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1. A Predictive and an Optimization Mathematical Model for Device Design in Cardiac Pulsed Field Ablation Using Design of Experiments

Author: Eoghan Dunne, Jara M. Baena-Montes, Kevin Donaghey, Cormac Clarke, Marcin J. Kraśny, Bilal Amin, Tony O’Halloran, Leo R. Quinlan, Adnan Elahi, and Martin O’Halloran
Subjects: pulsed field ablation, atrial fibrillation, in vitro, cardiomyocytes, design of experiments, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Cardiac catheter ablation (CCA) is a common method used to correct cardiac arrhythmia. Pulsed Field Ablation (PFA) is a recently-adapted CCA technology whose ablation is dependent on electrode and waveform parameters (factors). In this work, the use of the Design of Experiments (DoE) methodology is investigated for the design and optimization of a PFA device. The effects of the four factors (input voltage, electrode spacing, electrode width, and on-time) and their interactions are analyzed. An empirical model is formed to predict and optimize the ablation size responses. Based on the ranges tested, the significant factors were the input voltage, the electrode spacing, and the on time, which is in line with the literature. Two-factor interactions were found to be significant and need to be considered in the model. The resulting empirical model was found to predict ablation sizes with less than 2.1% error in the measured area and was used for optimization. The findings and the strong predictive model developed highlight that the DoE approach can be used to help determine PFA device design, to optimize for certain ablation zone sizes, and to help inform device design to tackle specific cardiac arrhythmias.
Published: 2023
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2. CHROMOSOME NUMBER VARIATION IN PART OF THE FLORA OF PROTECTED WILD AREAS IN THE ARAUCANiA REGION OF SOUTHERN CHILE

Author: Jara-Seguel P., Urrutia-Estrada J., Vallejos N., Andrade E., and Jara M.
Subjects: chromosome number heterogeneity, floristic diversity, chilean flora, Genetics, QH426-470
Abstract: An analysis was made of the correspondence between species diversity and chromosome number (CN) diversity across 13 Protected Wild Areas (PWA) in the Araucanía Region of southern Chile, encompassing 84 plant species with available cytogenetic data. Our aim was to establish whether higher species diversity within a PWA entails higher CN variation as based on the index of chromosome number heterogeneity (ICNH). The CN data were extracted from databases for Chilean plants, and the ICNH for the flora of each PWA was calculated. Results showed that in nine PWA the species diversity clearly correlates with CN diversity. However, four PWA do not fit this trend. The percentage of species with CN data varied between 9.6% and 24.5% among PWA, with 11 PWA presenting percentages higher than 11%. A 27.3% of the Chilean vascular plant species with available cytogenetic data were studied here for the 13 PWA. The results obtained by studying one part of the flora with available CN data suggest that the PWA could be an important reservoir of genetic diversity at a chromosome level, thus justifying the protective role of the PWA as biodiversity conservation sites.
Published: 2020
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3. Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic

Author: Anna M. Cervantes-Arslanian, MD, Chakradhar Venkata, MD, Pria Anand, MD, Joseph D. Burns, MD, Charlene J. Ong, MD, Allison M. LeMahieu, MS, Phillip J. Schulte, PhD, Tarun D. Singh, MD, Alejandro A. Rabinstein, MD, Neha Deo, BS, Vikas Bansal, MBBS, MPH, Karen Boman, BS, Juan Pablo Domecq Garces, MD, Donna Lee Armaignac, PhD, APRN, Amy B. Christie, MD, Roman R. Melamed, MD, Yasir Tarabichi, MD, MSCR, Sreekanth R. Cheruku, MD, MPH, Ashish K. Khanna, MD, FCCP, FCCM, FASA, Joshua L. Denson, MD, MS, Valerie M. Banner-Goodspeed, MPH, Harry L. Anderson, III, MD, FACS, FICS, FCCM, FCCP, FAIM, Ognjen Gajic, MD, MS, Vishakha K. Kumar, MD, MBA, Allan Walkey, MD, Rahul Kashyap, MD, MBA, on behalf of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group, Jean-Baptiste Mesland, Pierre Henin, Hélène Petre, Isabelle Buelens, Anne-Catherine Gerard, Philippe Clevenbergh, Rolando Claure-Del Granado, Jose A. Mercado, Esdenka Vega-Terrazas, Maria F. Iturricha-Caceres, Ruben Garza, Eric Chu, Victoria Chan, Oscar Y Gavidia, Felipe Pachon, Yeimy A Sanchez, Danijel knežević, Mohamed El Kassas, Mohamed Badr, Ahmed Tawheed, Hend Yahia, Dimitrios Kantas, Vasileios Koulouras, Estela Pineda, Gabina María Reyes Guillen, Helin Archaga Soto, Ana Karen Vallecillo Lizardo, Csaba Kopitkó, Ágnes Bencze, István Méhész, Zsófia Gerendai,, Girish Vadgaonkar, Rekha Ediga, Shilpa Basety, Shwetha Dammareddy, Phani Sreeharsha Kasumalla, Smitha S. Segu, Tuhin Chakraborty, Epcebha Joyce, Sridhar Papani, Mahesh Kamuram, Mradul Kumar Daga, Munisha Agarwal, Ishan Rohtagi, Anusha Cherian, Sreejith Parameswaran, Magesh Parthiban, Phaneendra Doddaga, Neethi Chandra, Puneet Rijhwani, Ashish Jain, Aviral Gupta, Ram Mohan Jaiswal, Ambika Tyagi, Nimish Mathur, Madhav Prabhu, Vishal Jakati, Mukur Petrolwala, Bharat Ladva, Surapaneni Krishna Mohan, Ekambaram Jyothisree, Umamaheswara Raju, Janaki Manduva, Naresh Kolakani, Shreeja Sripathi, Sheetal Chaitanya, Kamlesh Kumar Agrawal, Vijendra Baghel, Kirti Kumar Patel, Nooshin Dalili, Mohsen Nafa, Wataru Matsuda, Reina Suzuki, Michihito Kyo, Shu Tahara, Mineji Hayakawa, Kunihiko Maekawa, Masamitsu Sanui, Sho Horikita, Yuki Itagaki, Akira Kodate, Yuki Takahashi, Koyo Moriki, Takuya Shiga, Yudai Iwasaki, Hidenobu Shigemitsu, Yuka Mishima, Nobuyuki Nosaka, Michio Nagashima, Abdulrahman Al-Fares, Rene Rodriguez-Gutierrez, Jose Gerardo Gonzalez-Gonzalez, Alejandro Salcido-Montenegro, Adrian Camacho-Ortiz, Mariana Janeth Hermosillo Ulloa, Fatimah Hassan-Hanga, Hadiza Galadanci, Abubakar Shehu Gezawa, Halima M. S. Kabara, Taiwo Gboluwaga Amole, Halima Kabir, Dalha Gwarzo Haliru, Abdullahi S Ibrahim, Muhammad Sohaib Asghar, Mashaal Syed, Syed Anosh Ali Naqvi, Igor Borisovich Zabolotskikh,, Konstantin Dmitrievich Zybin, Sergey Vasilevich Sinkov, Tatiana Sergeevna Musaeva, Razan K Alamoudi, Hassan M. AlSharif, Sarah A. Almazwaghi, Mohammed S Elsakran, Mohamed A Aid, Mouaz A Darwich, Omnia M Hagag, Salah A Ali, Alona rocacorba, Kathrine Supeña, Efren Ray Juane, Jenalyn Medina, Jowany Baduria, Marwa Ridha Amer, Mohammed Abdullah, Bawazeer, Talal I. Dahhan, Eiad Kseibi, Abid Shahzad Butt, Syed Moazzum Khurshid, Muath Rabee, Mohammed Abujazar, Razan Alghunaim, Maal Abualkhair, Abeer Turki AlFirm, Yaseen M Arabi, Sheryl Ann Abdukahil, Mohammed A Almazyad, Mohammed I Alarifi, Jara M Macarambon, Ahmad Abdullah Bukhari, Hussain A. Albahrani, Kazi N Asfina, Kaltham M Aldossary, Marija Zdravkovic, Zoran Todorovic, Viseslav Popadic, Slobodan Klasnja, Ana Andrijevic, Srdjan Gavrilovic, Vladimir Carapic, Bojan Kovacevic, Jovana Bojicic, Stevanovic Predrag, Dejan S Stojakov, Duska K Ignjatovic, Suzana C Bojic, Marina M Bobos, Irina B Nenadic, Milica S Zaric, Marko D Djuric, Vladimir R Djukic, Santiago Y. Teruel, Belen C. Martin, Uluhan Sili, Huseyin Bilgin, Pinar Ay, Varsha P Gharpure, Usman Raheemi, Kenneth W. Dodd, Nicholas Goodmanson, Kathleen Hesse, Paige Bird, Chauncey Weinert, Nathan Schoenrade, Abdulrahman Altaher, Esmael Mayar, Matthew Aronson, Tyler Cooper, Monica Logan, Brianna Miner, Gisele Papo, Eric M. Siegal, Phyllis Runningen, Suzanne Barry, Christopher Woll, Gregory Wu, Erin Carrole, Kathryn Burke, Mustafa Mohammed, Roman R. Melamed, David M. Tierney, Love A. Patel, Vino S. Raj, Barite U. Dawud, Narayana Mazumder, Abbey Sidebottom, Alena M. Guenther, Benjamin D. Krehbiel, Nova J. Schmitz, Stacy L. Jepsen, Lynn Sipsey, Anna Schulte, Whitney Wunderlich, Cecely Hoyt, Abhijit A Raval, Andrea Franks, Katherine Irby, Ronald C. Sanders, Jr., Glenda Hefley, Jennifer M. Jarvis, Anmol Kharbanda, Sunil Jhajhria, Zachary Fyffe, Stephen Capizzi, Bethany Alicie, Martha Green, Lori Crockarell, Amelia Drennan, Kathleen Dubuque, Tonya Fambrough, Nikole Gasaway, Briana Krantz, Peiman Nebi, Jan Orga, Margaret Serfass, Alina Simion, Kimberly Warren, Cassie Wheeler, CJ Woolman, Amy B. Christie, Dennis W. Ashley, Rajani Adiga, Andrew S. Moyer, George M. Verghese, Andrea Sikora Newsome, Christy C. Forehand, Rebecca Bruning, Timothy W. Jones, Moldovan Sabov, Fatema Zaidi, Fiona Tissavirasingham, Dhatri Malipeddi, Jarrod M Mosier, Karen Lutrick, Beth Salvagio Campbell, Cathleen Wilson, Patrick Rivers, Jonathan Brinks, Mokenge Ndiva Mongoh, Boris Gilson, Donna Lee Armaignac, Don Parris, Maria Pilar Zuniga, Ilea Vargas, Viviana Boronat, Anneka Hutton, Navneet Kaur, Prashank Neupane, Nohemi Sadule-Rios, Lourdes M. Rojas, Aashish Neupane, Priscilla Rivera, Carlos Valle Carlos, Gregory Vincent, Mahesh Amin, Mary E Schelle, Amanda Steadham, Christopher M Howard, Cameron McBride, Jocelyn Abraham, Orlando Garner, Katherine Richards, Keegan Collins, Preethi Antony, Sindhu Mathew, Valerie C. Danesh, Gueorgui Dubrocq, Amber L. Davis, Marissa J Hammers, ill M. McGahey, Amanda C. Farris, Elisa Priest, Robyn Korsmo, Lorie Fares, Kathy Skiles, Susan M. Shor, Kenya Burns, Corrie A Dowell, Gabriela “Hope” Gonzales, Melody Flores, Lindsay Newman, Debora A Wilk, Jason Ettlinger, Jaccallene Bomar, Himani Darji, Alejandro Arroliga, Alejandro C Arroliga, Corrie A. Dowell, Gabriela Hope Conzales, Debora A. Wilk, Paras B. Khandhar, Elizabeth Kring, Valerie M. Banner-Goodspeed, Somnath Bose, Lauren E. Kelly, Melisa Joseph, Marie McGourty, Krystal Capers, Benjamin Hoenig, Maria C. Karamourtopoulos, Anica C. Law, Elias N. Baedorf Kassis, Allan J. Walkey, Sushrut S. Waikar, Michael A. Garcia, Mia Colona, Zoe Kibbelaar, Michael Leong, Daniel Wallman, Kanupriya Soni, Jennifer Maccarone, Joshua Gilman, Ycar Devis, Joseph Chung, Munizay Paracha, David N. Lumelsky, Madeline DiLorenzo, Najla Abdurrahman, Shelsey Johnson, Maj Andrew M. Hersh, CPT Stephanie L Wachs, Brittany S. Swigger, Stephanie L Wachs, Capt Lauren A. Sattler, Capt Michael N. Moulton, Kimberly Zammit, Patrick, J McGrath, William Loeffler, Maya, R. Chilbert, Aaron S. Miller, Edwin L. Anderson, Rosemary Nagy, Ravali R. Inja, Pooja A. Nawathe, Isabel Pedraza, Jennifer Tsing, Karen Carr, Anila Chaudhary, Kathleen Guglielmino, Raghavendra Tirupathi, Alymer Tang, Arshad Safi, Cindy Green, Jackie Newell, Rayan E. Ihle, Shelda A. Martin, Elaine A. Davis, Katja M. Gist, Imran A Sayed, John Brinton, Larisa Strom, Kathleen Chiotos, Allison M. Blatz, Giyoung Lee, Ryan H. Burnett, Guy I. Sydney, Danielle M. Traynor, Karissa Nauert, Annika Gonzalez, Mariel Bagley, Anita Santpurkar, Salim Surani, Joshua White, Aftab Khan, Rahul Dhahwal, Sreekanth Cheruku, Farzin Ahmed, Christopher Deonarine, Ashley Jones, Mohammad-Ali Shaikh, David Preston, Jeanette Chin, Vidula Vachharajani, Abhijit Duggal, Prabalini Rajendram, Omar Mehkri, Siddharth Dugar, Michelle Biehl, Gretchen Sacha, Stuart Houltham, Alexander King, Kiran Ashok, Bryan Poynter, Mary Beukemann, Richard Rice, Susan Gole, Valerie Shaner, Adarsh Conjeevaram, Michelle Ferrari, Narendrakumar Alappan, Steven Minear, Jaime Hernandez-Montfort, Syed Sohaib Nasim, Ravi Sunderkrishnan, Debasis Sahoo, Patrick S. Milligan, Sandeep K. Gupta, Joy M. Koglin, Regina Gibson, Lana Johnson, Felicia Preston, Crimson Scott, Bethany Nungester, Dana D Byrne, Christa A Schorr, Katie Grant, Katherine L Doktor, Maura C Porto, Olga Kaplan, James E. Siegler, III, Brian Schonewald, Ashley Woodford, Alan Tsai, Savina Reid, Kuntal Bhowmick, Saba Daneshpooy, Cyrus Mowdawalla, Trishna Akshay Dave, Wilhemina Kennedy, Connor Crudeli, Christopher Ferry, Long Nguyen, Sneha Modi, Niharika Padala, Pavan Jitendra Patel, Belle Lin, Lena Chatterjee, Jamie Qiuyun, Fan Mandi Liu, Rasagna Kota, Annesha Banerjee, Steven K. Daugherty, Sam Atkinson, Kelly Shrimpton, Sidney Ontai, Brian Contreras, Uzoma Obinwanko, Nneka Amamasi, Amir Sharafi, Sarah Lee, Zahia Esber, Chetna Jinjvadia, Raquel R Bartz, Vijay Krishnamoorthy, Bryan Kraft, Aaron Pulsipher, Eugene Friedman, Sachin Mehta, Margit Kaufman, Gregg Lobel, Nisha Gandhi, Amr Abdelaty, Elizabeth Shaji, Kiana Lim, Juan Marte, Dani Ashley Sosa, David P. Yamane, Ivy Benjenk, Nivedita Prasanna, Nicholas Perkins, Prera J. Roth, Banu Sivaraj, Haley Fulton, Madison G Herin, Marissa Crum, Morgan E. Fretwell, Emily-Rose Zhou, Christine Waller, Kara Kallies, Jonean Thorsen, Alec Fitzsimmons, Haley Olsen, Heda R. Dapul, Sourabh Verma, Alan Salas, Ariel Daube, Michelle Korn, Michelle Ramirez, Logi Rajagopalan, Laura Santos, Héctor Collazo Santiago, Ricardo Alan Hernandez, Norma Smalls, Asher G Bercow, Mark Shlomovich, Christine Crandall, Sasko Stojanovski, Kristin Johnson, Kelly Michienzi, Steven Q. Davis, Valentina Jovic, Max Masuda, Amanda Hayes, Katharine Nault, Michael Smith, William Snow, Riley Liptak, Hannah Durant, Valerie Pendleton, Alay Nanavati, Risa Mrozowsk, Namrata Nag, Jeff Brauer, Ashwin Dharmadhikari, Sahib Singh, Franco Laghi, Ghania Naeem, Andrew Wang, Kevin Bliden, Amit Rout, Jaime Barnes, Martin Gesheff, Asha Thomas, Melbin Thomas, Alicia R. Liendo, Jovan Milosavljevic, Kenan Abbasi, Nicholas B. Burley, Nicole Rapista, Samuel Amankwah, Sanjay K Poude, Saroj Timilsina, Sauradeep Sarkar, Oluwasayo Akinyosoye, Shashi K. Yalamanchili, Sheena Moorthy, Sonia Sugumar, Jonathan Ford, Martin C. Taylor, Charlotte Dunderdale, Alyssa Henshaw, Mary K. Brunk, Jessica Hagy, Shehryar Masood, Sushrutha Sridhar, Yuk Ming Liu, Sarah Zavala, Esther Shim, Ronald A. Reilkoff, Julia A. Heneghan, Sarah Eichen, Lexie Goertzen, Scott Rajala, Ghislaine Feussom, Ben Tang, Christine C. Junia, Robert Lichtenberg, Hasrat Sidhu, Diana Espinoza, Shelden Rodrigues, Maria Jose Zabala, Daniela Goyes, Ammu Susheela, Buddhi Hatharaliyadda, Naveen Rameshkumar, Amulya Kasireddy, Genessis Maldonado, Lisseth Beltran, Akshata Chaugule, Hassan Khan, Namrata Patil, Ruhi Patil, Rodrigo Cartin-Ceba, Ayan Sen, Fahimeh Talaei, Rahul Kashyap, Juan Pablo Domecq, Ognjen Gajic, Vikas Bansal, Aysun Tekin, Amos Lal, John C. O’Horo, Neha N. Deo, Mayank Sharma, Shahraz Qamar, Romil Singh, Diana J. Valencia Morales, Abigail T. La Nou, Marija Bogojevic, Simon Zec, Devang Sanghavi, Pramod Guru, Pablo Moreno Franco, Karthik Gnanapandithan, Hollie Saunders, Zachary Fleissner, Juan Garcia, Alejandra Yu Lee Mateus, Siva Naga Yarrarapu, Nirmaljot Kaur, Abhisekh Giri, Mohammed Mustafa Hasan, Ashrita Donepudi, Syed Anjum Khan, Nitesh Kumar Jain, Thoyaja Koritala, Alexander Bastidas, Gabriela Orellana, Adriana Briceno Bierwirth, Eliana Milazzo, Juan Guillermo Sierra, Thao Dang, Rahul S Nanchal, Paul A Bergl, Jennifer L Peterson, Jessica Timmer, Kimberly Welker, Travis Yamanaka, Nicholas A. Barreras, Michael Markos, Anita Fareeduddin, Rohan Mehta, Chakradhar Venkata, Miriam Engemann, Annamarie Mantese, Yasir Tarabichi, Adam Perzynski, Christine Wang, Dhatri Kotekal, Adriana C Briceno Bierwirth, Gabriela M Orellana, Gerardo Catalasan, Shohana Ahmed, Carlos F Matute, Ahmad Hamdan, Ivania Salinas, Genesis Del Nogal, Angel Tejada, Anna Eschler, Mary Hejna, Emily Lewandowski, Kristen Kusmierski, Clare Martin, Jen-Ting Chen, Aluko Hope, Zoe Tsagaris, Elise Ruen, Aram Hambardzumyan, Nasar A Siddiqi, Lesly Jurado, Lindsey Tincher, Carolyn Brown, Prithvi Sendi, Meghana Nadiger, Balagangadhar Totapally, Bhagat S. Aulakh, Sandeep Tripathi, Jennifer A. Bandy, Lisa M. Kreps, Dawn R. Bollinger, Neha Gupta, Brent R Brown, Tracy L Jones, Kassidy Malone, Lauren A Sinko, Amy B Harrell, Shonda C Ayers, Lisa M Settle, Taylor J Sears, Roger Scott Stienecker, Andre G. Melendez, Tressa A. Brunner, Sue M Budzon, Jessica L. Heffernan, Janelle M. Souder, Tracy L. Miller, Andrea G. Maisonneuve, Roberta E. Redfern, Jessica Shoemaker, Jennifer Micham, Lynn Kenney, Gabriel Naimy, Victoria Schauf, Sara Utley, Holly Balcer, Kerry P. J. Pulver, Jennifer Yehle, Alicia Weeks, Terra Inman, Majdi Hamarshi, Jeannette Ploetz, Nick Bennett, Kyle Klindworth, Moustafa Younis, Adham Mohamed, Brian L. Delmonaco, Anthony Franklin, Mitchell Heath, Diane Barkas, Antonia L. Vilella, Sara B. Kutner, Kacie Clark, Danielle Moore, Shina Menon, John K McGuire, Deana Rich, Harry L. Anderson, III, Dixy Rajkumar, Ali Abunayla, Jerrilyn Heiter, Howard A. Zaren, Stephanie J. Smith, Grant C. Lewis, Lauren Seames, Cheryl Farlow, Judy Miller, Gloria Broadstreet, John Lin, Cindy Terrill, Brock Montgomery, Sydney Reyes, Summer Reyes, Alex Plattner, Anthony Martinez, Micheal Allison, Aniket Mittal, Rafael Ruiz, Aleta Skaanland, Robert Ross, Umang Patel, Jordesha Hodge, Krunal Kumar Patel, Shivani Dalal, Himanshu Kavani, Sam Joseph, Michael A. Bernstein, Ian K. Goff, Matthew Naftilan, Amal Mathew, Deborah Williams, Sue Murdock, Maryanne Ducey, Kerianne Nelson, Jason Block, James Mitchel, Connor G O’Brien, Sylvan Cox, William Marx, Ioana Amzuta, Asad J. Choudhry, Mohammad T. Azam, Kristina L Carter, Michael A Olmos, Brittany M Parker, Julio Quintanilla, Tara A Craig, Brendon J Clough, Jeffrey T Jameson, Utpal S. Bhalala, Joshua Kuehne, Melinda Garcia, Morgan Beebe, Heather Herrera, Chris Fiack, Stephanie Guo, May Vawer, Beth Blackburn, Caleb Darby, Kristy Page, Amanda Brown, Jessie McAbee, Katherine A. Belden, Michael Baram, Devin M. Weber, Rosalie DePaola, Yuwei Xia, Hudson Carter, Aaron Tolley, Mary Barletta, Mark Steele, Laurie Kemble, Joshua L. Denson, A. Scott Gillet, Margo Brown, Rachael Stevens, Andrew Wetherbie, Kevin Tea, Mathew Moore, Abdurrahman Husain, Atul Malhotra, Qais Zawaydeh, Benjamin J Sines, Thomas J Bice, Emily A. Vail, Susannah Nicholson, Rachelle B. Jonas, AnnaRose E. Dement, William Tang, Mark DeRosa, Robert E. Villarreal, Rajany V. Dy, Alfredo Iardino, Jill Sharma, Richard Czieki, Julia Christopher, Ryan Lacey, Marwan Mashina, Kushal Patel, Erica C. Bjornstad, Nancy M. Tofil, Scott House, Isabella Aldana, Nikhil K. Meena, Jose D. Caceres, Nikhil K Meena, Sarenthia M. Epps, Harmeen Goraya, Kelsey R. Besett, Ryan James, Lana Y. Abusalem, Akash K. Patel, Lana S Hasan, Dina Gomaa, Michael Goodman, Devin Wakefield, Anthony Spuzzillo, John O. Shinn II, Robert MacLaren, Azra Bihorac, Tezcan Ozrazgat Baslanti, George Omalay, Haleh Hashemighouchani, Julie S. Cupka, Matthew M Ruppert, Patrick W. McGonagill, Colette Galet, Janice Hubbard, David Wang, Lauren Allan, Aditya Badheka, Madhuradhar Chegondi, Usman Nazir, Garrett Rampon, Jake Riggle, Nathan Dismang, Vicki Montgomery, Janice Sullivan, Sarah Morris, Jennifer Nason, Ozan Akca, Rainer Lenhardt, Rodrigo S. Cavallazzi, Ann Jerde, Alexa Black, Allison Polidori, Haily Griffey, Justin Winkler, Thomas Brenzel, Roger A. Alvarez, Amarilys Alarcon-Calderon, Marie Anne Sosa, Sunita K. Mahabir, Mausam J. Patel, Pauline Park, Andrew Admon, Sinan Hanna, Rishi Chanderraj, Maria Pliakas, Ann Wolski, Jennifer Cirino, Dima Dandachi, Hariharan Regunath, Maraya N. Camazine, Grant. E. Geiger, Abdoulie O. Njai, Baraa M. Saad, Faraaz Ali Shah, Byron Chuan, Sagar L. Rawal, Manal Piracha, Joseph E. Tonna, Nicholas M. Levin, Kayte Suslavich, Rachel Tsolinas, Zachary T. Fica, Chloe R. Skidmore, Renee D. Stapleton, Anne E. Dixon, Olivia Johnson, Sara S. Ardren, Stephanie Burns, Anna Raymond, Erika Gonyaw, Kevin Hodgdon, Chloe Housenger, Benjamin Lin, Karen McQuesten, Heidi Pecott-Grimm, Julie Sweet, Sebastian Ventrone, Nita Khandelwal, T. Eoin West, Ellen S. Caldwell, Lara Lovelace-Macon, Navya Garimella, Denisse B. Dow, Sreekanth R. Cheruku, Catherine Chen, Murtaza Akhter, Rania Abdul Rahman, Mary Mulrow, Erin M. Wilfong, Kelsi Vela, Ashish K. Khanna, Lynne Harris, Bruce Cusson, Jacob Fowler, David Vaneenenaam, Glen McKinney, Imoh Udoh, Kathleen Johnson, Patrick G. Lyons, Andrew P Michelson, Sara S. Haluf, Lauren M. Lynch, Nguyet M. Nguyen, Aaron Steinberg, Nicholas Braus, Vishwanath Pattan, Jessica Papke, Ismail Jimada, Nida Mhid, Samuel Chakola, Kevin Sheth, Abdalla Ammar, Mahmoud Ammar, Victor Torres Lopez, Charles Dela Cruz,, Akhil Khosla, and Samir Gautam
Subjects: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: OBJECTIVES:. To describe the prevalence, associated risk factors, and outcomes of serious neurologic manifestations (encephalopathy, stroke, seizure, and meningitis/encephalitis) among patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. DESIGN:. Prospective observational study. SETTING:. One hundred seventy-nine hospitals in 24 countries within the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 Registry. PATIENTS:. Hospitalized adults with laboratory-confirmed SARS-CoV-2 infection. INTERVENTIONS:. None. RESULTS:. Of 16,225 patients enrolled in the registry with hospital discharge status available, 2,092 (12.9%) developed serious neurologic manifestations including 1,656 (10.2%) with encephalopathy at admission, 331 (2.0%) with stroke, 243 (1.5%) with seizure, and 73 (0.5%) with meningitis/encephalitis at admission or during hospitalization. Patients with serious neurologic manifestations of COVID-19 were older with median (interquartile range) age 72 years (61.0–81.0 yr) versus 61 years (48.0–72.0 yr) and had higher prevalence of chronic medical conditions, including vascular risk factors. Adjusting for age, sex, and time since the onset of the pandemic, serious neurologic manifestations were associated with more severe disease (odds ratio [OR], 1.49; p < 0.001) as defined by the World Health Organization ordinal disease severity scale for COVID-19 infection. Patients with neurologic manifestations were more likely to be admitted to the ICU (OR, 1.45; p < 0.001) and require critical care interventions (extracorporeal membrane oxygenation: OR, 1.78; p = 0.009 and renal replacement therapy: OR, 1.99; p < 0.001). Hospital, ICU, and 28-day mortality for patients with neurologic manifestations was higher (OR, 1.51, 1.37, and 1.58; p < 0.001), and patients had fewer ICU-free, hospital-free, and ventilator-free days (estimated difference in days, –0.84, –1.34, and –0.84; p < 0.001). CONCLUSIONS:. Encephalopathy at admission is common in hospitalized patients with SARS-CoV-2 infection and is associated with worse outcomes. While serious neurologic manifestations including stroke, seizure, and meningitis/encephalitis were less common, all were associated with increased ICU support utilization, more severe disease, and worse outcomes.
Published: 2022
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4. Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19

Author: Shelsey W. Johnson, MD, Michael A. Garcia, MD, Emily K. Q. Sisson, MA, Christopher R. Sheldrick, PhD, Vishakha K. Kumar, MD, MBA, Karen Boman, BA, Scott Bolesta, PharmD, Vikas Bansal, MBBS, MPH, Amos Lal, MBBS, J. P. Domecq, MD, MS, Roman R. Melamed, MD, Amy B. Christie, MD, Abdurrahman Husain, MD, Santiago Yus, MBBS, Ognjen Gajic, MD, MSc, Rahul Kashyap, MBBS, MBA, Allan J. Walkey, MD, MSc, from the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group, Oscar Y. Gavidia, Felipe Pachon, Yeimy A. Sanchez, Mohamed El Kassas, Mohamed Badr, Ahmed Tawheed, Hend Yahia, Wataru Matsuda, Reina Suzuki, Masamitsu Sanui, Sho Horikita, Yuki Itagaki, Akira Kodate, Yuki Takahashi, Koyo Moriki, Muhammad Sohaib, Asghar, Mashaal Syed, Syed Anosh, Ali Naqvi, Borisovich Zabolotskikh, Konstantin Dmitrievich Zybin, Sergey Vasilevich Sinkov, Tatiana Sergeevna Musaeva, Mohammed A. Almazyad, Mohammed I. Alarifi, Jara M. Macarambon, Ahmad Abdullah Bukhari, Hussain A. Albahrani, Kazi N. Asfina, Kaltham M. Aldossary, Marija Zdravkovic, Zoran Todorovic, Viseslav Popadic, Slobodan Klasnja, Predrag D. Stevanovic, Dejan S. Stojakov, Duska K. Ignjatovic, Suzana C. Bojic, Marina M. Bobos, Irina B. Nenadic, Milica S. Zaric, Marko D. Djuric, Vladimir R. Djukic, Santiago Yus, Belen C. Martin, Uluhan Sili, Huseyin Bilgin, Pinar Ay, Roman R. Melamed, David M. Tierney, Love A. Patel, Vino S. Raj, Barite U. Dawud, Narayana Mazumder, Abbey Sidebottom, Alena M. Guenther, Benjamin D. Krehbiel, Nova J. Schmitz, Stacy L. Jepsen, Lynn Sipsey, Anna Schulte, Whitney Wunderlich, Cecely Hoyt, Kenneth W. Dodd, Nicholas Goodmanson, Kathleen Hesse, Paige Bird, Chauncey Weinert, Nathan Schoenrade, Abdulrahman Altaher, Esmael Mayar, Matthew Aronson, Tyler Cooper, Monica Logan, Brianna Miner, Gisele Papo, Abdulrahman Al-Fares, Anmol Kharbanda, Sunil Jhajhria, Zachary Fyffe, Amy B. Christie, Dennis W. Ashley, Rajani Adiga, Andrea Sikora Newsome, Christy C. Forehand, Rebecca Bruning, Timothy W. Jones, Moldovan Sabov, Fatema Zaidi, Fiona Tissavirasingham, Dhatri Malipeddi, Valerie M. Banner-Goodspeed, Somnath Bose, Lauren E. Kelly, Melisa Joseph, Marie McGourty, Krystal Capers, Benjamin Hoenig, Maria C. Karamourtopoulos, Anica C. Law, Elias N. Baedorf Kassis, Allan J. Walkey, Sushrut S. Waikar, Michael A. Garcia, Mia Colona, Zoe Kibbelaar, Michael Leong, Daniel Wallman, Kanupriya Soni, Jennifer Maccarone, Joshua Gilman, Ycar Devis, Joseph Chung, Munizay Paracha, David N. Lumelsky, Madeline DiLorenzo, Najla Abdurrahman, Shelsey Johnson, Kimberly Zammit, Patrick J. McGrath, William Loeffler, Maya R. Chilbert, Jean-Baptiste Mesland, Pierre Henin, Hélène Petre, Isabelle Buelens, Anne-Catherine Gerard, Rayan E. Ihle, Shelda A. Martin, Elaine A. Davis, Salim Surani, Joshua White, Aftab Khan, Rahul Dhahwal, Sreekanth Cheruku, Farzin Ahmed, Christopher Deonarine, Ashley Jones, Mohammad-Ali Shaikh, David Preston, Jeanette Chin, Steven K. Daugherty, Sam Atkinson, Kelly Shrimpton, Raquel R. Bartz, Vijay Krishnamoorthy, Bryan Kraft, Aaron Pulsipher, Eugene Friedman, Sachin Mehta, David P. Yamane, Ivy Benjenk, Nivedita Prasanna, Katharine Nault, Ronald A. Reilkoff, Julia A. Heneghan, Sarah Eichen, Lexie Goertzen, Scott Rajala, Ghislaine Feussom, Ben Tang, Mayo Clinic Arizona, Rodrigo Cartin-Ceba, Ayan Sen, Amanda Palacios, Giyth M. Mahdi, Rahul Kashyap, Ognjen Gajic, Vikas Bansal, Aysun Tekin, Amos Lal, John C. O’Horo, Neha N. Deo, Mayank Sharma, Shahraz Qamar, Juan Pablo Domecq, Romil Singh, Alex Niven, Mayo Clinic, Eau Claire, Abigail T. La Nou, Marija Bogojevic, Barbara Mullen, Devang Sanghavi, Pramod Guru, Pablo Moreno Franco, Karthik Gnanapandithan, Hollie Saunders, Zachary Fleissner, Juan Garcia, Alejandra Yu Lee Mateus, Siva Naga Yarrarapu, Nirmaljot Kaur, Abhisekh Giri, Syed Anjum Khan, Nitesh Kumar Jain, Thoyaja Koritala, Chakradhar Venkata, Miriam Engemann, Annamarie Mantese, Yasir Tarabichi, Adam Perzynski, Christine Wang, Dhatri Kotekal, Bhagat S. Aulakh, Sandeep Tripathi, Jennifer A. Bandy, Lisa M. Kreps, Dawn R. Bollinger, Roger Scott Stienecker, Andre G. Melendez, Tressa A. Brunner, Sue M. Budzon, Jessica L. Heffernan, Janelle M. Souder, Tracy L. Miller, Andrea G. Maisonneuve, Antonia L. Vilella, Sara B. Kutner, Kacie Clark, Danielle Moore, Harry L. Anderson, III, Dixy Rajkumar, Ali Abunayla, Jerrilyn Heiter, Howard A. Zaren, Stephanie J. Smith, Grant C. Lewis, Lauren Seames, Cheryl Farlow, Judy Miller, Gloria Broadstreet, Anthony Martinez, Micheal Allison, Aniket Mittal, Rafael Ruiz, Aleta Skaanland, Robert Ross, Neha Gupta, Tracy L. Jones, Shonda C. Ayers, Amy B. Harrell, Dr. Brent R. Brown, Abdurrahman Husain, Atul Malhotra, Qais Zawaydeh, Dragana Markotić, Ivana Bošnjak, Emily A. Vail, Susannah Nicholson, Rachelle B. Jonas, AnnaRose E. Dement, William Tang, Mark DeRosa, Robert E. Villarreal, Patrick W. McGonagill, Colette Galet, Janice Hubbard, David Wang, Lauren Allan, Aditya Badheka, Madhuradhar Chegondi, Roger A. Alvarez, Amarilys Alarcon-Calderon, Marie Anne Sosa, Sunita K. Mahabir, Mausam J. Patel, Faraaz Ali Shah, Byron Chuan, Sagar L. Rawal, Manal Piracha, Joseph E. Tonna, Nicholas M. Levin, Kayte Suslavich, Rachel Tsolinas, Zachary T. Fica, Chloe R. Skidmore, Renee D. Stapleton, Anne E. Dixon, Olivia Johnson, Sara S. Ardren, Stephanie Burns, Anna Raymond, Erika Gonyaw, Kevin Hodgdon, Chloe Housenger, Benjamin Lin, Karen McQuesten, Heidi Pecott-Grimm, Julie Sweet, Sebastian Ventrone, Murtaza Akhter, Rania Abdul Rahman, Mary Mulrow, Ashish K. Khanna, Lynne Harris, Bruce Cusson, Jacob Fowler, David Vaneenenaam, Glen McKinney, Imoh Udoh, Kathleen Johnson, Vishwanath Pattan, Jessica Papke, Ismail Jimada, Nida Mhid, and Samuel Chakola
Subjects: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: OBJECTIVES:. To describe hospital variation in use of “guideline-based care” for acute respiratory distress syndrome (ARDS) due to COVID-19. DESIGN:. Retrospective, observational study. SETTING:. The Society of Critical Care Medicine’s Discovery Viral Infection and RESPIRATORY ILLNESS UNIVERSAL STUDY COVID-19 REGISTRY. PATIENTS:. Adult patients with ARDS due to COVID-19 between February 15, 2020, and April 12, 2021. INTERVENTIONS:. Hospital-level use of “guideline-based care” for ARDS including low-tidal-volume ventilation, plateau pressure less than 30 cm H2O, and prone ventilation for a Pao2/Fio2 ratio less than 100. MEASUREMENTS AND MAIN RESULTS:. Among 1,495 adults with COVID-19 ARDS receiving care across 42 hospitals, 50.4% ever received care consistent with ARDS clinical practice guidelines. After adjusting for patient demographics and severity of illness, hospital characteristics, and pandemic timing, hospital of admission contributed to 14% of the risk-adjusted variation in “guideline-based care.” A patient treated at a randomly selected hospital with higher use of guideline-based care had a median odds ratio of 2.0 (95% CI, 1.1–3.4) for receipt of “guideline-based care” compared with a patient receiving treatment at a randomly selected hospital with low use of recommended therapies. Median-adjusted inhospital mortality was 53% (interquartile range, 47–62%), with a nonsignificantly decreased risk of mortality for patients admitted to hospitals in the highest use “guideline-based care” quartile (49%) compared with the lowest use quartile (60%) (odds ratio, 0.7; 95% CI, 0.3–1.9; p = 0.49). CONCLUSIONS:. During the first year of the COVID-19 pandemic, only half of patients received “guideline-based care” for ARDS management, with wide practice variation across hospitals. Strategies that improve adherence to recommended ARDS management strategies are needed.
Published: 2022
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5. Variation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group

Author: Michael A. Garcia, MD, Shelsey W. Johnson, MD, Nicholas A. Bosch, MD, MSc, Emily K. Sisson, MA, Christopher R. Sheldrick, PhD, Vishakha K. Kumar, MD, MBA, Karen Boman, BS, Scott Bolesta, PharmD, Vikas Bansal, MBBS, MPH, Neha Deo, BS, J. P. Domecq, MD, Amos Lal, MD, Amy B. Christie, MD, Valerie M. Banner-Goodspeed, MPH, Devang Sanghavi, MD, MHA, Girish Vadgaonkar, MBBS, Ognjen Gajic, MD, MSc, Rahul Kashyap, MBBS, MBA, Allan J. Walkey, MD, MSc, for the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Investigators, Jean-Baptiste Mesland, Pierre Henin, Hélène Petre, Isabelle Buelens, Anne-Catherine Gerard, Philippe Clevenbergh, Dragana Markotić, Ivana Bošnjak, Ruben Garza, Eric Chu, Victoria Chan, Oscar Y Gavidia, Felipe Pachon, Yeimy A Sanchez, Mohamed El Kassas, Mohamed Badr, Ahmed Tawheed, Hend Yahia, Jose Luis Ramos Coello, Guillermo Perez, Ana Karen Vallecillo Lizardo, Gabina María Reyes Guillen, Helin Archaga Soto, Smitha S. Segu, Tuhin Chakraborty, Epcebha Joyce, Girish Vadgaonkar, Rekha Ediga, Shilpa Basety, Shwetha Dammareddy, Phani Sreeharsha Kasumalla, Umamaheswara Raju, Janaki Manduva, Naresh Kolakani, Shreeja Sripathi, Sheetal Chaitanya, Mradul Kumar Daga, Munisha Agarwal, Ishan Rohtagi, Sridhar Papani, Mahesh Kamuram, Kamlesh Kumar Agrawal, Vijendra Baghel, Kirti Kumar Patel, Surapaneni Krishna Mohan, Ekambaram Jyothisree, Wataru Matsuda, Reina Suzuki, Michihito Kyo, Yuki Itagaki, Akira Kodate, Yuki Takahashi, Koyo Moriki, Fatimah Hassan-Hanga, Hadiza Galadanci, Abubakar Shehu Gezawa, Halima M. S. Kabara, Taiwo Gboluwaga Amole, Halima Kabir, Dalha Gwarzo Haliru, Abdullahi S Ibrahim, Muhammad Sohaib Asghar, Mashaal Syed, Syed Anosh Ali Naqvi, Igor Borisovich Zabolotskikh, Konstantin Dmitrievich Zybin, Sergey Vasilevich Sinkov, Tatiana Sergeevna Musaeva, Mohammed A Almazyad, Mohammed I Alarifi, Jara M Macarambon, Ahmad Abdullah Bukhari, Hussain A. Albahrani, Kazi N Asfina, Kaltham M Aldossary, Marija Zdravkovic, Zoran Todorovic, Viseslav Popadic, Slobodan Klasnja, Bojan Kovacevic, Jovana Bojicic, Predrag D Stevanovic, Dejan S Stojakov, Duska K Ignjatovic, Suzana C Bojic, Marina M Bobos, Irina B Nenadic, Milica S Zaric, Marko D Djuric, Vladimir R Djukic, Santiago Y. Teruel, Belen C. Martin, Uluhan Sili, Huseyin Bilgin, Pinar Ay, Abhijit A Raval, Andrea Franks, Anmol Kharbanda, Sunil Jhajhria, Zachary Fyffe, Stephen Capizzi, Bethany Alicie, Martha Green, Lori Crockarell, Amelia Drennan, Kathleen Dubuque, Tonya Fambrough, Nikole Gasaway, Briana Krantz, Peiman Nebi, Jan Orga, Margaret Serfass, Alina Simion, Kimberly Warren, Cassie Wheeler, CJ Woolman, Amy B. Christie, Dennis W. Ashley, Rajani Adiga, Andrew S. Moyer, George M. Verghese, Andrea Sikora Newsome, Christy C. Forehand, Rebecca Bruning, Timothy W. Jones, Moldovan Sabov, Fatema Zaidi, Fiona Tissavirasingham, Dhatri Malipeddi, Donna Lee Armaignac, Don Parris, Maria Pilar Zuniga, Ilea Vargas, Viviana Boronat, Anneka Hutton, Navneet Kaur, Prashank Neupane, Nohemi Sadule-Rios, Lourdes M. Rojas, Aashish Neupane, Priscilla Rivera, Carlos Valle Carlos, Gregory Vincent, Valerie M. Banner-Goodspeed, Somnath Bose, Lauren E. Kelly, Melisa Joseph, Marie McGourty, Krystal Capers, Benjamin Hoenig, Maria C. Karamourtopoulos, Anica C. Law, Elias N. Baedorf Kassis, Allan J. Walkey, Sushrut S. Waikar, Michael A. Garcia, Mia Colona, Zoe Kibbelaar, Michael Leong, Daniel Wallman, Kanupriya Soni, Jennifer Maccarone, Joshua Gilman, Ycar Devis, Joseph Chung, Munizay Paracha, David N. Lumelsky, Madeline DiLorenzo, Najla Abdurrahman, Shelsey Johnson, Kimberly Zammit, Patrick, J McGrath, William Loeffler, Maya, R Chilbert, Raghavendra Tirupathi, Alymer Tang, Arshad Safi, Cindy Green, Jackie Newell, Katja M. Gist, Imran A Sayed, John Brinton, Larisa Strom, Steven K. Daugherty, Sam Atkinson, Kelly Shrimpton, David P. Yamane, Ivy Benjenk, Nivedita Prasanna, Norma Smalls, Michael Smith, William Snow, Riley Liptak, Hannah Durant, Valerie Pendleton, Alay Nanavati, Risa Mrozowsk, Yuk Ming Liu, Sarah Zavala, Esther Shim, Ronald A. Reilkoff, Julia A. Heneghan, Sarah Eichen, Lexie Goertzen, Scott Rajala, Ghislaine Feussom, Ben Tang, Christine C. Junia, Robert Lichtenberg, Hasrat Sidhu, Diana Espinoza, Shelden Rodrigues, Maria Jose Zabala, Daniela Goyes, Ammu Susheela, Buddhi Hatharaliyadda, Naveen Rameshkumar, Amulya Kasireddy, Genessis Maldonado, Lisseth Beltran, Akshata Chaugule, Hassan Khan, Rodrigo Cartin-Ceba, Ayan Sen, Amanda Palacios, Giyth M. Mahdi, Rahul Kashyap, Ognjen Gajic, Vikas Bansal, Aysun Tekin, Amos Lal, John C. O’Horo, Neha N. Deo, Mayank Sharma, Shahraz Qamar, Juan Pablo Domecq, Romil Singh, Alex Niven, Abigail La Nou, Marija Bogojevic, Barbara Mullen, Devang Sanghavi, Pablo Moreno Franco, Pramod Guru, Karthik Gnanapandithan, Hollie Saunders, Zachary Fleissner, Juan Garcia, Alejandra Yu, Lee Mateus, Siva Naga Yarrarapu, Nirmaljot Kaur, Abhisekh Giri, Syed Anjum Khan, Nitesh Kumar Jain, Thoyaja Koritala, Jessica Timmer, Kimberly Welker, Chakradhar Venkata, Miriam Engemann, Annamarie Mantese, Anna Eschler, Mary Hejna, Emily Lewandowski, Kristen Kusmierski, Clare Martin, Bhagat S. Aulakh, Sandeep Tripathi, Jennifer A. Bandy, Lisa M. Kreps, Dawn R. Bollinger, Roger Scott Stienecker, Andre G. Melendez, Tressa A. Brunner, Sue M Budzon, Jessica L. Heffernan, Janelle M. Souder, Tracy L. Miller, Andrea G. Maisonneuve, Brian L. Delmonaco, Anthony Franklin, Mitchell Heath, Antonia L. Vilella, Sara B. Kutner, Kacie Clark, Danielle Moore, Harry L. Anderson, III, Dixy Rajkumar, Ali Abunayla, Jerrilyn Heiter, Howard A. Zaren, Stephanie J. Smith, Grant C. Lewis, Lauren Seames, Cheryl Farlow, Judy Miller, Gloria Broadstreet, Anthony Martinez, Micheal Allison, Aniket Mittal, Rafael Ruiz, Aleta Skaanland, Robert Ross, Paul K Mohabir, Connor G O’Brien, Komal Dasani, Neha Gupta, Tracy L Jones, Shonda C Ayers, Amy B Harrell, Brent R Brown, Megan Edwards, Caleb Darby, Kristy Page, Amanda Brown, Jessie McAbee, Katherine A. Belden, Michael Baram, Devin M. Weber, Rosalie DePaola, Yuwei Xia, Hudson Carter, Aaron Tolley, Mary Barletta, Mary Ferranti, Benjamin J Sines, Thomas J Bice, Patrick W. McGonagill, Colette Galet, Janice Hubbard, David Wang, Lauren Allan, Aditya Badheka, Madhuradhar Chegondi, Usman Nazir, Garrett Rampon, Jake Riggle, Nathan Dismang, Roger A. Alvarez, Amarilys Alarcon-Calderon, Marie Anne Sosa, Sunita K. Mahabir, Mausam J. Patel, Dima Dandachi, Hariharan Regunath, Maraya N. Camazine, Grant. E. Geiger, Abdoulie O. Njai, Baraa M. Saad, Renee D. Stapleton, Anne E. Dixon, Olivia Johnson, Sara S. Ardren, Stephanie Burns, Anna Raymond, Erika Gonyaw, Kevin Hodgdon, Chloe Housenger, Benjamin Lin, Karen McQuesten, Heidi Pecott-Grimm, Julie Sweet, Sebastian Ventrone, Ashish K. Khanna, Lynne Harris, Bruce Cusson, Jacob Fowler, David Vaneenenaam, Glen McKinney, Imoh Udoh, Kathleen Johnson, Vishwanath Pattan, Jessica Papke, Ismail Jimada, Nida Mhid, Samuel Chakola, Kevin Sheth, Abdalla Ammar, Mahmoud Ammar, Victor Torres Lopez, Charles Dela Cruz, Akhil Khosla, and Samir Gautam
Subjects: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: IMPORTANCE:. At the start of the coronavirus disease 2019 pandemic, medications repurposed for management of coronavirus disease 2019 were used in the absence of clinical trial evidence. OBJECTIVES:. To describe the variation and evolution in use of repurposed medications for coronavirus disease 2019. DESIGN, SETTING, AND PARTICIPANTS:. Observational cohort study of adults hospitalized with coronavirus disease 2019 between February 15, 2020, and April 12, 2021, across 76 United States and international hospitals within the Society of Critical Care Medicine’s Discovery Viral Infection and Respiratory Illness Universal Study coronavirus disease 2019 registry. MAIN OUTCOMES AND MEASURES:. Hospital variation was quantified using multivariable adjusted random effects logistic regression models and unsupervised clustering. Repurposed medications included antivirals, corticosteroids, hydroxychloroquine, immunomodulators, and therapeutic dose anticoagulants. RESULTS:. Among 7,069 adults hospitalized with coronavirus disease 2019, 1,979 (28%) received antivirals, 2,876 (41%) received corticosteroids, 1,779 (25%) received hydroxychloroquine, 620 (9%) received immunomodulators, and 2,154 (31%) received therapeutic dose anticoagulants. Contribution of hospital site to risk-adjusted variation was 46% for antivirals, 30% for corticosteroids, 48% for hydroxychloroquine, 46% for immunomodulators, and 52% for therapeutic dose anticoagulants. Compared with the early pandemic, the later pandemic practice phenotypes converged with increased use of antivirals (odds ratio, 3.14; 95% CI, 2.40–4.10) and corticosteroids (odds ratio, 5.43; 95% CI, 4.23–6.97), with decreased use of hydroxychloroquine (odds ratio, 0.02; 95% CI, 0.01–0.04) and immunomodulators (odds ratio, 0.49; 95% CI, 0.34–0.70). There was no clinically significant change in the use of therapeutic dose anticoagulants (odds ratio, 1.01; 95% CI, 1.01–1.02). There were no differences in risk-adjusted mortality between hospitals with high rates of repurposed medication use compared with hospitals with low rates of use. CONCLUSIONS AND RELEVANCE:. Hospital variation in the use of repurposed medications varied widely across hospitals early in the pandemic and later converged with the emergence of randomized clinical trials. Platforms developed for rapid activation and enrollment in clinical trials of repurposed medications are needed prior to the next pandemic to expedite effective, evidence-based practice.
Published: 2021
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6. Risk Factors for Critical Coronavirus Disease 2019 and Mortality in Hospitalized Young Adults: An Analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) Coronavirus Disease 2019 Registry

Author: Sandeep Tripathi, MD, MS, Imran A. Sayed, MD, Heda Dapul, MD, Jeremy S. McGarvey, MS, Jennifer A. Bandy, RN, Karen Boman, BS, Vishakha K. Kumar, MD, MBA, Vikas Bansal, MBBS, MPH, Lynn Retford, CAE, Sreekanth Cheruku, MD, MPH, Margit Kaufman, MD, FASA, Smith F. Heavner, MS, RN, Valerie C. Danesh, PhD, RN, Catherine A. St. Hill, DVM, PhD, Ashish K. Khanna, MD, Utpal Bhalala, MD, Rahul Kashyap, MBBS, MBA, Ognjen Gajic, MD, MS, Allan J. Walkey, MD, MS, Katja M. Gist, DO, MSc, for The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group, Jean-Baptiste Mesland, Pierre Henin, Hélène Petre, Isabelle Buelens, Anne-Catherine Gerard, Philippe Clevenbergh, Rolando Claure-Del Granado, Jose A. Mercado, Esdenka Vega-Terrazas, Maria F. Iturricha-Caceres, Ruben Garza, Eric Chu, Victoria Chan, Oscar Y Gavidia, Felipe Pachon, Yeimy A Sanchez, Mohamed El Kassas, Mohamed Badr, Ahmed Tawheed, Hend Yahia, Sierra-Hoffman, Fernando Valerio, Oscar Diaz, Jose Luis Ramos Coello, Guillermo Perez, Ana Karen Vallecillo Lizardo, Gabina María Reyes Guillen, Helin Archaga Soto, Mradul Kumar Daga, Munisha Agarwal, Ishan Rohtagi, Anusha Cherian, Sreejith Parameswaran, Magesh Parthiban, Menu Priya A., Girish Vadgaonkar, Rekha Ediga, Shilpa Basety, Shwetha Dammareddy, Phani Sreeharsha Kasumalla, Sridhar Papani, Mahesh Kamuram, Smitha S. Segu, Tuhin Chakraborty, Epcebha Joyce, Umamaheswara Raju, Janaki Manduva, Naresh Kolakani, Shreeja Sripathi, Sheetal Chaitanya, Surapaneni Krishna Mohan, Ekambaram Jyothisree, Kamlesh Kumar Agrawal, Vijendra Baghel, Kirti Kumar Patel, Nooshin Dalili, Mohsen Nafa, Sandeep Tripathi, Yuki Itagaki, Akira Kodate, Reina Suzuki, Yuki Takahashi, Koyo Moriki, Michihito Kyo, Masamitsu Sanui, Sho Horikita, Wataru Matsuda, Shu Tahara, Mineji Hayakawa, Kunihiko Maekawa, Takuya Shiga, Yudai Iwasaki, Abdulrahman AlFares, Rene Rodriguez-Gutierrez, Jose Gerardo Gonzalez-Gonzalez, Alejandro Salcido-Montenegro, Adrian Camacho-Ortiz, Fatimah Hassan-Hanga, Hadiza Galadanci, Abubakar Shehu Gezawa, Halima M. S. Kabara, Taiwo Gboluwaga Amole, Halima Kabir, Dalha Gwarzo, Haliru, Abdullahi S Ibrahim, Muhammad Sohaib Asghar, Mashaal Syed, Syed Anosh Ali Naqvi, Igor Borisovich Zabolotskikh, Konstantin Dmitrievich Zybin, Sergey Vasilevich Sinkov, Tatiana Sergeevna Musaeva, Marwa Ridha Amer, Mohammed Abdullah Bawazeer, Talal I. Dahhan, Eiad Kseibi, Abid Shahzad Butt, Syed Moazzum Khurshid, Muath Rabee, Mohammed Abujazar, Razan Alghunaim, Maal Abualkhair, Abeer Turki AlFirm, Razan K Alamoudi, Hassan M. AlSharif, Sarah A. Almazwaghi, Mohammed S Elsakran, Mohamed A Aid, Mouaz A Darwich, Omnia M Hagag, Salah A Ali, Alona rocacorba, Kathrine Supeña, Efren Ray Juane, Jenalyn Medina, Jowany Baduria, Mohammed A Almazyad, Mohammed I Alarifi, Jara M Macarambon, Ahmad Abdullah Bukhari, Hussain A. Albahrani, Kazi N Asfina, Kaltham M Aldossary, Predrag D Stevanovic, Dejan S Stojakov, Duska K Ignjatovic, Suzana C Bojic, Marina M Bobos, Irina B Nenadic, Milica S Zaric, Marko D Djuric, Vladimir R Djukic, Bojan Kovacevic, Jovana Bojicic, Marija Zdravkovic, Zoran Todorovic, Viseslav Popadic, Slobodan Klasnja, Santiago Y. Teruel, Belen C. Martin, Himat Sulaimonov, Firuza Khudonazarova, Nabi Bakhtibekov, Nekruz Jamshedov, Uluhan Sili, Huseyin Bilgin, Pinar Ay, Varsha P Gharpure, Usman Raheemi, Kenneth W. Dodd, Nicholas Goodmanson, Kathleen Hesse, Paige Bird, Chauncey Weinert, Nathan Schoenrade, Abdulrahman Altaher, Esmael Mayar, Matthew Aronson, Tyler Cooper, Monica Logan, Brianna Miner, Gisele Papo, Eric M. Siegal, Phyllis Runningen, Catherine A. St. Hill, Roman R. Melamed, David M. Tierney, Love A. Patel, Vino S. Raj, Barite U. Dawud, Narayana Mazumder, Abbey Sidebottom, Alena M. Guenther, Benjamin D. Krehbiel, Nova J. Schmitz, Stacy L. Jepsen, Abhijit A Raval, Andrea Franks, Katherine Irby, Ronald C. Sanders, Jr., Glenda Hefley, Anmol Kharbanda, Sunil Jhajhria, Zachary Fyffe, Stephen Capizzi, Bethany Alicie, Martha Green, Lori Crockarell, Amelia Drennan, Kathleen Dubuque, Tonya Fambrough, Nikole Gasaway, Briana Krantz, Peiman Nebi, Jan Orga, Margaret Serfass, Alina Simion, Kimberly Warren, Cassie Wheeler, CJ Woolman, Andrew S. Moyer, George M. Verghese, Andrea Sikora Newsome, Christy C. Forehand, Rebecca Bruning, Timothy W. Jones, Moldovan Sabov, Fatema Zaidi, Fiona Tissavirasingham, Dhatri Malipeddi, Jarrod M Mosier, Karen Lutrick, Beth Salvagio Campbell, Cathleen Wilson, Patrick Rivers, Jonathan Brinks, Mokenge Ndiva Mongoh, Boris Gilson, Donna Lee Armaignac, Don Parris, Maria Pilar Zuniga, Ilea Vargas, Viviana Boronat, Anneka Hutton, Navneet Kaur, Prashank Neupane, Nohemi Sadule-Rios, Lourdes M. Rojas, Aashish Neupane, Priscilla Rivera, Carlos Valle Carlos, Gregory Vincent, Mahesh Amin, Mary E Schelle, Amanda Steadham, Christopher M Howard, Cameron McBride, Jocelyn Abraham, Orlando Garner, Katherine Richards, Keegan Collins, Preethi Antony, Sindhu Mathew, Valerie C. Danesh, Gueorgui Dubrocq, Amber L. Davis, Marissa J Hammers, ill M. McGahey, Amanda C. Farris, Elisa Priest, Robyn Korsmo, Lorie Fares, Kathy Skiles, Susan M. Shor, Kenya Burns, Corrie A Dowell, Melody Flores, Lindsay Newman, Debora A Wilk, Jason Ettlinger, Jaccallene Bomar, Himani Darji, Alejandro Arroliga, Alejandro C Arroliga, Corrie A. Dowell, Gabriela Hope Conzales, Debora A. Wilk, Paras B. Khandhar, Elizabeth Kring, Valerie M. Banner-Goodspeed, Somnath Bose, Lauren E. Kelly, Melisa Joseph, Marie McGourty, Krystal Capers, Benjamin Hoenig, Maria C. Karamourtopoulos, Anica C. Law, Elias N. Baedorf Kassis, Allan J. Walkey, Sushrut S. Waikar, Michael A. Garcia, Mia Colona, Zoe Kibbelaar, Michael Leong, Daniel Wallman, Kanupriya Soni, Jennifer Maccarone, Joshua Gilman, Ycar Devis, Joseph Chung, Munizay Paracha, David N. Lumelsky, Madeline DiLorenzo, Najla Abdurrahman, Shelsey Johnson, Andrew M. Hersh, Stephanie L Wachs, Brittany S. Swigger, Lauren A. Sattler, Michael N. Moulton, Kimberly Zammit, J Patrick, William McGrath, Maya Loeffler, R Chilbert, Aaron S. Miller, Edwin L. Anderson, Rosemary Nagy, Ravali R. Inja, Raghavendra Tirupathi, Alymer Tang, Arshad Safi, Cindy Green, Jackie Newell, Rayan E. Ihle, Shelda A. Martin, Elaine A. Davis, Katja M. Gist, Imran A Sayed, John Brinton, Larisa Strom, Kathleen Chiotos, Allison M. Blatz, Giyoung Lee, Ryan H. Burnett, Guy I. Sydney, Danielle M. Traynor, Karissa Nauert, Annika Gonzalez, Mariel Bagley, Anita Santpurkar, Salim Surani, Joshua White, Aftab Khan, Rahul Dhahwal, Sreekanth Cheruku, Farzin Ahmed, Christopher Deonarine, Ashley Jones, Mohammad-Ali Shaikh, David Preston, Jeanette Chin, Vidula Vachharajani, Abhijit Duggal, Prabalini Rajendram, Omar Mehkri, Siddharth Dugar, Michelle Biehl, Gretchen Sacha, Stuart Houltham, Alexander King, Kiran Ashok, Bryan Poynter, Mary Beukemann, Richard Rice, Susan Gole, Valerie Shaner, Adarsh Conjeevaram, Michelle Ferrari, Narendrakumar Alappan, Steven Minear, Jaime Hernandez-Montfort, Syed Sohaib Nasim, Ravi Sunderkrishnan, Debasis Sahoo, Patrick S. Milligan, Sandeep K. Gupta, Joy M. Koglin, Regina Gibson, Lana Johnson, Felicia Preston, Crimson Scott, Bethany Nungester, Steven K. Daugherty, Sam Atkinson, Kelly Shrimpton, Sidney Ontai, Brian Contreras, Uzoma Obinwanko, Nneka Amamasi, Amir Sharafi, Sarah Lee, Zahia Esber, Chetna Jinjvadia, Kimberly Welker, Francis M. Maguire, Jessica Timmer, Raquel R Bartz, Vijay Krishnamoorthy, Bryan Kraft, Aaron Pulsipher, Eugene Friedman, Sachin Mehta, Margit Kaufman, Gregg Lobel, Nisha Gandhi, Amr Abdelaty, Elizabeth Shaji, Kiana Lim, Juan Marte, Dani Ashley Sosa, David P. Yamane, Ivy Benjenk, Nivedita Prasanna, Smith F. Heavner-Sullivan, Prera J. Roth, Banu Sivaraj, Haley Fulton, Madison G Herin, Marissa Crum, Morgan E. Fretwell, Emily-Rose Zhou, Christine Waller, Kara Kallies, Jonean Thorsen, Alec Fitzsimmons, Haley Olsen, Heda R. Dapul, Sourabh Verma, Alan Salas, Ariel Daube, Michelle Korn, Michelle Ramirez, Logi Rajagopalan, Laura Santos, Orma Smalls, Atul Malhotra, Abdurrahman Husain, Qais Zawaydeh, J.H. Steuernagle, Steven Q. Davis, Valentina Jovic, Max Masuda, Amanda Hayes, Katharine Nault, Michael Smith, William Snow, Riley Liptak, Hannah Durant, Valerie Pendleton, Alay Nanavati, Risa Mrozowsk, LiManoj K Gupta, Franscene E. Oulds, Akshay Nandavar, Yuk Ming Liu, Sarah Zavala, Esther Shim, Ronald A. Reilkoff, Julia A. Heneghan, Sarah Eichen, Lexie Goertzen, Scott Rajala, Ghislaine Feussom, Ben Tang, Christine C. Junia, Robert Lichtenberg, Hasrat Sidhu, Diana Espinoza, Shelden Rodrigues, Maria Jose Zabala, Daniela Goyes, Ammu Susheela, Buddhi Hatharaliyadda, Naveen Rameshkumar, Amulya Kasireddy, Genessis Maldonado, Lisseth Beltran, Akshata Chaugule, Hassan Khan, Namrata Patil, Ruhi Patil, Rodrigo Cartin-Ceba, Ayan Sen, Amanda Palacios, Giyth M. Mahdi, Rahul Kashyap, Ognjen Gajic, Vikas Bansal, Aysun Tekin, Amos Lal, John C. O’Horo, Neha N. Deo, Mayank Sharma, Shahraz Qamar, Cory J. Kudrna, Juan Pablo Domecq Garces, Abigail T. La Nou, Marija Bogojevic, Devang Sanghavi, Pramod Guru, Karthik Gnanapandithan, Hollie Saunders, Zachary Fleissner, Juan Garcia, Alejandra Yu Lee Mateus, Siva Naga Yarrarapu, Syed Anjum Khan, Juan Pablo Domecq, Nitesh Kumar Jain, Thoyaja Koritala, Alexander Bastidas, Gabriela Orellana, Adriana Briceno Bierwirth, Eliana Milazzo, Juan Guillermo Sierra, Thao Dang, Amy B. Christie, Dennis W. Ashley, Rajani Adiga, Rahul S Nanchal, Paul A Bergl, Jennifer L Peterson, Travis Yamanaka, Nicholas A. Barreras, Michael Markos, Anita Fareeduddin, Rohan Mehta, Chakradhar Venkata, Miriam Engemann, Annamarie Mantese, Yasir Tarabichi, Adam Perzynski, Christine Wang, Dhatri Kotekal, Adriana C Briceno Bierwirth, Gabriela M Orellana, Gerardo Catalasan, Shohana Ahmed, Carlos F Matute, Ahmad Hamdan, Ivania Salinas, Genesis Del Nogal, Angel Tejada, Anna Eschler, Mary Hejna, Emily Lewandowski, Kristen Kusmierski, Clare Martin, Jen-Ting Chen, Aluko Hope, Zoe Tsagaris, Elise Ruen, Aram Hambardzumyan, Prithvi Sendi, Meghana Nadiger, Balagangadhar Totapally, Bhagat S. Aulakh, Jennifer A. Bandy, Lisa M. Kreps, Dawn R. Bollinger, Roger Scott Stienecker, Andre G. Melendez, Tressa A. Brunner, Sue M Budzon, Jessica L. Heffernan, Janelle M. Souder, Tracy L. Miller, Andrea G. Maisonneuve, Roberta E. Redfern, Jessica Shoemaker, Jennifer Micham, Lynn Kenney, Gabriel Naimy, Sara Utley, Holly Balcer, Kerry P. J. Pulver, Jennifer Yehle, Alicia Weeks, Terra Inman, Brian L. Delmonaco, Anthony Franklin, Mitchell Heath, Antonia L. Vilella, Sara B. Kutner, Kacie Clark, Danielle Moore, Shina Menon, John K McGuire, Deana Rich, Harry L. Anderson, III, Dixy Rajkumar, Ali Abunayla, Jerrilyn Heiter, Howard A. Zaren, Stephanie J. Smith, Grant C. Lewis, Lauren Seames, Cheryl Farlow, Judy Miller, Gloria Broadstreet, John Lin, Cindy Terrill, Brock Montgomery, Sydney Reyes, Summer Reyes, Alex Plattner, Anthony Martinez, Micheal Allison, Aniket Mittal, Rafael Ruiz, Aleta Skaanland, Robert Ross, Umang Patel, Jordesha Hodge, KrunalKumar Patel, Shivani Dalal, Himanshu Kavani, Sam Joseph, Michael A. Bernstein, Ian K. Goff, Matthew Naftilan, Amal Mathew, Deborah Williams, Sue Murdock, Maryanne Ducey, Kerianne Nelson, Paul K Mohabir, Connor G O’Brien, Komal Dasani, William Marx, Ioana Amzuta, Asad J. Choudhry, Mohammad T. Azam, Kristina L Carter, Michael A Olmos, Brittany M Parker, Julio Quintanilla, Tara A Craig, Brendon J Clough, Jeffrey T Jameson, Neha Gupta, Tracy L Jones, Shonda C Ayers, Amy B Harrell, Dr.Brent R Brown, Utpal S. Bhalala, Joshua Kuehne, Melinda Garcia, Morgan Beebe, Heather Herrera, Chris Fiack, Stephanie Guo, May Vawer, Beth Blackburn, Megan Edwards, Caleb Darby, Kristy Page, Amanda Brown, Jessie McAbee, Katherine A. Belden, Michael Baram, Devin M. Weber, Rosalie DePaola, Yuwei Xia, Hudson Carter, Aaron Tolley, Mark Steele, Laurie Kemble, Joshua L. Denson, A. Scott Gillet, Margo Brown, Rachael Stevens, Andrew Wetherbie, Kevin Tea, Mathew Moore, Benjamin J Sines, Thomas J Bice, Emily A. Vail, Susannah Nicholson, Rachelle B. Jonas, AnnaRose E. Dement, William Tang, Mark DeRosa, Robert E. Villarreal, Rajany V. Dy, Alfredo Iardino, Jill Sharma, Richard Czieki, Julia Christopher, Ryan Lacey, Marwan Mashina, Kushal Patel, Erica C. Bjornstad, Nancy M. Tofil, Scott House, Isabella Aldana, Nikhil K. Meena, Jose D. Caceres, Nikhil K Meena, Sarenthia M. Epps, Harmeen Goraya, Kelsey R. Besett, Ryan James, Lana Y. Abusalem, Akash K. Patel, Lana S Hasan, Dina Gomaa, Michael Goodman, Devin Wakefield, Anthony Spuzzillo, John O. Shinn, II, Azra Bihorac, Tezcan Ozrazgat Baslanti, George Omalay, Haleh Hashemighouchani, Julie S. Cupka, Matthew M Ruppert, Patrick W. McGonagill, Colette Galet, Janice Hubbard, David Wang, Lauren Allan, Aditya Badheka, Madhuradhar Chegondi, Usman Nazir, Garrett Rampon, Jake Riggle, Nathan Dismang, Vicki Montgomery, Janice Sullivan, Sarah Morris, Jennifer Nason, Roger A. Alvarez, Amarilys Alarcon-Calderon, Marie Anne Sosa, Sunita K. Mahabir, Mausam J. Patel, Pauline Park, Andrew Admon, Sinan Hanna, Rishi Chanderraj, Maria Pliakas, Ann Wolski, Jennifer Cirino, Dima Dandachi, Hariharan Regunath, Maraya N. Camazine, Grant. E. Geiger, Abdoulie O. Njai, Baraa M. Saad, Faraaz Ali Shah, Byron Chuan, Sagar L. Rawal, Manal Piracha, Joseph E. Tonna, Nicholas M. Levin, Kayte Suslavich, Rachel Tsolinas, Zachary T. Fica, Chloe R. Skidmore, Renee D. Stapleton, Anne E. Dixon, Olivia Johnson, Sara S. Ardren, Stephanie Burns, Anna Raymond, Erika Gonyaw, Kevin Hodgdon, Chloe Housenger, Benjamin Lin, Karen McQuesten, Heidi Pecott-Grimm, Julie Sweet, Sebastian Ventrone, Nita Khandelwal, T. Eoin West, Ellen S. Caldwell, Lara Lovelace-Macon, Navya Garimella, Denisse B. Dow, Murtaza Akhter, Rania Abdul Rahman, Mary Mulrow, Erin M. Wilfong, Kelsi Vela, Ashish K. Khanna, Lynne Harris, Bruce Cusson, Jacob Fowler, David Vaneenenaam, Glen McKinney, Imoh Udoh, Kathleen Johnson, Patrick G. Lyons, Andrew P Michelson, Sara S. Haluf, Lauren M. Lynch, Nguyet M. Nguyen, Aaron Steinberg, Nicholas Braus, Vishwanath Pattan, Jessica Papke, Ismail Jimada, Nida Mhid, and Samuel Chakola
Subjects: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: IMPORTANCE:. Even with its proclivity for older age, coronavirus disease 2019 has been shown to affect all age groups. However, there remains a lack of research focused primarily on the young adult population. OBJECTIVES:. To describe the epidemiology and outcomes of coronavirus disease 2019 and identify the risk factors associated with critical illness and mortality in hospitalized young adults. DESIGN, SETTINGS, AND PARTICIPANTS:. A retrospective cohort study of the Society of Critical Care Medicine’s Viral Infection and Respiratory Illness Universal Study registry. Patients 18–40 years old, hospitalized from coronavirus disease 2019 from March 2020 to April 2021, were included in the analysis. MAIN OUTCOMES AND MEASURES:. Critical illness was defined as a composite of mortality and 21 predefined interventions and complications. Multivariable logistic regression was used to assess associations with critical illness and mortality. RESULTS:. Data from 4,005 patients (152 centers, 19 countries, 18.6% non-U.S. patients) were analyzed. The median age was 32 years (interquartile range, 27–37 yr); 51% were female, 29.4% Hispanic, and 42.9% had obesity. Most patients (63.2%) had comorbidities, the most common being hypertension (14.5%) and diabetes (13.7%). Hospital and ICU mortality were 3.2% (129/4,005) and 8.3% (109/1,313), respectively. Critical illness occurred in 25% (n = 996), and 34.3% (n = 1,376) were admitted to the ICU. Older age (p = 0.03), male sex (adjusted odds ratio, 1.83 [95% CI, 1.2–2.6]), and obesity (adjusted odds ratio, 1.6 [95% CI, 1.1–2.4]) were associated with hospital mortality. In addition to the above factors, the presence of any comorbidity was associated with critical illness from coronavirus disease 2019. Multiple sensitivity analyses, including analysis with U.S. patients only and patients admitted to high-volume sites, showed similar risk factors. CONCLUSIONS:. Among hospitalized young adults, obese males with comorbidities are at higher risk of developing critical illness or dying from coronavirus disease 2019.
Published: 2021
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7. Electroporation Parameters for Human Cardiomyocyte Ablation In Vitro

Author: Jara M. Baena-Montes, Tony O’Halloran, Cormac Clarke, Kevin Donaghey, Eoghan Dunne, Martin O’Halloran, and Leo R. Quinlan
Subjects: irreversible electroporation, atrial fibrillation, cardiac ablation, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Cardiac ablation with irreversible electroporation (IRE) is quickly being established as a modality of choice for atrial fibrillation treatment. While it has not yet been optimised, IRE has the potential to significantly limit collateral damage and improve cell-specific targeting associated with other energy sources. However, more tissue and cell-specific evidence is required to demonstrate the selective threshold parameters for human cells. The aim here is to determine the optimal ablation threshold parameters related to lesion size for human cardiomyocytes in 2D culture. Conventional biphasic pulses of different field strengths and on-times were delivered in a monolayer culture system of human AC16 cardiomyocytes. The dynamics of cell death and lesion dimensions were examined at different time points. Human cardiomyocytes are susceptible to significant electroporation and cell death at a field strength of 750 V/cm or higher with 100 μs pulses. Increasing the IRE on-time from 3 ms to 60 ms reduces the effective field threshold to 250 V/cm. Using very short pulses of 2 μs and 5 μs also causes significant cell death, but only at fields higher than 1000 V/cm. A longer on-time results in more cell death and induced greater lesion area in 2D models. In addition, different forms of cell death are predicted based on the evolution of cell death over time. This study presents important findings on the ability of different IRE parameters to induce human cardiomyocyte cell death. Lesion size can be tuned by appropriate choice of IRE parameters and cardiomyocytes display an upregulation of delayed cell death 24 h after electroporation, which is an important consideration for clinical practice.
Published: 2022
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8. CLT for NESS of a reaction-diffusion model

Author: Gonçalves, P., Jara, M., Marinho, R., and Menezes, O.
Published: 2024
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9. Non-equilibrium fluctuations for SEP($\alpha$) with open boundary

Author: Franceschini, C., Gonçalves, P., Jara, M., and Salvador, B.
Subjects: Mathematics - Probability, 60J27, 60K35, 82C22, 60F17, 60H15
Abstract: We analyze the non-equilibrium fluctuations of the partial symmetric simple exclusion process, SEP($\alpha$), which allows at most $\alpha \in \mathbb{N}$ particles per site, and we put it in contact with stochastic reservoirs whose strength is regulated by a parameter $\theta \in \mathbb{R}$. Setting $\alpha = 1$, we find the results of [22, 16, 17] and extend the known results to cover all range of $\theta$., Comment: 45 pages, 4 figures
Published: 2023

10. Safety profile of dalfampridine extended release in multiple sclerosis: 5-year postmarketing experience in the United States

Author: Jara M, Aquilina T, Aupperle P, and Rabinowicz AL
Subjects: dalfampridine, fampridine, multiple sclerosis, adverse events, postmarketing safety, Medicine (General), R5-920
Abstract: Michele Jara, Thomas Aquilina, Peter Aupperle, Adrian L Rabinowicz Acorda Therapeutics, Inc., Ardsley, NY, USA Background: Dalfampridine extended release tablets (dalfampridine-ER; prolonged-, modified, or sustained-release fampridine outside the US), 10 mg twice daily, was approved by the US Food and Drug Administration (FDA) in January 2010 to improve walking in people with multiple sclerosis, as determined by an increase in walking speed. Objective: To provide a descriptive analysis of reported adverse events (AEs) for commercially available dalfampridine-ER from March 2010 through March 31, 2015. Methods: Five-year postmarketing data for dalfampridine-ER were available from the exposure of approximately 107,000 patients in the US (103,700 patient-years). Commonly reported AEs (≥2% of all reported AEs) and serious AEs were determined. The incidence of reported seizures was determined and the events were further investigated. Results: Among the 107,000 patients exposed to dalfampridine-ER (70% female; mean age 52.1), the most common AEs were dizziness (3.7%), insomnia (3.2%), balance disorder (3%), fall (2.4%), headache (2.4%), nausea (2.1%), and urinary tract infection (2%). Other common AEs were drug ineffectiveness (5.8%), gait disturbance (4.6%), and inappropriate dosing (3.1%). Serious AEs included rare anaphylactic reactions (five cases) and drug hypersensitivity reactions (eight cases). A total of 657 seizure cases were reported (6.3/1,000 patient-years); of these, 324 were medically confirmed (3.1/1,000 patient-years). Incidence of reported seizures was stable over time. Duration of treatment prior to a seizure ranged from a single dose to >4 years; 12% of the seizures occurred within a week of starting treatment. Conclusion: The 5-year US postmarketing safety data of dalfampridine-ER is consistent with the safety profile observed in clinical trials. Incidence of reported seizures remained stable over time. Since commercial availability in March 2010, a warning regarding the risk of anaphylaxis and severe allergic reactions was added to the US prescribing information. Keywords: dalfampridine, fampridine, multiple sclerosis, adverse events, postmarketing safety
Published: 2015

11. Prescriber utilization of dalfampridine extended release tablets in multiple sclerosis: a retrospective pharmacy and medical claims analysis

Author: Jara M, Sidovar MF, and Henney III HR
Subjects: Therapeutics. Pharmacology, RM1-950
Abstract: Michele Jara,1 Matthew F Sidovar,2 Herbert R Henney III2 1Drug Safety and Risk Management, 2Clinical Development and Medical Affairs, Acorda Therapeutics, Inc, Ardsley, NY, USA Purpose: This study aimed to characterize the prescribing of dalfampridine extended release (D-ER) 10 mg tablet treatment in people with multiple sclerosis (MS). Methods: A retrospective cohort study was performed using Medco pharmacy and medical claims. Medical claims were used to identify MS patients with more than one prescription for D-ER with 1 year of prior continuous enrollment (n=704). These patients were matched 2:1 on age, sex, and health insurance source with a comparison group of MS patients who were treatment naïve for D-ER (n=1,403). Categorical data were analyzed by Χ2 test; ordinal data by Wilcoxon rank sum test; and continuous data by Student’s t-test. Results: Most patients were women aged 45–64 years. In the year preceding D-ER initiation, the prevalence of seizure and renal impairment was numerically lower in the D-ER cohort relative to those who were D-ER naïve (seizure: 3.1% versus 4.7%, respectively; renal impairment: 4.3% versus 5.1%, respectively); however, prescriptions for antiepileptic drugs in the two cohorts were comparable. In the year preceding treatment initiation, 62% of the D-ER cohort was prescribed MS-specific disease-modifying therapies relative to 45% who were D-ER naïve. Conclusion: Seizure and renal impairment rates among D-ER-naïve patients were consistent with published literature, yet rates among those prescribed D-ER during the year preceding treatment initiation were slightly lower than rates among D-ER-naïve patients. Given that D-ER is contraindicated in patients with history of seizure or moderate or severe renal impairment, lower rates may indicate that risk-minimization strategies contributed to the lower prevalence. Keywords: disease-modifying therapy, database, seizures, renal impairment, pharmacoepidemiology
Published: 2014

12. Dalfampridine extended release tablets: 1 year of postmarketing safety experience in the US

Author: Jara M, Barker G, and Henney 3rd HR
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Michele Jara,1 Graham Barker,2 Herbert R Henney 3rd1 1Acorda Therapeutics, Inc, Ardsley, NY, USA; 2Biogen Idec, Inc, Maidenhead, Berkshire, UK Background: Dalfampridine extended release tablets (dalfampridine-ER; prolonged-, modified, or sustained-release fampridine in some countries) were approved in the US to improve walking in patients with multiple sclerosis, as demonstrated by improvement in walking speed. Postmarketing safety experience is available from exposure of approximately 46,000 patients in the US from product approval through March 2011. Objective: To provide a descriptive analysis of all spontaneously reported postmarketing adverse events (AEs) for dalfampridine-ER since product launch. Methods: AE data were extracted from the safety database from product launch through March 31, 2011; AEs were classified using the Medical Dictionary for Regulatory Activities. Seizure cases were reviewed for patient demographics, time to event from treatment onset, and presence of additional risk factors. Results: The most frequently reported postmarketing AEs were similar to those reported during clinical development: dizziness, insomnia, balance disorder, headache, nausea, urinary tract infection, asthenia, and back pain (all included in US product labeling). New clinically significant findings are related to lack of efficacy and inappropriate dosing. Of the approximately 46,000 patients exposed, 85 seizures were reported (~5.4/1000 patient-years), of which 82 were reported or confirmed by a health care practitioner (~5.2/1000 patient-years). Beyond the intrinsic multiple sclerosis-related seizure risk, more than half of the 85 cases (62%) had an additional potential risk factor for seizure including a previous history of convulsions, renal impairment, incorrect dosing, or use of concurrent medications with a labeled seizure risk. Duration of treatment prior to the seizure ranged from one dose to 365 days; 26/85 (31%) patients suffered a seizure within a week of starting treatment. Conclusion: Spontaneous safety data from the US postmarketing experience were consistent with the safety profile seen during clinical development. Although first-year seizure incidence was not substantially different from that observed in dalfampridine-ER clinical trials, patients should be monitored for concomitant use of drugs that lower seizure threshold. Keywords: dalfampridine, fampridine, multiple sclerosis, adverse events, postmarketing safety, seizure
Published: 2013

13. CLT for NESS of a reaction-diffusion model

Author: Gonçalves, P., Jara, M., Marinho, R., and Menezes, O.
Subjects: Mathematics - Probability, Mathematical Physics, 60K35
Abstract: We study the scaling properties of the non-equilibrium stationary states (NESS) of a reaction-diffusion model. Under a suitable smallness condition, we show that the density of particles satisfies a law of large numbers with respect to the NESS, with an explicit rate of convergence, and we also show that at mesoscopic scales the NESS is well approximated by a local equilibrium (product) measure, in the total variation distance. In addition, in dimensions $d \leq3$ we show a central limit theorem (CLT) for the density of particles under the NESS. The corresponding Gaussian limit can be represented as an independent sum of a white noise and a massive Gaussian free field, and in particular it presents macroscopic correlations., Comment: 33 pages
Published: 2022

14. Scaling limits for Rudvalis card shuffles

Author: Gonçalves, P., Jara, M., Marinho, R., and Moreira, D.
Subjects: Mathematics - Probability, 82C22
Abstract: We consider the Rudvalis card shuffle and some of its variations that were introduced by Diaconis and Saloff-Coste in \cite{symmetrized}, and we project them to some stochastic interacting particle system. For the latter, we derive the hydrodynamic limits and we study the equilibrium fluctuations. Our results show that, for these shuffles, when we consider an asymmetric variation of the Rudvalis shuffle, the hydrodynamic limit in Eulerian scale is given in terms of a transport equation with a constant that depends on the exchange rates of the system; while for symmetric and weakly asymmetric variations of this shuffle, in diffusive time scale, the evolution is given by the solution of a martingale problem., Comment: 17 pages, 1 figure
Published: 2022

15. Statin use is not associated with improved progression free survival in cetuximab treated KRAS mutant metastatic colorectal cancer patients: results from the CAIRO2 study.

Author: Lisanne L Krens, Lieke H J Simkens, Jara M Baas, Els R Koomen, Hans Gelderblom, Cornelis J A Punt, and Henk-Jan Guchelaar
Subjects: Medicine, Science
Abstract: Statins may inhibit the expression of the mutant KRAS phenotype by preventing the prenylation and thus the activation of the KRAS protein. This study was aimed at retrospectively evaluating the effect of statin use on outcome in KRAS mutant metastatic colorectal cancer patients (mCRC) treated with cetuximab. Treatment data were obtained from patients who were treated with capecitabine, oxaliplatin bevacizumab ± cetuximab in the phase III CAIRO2 study. A total of 529 patients were included in this study, of whom 78 patients were on statin therapy. In patients with a KRAS wild type tumor (n = 321) the median PFS was 10.3 vs. 11.4 months for non-users compared to statin users and in patients with a KRAS mutant tumor (n = 208) this was 7.6 vs. 6.2 months, respectively. The hazard ratio (HR) for PFS for statin users was 1.12 (95% confidence interval 0.78-1.61) and was not influenced by treatment arm, KRAS mutation status or the KRAS*statin interaction. Statin use adjusted for covariates was not associated with increased PFS (HR = 1.01, 95% confidence interval 0.71-1.54). In patients with a KRAS wild type tumor the median OS for non-users compared to statin users was 22.4 vs. 19.8 months and in the KRAS mutant tumor group the OS was 18.1 vs. 14.5 months. OS was significantly shorter in statin users versus non-users (HR = 1.54; 95% confidence interval 1.06-2.22). However, statin use, adjusted for covariates was not associated with increased OS (HR = 1.41, 95% confidence interval 0.95-2.10). In conclusion, the use of statins at time of diagnosis was not associated with an improved PFS in KRAS mutant mCRC patients treated with chemotherapy and bevacizumab plus cetuximab.
Published: 2014
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16. Non-equilibrium fluctuations for SEP([formula omitted]) with open boundary

Author: Franceschini, C., Gonçalves, P., Jara, M., and Salvador, B.
Published: 2024
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17. Variation in Sedative and Analgesic Use During the COVID-19 Pandemic and Associated Outcomes

Author: Mesland, Jean-Baptiste, Henin, Pierre, Petre, Hélène, Buelens, Isabelle, Gerard, Anne-Catherine, Markotić, Dragana, Bošnjak, Ivana, Garza, Ruben, Chu, Eric, Chan, Victoria, Gavidia, Oscar Y., Pachon, Felipe, El Kassas, Mohamed, Tawheed, Ahmed, Matsuda, Wataru, Itagaki, Yuki, Kodate, Akira, Suzuki, Reina, Takahashi, Yuki, Moriki, Koyo, Amer, Marwa Ridha, Bawazeer, Mohammed Abdullah, Dahhan, Talal I., Kseibi, Eiad, Butt, Abid Shahzad, Khurshid, Syed Moazzum, Rabee, Muath, Abujazar, Mohammed, Alghunaim, Razan, Abualkhair, Maal, AlFirm, Abeer Turki, Almazyad, Mohammed A., Alarifi, Mohammed I., Macarambon, Jara M., Bukhari, Ahmad Abdullah, Albahrani, Hussain A., Asfina, Kazi N., Aldossary, Kaltham M., Bojicic, Jovana, Kovacevic, Bojan, Predrag, Stevanovic, Stojakov, Dejan S., Ignjatovic, Duska K., Bojic, Suzana C., Bobos, Marina M., Nenadic, Irina B., Zaric, Milica S., Djuric, Marko D., Djukic, Vladimir R., Teruel, Santiago Y., Martin, Belen C., Kharbanda, Anmol, Jhajhria, Sunil, Fyffe, Zachary, Capizzi, Stephen, Alicie, Bethany, Green, Martha, Crockarell, Lori, Drennan, Amelia, Dubuque, Kathleen, Fambrough, Tonya, Gasaway, Nikole, Krantz, Briana, Nebi, Peiman, Orga, Jan, Serfass, Margaret, Simion, Alina, Warren, Kimberly, Wheeler, Cassie, Woolman, C.J., Christie, Amy B., Ashley, Dennis W., Adiga, Rajani, Newsome, Andrea Sikora, Forehand, Christy C., Bruning, Rebecca, Jones, Timothy W., Walkey, Allan J., Waikar, Sushrut S., Garcia, Michael A., Colona, Mia, Kibbelaar, Zoe, Leong, Michael, Wallman, Daniel, Soni, Kanupriya, Maccarone, Jennifer, Gilman, Joshua, Devis, Ycar, Chung, Joseph, Paracha, Munizay, Lumelsky, David N., DiLorenzo, Madeline, Abdurrahman, Najla, Johnson, Shelsey, Tirupathi, Raghavendra, Tang, Alymer, Safi, Arshad, Green, Cindy, Newell, Jackie, Ramani, Naga, Ganti, Bhavani Harika, Daugherty, Steven K., Atkinson, Sam, Shrimpton, Kelly, Smalls, Norma, Reilkoff, Ronald A., Heneghan, Julia A., Eichen, Sarah, Goertzen, Lexie, Rajala, Scott, Feussom, Ghislaine, Tang, Ben, Cartin-Ceba, Rodrigo, Sen, Ayan, Talaei, Fahimeh, Kashyap, Rahul, Domecq, Juan Pablo, Gajic, Ognjen, Bansal, Vikas, Tekin, Aysun, Lal, Amos, O'Horo, John C., Deo, Neha N., Sharma, Mayank, Qamar, Shahraz, Singh, Romil, Valencia Morales, Diana J., Sharma, Nikhil, Khan, Syed Anjum, Jain, Nitesh Kumar, Koritala, Thoyaja, Khedr, Anwar M., Mushtaq, Hisham A., Jama, Abbas B., Venkata, Chakradhar, Engemann, Miriam, Mantese, Annamarie, Aulakh, Bhagat S., Tripathi, Sandeep, Bandy, Jennifer A., Kreps, Lisa M., Bollinger, Dawn R., Stienecker, Roger Scott, Melendez, Andre G., Brunner, Tressa A., Budzon, Sue M., Heffernan, Jessica L., Souder, Janelle M., Miller, Tracy L., Maisonneuve, Andrea G., Vilella, Antonia L., Kutner, Sara B., Clark, Kacie, Moore, Danielle, Zaren, Howard A., Smith, Stephanie J., Lewis, Grant C., Seames, Lauren, Farlow, Cheryl, Miller, Judy, Broadstreet, Gloria, Martinez, Anthony, Allison, Micheal, Mittal, Aniket, Ruiz, Rafael, Skaanland, Aleta, Ross, Robert, Bernstein, Michael A., Goff, Ian K., Naftilan, Matthew, Mathew, Amal, Williams, Deborah, Murdock, Sue, Ducey, Maryanne, Nelson, Kerianne, Gupta, Neha, Jones, Tracy L., Ayers, Shonda C., Harrell, Amy B., Brown, Brent R., Malone, Kassidy, Sinko, Lauren A., Settle, Lisa M., Sears, Taylor J., McGonagill, Patrick W., Galet, Colette, Hubbard, Janice, Wang, David, Allan, Lauren, Badheka, Aditya, Chegondi, Madhuradhar, Stapleton, Renee D., Dixon, Anne E., Johnson, Olivia, Ardren, Sara S., Burns, Stephanie, Raymond, Anna, Gonyaw, Erika, Hodgdon, Kevin, Housenger, Chloe, Lin, Benjamin, McQuesten, Karen, Pecott-Grimm, Heidi, Sweet, Julie, Ventrone, Sebastian, Khanna, Ashish K., Harris, Lynnette, Cusson, Bruce, Reeves, Brandon, Fanelli, Jessica, Disher, Nataya, Samant, Anusha, DeGroot, Chritian, Youshock, Evan, Ligon, R. Miller, McCartney, Katherine, Garcia, Julio, Iloabachie, Chidi, Flores, Kelsey, VanEenenaam, David, Sands, Lauren, Robinson, Samuel, Sweatt, Nia, Fowler, Jacob, Fram, Madeline, Howard, Easton, Johnson, Kathleen, Udoh, Imoh, Nosow, Lillian, Howard, Lucy Winesett, Minh Pham, Quan Duc, Irfanullah, Aman, Ong, Tiffany, Enwezor, Chukwunyelu Henry, Dabagian, Hannah, Mendoza, Rafael, Rucci, Justin M., Law, Anica C., Bolesta, Scott, Quinn, Emily K., Boman, Karen, Yus, Santiago, Goodspeed, Valerie M., and Kumar, Vishakha
Published: 2024
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18. Influence of freezing skin grapes to extract phenolic compounds during red wine maceration

Author: Alegria M., Jara M., Cataldo A., Aguirre P., Gonzalez A., and Bordeu E.
Subjects: Microbiology, QR1-502, Physiology, QP1-981, Zoology, QL1-991
Abstract: Wine quality depends on phenolic and aromatic compounds that are mainly located in skins and seeds of grapes and can be better extracted if suitable extraction technologies are applied. An increase in extractability has impact in the mouth feel, color and age ability of the wines. Using liquid or solid CO2 is a way to promote the breakdown of the cells membranes and enhance extraction of these compounds and protecting grapes and wine from oxidation. The main goal was to test the impact of solid CO2 addition to destemmed grapes with a new CO2 dispenser equipment in order to freeze the berry skins and improve the phenolic extraction in an economic and sustainable way in cv. Cabernet Sauvignon and Pinot Noir. The experiment designed for both cultivars was a treatment with CO2 addition and a control without CO2 addition each one with three replicates. Destemmed grapes submitted to carbonic snow reached temperature of the skins between − 1 and − 4 °C during four minutes under equipment treatment. The consumption of carbon dioxide was estimated around 0.3(kg ⋅kg−1)CO2 per berries. Wines of Cabernet Sauvignon and Pinot noir from fresh grapes and frozen grapes were made and were being compared in phenolic composition and sensory attributes.
Published: 2014
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19. Scaling limits for Rudvalis card shuffles

Author: Gonçalves, P., Jara, M., Marinho, R., and Moreira, D.
Published: 2023
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20. Derivation of viscous Burgers equations from weakly asymmetric exclusion processes

Author: Jara, M., Landim, C., and Tsunoda, K.
Subjects: Mathematics - Probability, 60K35 (Primary), 82C22 (secondary)
Abstract: We consider weakly asymmetric exclusion processes whose initial density profile is a small perturbation of a constant. We show that in the diffusive time-scale, in all dimensions, the density defect evolves as the solution of a viscous Burgers equation.
Published: 2019

21. Use of satellite data to determine the cloud optical depths present during overirradiance conditions.

Author: Zamalloa-Jara, M A, Grieseler, R, and Töfflinger, J A
Published: 2024
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22. Stokes vector characterization by strongly measuring weak values

Author: Montenegro, C., primary, Jara, M., additional, Marrou, J. P., additional, and De Zela, F., additional
Published: 2024
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23. Variation in Sedative and Analgesic Use During the COVID-19 Pandemic and Associated Outcomes

Author: Rucci, Justin M., primary, Law, Anica C., additional, Bolesta, Scott, additional, Quinn, Emily K., additional, Garcia, Michael A., additional, Gajic, Ognjen, additional, Boman, Karen, additional, Yus, Santiago, additional, Goodspeed, Valerie M., additional, Kumar, Vishakha, additional, Kashyap, Rahul, additional, Walkey, Allan J., additional, Mesland, Jean-Baptiste, additional, Henin, Pierre, additional, Petre, Hélène, additional, Buelens, Isabelle, additional, Gerard, Anne-Catherine, additional, Markotić, Dragana, additional, Bošnjak, Ivana, additional, Garza, Ruben, additional, Chu, Eric, additional, Chan, Victoria, additional, Gavidia, Oscar Y., additional, Pachon, Felipe, additional, El Kassas, Mohamed, additional, Tawheed, Ahmed, additional, Matsuda, Wataru, additional, Itagaki, Yuki, additional, Kodate, Akira, additional, Suzuki, Reina, additional, Takahashi, Yuki, additional, Moriki, Koyo, additional, Amer, Marwa Ridha, additional, Bawazeer, Mohammed Abdullah, additional, Dahhan, Talal I., additional, Kseibi, Eiad, additional, Butt, Abid Shahzad, additional, Khurshid, Syed Moazzum, additional, Rabee, Muath, additional, Abujazar, Mohammed, additional, Alghunaim, Razan, additional, Abualkhair, Maal, additional, AlFirm, Abeer Turki, additional, Almazyad, Mohammed A., additional, Alarifi, Mohammed I., additional, Macarambon, Jara M., additional, Bukhari, Ahmad Abdullah, additional, Albahrani, Hussain A., additional, Asfina, Kazi N., additional, Aldossary, Kaltham M., additional, Bojicic, Jovana, additional, Kovacevic, Bojan, additional, Predrag, Stevanovic, additional, Stojakov, Dejan S., additional, Ignjatovic, Duska K., additional, Bojic, Suzana C., additional, Bobos, Marina M., additional, Nenadic, Irina B., additional, Zaric, Milica S., additional, Djuric, Marko D., additional, Djukic, Vladimir R., additional, Teruel, Santiago Y., additional, Martin, Belen C., additional, Kharbanda, Anmol, additional, Jhajhria, Sunil, additional, Fyffe, Zachary, additional, Capizzi, Stephen, additional, Alicie, Bethany, additional, Green, Martha, additional, Crockarell, Lori, additional, Drennan, Amelia, additional, Dubuque, Kathleen, additional, Fambrough, Tonya, additional, Gasaway, Nikole, additional, Krantz, Briana, additional, Nebi, Peiman, additional, Orga, Jan, additional, Serfass, Margaret, additional, Simion, Alina, additional, Warren, Kimberly, additional, Wheeler, Cassie, additional, Woolman, C.J., additional, Christie, Amy B., additional, Ashley, Dennis W., additional, Adiga, Rajani, additional, Newsome, Andrea Sikora, additional, Forehand, Christy C., additional, Bruning, Rebecca, additional, Jones, Timothy W., additional, Waikar, Sushrut S., additional, Colona, Mia, additional, Kibbelaar, Zoe, additional, Leong, Michael, additional, Wallman, Daniel, additional, Soni, Kanupriya, additional, Maccarone, Jennifer, additional, Gilman, Joshua, additional, Devis, Ycar, additional, Chung, Joseph, additional, Paracha, Munizay, additional, Lumelsky, David N., additional, DiLorenzo, Madeline, additional, Abdurrahman, Najla, additional, Johnson, Shelsey, additional, Tirupathi, Raghavendra, additional, Tang, Alymer, additional, Safi, Arshad, additional, Green, Cindy, additional, Newell, Jackie, additional, Ramani, Naga, additional, Ganti, Bhavani Harika, additional, Daugherty, Steven K., additional, Atkinson, Sam, additional, Shrimpton, Kelly, additional, Smalls, Norma, additional, Reilkoff, Ronald A., additional, Heneghan, Julia A., additional, Eichen, Sarah, additional, Goertzen, Lexie, additional, Rajala, Scott, additional, Feussom, Ghislaine, additional, Tang, Ben, additional, Cartin-Ceba, Rodrigo, additional, Sen, Ayan, additional, Talaei, Fahimeh, additional, Domecq, Juan Pablo, additional, Bansal, Vikas, additional, Tekin, Aysun, additional, Lal, Amos, additional, O'Horo, John C., additional, Deo, Neha N., additional, Sharma, Mayank, additional, Qamar, Shahraz, additional, Singh, Romil, additional, Valencia Morales, Diana J., additional, Sharma, Nikhil, additional, Khan, Syed Anjum, additional, Jain, Nitesh Kumar, additional, Koritala, Thoyaja, additional, Khedr, Anwar M., additional, Mushtaq, Hisham A., additional, Jama, Abbas B., additional, Venkata, Chakradhar, additional, Engemann, Miriam, additional, Mantese, Annamarie, additional, Aulakh, Bhagat S., additional, Tripathi, Sandeep, additional, Bandy, Jennifer A., additional, Kreps, Lisa M., additional, Bollinger, Dawn R., additional, Stienecker, Roger Scott, additional, Melendez, Andre G., additional, Brunner, Tressa A., additional, Budzon, Sue M., additional, Heffernan, Jessica L., additional, Souder, Janelle M., additional, Miller, Tracy L., additional, Maisonneuve, Andrea G., additional, Vilella, Antonia L., additional, Kutner, Sara B., additional, Clark, Kacie, additional, Moore, Danielle, additional, Zaren, Howard A., additional, Smith, Stephanie J., additional, Lewis, Grant C., additional, Seames, Lauren, additional, Farlow, Cheryl, additional, Miller, Judy, additional, Broadstreet, Gloria, additional, Martinez, Anthony, additional, Allison, Micheal, additional, Mittal, Aniket, additional, Ruiz, Rafael, additional, Skaanland, Aleta, additional, Ross, Robert, additional, Bernstein, Michael A., additional, Goff, Ian K., additional, Naftilan, Matthew, additional, Mathew, Amal, additional, Williams, Deborah, additional, Murdock, Sue, additional, Ducey, Maryanne, additional, Nelson, Kerianne, additional, Gupta, Neha, additional, Jones, Tracy L., additional, Ayers, Shonda C., additional, Harrell, Amy B., additional, Brown, Brent R., additional, Malone, Kassidy, additional, Sinko, Lauren A., additional, Settle, Lisa M., additional, Sears, Taylor J., additional, McGonagill, Patrick W., additional, Galet, Colette, additional, Hubbard, Janice, additional, Wang, David, additional, Allan, Lauren, additional, Badheka, Aditya, additional, Chegondi, Madhuradhar, additional, Stapleton, Renee D., additional, Dixon, Anne E., additional, Johnson, Olivia, additional, Ardren, Sara S., additional, Burns, Stephanie, additional, Raymond, Anna, additional, Gonyaw, Erika, additional, Hodgdon, Kevin, additional, Housenger, Chloe, additional, Lin, Benjamin, additional, McQuesten, Karen, additional, Pecott-Grimm, Heidi, additional, Sweet, Julie, additional, Ventrone, Sebastian, additional, Khanna, Ashish K., additional, Harris, Lynnette, additional, Cusson, Bruce, additional, Reeves, Brandon, additional, Fanelli, Jessica, additional, Disher, Nataya, additional, Samant, Anusha, additional, DeGroot, Chritian, additional, Youshock, Evan, additional, Ligon, R. Miller, additional, McCartney, Katherine, additional, Garcia, Julio, additional, Iloabachie, Chidi, additional, Flores, Kelsey, additional, VanEenenaam, David, additional, Sands, Lauren, additional, Robinson, Samuel, additional, Sweatt, Nia, additional, Fowler, Jacob, additional, Fram, Madeline, additional, Howard, Easton, additional, Johnson, Kathleen, additional, Udoh, Imoh, additional, Nosow, Lillian, additional, Howard, Lucy Winesett, additional, Minh Pham, Quan Duc, additional, Irfanullah, Aman, additional, Ong, Tiffany, additional, Enwezor, Chukwunyelu Henry, additional, Dabagian, Hannah, additional, and Mendoza, Rafael, additional
Published: 2024
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24. Equilibrium Fluctuations for a Discrete Atlas Model

Author: Hernández, F., Jara, M., and Valentim, Fabio J.
Subjects: Mathematics - Probability, Condensed Matter - Statistical Mechanics, 60K35, 60H15, 82C22
Abstract: We consider a discrete version of the Atlas model, which corresponds to a sequence of zero-range processes on a semi-infinite line, with a source at the origin and a diverging density of particles. We show that the equilibrium fluctuations of this model are governed by a stochastic heat equation with Neumann boundary conditions. As a consequence, we show that the current of particles at the origin converges to a fractional Brownian motion of Hurst exponent H=1/4., Comment: 17 pages
Published: 2015

25. A martingale problem for an absorbed diffusion: the nucleation phase of condensing zero range processes

Author: Beltrán, J., Jara, M., and Landim, C.
Subjects: Mathematics - Probability
Abstract: We prove uniqueness of a martingale problem with boundary conditions on a simplex associated to a differential operator with an unbounded drift. We show that the solution of the martingale problem remains absorbed at the boundary once it attains it, and that, after hitting the boundary, it performs a diffusion on a lower dimensional simplex, similar to the original one. We also prove that in the diffusive time scale condensing zero-range processes evolve as this absorbed diffusion.
Published: 2015

26. Non-equilibrium and stationary fluctuations for the SSEP with slow boundary

Author: Gonçalves, P., Jara, M., Menezes, O., and Neumann, A.
Published: 2020
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27. Lattice model for fast diffusion equation

Author: Hernández, F., Jara, M., and Valentim, F.
Published: 2020
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28. P453 Surveillance for colorectal dysplasia and neoplasia in Latin American patients with Ulcerative Colitis

Author: Parra Izquierdo, L V, primary, Frías-Ordoñez, J, additional, Gil, F L, additional, Puentes-Manosalva, F, additional, Suarez, K E, additional, Villa-Ovalles, K, additional, Paredes, J, additional, Jara, M L, additional, Andrade, D, additional, Ibañez, E, additional, and Florez-Sarmiento, C, additional
Published: 2024
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29. Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19

Author: Johnson, Shelsey W., Garcia, Michael A., Sisson, Emily K. Q., Sheldrick, Christopher R., Kumar, Vishakha K., Boman, Karen, Bolesta, Scott, Bansal, Vikas, Lal, Amos, Domecq, J. P., Melamed, Roman R., Christie, Amy B., Husain, Abdurrahman, Yus, Santiago, Gajic, Ognjen, Kashyap, Rahul, Walkey, Allan J., Gavidia, Oscar Y., Pachon, Felipe, Sanchez, Yeimy A., Kassas, Mohamed El, Badr, Mohamed, Tawheed, Ahmed, Tawheed, Ahmed, Yahia, Hend, Matsuda, Wataru, Suzuki, Reina, Suzuki, Reina, Sanui, Masamitsu, Horikita, Sho, Itagaki, Yuki, Kodate, Akira, Suzuki, Reina, Kodate, Akira, Takahashi, Yuki, Moriki, Koyo, Sohaib, Muhammad, Syed, Asghar Mashaal, Anosh, Syed, Naqvi, Ali, Zabolotskikh, Borisovich, Zybin, Konstantin Dmitrievich, Sinkov, Sergey Vasilevich, Musaeva, Tatiana Sergeevna, Almazyad, Mohammed A., Alarifi, Mohammed I., Macarambon, Jara M., Bukhari, Ahmad Abdullah, Albahrani, Hussain A., Asfina, Kazi N., Aldossary, Kaltham M., Zdravkovic, Marija, Todorovic, Zoran, Popadic, Viseslav, Klasnja, Slobodan, Stevanovic, Predrag D., Stojakov, Dejan S., Ignjatovic, Duska K., Bojic, Suzana C., Bobos, Marina M., Nenadic, Irina B., Zaric, Milica S., Djuric, Marko D., Djukic, Vladimir R., Yus, Santiago, Martin, Belen C., Sili, Uluhan, Bilgin, Huseyin, Ay, Pinar, Melamed, Roman R., Tierney, David M., Patel, Love A., Raj, Vino S., Dawud, Barite U., Mazumder, Narayana, Sidebottom, Abbey, Guenther, Alena M., Krehbiel, Benjamin D., Schmitz, Nova J., Jepsen, Stacy L., Sipsey, Lynn, Schulte, Anna, Wunderlich, Whitney, Hoyt, Cecely, Dodd, Kenneth W., Goodmanson, Nicholas, Hesse, Kathleen, Bird, Paige, Weinert, Chauncey, Schoenrade, Nathan, Altaher, Abdulrahman, Mayar, Esmael, Aronson, Matthew, Cooper, Tyler, Logan, Monica, Miner, Brianna, Papo, Gisele, Al-Fares, Abdulrahman, Kharbanda, Anmol, Jhajhria, Sunil, Fyffe, Zachary, Christie, Amy B., Ashley, Dennis W., Adiga, Rajani, Newsome, Andrea Sikora, Forehand, Christy C., Bruning, Rebecca, Jones, Timothy W., Sabov, Moldovan, Zaidi, Fatema, Tissavirasingham, Fiona, Malipeddi, Dhatri, Banner-Goodspeed, Valerie M., Bose, Somnath, Kelly, Lauren E., Joseph, Melisa, McGourty, Marie, Capers, Krystal, Hoenig, Benjamin, Karamourtopoulos, Maria C., Law, Anica C., Baedorf Kassis, Elias N., Walkey, Allan J., Waikar, Sushrut S., Garcia, Michael A., Colona, Mia, Kibbelaar, Zoe, Leong, Michael, Wallman, Daniel, Soni, Kanupriya, Maccarone, Jennifer, Gilman, Joshua, Devis, Ycar, Chung, Joseph, Paracha, Munizay, Lumelsky, David N., DiLorenzo, Madeline, Abdurrahman, Najla, Johnson, Shelsey, Zammit, Kimberly, McGrath, Patrick J., Loeffler, William, Chilbert, Maya R., Mesland, Jean-Baptiste, Henin, Pierre, Petre, Hélène, Buelens, Isabelle, Gerard, Anne-Catherine, Ihle, Rayan E., Martin, Shelda A., Davis, Elaine A., Surani, Salim, White, Joshua, Khan, Aftab, Dhahwal, Rahul, Cheruku, Sreekanth, Ahmed, Farzin, Deonarine, Christopher, Jones, Ashley, Shaikh, Mohammad-Ali, Preston, David, Chin, Jeanette, Daugherty, Steven K., Atkinson, Sam, Shrimpton, Kelly, Bartz, Raquel R., Krishnamoorthy, Vijay, Kraft, Bryan, Pulsipher, Aaron, Friedman, Eugene, Mehta, Sachin, Yamane, David P., Benjenk, Ivy, Prasanna, Nivedita, Nault, Katharine, Reilkoff, Ronald A., Heneghan, Julia A., Eichen, Sarah, Goertzen, Lexie, Rajala, Scott, Feussom, Ghislaine, Tang, Ben, Arizona, Mayo Clinic, Cartin-Ceba, Rodrigo, Sen, Ayan, Palacios, Amanda, Mahdi, Giyth M., Kashyap, Rahul, Gajic, Ognjen, Bansal, Vikas, Tekin, Aysun, Lal, Amos, O’Horo, John C., Deo, Neha N., Sharma, Mayank, Qamar, Shahraz, Domecq, Juan Pablo, Singh, Romil, Niven, Alex, Clinic, Mayo, Claire, Eau, La Nou, Abigail T., Bogojevic, Marija, Mullen, Barbara, Sanghavi, Devang, Guru, Pramod, Franco, Pablo Moreno, Gnanapandithan, Karthik, Saunders, Hollie, Fleissner, Zachary, Garcia, Juan, Yu Lee Mateus, Alejandra, Yarrarapu, Siva Naga, Kaur, Nirmaljot, Giri, Abhisekh, Khan, Syed Anjum, Jain, Nitesh Kumar, Koritala, Thoyaja, Venkata, Chakradhar, Engemann, Miriam, Mantese, Annamarie, Tarabichi, Yasir, Perzynski, Adam, Wang, Christine, Kotekal, Dhatri, Aulakh, Bhagat S., Tripathi, Sandeep, Bandy, Jennifer A., Kreps, Lisa M., Bollinger, Dawn R., Bandy, Jennifer A., Stienecker, Roger Scott, Melendez, Andre G., Brunner, Tressa A., Budzon, Sue M., Heffernan, Jessica L., Souder, Janelle M., Miller, Tracy L., Maisonneuve, Andrea G., Vilella, Antonia L., Kutner, Sara B., Clark, Kacie, Moore, Danielle, Anderson, Harry L., III, Rajkumar, Dixy, Abunayla, Ali, Heiter, Jerrilyn, Zaren, Howard A., Smith, Stephanie J., Lewis, Grant C., Seames, Lauren, Farlow, Cheryl, Miller, Judy, Broadstreet, Gloria, Martinez, Anthony, Allison, Micheal, Mittal, Aniket, Ruiz, Rafael, Skaanland, Aleta, Ross, Robert, Gupta, Neha, Jones, Tracy L., Ayers, Shonda C., Harrell, Amy B., Brown, Dr. Brent R., Husain, Abdurrahman, Malhotra, Atul, Zawaydeh, Qais, Markotić, Dragana, Bošnjak, Ivana, Vail, Emily A., Nicholson, Susannah, Jonas, Rachelle B., Dement, AnnaRose E., Tang, William, DeRosa, Mark, Villarreal, Robert E., McGonagill, Patrick W., Galet, Colette, Hubbard, Janice, Wang, David, Allan, Lauren, Badheka, Aditya, Chegondi, Madhuradhar, Alvarez, Roger A., Alarcon-Calderon, Amarilys, Sosa, Marie Anne, Mahabir, Sunita K., Patel, Mausam J., Shah, Faraaz Ali, Chuan, Byron, Rawal, Sagar L., Piracha, Manal, Tonna, Joseph E., Levin, Nicholas M., Suslavich, Kayte, Tsolinas, Rachel, Fica, Zachary T., Skidmore, Chloe R., Stapleton, Renee D., Dixon, Anne E., Johnson, Olivia, Ardren, Sara S., Burns, Stephanie, Raymond, Anna, Gonyaw, Erika, Hodgdon, Kevin, Housenger, Chloe, Lin, Benjamin, McQuesten, Karen, Pecott-Grimm, Heidi, Sweet, Julie, Ventrone, Sebastian, Akhter, Murtaza, Rahman, Rania Abdul, Mulrow, Mary, Khanna, Ashish K., Harris, Lynne, Cusson, Bruce, Fowler, Jacob, Vaneenenaam, David, McKinney, Glen, Udoh, Imoh, Johnson, Kathleen, Pattan, Vishwanath, Papke, Jessica, Jimada, Ismail, Mhid, Nida, and Chakola, Samuel
Published: 2022
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30. Regularization by noise and stochastic Burgers equations

Author: Gubinelli, M. and Jara, M.
Subjects: Mathematics - Probability
Abstract: We study a generalized 1d periodic SPDE of Burgers type: $$ \partial_t u =- A^\theta u + \partial_x u^2 + A^{\theta/2} \xi $$ where $\theta > 1/2$, $-A$ is the 1d Laplacian, $\xi$ is a space-time white noise and the initial condition $u_0$ is taken to be (space) white noise. We introduce a notion of weak solution for this equation in the stationary setting. For these solutions we point out how the noise provide a regularizing effect allowing to prove existence and suitable estimates when $\theta>1/2$. When $\theta>5/4$ we obtain pathwise uniqueness. We discuss the use of the same method to study different approximations of the same equation and for a model of stationary 2d stochastic Navier-Stokes evolution., Comment: clarifications and small corrections
Published: 2012

31. Universality of trap models in the ergodic time scale

Author: Jara, M., Landim, C., and Teixeira, A.
Subjects: Mathematics - Probability
Abstract: Consider a sequence of possibly random graphs $G_N=(V_N, E_N)$, $N\ge 1$, whose vertices's have i.i.d. weights $\{W^N_x : x\in V_N\}$ with a distribution belonging to the basin of attraction of an $\alpha$-stable law, $0<\alpha<1$. Let $X^N_t$, $t \ge 0$, be a continuous time simple random walk on $G_N$ which waits a \emph{mean} $W^N_x$ exponential time at each vertex $x$. Under considerably general hypotheses, we prove that in the ergodic time scale this trap model converges in an appropriate topology to a $K$-process. We apply this result to a class of graphs which includes the hypercube, the $d$-dimensional torus, $d\ge 2$, random $d$-regular graphs and the largest component of super-critical Erd\"os-R\'enyi random graphs.
Published: 2012

32. Quenched scaling limits of trap models

Author: Jara, M., Landim, C., and Teixeira, A.
Subjects: Mathematics - Probability, 60K35
Abstract: Fix a strictly positive measure $W$ on the $d$-dimensional torus $\bb T^d$. For an integer $N\ge 1$, denote by $W^N_x$, $x=(x_1, ..., x_d)$, $0\le x_i 1$, if $W$ is a finite discrete measure, $W=\sum_{i\ge 1} w_i \delta_{x_i}$, we prove that the random walk which jumps from $x/N$ uniformly to one of its neighbors at rate $(W^N_x)^{-1}$ has a metastable behavior, as defined in \cite{bl1}, described by the $K$-process introduced in \cite{fm1}.
Published: 2009

33. Current and density fluctuations for interacting particle systems with anomalous diffusive behavior

Author: Jara, M.
Subjects: Mathematics - Probability, 65K35, 60G20
Abstract: We prove density and current fluctuations for two examples of symmetric, interacting particle systems with anomalous diffusive behavior: the zero-range process with long jumps and the zero-range process with degenerated bond disorder. As an application, we obtain subdiffusive behavior of a tagged particle in a simple exclusion process with variable diffusion coefficient., Comment: 41 pages
Published: 2009

34. A Predictive and an Optimization Mathematical Model for Device Design in Cardiac Pulsed Field Ablation Using Design of Experiments

Author: Dunne, Eoghan, primary, Baena-Montes, Jara M., additional, Donaghey, Kevin, additional, Clarke, Cormac, additional, Kraśny, Marcin J., additional, Amin, Bilal, additional, O’Halloran, Tony, additional, Quinlan, Leo R., additional, Elahi, Adnan, additional, and O’Halloran, Martin, additional
Published: 2023
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35. CHANGE IN FIBROSIS-4 INDEX (FIB4) OVER TIME IS ASSOCIATED WITH SUBSEQUENT RISK OF LIVER EVENTS, CARDIOVASCULAR EVENTS, AND ALL-CAUSE MORTALITY IN PATIENTS WITH OBESITY AND/OR TYPE 2 DIABETES

Author: Sebastiani, G., primary, Anstee, Q., additional, Berentzen, T., additional, Nitze, L., additional, Jara, M., additional, Jensen, A., additional, Kjaer, M., additional, Mangla, K., additional, Tarp, J., additional, and Khunti, K., additional
Published: 2023
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36. Miniaturised Four-Electrode Conductivity Probe with PEDOT:PSS Coating

Author: Ištuk, Niko, primary, Matta, Rita, additional, Benchakroun, Hamza, additional, Baena-Montes, Jara M., additional, Quinlan, Leo, additional, Moreau, David, additional, O’Connor, Rodney, additional, Dunne, Eoghan, additional, Elahi, Adnan M., additional, and O’Halloran, Martin, additional
Published: 2023
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37. In Vitro Models for Improved Therapeutic Interventions in Atrial Fibrillation

Author: Baena-Montes, Jara M., primary, Kraśny, Marcin J., additional, O’Halloran, Martin, additional, Dunne, Eoghan, additional, and Quinlan, Leo R., additional
Published: 2023
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38. Hydrodynamic limit of particle systems with long jumps

Author: Jara, M.
Subjects: Mathematics - Probability, 60K35, 35K55
Abstract: We consider some interacting particle processes with long-range dynamics: the zero-range and exclusion processes with long jumps. We prove that the hydrodynamic limit of these processes corresponds to a (possibly non-linear) fractional heat equation. The scaling in this case is superdiffusive. In addition, we discuss a central limit theorem for a tagged particle on the zero-range process and existence and uniqueness of solutions of the Cauchy problem for the fractional heat equation., Comment: Extended version, uniqueness of hydrodynamic equation and general initial profiles added
Published: 2008

39. Hydrodynamic limit for a zero-range process in the Sierpinski gasket

Author: Jara, M.
Subjects: Mathematical Physics, Mathematics - Probability, 60K35, 28A80, 35K55
Abstract: We prove that the hydrodynamic limit of a zero-range process evolving in graphs approximating the Sierpinski gasket is given by a nonlinear heat equation. We also prove existence and uniqueness of the hydrodynamic equation by considering a finite-difference scheme., Comment: 24 pages, 1 figure
Published: 2008
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40. Hydrodynamic behavior of one dimensional subdiffusive exclusion processes with random conductances

Author: Faggionato, A., Jara, M., and Landim, C.
Subjects: Mathematics - Probability, Mathematical Physics, 60K35, 60K37, 82C44
Abstract: Consider a system of particles performing nearest neighbor random walks on the lattice $\ZZ$ under hard--core interaction. The rate for a jump over a given bond is direction--independent and the inverse of the jump rates are i.i.d. random variables belonging to the domain of attraction of an $\a$--stable law, $0<\a<1$. This exclusion process models conduction in strongly disordered one-dimensional media. We prove that, when varying over the disorder and for a suitable slowly varying function $L$, under the super-diffusive time scaling $N^{1 + 1/\alpha}L(N)$, the density profile evolves as the solution of the random equation $\partial_t \rho = \mf L_W \rho$, where $\mf L_W$ is the generalized second-order differential operator $\frac d{du} \frac d{dW}$ in which $W$ is a double sided $\a$--stable subordinator. This result follows from a quenched hydrodynamic limit in the case that the i.i.d. jump rates are replaced by a suitable array $\{\xi_{N,x} : x\in\bb Z\}$ having same distribution and fulfilling an a.s. invariance principle. We also prove a law of large numbers for a tagged particle.
Published: 2007

41. Nonequilibrium fluctuations for a tagged particle in mean-zero one-dimensional zero-range processes

Author: Jara, M. D., Landim, C., and Sethuraman, S.
Subjects: Mathematics - Probability, Mathematical Physics, 60K35
Abstract: We prove a non-equilibrium functional central limit theorem for the position of a tagged particle in mean-zero one-dimensional zero-range process. The asymptotic behavior of the tagged particle is described by a stochastic differential equation governed by the solution of the hydrodynamic equation., Comment: 20 pages
Published: 2007

42. Scaling limits for gradient systems in random environment

Author: Goncalves, P. and Jara, M. D.
Subjects: Mathematics - Probability, Mathematical Physics, 60K35
Abstract: For interacting particle systems that satisfies the gradient condition, the hydrodynamic limit and the equilibrium fluctuations are well known. We prove that under the presence of a symmetric random environment, these scaling limits also hold for almost every choice of the environment, with homogenized coefficients that does not depend on the particular realization of the random environment., Comment: 24 pages
Published: 2007
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43. Equilibrium fluctuations for the zero-range process on the Sierpinski gasket

Author: Jara, M. D.
Subjects: Mathematics - Probability, Mathematical Physics, 60K35, 82C22
Abstract: We obtain the equilibrium fluctuations for the empirical density of particles for the zero-range process in the Sierpinski gasket. The limiting process is a generalized Ornstein-Uhlenbeck process generated by the Neumann Laplacian and its corresponding Dirichlet form on the gasket., Comment: 9 pages
Published: 2006

44. Quenched nonequilibrium central limit theorem for a tagged particle in the exclusion process with bond disorder

Author: Jara, M. D. and Landim, C.
Subjects: Mathematics - Probability, Mathematical Physics, 60K35
Abstract: For a sequence of i.i.d. random variables $\{\xi_x : x\in \bb Z\}$ bounded above and below by strictly positive finite constants, consider the nearest-neighbor one-dimensional simple exclusion process in which a particle at $x$ (resp. $x+1$) jumps to $x+1$ (resp. $x$) at rate $\xi_x$. We examine a quenched nonequilibrium central limit theorem for the position of a tagged particle in the exclusion process with bond disorder $\{\xi_x : x\in \bb Z\}$. We prove that the position of the tagged particle converges under diffusive scaling to a Gaussian process if the other particles are initially distributed according to a Bernoulli product measure associated to a smooth profile $\rho_0:\bb R\to [0,1]$.
Published: 2006

45. Nonequilibrium Central Limit Theorem for a Tagged Particle in Symmetric Simple Exclusion

Author: Jara, M. D. and Landim, C.
Subjects: Mathematics - Probability
Abstract: We prove a nonequilibirum central limit theorem for the position of a tagged particle in the one-dimensional nearest-neighbor symmetric simple exclusion process under diffusive scaling starting from a Bernoulli product measure associated to a smooth profile $\rho_0:\bb R\to [0,1]$.
Published: 2005
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46. Experiencia con intervención basada en mindfulness (atención plena) en pacientes de un centro de salud urbano

Author: Garzón de la Iglesia, J., Caparrós de la Jara, M., and Fernández Horcajuelo, J.
Published: 2018
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47. Efecto reparador del suero autólogo en lesiones corneales producidas por agentes químicos. Ensayo preclínico aleatorio a doble ciego en conejos

Author: Hernández-Patiño, I., Rossani, G., Borobio, E., Talavera, E., Pilar Quiñones, M., Rozas L.L., R., Carlos Roque, Juan, Jara, M., and de la Cruz-Vargas, Jhony A.
Published: 2021
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48. Análisis Comparativo del Potencial Energético Extraíble entre Paneles Fotovoltaicos Fijo y con Sistema de Seguimiento de un Eje Instalados en la ULEAM.

Author: Moreira-Espinoza, A. A., Intriago, J. C., Pazmiño, I. P., Ponce-Jara, M. A., and Moreano, M. E.
Subjects: ELECTRONIC equipment, PHOTOVOLTAIC power systems, ELECTRIC power production, ELECTRICAL energy, SOLAR energy
Abstract: Copyright of Revista Técnica Energía is the property of Centro Nacional de Control de Energia CENACE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2024
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49. Explicit LDP for a slowed RW driven by a symmetric exclusion process

Author: Avena, L., Jara, M., and Völlering, F.
Published: 2018
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50. Concordance Between Capillary And Plasma Glycaemia In Hospitalised Patients Receiving Total Parenteral Nutrition

Author: López, M.C., primary, Ruiz de Asín, A., additional, Moya, A.J., additional, Jara, M., additional, Sirvent, A.E., additional, Pérez, J., additional, Quílez, R.P., additional, García-Blasco, L., additional, Pinés, P.J., additional, and Alfaro, J.J., additional
Published: 2023
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