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1. Local alterations of left arcuate fasciculus and transcallosal white matter microstructure in schizophrenia patients with medication-resistant auditory verbal hallucinations: A pilot study

Author

Thomas, Fanny, Gallea, Cécile, Moulier, Virginie, Bouaziz, Noomane, Valero-Cabré, Antoni, and Januel, Dominique

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

Auditory verbal hallucinations (AVH) in schizophrenia (SZ) have been associated with abnormalities of the left arcuate fasciculus and transcallosal white matter projections linking homologous language areas of both hemispheres. While most studies have used a whole-tract approach, here we focused on analyzing local alterations of the above-mentioned pathways in SZ patients suffering medication-resistant AVH.Fractional anisotropy (FA) was estimated along the left arcuate fasciculus and interhemispheric projections of the rostral and caudal corpus callosum. Then, potential associations between white matter tracts and SZ symptoms were explored by correlating local site-by-site FA values and AVH severity estimated via the Auditory Hallucinations Rating Scale (AHRS). Compared to a sample of healthy controls, SZ patients displayed lower FA values in the rostral portion of the left arcuate fasciculus, near the frontal operculum, and in the left and right lateral regions of the rostral portion of the transcallosal pathways. In contrast, SZ patients showed higher FA values than healthy controls in the medial portion of the latter transcallosal pathway and in the midsagittal section of the interhemispheric auditory pathway. Finally, significant correlations were found between local FA values in the left arcuate fasciculus and the severity of the AVH's attentional salience. Contributing to the study of associations between local white matter alterations of language networks and SZ symptoms, our findings highlight local alterations of white matter integrity in these pathways linking language areas in SZ patients with AVH. We also hypothesize a link between the left arcuate fasciculus and the attentional capture of AVH., Comment: Neuroscience, Elsevier - International Brain Research Organization, 2022

Published
2022
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4. Clinical characteristics associated with discrepancies between self- and clinician-rated suicidal ideation in patients with bipolar disorder (FACE-BD cohort)

Author

Nobile, Bénédicte, Belzeaux, Raoul, Aouizerate, Bruno, Dubertret, Caroline, Haffen, Emmanuel, Llorca, Pierre-Michel, Roux, Paul, Polosan, Mircea, Schwan, Raymund, Walter, Michel, Rey, Romain, Januel, Dominique, Leboyer, Marion, Bellivier, Frank, Etain, Bruno, Courtet, Philippe, and Olié, Emilie

Published
2023
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5. Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort

Author

Lengvenyte, Aiste, Strumila, Robertas, Belzeaux, Raoul, Aouizerate, Bruno, Dubertret, Caroline, Haffen, Emmanuel, Llorca, Pierre-Michel, Roux, Paul, Polosan, Mircea, Schwan, Raymund, Walter, Michel, D'Amato, Thierry, Januel, Dominique, Leboyer, Marion, Bellivier, Frank, Etain, Bruno, Navickas, Alvydas, Olié, Emilie, and Courtet, Philippe

Published
2023
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6. Prospective survey of psychiatric patients during the first confinement of the COVID 2019 pandemic

Author

Januel, Dominique, Fourati, Taoufik, Moulier, Virginie, Ledosseur, Yann, Bolloré, Ombline, Isaac, Clémence, Senouci, Habib, Benadhira, René, Stamatiadis, Laurence, Saba, Ghassen, Mascarenhas, Eugenia, Beaucousin, Marie Christine, Ernouf, Thibault, Slama, Frédéric, Motut, Alex, Rosetti, Raluca, Vassal, Laurent, Pecot, Fabrice, Chammas, Francesca, Baha, Djamel, Rejeb, Hammadi Ben, and Bouaziz, Noomane

Published
2021
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7. L’identitovigilance en psychiatrie

Author

Jabri, Samir, primary, Horpin, Aurélia, additional, Thomas, Fanny, additional, Januel, Dominique, additional, Moulier, Virginie, additional, and Bouaziz, Noomane, additional

Published
2024
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13. Troubles de l’humeur : quand recourir à la stimulation magnétique transcrânienne ?

Author

Bulteau, Samuel, Guirette, Charline, Brunelin, Jérôme, Poulet, Emmanuel, Trojak, Benoît, Richieri, Raphaëlle, Szekely, David, Bennabi, Djamila, Yrondi, Antoine, Rotharmel, Maud, Bougerol, Thierry, Dall’Igna, Gaëlle, Attal, Jérôme, Benadhira, René, Bouaziz, Noomane, Bubrovszky, Maxime, Calvet, Benjamin, Dollfus, Sonia, Foucher, Jack, Galvao, Filipe, Gay, Aurélia, Haesebaert, Frédéric, Haffen, Emmanuel, Jalenques, Isabelle, Januel, Dominique, Jardri, Renaud, Millet, Bruno, Nathou, Clément, Nauczyciel, Cecilia, Plaze, Marion, Rachid, Fady, Vanelle, Jean-Marie, and Sauvaget, Anne

Published
2019
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14. Link between metacognition and social cognition in schizophrenia: a systematic review and meta-analysis.

Author

Motut, Alex, Isaac, Clémence, Castillo, Marie-Carmen, and Januel, Dominique

Subjects
SOCIAL perception, METACOGNITION, THEORY of mind, SOCIAL cues, SCHIZOPHRENIA
Abstract

Introduction: Metacognition is the ability to reflect on one's own cognitive processes, monitor and regulate them to enhance mental performance. Social cognition involves the capacity to perceive and respond to social cues from others. The study of metacognition and social cognition is an expanding research field in psychiatry. Both domains are related to neurocognition, symptoms and psychosocial functioning in schizophrenia. Understanding the relationship between social cognition and metacognition may be pivotal for enhancing the treatment of cognitive symptoms in schizophrenia. Methods: We conducted a PRISMA systematic review and meta-analysis on quantitative studies comparing metacognition to social cognitive outcomes in adult outpatients with a schizophrenia spectrum disorder. Reports were retrieved from the Medline, ScienceDirect and PsycINFO databases up to July 13th, 2023. Risk of bias was assessed with the Cochrane tool. Results: Our review included 1,036 participants across 17 reports, with 12 reports included in the meta-analysis. We found a significant positive correlation (r = 0.28, 95% CI: [0.14, 0.41]) between social cognition and metacognition. Subgroup analyses indicated that metacognition was specifically associated with theory of mind, attribution, and emotion processing. Different patterns of correlations were observed according to the assessment of metacognition and its subdimensions. Conclusion: Despite discrepancies among the included studies, no publication bias was detected. The results suggest that metacognition and social cognition are distinct but related constructs. Those processes should be assessed and treated together, along with neurocognition, in schizophrenia. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study.

Author

Risch, Nathan, Dubois, Jonathan, Etain, Bruno, Aouizerate, Bruno, Bellivier, Frank, Belzeaux, Raoul, Dubertret, Caroline, Haffen, Emmanuel, Januel, Dominique, Leboyer, Marion, Lefrere, Antoine, Samalin, Ludovic, Polosan, Mircea, Rey, Romain, Roux, Paul, Schwan, Raymund, Walter, Michel, Courtet, Philippe, and Olié, Emilie

Subjects
LITHIUM carbonate, BIPOLAR disorder, SLEEP quality, SUICIDE risk factors, ATTEMPTED suicide
Abstract

Background. Physical pain is a common issue in people with bipolar disorder (BD). It worsens mental health and quality of life, negatively impacts treatment response, and increases the risk of suicide. Lithium, which is prescribed in BD as a mood stabilizer, has shown promising effects on pain. Methods. This naturalistic study included 760 subjects with BD (FACE-BD cohort) divided in two groups: with and without self-reported pain (evaluated with the EQ-5D-5L questionnaire). In this sample, 176 subjects were treated with lithium salts. The objectives of the study were to determine whether patients receiving lithium reported less pain, and whether this effect was associated with the recommended mood-stabilizing blood concentration of lithium. Results. Subjects with lithium intake were less likely to report pain (odds ratio [OR] = 0.59, 95% confidence interval [CI], 0.35-0.95; p = 0.036) after controlling for sociodemographic variables, BD type, lifetime history of psychiatric disorders, suicide attempt, personality traits, current depression and anxiety levels, sleep quality, and psychomotor activity. Subjects taking lithium were even less likely to report pain when lithium concentration in blood was =0.5 mmol/l (OR = 0.45, 95% CI, 0.24-0.79; p = 0.008). Conclusions. This is the first naturalistic study to show lithium's promising effect on pain in subjects suffering from BD after controlling for many confounding variables. This analgesic effect seems independent of BD severity and comorbid conditions. Randomized controlled trials are needed to confirm the analgesic effect of lithium salts and to determine whether lithium decreases pain in other vulnerable populations. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Moving to accelerated protocols of tDCS in catatonia: a case report.

Author

Bouaziz, Noomane, Luisada, Jean-Charles, Jabri, Samir, Andrianisaina, Palmyre S.-K., Bellis, Avicenne, and Januel, Dominique

Subjects
TRANSCRANIAL direct current stimulation, CATATONIA, ELECTROCONVULSIVE therapy, HEALTH facilities, TEMPOROPARIETAL junction
Abstract

Catatonia is a severe and potentially life-threatening neuropsychiatric condition. Electroconvulsive therapy (ECT) is the gold standard second-line intervention for catatonia after benzodiazepine failure. However, the access to ECT can be particularly challenging, especially during periods of increased strain on medical facilities, such as the COVID-19 pandemic. Several case reports have suggested the potential efficacy of transcranial direct current stimulation (tDCS) in addressing catatonia. In our case, we present the successful application of intensive tDCS, delivering five sessions per day, each lasting 20 min, with an intensity of 2 mA. The tDCS montage involved placing the anode on the left dorsolateral prefrontal cortex (DLPFC) and the cathode on the left temporoparietal junction (TPJ). This approach was well-tolerated and resulted in a significant improvement in a 70-year-old patient with catatonia, for whom ECT was deemed necessary. While these results are promising, it is crucial to confirm them through a randomized controlled study. [ABSTRACT FROM AUTHOR]

Published
2024
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18. No place in France for repetitive transcranial magnetic stimulation in the therapeutic armamentarium of treatment-resistant depression?

Author

Batail, Jean-Marie, primary, Gaillard, Raphaël, additional, Haffen, Emmanuel, additional, Poulet, Emmanuel, additional, Sauvaget, Anne, additional, Szekely, David, additional, Brunelin, Jérôme, additional, Bulteau, Samuel, additional, Bubrovszky, Maxime, additional, Smadja, Julien, additional, Bourla, Alexis, additional, Bouaziz, Noomane, additional, Januel, Dominique, additional, Rotharmel, Maud, additional, Arns, Martijn, additional, Downar, Jonathan, additional, Fitzgerald, Paul B., additional, Brunoni, André R., additional, Pallanti, Stefano, additional, D'Urso, Giordano, additional, Baeken, Chris, additional, Williams, Nolan R., additional, Millet, Bruno, additional, Lefaucheur, Jean-Pascal, additional, and Drapier, Dominique, additional

Published
2023
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19. Real world transcranial magnetic stimulation for major depression: A multisite, naturalistic, retrospective study

Author

Bouaziz, Noomane, primary, Laidi, Charles, additional, Bulteau, Samuel, additional, Berjamin, Caroline, additional, Thomas, Fanny, additional, Moulier, Virginie, additional, Benadhira, René, additional, Szekely, David, additional, Poulet, Emmanuel, additional, Galvao, Filipe, additional, Guillin, Olivier, additional, Castillo, Marie-Carmen, additional, Sauvaget, Anne, additional, Plaze, Marion, additional, Januel, Dominique, additional, Brunelin, Jérôme, additional, and Rotharmel, Maud, additional

Published
2023
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23. La mémoire de la source

Author

Braha-Zeitoun, Sonia, Schenin-King, Palmyre, Bouaziz, Noomane, Isaac, Clémence, Moulier, Virginie, Gaudeau-Bosma, Christian, and Januel, Dominique

Published
2015
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30. Specific vs general cognitive remediation for executive functioning in schizophrenia: A multicenter randomized trial

Author

Franck, Nicolas, Duboc, Chloé, Sundby, Charlotte, Amado, Isabelle, Wykes, Til, Demily, Caroline, Launay, Corinne, Le Roy, Vincent, Bloch, Pascal, Willard, Dominique, Todd, Aurélia, Petitjean, François, Foullu, Sandrine, Briant, Patrick, Grillon, Marie-Laure, Deppen, Patricia, Verdoux, Hélène, Bralet, Marie-Cécile, Januel, Dominique, Riche, Benjamin, Roy, Pascal, and Vianin, Pascal

Published
2013
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34. Effect of Intermittent Theta Burst Stimulation on the Neural Processing of Emotional Stimuli in Healthy Volunteers

Author

Moulier, Virginie, primary, Gaudeau-Bosma, Christian, additional, Thomas, Fanny, additional, Isaac, Clémence, additional, Thomas, Maxence, additional, Durand, Florence, additional, Schenin-King Andrianisaina, Palmyre, additional, Valabregue, Romain, additional, Laidi, Charles, additional, Benadhira, René, additional, Bouaziz, Noomane, additional, and Januel, Dominique, additional

Published
2021
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39. Cognitive Impact of Cerebellar Non-invasive Stimulation in a Patient With Schizophrenia

Author

Laidi, Charles, Levenes, Carole, Suarez-Perez, Alex, Février, Caroline, Durand, Florence, Bouaziz, Noomane, Januel, Dominique, Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, IMRB - 'Neuropsychiatrie translationnelle' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Unité de recherche en NeuroImagerie Applicative Clinique et Translationnelle (UNIACT), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Fondation FondaMental [Créteil], Centre Neurosciences intégratives et Cognition (INCC - UMR 8002), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Unité de Recherche Clinique de l'Hôpital de Ville-Evrard [Neuilly-sur-​Marne] (URCVE), Etablissement public de santé de Ville-Evrard (EPS), and Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Psychiatry, cognition, schizophrenia, tDCS—transcranial direct current stimulation, cerebellum, Case Report, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], eyeblink conditioning
Abstract

International audience; Cerebellum plays a role in the regulation of cognitive processes. Cerebellar alterations could explain cognitive impairments in schizophrenia. We describe the case of a 50 years old patient with schizophrenia whom underwent cerebellar transcranial direct current stimulation (tDCS). In order to study the effect of cerebellar stimulation on cognitive functions, the patient underwent a neuropsychological assessment and an eyeblink conditioning (EBC) protocol. Although the effect of brain stimulation cannot be only assessed in a single-case study, our results suggest that cerebellar stimulation may have an effect on a broad range of cognitive functions typically impaired in patients with schizophrenia, including verbal episodic, short term, and working memory. In addition to neuropsychological tests, we evaluated the cerebellar function by performing EBC before and after tDCS. Our data suggest that tDCS can improve EBC. Further clinical trials are required for better understanding of how cerebellar stimulation can modulate cognitive processes in patients with schizophrenia and healthy controls.

Published
2020

43. Psychiatric symptoms and quality of life in older adults with schizophrenia spectrum disorder: results from a multicenter study

Author

Bulteau, Samuel, Guirette, Charline, Brunelin, Jérôme, Poulet, Emmanuel, Trojak, Benoit, Richieri, Raphaëlle, Szekely, David, Bennabi, Djamila, Yrondi, Antoine, Rotharmel, Maud, Bougerol, Thierry, Dall’igna, Gaëlle, Attal, Jérôme, Benadhira, René, Bouaziz, Noomane, Bubrovszky, Maxime, Calvet, Benjamin, Dollfus, Sonia, Foucher, Jack, Galvao, Filipe, Gay, Aurélia, Haesebaert, Frédéric, Haffen, Emmanuel, Jalenques, Isabelle, Januel, Dominique, Jardri, Renaud, Millet, Bruno, Nathou, Clément, Nauczyciel, Cecilia, Plaze, Marion, Vanelle, Jean-Marie, Sauvaget, Anne, Hoertel, Nicolas, Rotenberg, Léa, Blanco, Carlos, Pascal de Raykeer, Rachel, Hanon, Cécile, Kaladjian, Arthur, Limosin, Frédéric, Service d'addictologie[CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Désordres psychiatriques, de la résistance à la réponse [Bron] (PsyR2), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de psychiatrie générale et addictologie [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Laboratoire de santé publique évaluation des systèmes de soins et santé perçue, ANTE-INSERM U836, équipe 11, Fonctions cérébrales et neuromodulation, Unité Traitements Biologiques, CHU Grenoble-Clinique Universitaire de Psychiatrie-CHU Grenoble-Clinique Universitaire de Psychiatrie, Université Bourgogne Franche-Comté [COMUE] (UBFC), Toulouse Neuro Imaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique du cancer et des maladies neuropsychiatriques (GMFC), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinique Psychiatrique, CHU Grenoble-Pavillon Dominique-Villars, Neuropsychiatrie : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratoire de Psychopathologie et Neuropsychologie (LPN), Université Paris 8 Vincennes-Saint-Denis (UP8), Unité de Recherche Clinique [Ville-Evrard], Ville-Evrard: Etablissement de Ville-Evrard santé mentale psychiatrie 93, Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Service de Psychiatrie [CHU Limoges], CHU Limoges, Service de psychiatrie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Laboratoire de Psychopathologie et de Pharmacologie de la Cognition, IFR37-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier le Vinatier [Bron], Département de psychiatrie et d'addictologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)-Hôpital Nord (Saint Etienne), Fondation FondaMental [Créteil], Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Guillaume Régnier (CHGR), CH Régnier, Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Service de psychiatrie adultes et de psychologie médicale [Rennes], Neuroimagerie en psychiatrie (U1000), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Sud - Paris 11 (UP11), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Corentin Celton [Issy-les-Moulineaux], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Universitaire de Reims (CHU Reims), Service de psychiatrie, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Corentin Celton [Issy-les-Moulineaux], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Psychiatric Disorders, Neuroscience Research and Clinical Research (PSYR2), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Service de Psychiatrie et d'Addictologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Psychiatrie et Neurosciences (U894), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Corentin Celton [Issy-les-Moulineaux], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Sud - Paris 11 (UP11), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), and IFR37-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SCCO.NEUR]Cognitive science/Neuroscience, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

44. Biomarqueurs cérébraux structurels et fonctionnels de la réponse clinique à la SMTr des hallucinations auditives résistantes aux médicaments chez les patients atteints de schizophrénie: protocole d'étude pour un essai clinique randomisé en double aveugle contrôlé de façon fictive

Author

Thomas, Fanny, Bouaziz, Noomane, Gallea, Cécile, Schenin-King Andrianisaina, Palmyre, Durand, Florence, Bolloré, Ombline, Benadhira, René, Isaac, Clémence, Braha-Zeitoun, Sonia, Moulier, Virginie, Januel, Dominique, Direction de l'évaluation, de la prospective et de la performance (DEPP), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Unité de Recherche Clinique [Ville-Evrard], Ville-Evrard: Etablissement de Ville-Evrard santé mentale psychiatrie 93, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Psychopathologie et Neuropsychologie (LPN), Université Paris 8 Vincennes-Saint-Denis (UP8), Unité de recherche clinique 93G03, établissement public de santé de Ville Evrard, 93330 Neuilly-sur-Marne, France., Action-Neuroimagerie-Modelisation (ANIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [APHP]

Subjects
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SCCO.NEUR]Cognitive science/Neuroscience, Sprague effect, paradoxical lesion effects, PhD Corresponding Author's Institution: University of Picardy Jules Verne, lesion inference, visuo-spatial attention, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, neglect Corresponding Author: Dr Monica N Toba, functional restoration
Abstract

International audience; Background: The potential of non-invasive repetitive transcranial magnetic stimulation (rTMS) to improve auditory verbal hallucinations (AVH) in schizophrenia patients has been increasingly explored over the past decade. Despite highly promising results, high inter-individual variability of clinical response and ineffective outcomes in a significant number of patients underscored the need to identify factors associated with the clinical response to rTMS. It should help improve the efficacy of rTMS in patients with medication-resistant AVH, and allow a better understanding of its neural impact. Here, we describe an exploratory study protocol which aims to identify structural and functional brain biomarkers associated with clinical response after an rTMS treatment for medication-resistant AVH in schizophrenia.; Contexte: Le potentiel de la stimulation magnétique transcrânienne répétitive non invasive (SMTr) pour améliorer les hallucinations verbales auditives (AVH) chez les patients schizophrènes a été de plus en plus exploré au cours de la dernière décennie. Malgré des résultats très prometteurs, la forte variabilité interindividuelle de la réponse clinique et les résultats inefficaces chez un nombre important de patients ont souligné la nécessité d'identifier les facteurs associés à la réponse clinique à la SMTr. Il devrait aider à améliorer l'efficacité de la SMTr chez les patients atteints d'AVH résistant aux médicaments et permettre une meilleure compréhension de son impact neuronal. Ici, nous décrivons un protocole d'étude exploratoire qui vise à identifier les biomarqueurs cérébraux structurels et fonctionnels associés à la réponse clinique après un traitement rTMS pour AVH résistant aux médicaments dans la schizophrénie.

Published
2019

45. Additional file 1: of Structural and functional brain biomarkers of clinical response to rTMS of medication-resistant auditory hallucinations in schizophrenia patients: study protocol for a randomized sham-controlled double-blind clinical trial

Author

Thomas, Fanny, Noomane Bouaziz, Gallea, Cécile, Andrianisaina, Palmyre Schenin-King, Durand, Florence, Bolloré, Ombline, Benadhira, René, Isaac, Clémence, Braha-Zeitoun, Sonia, Moulier, Virginie, Valero-Cabré, Antoni, and Januel, Dominique

Abstract

SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 122 kb)

Published
2019
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