjeldsen-Kragh, Jens, Klenerman, Paul, Kotecha, Aditya, Krapp, Fiorella, Labanca, Luciana, Laing, Emma, Landin-Olsson, Mona, Laterre, Pierre-François, Lim, Lyn-Li, Lim, Jodor, Ljungquist, Oskar, Llaca-Díaz, Jorge M., López-Robles, Concepción, López-Cárdenas, Salvador, Lopez-Plaza, Ileana, Lucero, Josephine Anne C., Lundgren, Maria, Macías, Juan, Maganito, Sandy C., Malundo, Anna Flor G., Manrique, Rubén D., Manzini, Paola M., Marcos, Miguel, Marquez, Ignacio, Martínez-Marcos, Francisco Javier, Mata, Ana M., McArthur, Colin J., McQuilten, Zoe K., McVerry, Bryan J., Menon, David K., Meyfroidt, Geert, Mirasol, Ma. Angelina L., Misset, Benoît, Molton, James S., Mondragon, Alric V., Monsalve, Diana M., Moradi Choghakabodi, Parastoo, Morpeth, Susan C., Mouncey, Paul R., Moutschen, Michel, Müller-Tidow, Carsten, Murphy, Erin, Najdovski, Tome, Nichol, Alistair D., Nielsen, Henrik, Novak, Richard M., O’Sullivan, Matthew V. N., Olalla, Julian, Osibogun, Akin, Osikomaiya, Bodunrin, Oyonarte, Salvador, Pardo-Oviedo, Juan M., Patel, Mahesh C., Paterson, David L., Peña-Perez, Carlos A., Perez-Calatayud, Angel A., Pérez-Alba, Eduardo, Perkina, Anastasia, Perry, Naomi, Pouladzadeh, Mandana, Poyato, Inmaculada, Price, David J., Quero, Anne Kristine H., Rahman, Md. M., Rahman, Md. S., Ramesh, Mayur, Ramírez-Santana, Carolina, Rasmussen, Magnus, Rees, Megan A., Rego, Eduardo, Roberts, Jason A., Roberts, David J., Rodríguez, Yhojan, Rodríguez-Baño, Jesús, Rogers, Benjamin A., Rojas, Manuel, Romero, Alberto, Rowan, Kathryn M., Saccona, Fabio, Safdarian, Mehdi, Santos, Maria Clariza M., Sasadeusz, Joe, Scozzari, Gitana, Shankar-Hari, Manu, Sharma, Gorav, Snelling, Thomas, Soto, Alonso, Tagayuna, Pedrito Y., Tang, Amy, Tatem, Geneva, Teofili, Luciana, Tong, Steven Y. C., Turgeon, Alexis F., Veloso, Januario D., Venkatesh, Balasubramanian, Ventura-Enriquez, Yanet, Webb, Steve A., Wiese, Lothar, Wikén, Christian, Wood, Erica M., Yusubalieva, Gaukhar M., Zacharowski, Kai, Zarychanski, Ryan, Khanna, Nina, Moher, David, Goodman, Steven N., Ioannidis, John P. A., and Hemkens, Lars G.

Published
2021
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12. P408: COMBINATORIAL BCL-2 FAMILY EXPRESSION IN ACUTE MYELOID LEUKEMIA STEM CELLS PREDICTS CLINICAL RESPONSE TO AZACITIDINE/VENETOCLAX

Author

Renders, Simon, primary, Waclawiczek, Alexander, additional, Leppä, Aino-Maija, additional, Stumpf, Karolin, additional, Betz, Barbara, additional, Reyneri, Cecilia, additional, Donato, Elisa, additional, Janssen, Maike, additional, Unglaub, Julia, additional, Shahswar, Rabia, additional, Raffel, Simon, additional, Hundemer, Michael, additional, Heuser, Michael, additional, Müller-Tidow, Carsten, additional, Sauer, Tim, additional, and Trumpp, Andreas, additional

Published
2023
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14. Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients

Author

Stelmach, Patrick, Richter, Sarah, Sauer, Sandra, Fabre, Margarete A, Gu, Muxin, Rohde, Christian, Janssen, Maike, Liebers, Nora, Proynova, Rumyana, Weinhold, Niels, Raab, Marc S, Goldschmidt, Hartmut, Besenbeck, Birgit, Pavel, Petra, Laier, Sascha, Trumpp, Andreas, Dietrich, Sascha, Vassiliou, George S, Müller-Tidow, Carsten, Vassiliou, George [0000-0003-4337-8022], and Apollo - University of Cambridge Repository

Subjects
Transplantation, 5.2 Cellular and gene therapies, 3201 Cardiovascular Medicine and Haematology, Stem Cell Research - Nonembryonic - Human, FOS: Biological sciences, Genetics, 32 Biomedical and Clinical Sciences, Stem Cell Research - Nonembryonic - Non-Human, Hematology, Regenerative Medicine, Stem Cell Research, 5 Development of treatments and therapeutic interventions
Abstract

Clonal hematopoiesis (CH) is an age-related condition driven by stem- and progenitor cells harboring recurrent mutations linked to myeloid neoplasms. Currently, potential effects on hematopoiesis, stem cell function and regenerative potential under stress conditions are unknown. We performed targeted DNA sequencing of 457 hematopoietic stem cell grafts collected for autologous stem cell transplantation (ASCT) in myeloma patients and correlated our findings with high-dimensional longitudinal clinical and laboratory data (26,510 data points for blood cell counts/serum values in 25 days around transplantation). We detected CH-related mutations in 152 patients (33.3%). Since many patients (n = 54) harbored multiple CH mutations in one or more genes, we applied a non-negative matrix factorization (NMF) clustering algorithm to identify genes that are commonly co-mutated in an unbiased approach. Patients with CH were assigned to one of three clusters (C1-C3) and compared to patients without CH (C0) in a gene specific manner. To study the dynamics of blood cell regeneration following ASCT, we developed a time-dependent linear mixed effect model to validate differences in blood cell count trajectories amongst different clusters. The results demonstrated that C2, composed of patients with DNMT3A and PPM1D single and comutated CH, correlated with reduced stem cell yields and delayed platelet count recovery following ASCT. Also, the benefit of maintenance therapy was particularly strong in C2 patients. Taken together, these data indicate an impaired regenerative potential of hematopoietic stem cell grafts harboring CH with DNMT3A and PPM1D mutations.

Published
2023
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16. A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Djuka Fokou, Carine, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Lorenz, Hanns-Martin, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Kräusslich, Hans-Georg, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Published
2020
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17. Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients

Author

Stelmach, Patrick, primary, Richter, Sarah, additional, Sauer, Sandra, additional, Fabre, Margarete A., additional, Gu, Muxin, additional, Rohde, Christian, additional, Janssen, Maike, additional, Liebers, Nora, additional, Proynova, Rumyana, additional, Weinhold, Niels, additional, Raab, Marc S., additional, Goldschmidt, Hartmut, additional, Besenbeck, Birgit, additional, Pavel, Petra, additional, Laier, Sascha, additional, Trumpp, Andreas, additional, Dietrich, Sascha, additional, Vassiliou, George S., additional, and Müller-Tidow, Carsten, additional

Published
2023
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18. Supplementary Figure 3 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

Author

Waclawiczek, Alexander, primary, Leppä, Aino-Maija, primary, Renders, Simon, primary, Stumpf, Karolin, primary, Reyneri, Cecilia, primary, Betz, Barbara, primary, Janssen, Maike, primary, Shahswar, Rabia, primary, Donato, Elisa, primary, Karpova, Darja, primary, Thiel, Vera, primary, Unglaub, Julia M., primary, Grabowski, Susanna, primary, Gryzik, Stefanie, primary, Vierbaum, Lisa, primary, Schlenk, Richard F., primary, Röllig, Christoph, primary, Hundemer, Michael, primary, Pabst, Caroline, primary, Heuser, Michael, primary, Raffel, Simon, primary, Müller-Tidow, Carsten, primary, Sauer, Tim, primary, and Trumpp, Andreas, primary

Published
2023
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19. Supplementary Tables 1-7 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

Author

Waclawiczek, Alexander, primary, Leppä, Aino-Maija, primary, Renders, Simon, primary, Stumpf, Karolin, primary, Reyneri, Cecilia, primary, Betz, Barbara, primary, Janssen, Maike, primary, Shahswar, Rabia, primary, Donato, Elisa, primary, Karpova, Darja, primary, Thiel, Vera, primary, Unglaub, Julia M., primary, Grabowski, Susanna, primary, Gryzik, Stefanie, primary, Vierbaum, Lisa, primary, Schlenk, Richard F., primary, Röllig, Christoph, primary, Hundemer, Michael, primary, Pabst, Caroline, primary, Heuser, Michael, primary, Raffel, Simon, primary, Müller-Tidow, Carsten, primary, Sauer, Tim, primary, and Trumpp, Andreas, primary

Published
2023
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20. Data from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

Author

Waclawiczek, Alexander, primary, Leppä, Aino-Maija, primary, Renders, Simon, primary, Stumpf, Karolin, primary, Reyneri, Cecilia, primary, Betz, Barbara, primary, Janssen, Maike, primary, Shahswar, Rabia, primary, Donato, Elisa, primary, Karpova, Darja, primary, Thiel, Vera, primary, Unglaub, Julia M., primary, Grabowski, Susanna, primary, Gryzik, Stefanie, primary, Vierbaum, Lisa, primary, Schlenk, Richard F., primary, Röllig, Christoph, primary, Hundemer, Michael, primary, Pabst, Caroline, primary, Heuser, Michael, primary, Raffel, Simon, primary, Müller-Tidow, Carsten, primary, Sauer, Tim, primary, and Trumpp, Andreas, primary

Published
2023
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21. Supplementary Figure 2 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

Author

Waclawiczek, Alexander, primary, Leppä, Aino-Maija, primary, Renders, Simon, primary, Stumpf, Karolin, primary, Reyneri, Cecilia, primary, Betz, Barbara, primary, Janssen, Maike, primary, Shahswar, Rabia, primary, Donato, Elisa, primary, Karpova, Darja, primary, Thiel, Vera, primary, Unglaub, Julia M., primary, Grabowski, Susanna, primary, Gryzik, Stefanie, primary, Vierbaum, Lisa, primary, Schlenk, Richard F., primary, Röllig, Christoph, primary, Hundemer, Michael, primary, Pabst, Caroline, primary, Heuser, Michael, primary, Raffel, Simon, primary, Müller-Tidow, Carsten, primary, Sauer, Tim, primary, and Trumpp, Andreas, primary

Published
2023
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22. Supplementary Figure 5 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

Author

Waclawiczek, Alexander, primary, Leppä, Aino-Maija, primary, Renders, Simon, primary, Stumpf, Karolin, primary, Reyneri, Cecilia, primary, Betz, Barbara, primary, Janssen, Maike, primary, Shahswar, Rabia, primary, Donato, Elisa, primary, Karpova, Darja, primary, Thiel, Vera, primary, Unglaub, Julia M., primary, Grabowski, Susanna, primary, Gryzik, Stefanie, primary, Vierbaum, Lisa, primary, Schlenk, Richard F., primary, Röllig, Christoph, primary, Hundemer, Michael, primary, Pabst, Caroline, primary, Heuser, Michael, primary, Raffel, Simon, primary, Müller-Tidow, Carsten, primary, Sauer, Tim, primary, and Trumpp, Andreas, primary

Published
2023
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23. SupplementaryFigure 6 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

Author

Waclawiczek, Alexander, primary, Leppä, Aino-Maija, primary, Renders, Simon, primary, Stumpf, Karolin, primary, Reyneri, Cecilia, primary, Betz, Barbara, primary, Janssen, Maike, primary, Shahswar, Rabia, primary, Donato, Elisa, primary, Karpova, Darja, primary, Thiel, Vera, primary, Unglaub, Julia M., primary, Grabowski, Susanna, primary, Gryzik, Stefanie, primary, Vierbaum, Lisa, primary, Schlenk, Richard F., primary, Röllig, Christoph, primary, Hundemer, Michael, primary, Pabst, Caroline, primary, Heuser, Michael, primary, Raffel, Simon, primary, Müller-Tidow, Carsten, primary, Sauer, Tim, primary, and Trumpp, Andreas, primary

Published
2023
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24. Supplementary Figure 4 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

Author

Waclawiczek, Alexander, primary, Leppä, Aino-Maija, primary, Renders, Simon, primary, Stumpf, Karolin, primary, Reyneri, Cecilia, primary, Betz, Barbara, primary, Janssen, Maike, primary, Shahswar, Rabia, primary, Donato, Elisa, primary, Karpova, Darja, primary, Thiel, Vera, primary, Unglaub, Julia M., primary, Grabowski, Susanna, primary, Gryzik, Stefanie, primary, Vierbaum, Lisa, primary, Schlenk, Richard F., primary, Röllig, Christoph, primary, Hundemer, Michael, primary, Pabst, Caroline, primary, Heuser, Michael, primary, Raffel, Simon, primary, Müller-Tidow, Carsten, primary, Sauer, Tim, primary, and Trumpp, Andreas, primary

Published
2023
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25. Supplementary Figure 1 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

Author

Waclawiczek, Alexander, primary, Leppä, Aino-Maija, primary, Renders, Simon, primary, Stumpf, Karolin, primary, Reyneri, Cecilia, primary, Betz, Barbara, primary, Janssen, Maike, primary, Shahswar, Rabia, primary, Donato, Elisa, primary, Karpova, Darja, primary, Thiel, Vera, primary, Unglaub, Julia M., primary, Grabowski, Susanna, primary, Gryzik, Stefanie, primary, Vierbaum, Lisa, primary, Schlenk, Richard F., primary, Röllig, Christoph, primary, Hundemer, Michael, primary, Pabst, Caroline, primary, Heuser, Michael, primary, Raffel, Simon, primary, Müller-Tidow, Carsten, primary, Sauer, Tim, primary, and Trumpp, Andreas, primary

Published
2023
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26. Supplementary Figure 7 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

Author

Waclawiczek, Alexander, primary, Leppä, Aino-Maija, primary, Renders, Simon, primary, Stumpf, Karolin, primary, Reyneri, Cecilia, primary, Betz, Barbara, primary, Janssen, Maike, primary, Shahswar, Rabia, primary, Donato, Elisa, primary, Karpova, Darja, primary, Thiel, Vera, primary, Unglaub, Julia M., primary, Grabowski, Susanna, primary, Gryzik, Stefanie, primary, Vierbaum, Lisa, primary, Schlenk, Richard F., primary, Röllig, Christoph, primary, Hundemer, Michael, primary, Pabst, Caroline, primary, Heuser, Michael, primary, Raffel, Simon, primary, Müller-Tidow, Carsten, primary, Sauer, Tim, primary, and Trumpp, Andreas, primary

Published
2023
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27. Aspirin use and bleeding events during thrombocytopenia after autologous stem-cell transplantation for multiple myeloma

Author

Neuendorff, Nina Rosa, primary, Boshikova, Boryana, additional, Frankenstein, Lutz, additional, Kirchner, Marietta, additional, Rohde, Christian, additional, Goldschmidt, Hartmut, additional, Frey, Norbert, additional, Müller-Tidow, Carsten, additional, Jordan, Karin, additional, Sauer, Sandra, additional, and Janssen, Maike, additional

Published
2023
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28. Venetoclax-Based Salvage Therapy Improves Outcome in Relapsed/Refractory AML Patients Eligible for Intensive Treatment: A Propensity Score Matching Analysis

Author

Unglaub, Julia N., Schlenk, Richard F., Hanoun, Maher, Reinhardt, H. Christian, Middeke, Jan Moritz, Schäfer-Eckart, Kerstin, Steffen, Björn, Krause, Stefan W., Schliemann, Christoph, Kaufmann, Martin, Hänel, Mathias, Jost, Edgar, Crysandt, Martina, Fransecky, Lars, Einsele, Hermann, Kraus, Sabrina, Niemann, Dirk, Neubauer, Andreas, Seggewiss-Bernhardt, Ruth, Scholl, Sebastian, Klein, Stefan, Schmid, Christoph, Schaich, Markus, Platzbecker, Uwe, Baldus, Claudia D., Bornhäuser, Martin, Serve, Hubert, Röllig, Christoph, Kramer, Michael, Katelari, Elena, Janssen, Maike, Pabst, Caroline, Luft, Thomas, Dreger, Peter, Müller-Tidow, Carsten, and Sauer, Tim

Subjects
Immunology, ddc:610, Cell Biology, Hematology, Biochemistry
Published
2022

29. Combinatorial BCL-2 family expression in Acute Myeloid Leukemia Stem Cells predicts clinical response to Azacitidine/Venetoclax

Author

Waclawiczek, Alexander, primary, Leppa, Aino-Maija, additional, Renders, Simon, additional, Stumpf, Karolin, additional, Reyneri, Cecilia, additional, Betz, Barbara, additional, Janssen, Maike, additional, Shahswar, Rabia, additional, Donato, Elisa, additional, Karpova, Darja, additional, Thiel, Vera, additional, Unglaub, Julia M., additional, Grabowski, Susanna, additional, Gryzik, Stefanie, additional, Vierbaum, Lisa, additional, Schlenk, Richard F., additional, Rollig, Christoph, additional, Hundemer, Michael, additional, Pabst, Caroline, additional, Heuser, Michael, additional, Raffel, Simon, additional, Muller-Tidow, Carsten, additional, Sauer, Tim, additional, and Trumpp, Andreas, additional

Published
2023
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31. Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial

Author

Denkinger, Claudia M., primary, Janssen, Maike, additional, Schäkel, Ulrike, additional, Gall, Julia, additional, Leo, Albrecht, additional, Stelmach, Patrick, additional, Weber, Stefan F., additional, Krisam, Johannes, additional, Baumann, Lukas, additional, Stermann, Jacek, additional, Merle, Uta, additional, Weigand, Markus A., additional, Nusshag, Christian, additional, Bullinger, Lars, additional, Schrezenmeier, Jens-Florian, additional, Bornhäuser, Martin, additional, Alakel, Nael, additional, Witzke, Oliver, additional, Wolf, Timo, additional, Vehreschild, Maria J. G. T., additional, Schmiedel, Stefan, additional, Addo, Marylyn M., additional, Herth, Felix, additional, Kreuter, Michael, additional, Tepasse, Phil-Robin, additional, Hertenstein, Bernd, additional, Hänel, Mathias, additional, Morgner, Anke, additional, Kiehl, Michael, additional, Hopfer, Olaf, additional, Wattad, Mohammad-Amen, additional, Schimanski, Carl C., additional, Celik, Cihan, additional, Pohle, Thorsten, additional, Ruhe, Matthias, additional, Kern, Winfried V., additional, Schmitt, Anita, additional, Lorenz, Hanns-Martin, additional, Souto-Carneiro, Margarida, additional, Gaeddert, Mary, additional, Halama, Niels, additional, Meuer, Stefan, additional, Kräusslich, Hans-Georg, additional, Müller, Barbara, additional, Schnitzler, Paul, additional, Parthé, Sylvia, additional, Bartenschlager, Ralf, additional, Gronkowski, Martina, additional, Klemmer, Jennifer, additional, Schmitt, Michael, additional, Dreger, Peter, additional, Kriegsmann, Katharina, additional, Schlenk, Richard F., additional, and Müller-Tidow, Carsten, additional

Published
2022
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32. 1142. Plasma with high titers of anti-SARS-Cov2 antibodies improves outcome of COVID-19 in patients with hematological malignancy and cancer in a randomized controlled trial

Author

Denkinger, Claudia M, primary, Janssen, Maike, additional, Schäkel, Ulrike, additional, Gall, Julia, additional, Leo, Albrecht, additional, Stelmach, Patrick, additional, Weber, Stefan F, additional, Krisam, Johannes, additional, Baumann, Lukas, additional, Stermann, Jacek, additional, Merle, Uta, additional, Weigand, Markus, additional, Bullinger, Lars, additional, Schrezenmeier, Jens-Florian, additional, Bornhäuser, Martin, additional, Alakel, Nael, additional, Witzke, Oliver, additional, Wolf, Timo, additional, Vehreschild, Maria, additional, Schmiedel, Stefan, additional, Addo, Marylyn, additional, Herth, Felix, additional, Kreuter, Michael, additional, Tepasse, Phil-Robin, additional, Hertenstein, Bernd, additional, Hänel, Mathias, additional, Morgner, Anke, additional, Kiehl, Michael, additional, Hopfer, Olaf, additional, Wattad, Mohammad-Amen, additional, Schimanski, Carl, additional, Celik, Cihan, additional, Pohle, Thorsten, additional, Ruhe, Matthias, additional, Kern, Winfried, additional, Schmitt, Anita, additional, Schmitt, Michael, additional, Lorenz, Hanns-Martin, additional, Souto-Carneiro, Margarida, additional, Halama, Niels, additional, Meurer, Stefan, additional, Kräusslich, Hans-Georg, additional, Müller, Barbara, additional, Bartenschlager, Ralf, additional, Gronkowski, Martina, additional, Klemmer, Jennifer, additional, Kriegsmann, Katharina, additional, Schlenk, Richard, additional, and Müller-Tidow, Carsten, additional

Published
2022
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33. Macs - a Leukemic Stem Cell- Based Predictor of Clinical Response to Venetoclax and Other BH3 Mimetics for Acute Myeloid Leukemia

Author

Renders, Simon, primary, Waclawiczek, Alexander, additional, Leppä, Aino-Maija, additional, Reyneri, Cecilia, additional, Betz, Barbara, additional, Stumpf, Karolin, additional, Janssen, Maike, additional, Unglaub, Julia M., additional, Donato, Elisa, additional, Shahswar, Rabia, additional, Raffel, Simon, additional, Heuser, Michael, additional, Schlenk, Richard F., additional, Hundemer, Michael, additional, Sauer, Tim, additional, Müller-Tidow, Carsten, additional, and Trumpp, Andreas, additional

Published
2022
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34. Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

Author

Beneyto-Calabuig, Sergi, primary, Ludwig, Anne Kathrin, additional, Kniffka, Jonas-Alexander, additional, Szu-Tu, Chelsea, additional, Rohde, Christian, additional, Antes, Magdalena, additional, Waclawiczek, Alexander, additional, Gräßle, Sarah, additional, Pervan, Philip, additional, Janssen, Maike, additional, Landry, Jonathan J. M., additional, Benes, Vladimir, additional, Jauch, Anna, additional, Brough, Michaela, additional, Bauer, Marcus, additional, Besenbeck, Birgit, additional, Felden, Julia, additional, Bäumer, Sebastian, additional, Hundemer, Michael, additional, Sauer, Tim, additional, Pabst, Caroline, additional, Wickenhauser, Claudia, additional, Angenendt, Linus, additional, Schliemann, Christoph, additional, Trumpp, Andreas, additional, Haas, Simon, additional, Scherer, Michael, additional, Raffel, Simon, additional, Müller-Tidow, Carsten, additional, and Velten, Lars, additional

Published
2022
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35. CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia

Author

He, Lixiazi, primary, Arnold, Christian, additional, Thoma, Judith, additional, Rohde, Christian, additional, Kholmatov, Maksim, additional, Garg, Swati, additional, Hsiao, Cheng‐Chih, additional, Viol, Linda, additional, Zhang, Kaiqing, additional, Sun, Rui, additional, Schmidt, Christina, additional, Janssen, Maike, additional, MacRae, Tara, additional, Huber, Karin, additional, Thiede, Christian, additional, Hébert, Josée, additional, Sauvageau, Guy, additional, Spratte, Julia, additional, Fluhr, Herbert, additional, Aust, Gabriela, additional, Müller‐Tidow, Carsten, additional, Niehrs, Christof, additional, Pereira, Gislene, additional, Hamann, Jörg, additional, Tanaka, Motomu, additional, Zaugg, Judith B, additional, and Pabst, Caroline, additional

Published
2022
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36. Humoral Responses and Chronic GVHD Exacerbation after COVID-19 Vaccination Post Allogeneic Stem Cell Transplantation

Author

Pabst, Caroline, primary, Benning, Louise, additional, Liebers, Nora, additional, Janssen, Maike, additional, Caille, Leandra, additional, Speer, Claudius, additional, He, Lixiazi, additional, Schubert, Maria-Luisa, additional, Simons, Laura, additional, Hegenbart, Ute, additional, Schönland, Stefan, additional, Radujkovic, Aleksandar, additional, Schmitt, Michael, additional, Schnitzler, Paul, additional, Müller-Tidow, Carsten, additional, Dietrich, Sascha, additional, Dreger, Peter, additional, and Luft, Thomas, additional

Published
2022
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37. Validation of a proxy‐reported SARC‐F questionnaire for current and retrospective screening of sarcopenia‐related functional impairments

Author

Maurus, Johannes, primary, Terzer, Tobias, additional, Benner, Axel, additional, Goisser, Sabine, additional, Eidam, Annette, additional, Roth, Anja, additional, Janssen, Maike, additional, Jaramillo, Sonia, additional, Lorenz, Hannes Martin, additional, Micol, William, additional, Hauer, Klaus, additional, Müller‐Tidow, Carsten, additional, Bauer, Jürgen M., additional, Jordan, Karin, additional, and Neuendorff, Nina Rosa, additional

Published
2021
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38. CD33‐directed immunotherapy with third‐generation chimeric antigen receptor T cells and gemtuzumab ozogamicin in intact andCD33‐edited acute myeloid leukemia and hematopoietic stem and progenitor cells

Author

Liu, Yi, primary, Wang, Sanmei, additional, Schubert, Maria‐Luisa, additional, Lauk, Annika, additional, Yao, Hao, additional, Blank, Maximilian Felix, additional, Cui, Chunhong, additional, Janssen, Maike, additional, Schmidt, Christina, additional, Göllner, Stefanie, additional, Kleist, Christian, additional, Zhou, Fengbiao, additional, Rahfeld, Jens‐Ulrich, additional, Sauer, Tim, additional, Schmitt, Michael, additional, and Müller‐Tidow, Carsten, additional

Published
2021
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39. Leukemic Stem Cells of Monocytic AMLs Are Not-Resistant to BCL-2 Inhibition

Author

Renders, Simon, primary, Leppä, Aino-Maija, additional, Waclawiczek, Alexander, additional, Janssen, Maike, additional, Donato, Elisa, additional, Reyneri, Cecilia, additional, Unglaub, Julia M., additional, Hundemer, Michael, additional, Schlenk, Richard F., additional, Raffel, Simon, additional, Müller-Tidow, Carsten, additional, Sauer, Tim, additional, and Trumpp, Andreas, additional

Published
2021
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40. Venetoclax-Azacitidine As Salvage Therapy and Bridge to Allogeneic Cell Transplantation in Relapsed/Refractory AML Compared to Historical Data of the SAL Registry Study

Author

Unglaub, Julia M., primary, Schlenk, Richard F., additional, Hanoun, Maher, additional, Reinhardt, H. Christian, additional, Middeke, Jan Moritz, additional, Schäfer-Eckart, Kerstin, additional, Steffen, Björn, additional, Krause, Stefan W., additional, Schliemann, Christoph, additional, Kaufmann, Martin, additional, Haenel, Mathias, additional, Jost, Edgar, additional, Crysandt, Martina, additional, Fransecky, Lars, additional, Kraus, Sabrina, additional, Einsele, Hermann, additional, Niemann, Dirk, additional, Neubauer, Andreas, additional, Seggewiss-Bernhardt, Ruth, additional, Scholl, Sebastian, additional, Klein, Stefan, additional, Schmid, Christoph, additional, Schaich, Markus, additional, Platzbecker, Uwe, additional, Baldus, Claudia D., additional, Bornhäuser, Martin, additional, Serve, Hubert, additional, Rollig, Christoph, additional, Kramer, Michael, additional, Katelari, Elena, additional, Janssen, Maike, additional, Pabst, Caroline, additional, Luft, Thomas, additional, Dreger, Peter, additional, Müller-Tidow, Carsten, additional, and Sauer, Tim, additional

Published
2021
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42. Misslingensbedingungen einer Plattformintegration. Rekonstruktion eines Software-Entwicklungsprozesses für das Universitätskrankenhaus.

Author

Janssen, Maike

Subjects
STRUCTURAL health monitoring, DIGITAL technology, UNIVERSITY hospitals, SOCIAL structure
Abstract

Die Digitalisierung findet längst auch im Gesundheitswesen und mithin in seiner herausragenden Subinstitution, dem Krankenhaus, statt. Konkrete Digitalisierungsprojekte sind dabei häufig von Mehrdeutigkeiten und Widerständen begleitet, die auf die komplexen soziotechnischen Herstellungszusammenhänge verweisen, in denen sie realisiert werden. Dieser Artikel arbeitet anhand einer empirischen Fallstudie die Ge- bzw. Misslingensbedingungen für die Integration multipler Interessen in eine digitale Überwachungsplattform heraus und geht den strukturellen Effekten des Entwicklungsprozesses für das beteiligte Universitätskrankenhaus nach. Dabei zeigt sich: Erwartungs-, Deutungs- und Konstellationsstrukturen der organisierten Krankenbehandlung können insbesondere dann verändert werden, wenn auch die mehrdimensionale Kontrolle der ökonomischen Übersetzung, die Herstellung zeitlicher Kohärenz und die Kongruenz von digitaltechnischer und sozialer Konstellationsstruktur gelingen. Diese Momente situativer Schließung lassen sich ausgehend von den empirischen Übersetzungen einer digitalen Plattform rekonstruieren und als Bedingung der Möglichkeit für strukturelle Effekte aus dem Plattformentwicklungsprozess behandeln. Digitisation has long been taking place in the health sector and thus in its most prominent sub-institution, the hospital. Concrete digitisation projects are often accompanied by ambiguities and resistances that refer to the complex socio-technical production contexts in which they are realised. This article uses an empirical case study to work out the conditions for the integration of multiple interests in a digital monitoring platform and the structural effects of the development process on the university hospital involved. The study shows that structures of expectation, interpretation and constellation in organised health care can be changed if the multidimensional control of economic translation, the creation of temporal coherence and the congruence of digital and social constellation structures are successful. These moments of situational closure can be reconstructed based on the empirical translations of a digital platform and treated as a condition for the possibility of structural effects from the platform development process. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Hotspot DNMT3A mutations in Clonal Hematopoiesis and Acute Myeloid Leukemia sensitize cells to Azacytidine via viral mimicry response

Author

Scheller, Marina, primary, Ludwig, Anne Kathrin, additional, Göllner, Stefanie, additional, Rohde, Christian, additional, Krämer, Stephen, additional, Stäble, Sina, additional, Janssen, Maike, additional, Müller, James-Arne, additional, He, Lixiazi, additional, Bäumer, Nicole, additional, Arnold, Christian, additional, Gerß, Joachim, additional, Schönung, Maximilian, additional, Thiede, Christian, additional, Niederwieser, Christian, additional, Niederwieser, Dietger, additional, Serve, Hubert, additional, Berdel, Wolfgang E., additional, Thiem, Ulrich, additional, Hemmerling, Inga, additional, Leuschner, Florian, additional, Plass, Christoph, additional, Schlesner, Matthias, additional, Zaugg, Judith, additional, Milsom, Micheal, additional, Trumpp, Andreas, additional, Pabst, Caroline, additional, Lipka, Daniel B., additional, and Müller-Tidow, Carsten, additional

Published
2021
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44. CD33‐directed immunotherapy with third‐generation chimeric antigen receptor T cells and gemtuzumab ozogamicin in intact and CD33‐edited acute myeloid leukemia and hematopoietic stem and progenitor cells.

Author

Liu, Yi, Wang, Sanmei, Schubert, Maria‐Luisa, Lauk, Annika, Yao, Hao, Blank, Maximilian Felix, Cui, Chunhong, Janssen, Maike, Schmidt, Christina, Göllner, Stefanie, Kleist, Christian, Zhou, Fengbiao, Rahfeld, Jens‐Ulrich, Sauer, Tim, Schmitt, Michael, and Müller‐Tidow, Carsten

Subjects
CHIMERIC antigen receptors, HEMATOPOIETIC stem cells, ACUTE myeloid leukemia, STEM cell transplantation, ANTIBODY-drug conjugates
Abstract

Immunotherapies, such as chimeric antigen receptor (CAR) modified T cells and antibody‐drug conjugates (ADCs), have revolutionized the treatment of cancer, especially of lymphoid malignancies. The application of targeted immunotherapy to patients with acute myeloid leukemia (AML) has been limited in particular by the lack of a tumor‐specific target antigen. Gemtuzumab ozogamicin (GO), an ADC targeting CD33, is the only approved immunotherapeutic agent in AML. In our study, we introduce a CD33‐directed third‐generation CAR T‐cell product (3G.CAR33‐T) for the treatment of patients with AML. 3G.CAR33‐T cells could be expanded up to the end‐of‐culture, that is, 17 days after transduction, and displayed significant cytokine secretion and robust cytotoxic activity when incubated with CD33‐positive cells including cell lines, drug‐resistant cells, primary blasts as well as normal hematopoietic stem and progenitor cells (HSPCs). When compared to second‐generation CAR33‐T cells, 3G.CAR33‐T cells exhibited higher viability, increased proliferation and stronger cytotoxicity. Also, GO exerted strong antileukemia activity against CD33‐positive AML cells. Upon genomic deletion of CD33 in HSPCs, 3G.CAR33‐T cells and GO preferentially killed wildtype leukemia cells, while sparing CD33‐deficient HSPCs. Our data provide evidence for the applicability of CD33‐targeted immunotherapies in AML and its potential implementation in CD33 genome‐edited stem cell transplantation approaches. What's new? In the development of immunotherapy for acute myeloid leukemia (AML), a target of interest is CD33, which is expressed on blast cells in more than 90 percent of AML patients. CD33 is also expressed on healthy myeloid and progenitor cells, however, raising the risk for off‐target effects with CD33 therapies. Here, the authors introduce a CD33‐directed third‐generation chimeric antigen receptor (CAR) T‐cell product (3G.CAR33‐T). 3G.CAR33‐T cells were effective against CD33‐positive cells, including AML blasts, and successfully overcame AML drug resistance. Genomic deletion of CD33 in hematopoietic stem and progenitor cells resulted in preferential killing of leukemia cells by 3G.CAR33‐T cells. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Can we predict antibody responses in SARS-CoV-2? A cohort analysis

Author

Gaeddert, Mary, primary, Kitchen, Philip, additional, Broger, Tobias, additional, Weber, Stefan, additional, Bartenschlager, Ralf, additional, Plaszczyca, Anna, additional, Kräusslich, Hans-Georg, additional, Müller, Barbara, additional, Souto-Carneiro, Margarida, additional, Janssen, Maike, additional, Müller-Tidow, Carsten, additional, Merle, Uta, additional, Herrmann, Yannis, additional, Raedeker, Lukas, additional, Sebastian, Jakob, additional, Brindl, Niall, additional, Starck, Tim, additional, and Denkinger, Claudia M., additional

Published
2021
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46. Additional file 1 of A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Fokou, Carine Djuka, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Hanns-Martin Lorenz, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Hans-Georg Kräusslich, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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47. Additional file 2 of A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Fokou, Carine Djuka, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Hanns-Martin Lorenz, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Hans-Georg Kräusslich, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2020
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48. Additional file 3 of A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Fokou, Carine Djuka, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Hanns-Martin Lorenz, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Hans-Georg Kräusslich, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Subjects
Data_FILES
Abstract

Additional file 3.

Published
2020
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