106,185 results on '"Jaramillo A"'
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2. Página de título, Derechos de autor
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
3. CAPÍTULO 2. El pasado
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
4. Anexo
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
5. colofón
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
6. Lista de tablas
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
7. Recursos escriturales
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
8. A manera de colofón
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
9. Bibliografía
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
10. Prólogo
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
11. CAPÍTULO 4. Proceso vivido
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
12. CAPÍTULO 3. Atención primaria social en Caldas
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
13. Introducción
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
14. CAPÍTULO 1. El contexto
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Jaramillo Angel, Claudia P., Sanchez Palacio, Natalia, and Velez Alvarez, Consuelo
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- 2022
15. Evaluación morfológica del pimiento (capsicum annun l.) bajo coberturas plásticas de diferentes colores, Ecuador
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Batallas Sánchez, Pedro Andrés, Jaramillo Aguilar, Edwin Edison, and Luna-Romero, Ángel Eduardo
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mulch ,geotemperatura ,microclima ,flujo neto de calor. ,Agriculture (General) ,S1-972 ,Environmental sciences ,GE1-350 - Abstract
Debido a los retos que presenta la seguridad alimentaria, principalmente por los cambios en los patrones climáticos y degradación de los suelos, la agricultura ha adoptado nuevas técnicas como el uso de coberturas plásticas, que mejoran las propiedades físicas del suelo. Por eso en este estudio se evaluó morfológicamente el efecto que tienen las cubiertas plásticas de diferentes colores frente al suelo desnudo en el cultivo de pimiento. Se analizaron los parámetros de geotemperatura y flujo neto de calor en el suelo. Se realizaron cinco tratamientos: tratamiento control (T0, suelo sin cobertura), cubierta plástica de diferentes colores: negro (T1), rojo (T2), azul (T3) y verde (T4). Se utilizó diseño completamente al azar con tres repeticiones. El mulch plástico es capaz de modificar el microclima, e influye en la variabilidad de la geotemperatura en los primeros horizontes. Además, presentaron mayor energía acumulada con respecto al suelo desnudo. Las variables morfológicas del cultivo fueron influenciadas favorablemente por los tratamientos del mulch plástico, destacando el T3 y T2 en la altura de planta, en diámetro del tallo el T2 presenta mejores resultados, El número de hojas estuvieron influenciados por el T2 y T4.
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- 2022
16. Evaluación morfológica del pimiento (capsicum annun l.) bajo diferentes coberturas vegetales muertas, Ecuador
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Romero Delgado, Willy Fernando, Jaramillo Aguilar, Edwin Edison, and Luna-Romero, Ángel Eduardo
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geotemperatura ,microclima ,flujo neto de calor ,cobertura vegetal muerta. ,Agriculture (General) ,S1-972 ,Environmental sciences ,GE1-350 - Abstract
El sector agrícola ha tenido que adaptarse a elevados estándares de productividad, eficiencia y rentabilidad cada vez más altos lo que conlleva aplicar técnicas de preservación de suelo, como lo es el mulch. El objetivo del presente estudio fue evaluar el efecto de las cubiertas vegetales muertas frente al suelo sin cobertura en el cultivo de pimiento (Capsicum annum L.), sobre aspectos morfológicos, parámetros de geotemperatura y flujo neto de calor en el suelo, para la comprensión de la modificación del microclima. Se utilizó un diseño completamente al azar (DCA) con tres repeticiones, donde se evaluaron cinco tratamientos de estudio: Suelo desnudo (T0), cubierta de coronta (T1), tamo de arroz (T2), fibra de coco (T3) y aserrín (T4). Se observó que la aplicación de coberturas vegetales muertas es capaz de alterar el microclima. El mulch de tamo de arroz ha presentado una tendencia a reducir la geotemperatura en cada una de las profundidades evaluadas. La morfología se ha visto influenciada en cada una de las coberturas vegetales, denotando que el mejor resultado relacionado a altura de planta y numero de hojas y diámetro del tallo lo obtuvo el T2.
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- 2022
17. Fungicidas a base de azufre y bacillus sp. en manejo integrado de Sigatoka Negra
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García Sánchez, Harley Marcia, Jaramillo Aguilar, Edwin Edison, and Herrera Reyes, Sayda Noemi
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sigatoka negra ,azufre ,bacillus ,fungicidas. ,Agriculture (General) ,S1-972 ,Environmental sciences ,GE1-350 - Abstract
En Ecuador, en el cultivo de Banano (Musa spp.), la principal enfermedad es la Sigatoka negra, causada por el hongo Mycosphaerella fijiensis Morelet, se caracteriza por tener reproducción sexual y asexual (Paracercospora fijiensis), ocasionando una alta diseminación de esporas dentro de las plantaciones bananeras. La investigación tuvo como objetivo evaluar alternativas de fungicidas protectantes azufrados y microbiológicos, dentro de las combinaciones de fungicidas, como estrategias de control de la Sigatoka negra. Se utilizó un Diseño de bloques Completamente al Azar, conformado por 7 tratamientos y 10 repeticiones, el análisis estadístico se realizó mediante el análisis de varianza ANOVA y los promedios fueron comparados mediante la prueba de Tukey. Las variables evaluadas fueron porcentaje de área foliar afectada y el área bajo la curva del progreso de la enfermedad (ABCPE) durante toda la epidemia, evidenciándose el tratamiento T7 como la mejor estrategia de control frente a la enfermedad. Los resultados sugieren que el azufre elemental 800 gr/Kg a una dosis 3Kg/ha, puede integrarse en las combinaciones de fungicidas, como estrategia de control de la sigatoka negra, obteniendo buenos niveles de control.
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- 2022
18. Efecto de hongos entomopatógenos para el control de nematodos en el sistema radicular del banano
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López Aguilar, Carlos, Barrezueta-Unda, Salomón, and Jaramillo Aguilar, Edison
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muscaeas ,helicotylenchus spp. ,meloidogyne spp. ,nematicida ,pratylenchus spp. ,suelo ,radopholus similis . ,Agriculture (General) ,S1-972 ,Environmental sciences ,GE1-350 - Abstract
El objetivo de la investigación fue evaluar los efectos del producto MICOSPLAG® en las funcionalidades de las raíces y la altura de planta de banano. Se aplicó 100 g ha-1 de MICOSPLAG® en siete bananeras en las provincias de Guayas y El Oro. La extracción de raíces se realizó entre la madre y el hijo de sucesión a una profundidad de 30 cm, luego las raíces fueron llevadas a un laboratorio para la cuantificación de nematodos medidos en 100 g de suelo. No existe diferencia significativa entre los valores por provincia de las variables peso de raíces funcionales y no funcionales, tampoco en el porcentaje de raíces funcionales. Pero se obtuvo un incremento del peso de raíces funcionales de 113,75 g a 153 g en las fincas de Guayas y de 121,50 g a 170 g en El Oro. El número de Radopholus sp., al final del experimento fue de 3400 nematodos en Guayas y 1466 nematodos en El Oro. Mientras de Helicotylenchus sp., la población aumentó a 4900 nematodos (Guayas) y de 9930 nematodos (El Oro). Se recomienda el uso de MICOSPLAG para incrementar el peso de raíces funcionales.
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- 2022
19. HfO$_2$-based platform for high-index-contrast visible/UV integrated photonics
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Jaramillo, Oscar, Natarajan, Vighnesh, Rivy, Hamim Mahmud, Tensuan, Joshua, Massai, Leonardo, and Mehta, Karan K.
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Physics - Optics - Abstract
Ultraviolet and visible integrated photonics are enabling for applications in quantum information, sensing, and spectroscopy, among others. Few materials support low-loss photonics into the UV, and the relatively low refractive index of known depositable materials limits the achievable functionality. Here we present a high-index integrated photonics platform based on HfO$_2$ and Al$_2$O$_3$ composites deposited via Atomic Layer Deposition (ALD) with low loss in the visible and near-UV. We show that Al$_2$O$_3$ incorporation dramatically decreases bulk loss compared to pure HfO$_2$, consistent with inhibited crystallization due to the admixture of Al$_2$O$_3$. Composites exhibit refractive index $n$ following the average of that of HfO$_2$ and Al$_2$O$_3$, weighted by the HfO$_2$ fractional composition $x$. At $\lambda=375$ nm, composites with $x=0.67$ exhibit $n=2.08$ preserving most of HfO$_2$'s significantly higher index, and $3.8(7) $ dB/cm material loss. We further present fully etched and cladded waveguides, grating couplers, and ring resonators, realizing single-mode waveguide loss of $0.25(2)$ dB/cm inferred from resonators of 2.6 million intrinsic quality factor at $\lambda=729$ nm, $2.6(2)$ dB/cm at $\lambda=405$ nm, and $7.7(6)$ dB/cm at $\lambda=375$ nm. We measure the composite's thermo-optic coefficient (TOC) to be $2.44(3) \times 10^{-5}$ RIU/$^\circ$C near $\lambda=397$ nm. This work establishes (HfO$_2$)$_x$(Al$_2$O$_3$)$_{1-x}$ composites as a platform amenable to integration for low-loss, high-index photonics spanning the UV to NIR.
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- 2024
20. Quasi-normal mode expansions of black hole perturbations: a hyperboloidal Keldysh's approach
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Besson, Jérémy and Jaramillo, José Luis
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General Relativity and Quantum Cosmology ,Physics - Optics - Abstract
We study asymptotic quasinormal mode expansions of linear fields propagating on a black hole background by adopting a Keldysh scheme for the spectral construction of the resonant expansions. This scheme requires to cast quasinormal modes in terms of a non-selfadjoint problem, something achieved by adopting a hyperboloidal scheme for black hole perturbations. The method provides a spectral version of Lax-Phillips resonant expansions, adapted to the hyperboloidal framework, and extends and generalises Ansorg & Macedo black hole quasinormal mode expansions beyond one-dimensional problems. We clarify the role of scalar product structures in the Keldysh construction that prove non-necessary to construct the resonant expansion, in particular providing a unique quasinormal mode time-series at null infinity, but are required to define constant coefficients in the bulk resonant expansion by introducing a notion of 'size' (norm). By (numerical) comparison with the time-domain signal for test-bed initial data, we demonstrate the efficiency and accuracy of the Keldysh spectral approach. Indeed, we are able to recover Schwarzschild black hole tails, something that goes beyond the a priori limits of validity of the method and constitutes one of the main results. We also demonstrate the critical role of highly-damped quasinormal mode overtones to accurately account for the early time behaviour. As a by-product of the analysis, we present the Weyl law for the counting of quasinormal modes in black holes with different (flat, De Sitter, anti-De Sitter) asymptotics, as well as the $H^p$-Sobolev pseudospectra for the P\"oschl-Teller potential., Comment: 55 pages, 18 figures, 2 tables
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- 2024
21. Boson star superradiance with spinning effects and in time domain
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Chang, Fu-Ming, Gao, He-Yu, Jaramillo, Víctor, Meng, Xin, and Zhou, Shuang-Yong
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Theory - Abstract
Superradiance, the process by which waves are amplified through energy and angular momentum transfer, can also occur in horizonless objects like boson stars, due to both the real space and internal field space rotations. In this work, we study superradiance in the frequency and time domains for static and spinning boson stars, constructed within general relativity and with a self-interacting complex scalar field as a matter source. Using linear perturbation theory and three dimensional nonlinear simulations, we calculate amplification factors and analyze energy and angular momentum transfer in scattering processes, with results showing consistency between approaches. Wave scattering inside a cavity containing a boson star is also examined, demonstrating the effects of confinement on amplification., Comment: 26 pages, 19 figures
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- 2024
22. On the detectability of gravitational waves emitted from head-on collisions of $\ell$-boson stars
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Lira, Mariana, Villegas, Laura O., Antelis, Javier M., Jaramillo, Víctor, Moreno, Claudia, and Núñez, Darío
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General Relativity and Quantum Cosmology - Abstract
In this work, we investigate head-on collisions of $\ell$-boson stars, potential candidates for dark matter compact objects. We begin with a review of the general properties and features of these stars, leveraging results from prior studies to analyze the gravitational wave signals generated by such collisions. Considering a maximum distance of 100 Mpc for potential events, we identify the range of masses and scalar field frequencies for these stars that would render the gravitational waves detectable by current gravitational wave observatories. Additionally, we process the resulting signals to generate simulated observatory images, highlighting their similarities and differences compared to those produced by black hole collisions., Comment: 23 pages, 10 figures, corrected title
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- 2024
23. Assessing the physical risks of climate change for the financial sector: a case study from Mexico's Central Bank
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Estrada, Francisco, del Carmen, Miguel A. Altamirano, Calderon-Bustamante, Oscar, Botzen, W. J. Wouter, Martinez-Jaramillo, Serafin, and Battiston, Stefano
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Economics - General Economics ,Physics - Atmospheric and Oceanic Physics ,97M40 ,J.4 ,J.2 - Abstract
The financial sector is increasingly concerned with the physical risks of climate change, but economic and financial impact representations are still developing, particularly for chronic risks. Mexico's Central Bank conducted a comprehensive assessment using a suite of global models to evaluate both physical and transition risks. We present the analysis concerning with chronic physical risks, underlining innovations such as the use of a recent integrated assessment model that enables grid-cell level analysis and differentiates urban and non-urban areas, capturing the local effects of climate change more accurately. The model includes multiple damage functions and a probabilistic climate model for encompassing analyses and detailed economic impact insights. Under the Current Policies scenario, economic losses could exceed 35 percent of Mexico's GDP by 2100. Accounting for the urban heat island effect, losses could surpass 20 trillion (USD) in present value, over ten times Mexico's 2024 GDP. However, implementing a scenario aligned with the Paris Agreement significantly reduces these losses, showcasing the benefits of international mitigation efforts, though substantial residual impacts persist. This study emphasizes integrating chronic physical risks into financial evaluations, proposing new approaches, metrics, and methods that exploit detailed, spatially explicit measures to improve risk and loss estimation and facilitate communication., Comment: 19 pages, 7 figures
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- 2024
24. Non-commutative Stein's Method: Applications to Free Probability and Sums of Non-commutative Variables
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Díaz, Mario and Jaramillo, Arturo
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Mathematics - Probability ,60F05, 46L53, 60G50, 60B10 - Abstract
We present a straightforward formulation of Stein's method for the semicircular distribution, specifically designed for the analysis of non-commutative random variables. Our approach employs a non-commutative version of Stein's heuristic, interpolating between the target and approximating distributions via the free Ornstein-Uhlenbeck semigroup. A key application of this work is to provide a new perspective for obtaining precise estimates of accuracy in the semicircular approximation for sums of weakly dependent variables, measured under the total variation metric. We leverage the simplicity of our arguments to achieve robust convergence results, including: (i) A Berry-Esseen theorem under the total variation distance and (ii) Enhancements in rates of decay under the non-commutative Wasserstein distance towards the semicircular distribution, given adequate high-order moment matching conditions.
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- 2024
25. Understanding trade-offs in classifier bias with quality-diversity optimization: an application to talent management
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Jaramillo, Catalina M, Squires, Paul, and Togelius, Julian
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Computer Science - Neural and Evolutionary Computing - Abstract
Fairness,the impartial treatment towards individuals or groups regardless of their inherent or acquired characteristics [20], is a critical challenge for the successful implementation of Artificial Intelligence (AI) in multiple fields like finances, human capital, and housing. A major struggle for the development of fair AI models lies in the bias implicit in the data available to train such models. Filtering or sampling the dataset before training can help ameliorate model bias but can also reduce model performance and the bias impact can be opaque. In this paper, we propose a method for visualizing the biases inherent in a dataset and understanding the potential trade-offs between fairness and accuracy. Our method builds on quality-diversity optimization, in particular Covariance Matrix Adaptation Multi-dimensional Archive of Phenotypic Elites (MAP-Elites). Our method provides a visual representation of bias in models, allows users to identify models within a minimal threshold of fairness, and determines the trade-off between fairness and accuracy.
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- 2024
26. Thermalization of a Closed Sachdev-Ye-Kitaev System in the Thermodynamic Limit
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Jaramillo, Santiago Salazar, Jha, Rishabh, and Kehrein, Stefan
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Statistical Mechanics ,Quantum Physics - Abstract
The question of thermalization of a closed quantum system is of central interest in non-equilibrium quantum many-body physics. Here we present one such study analyzing the dynamics of a closed coupled Majorana SYK system. We have a large-$q$ SYK model prepared initially at equilibrium quenched by introducing a random hopping term, thus leading to non-equilibrium dynamics. We find that the final stationary state reaches thermal equilibrium with respect to the Green's functions and energy. Accordingly, the final state is characterized by calculating its final temperature and the thermalization rate. We provide a detailed review of analytical methods and derive the required Kadanoff-Baym equations, which are then solved using the algorithm developed in this work. Our results display rich thermalization dynamics in a closed quantum system in the thermodynamic limit., Comment: 31 pages, 15 figures
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- 2024
27. Dipoles and chains of solitons in the Friedberg-Lee-Sirlin model
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Jaramillo, Víctor and Zhou, Shuang-Yong
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
We construct static axisymmetric multisolitons in the Einstein-Friedberg-Lee-Sirlin model. This theory features a complex scalar field which gains mass through its interaction with a real scalar field that has a non-zero vacuum expectation value. By performing three-dimensional numerical relativity simulations, we identify stable dipolar boson stars in specific regions of the parameter space. Based on the dipole results, non-rotating odd parity chains with and without gravity can also be constructed when the mass of the real scalar field is sufficiently small. However, chains beyond the dipole case are found to be unstable., Comment: 38 pages, 16 figures
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- 2024
28. Full 3D nonlinear dynamics of charged and magnetized boson stars
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Jaramillo, Víctor, Núñez, Darío, Ruiz, Milton, and Zilhão, Miguel
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Gauged boson stars are exotic compact objects that can potentially mimic black holes or magnetized neutron stars in both their gravitational and electromagnetic signatures, offering a compelling new description or even an alternative explanation for various multimessenger phenomena. As a crucial step toward establishing boson stars as viable multimessenger sources, we perform 3D numerical simulations of the fully nonlinear Einstein-Maxwell-Klein-Gordon system, focusing on both spherical and axisymmetric boson star configurations that vary in their electromagnetic coupling between the neutral case up to values close to the critical case, and so their magnetic field content. For spherical configurations, we consistently find stable solutions. In contrast, for axially symmetric, electrically neutral, magnetized configurations, the dynamics are highly sensitive to the electromagnetic coupling. Configurations with stronger coupling develop a one-armed mode instability, which leads to collapse into black holes. Configurations with weaker coupling undergo a two-stage process: an initial bar-mode instability that triggers a one-armed spiral deformation. This eventually also results in black hole formation, accompanied by emissions of both gravitational and electromagnetic radiation. A similar instability and two-stage pattern is observed in all charged rotating boson stars analyzed. However, all of these configurations become stable when self-interactions are introduced., Comment: 22 pages, 12 figures
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- 2024
29. Imaging heat transport in suspended diamond nanostructures with integrated spin defect thermometers
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Goblot, Valentin, Wu, Kexin, Di Lucente, Enrico, Zhu, Yuchun, Losero, Elena, Jobert, Quentin, Concha, Claudio Jaramillo, Marzari, Nicola, Simoncelli, Michele, and Galland, Christophe
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Among all materials, mono-crystalline diamond has one of the highest measured thermal conductivities, with values above 2000 W/m/K at room temperature. This stems from momentum-conserving `normal' phonon-phonon scattering processes dominating over momentum-dissipating `Umklapp' processes, a feature that also suggests diamond as an ideal platform to experimentally investigate phonon heat transport phenomena that violate Fourier's law. Here, we introduce dilute nitrogen-vacancy color centers as in-situ, highly precise spin defect thermometers to image temperature inhomogeneities in single-crystal diamond microstructures heated from ambient conditions. We analyze cantilevers with cross-sections in the range from about 0.2 to 2.6 $\mathrm{\mu m}^2$, observing a relation between cross-section and heat flux that departs from Fourier's law predictions. We rationalize such behavior relying on first-principles simulations based on the linearized phonon Boltzmann transport equation, also discussing how fabrication-induced impurities influence conduction. Our temperature-imaging method can be applied to diamond devices of arbitrary geometry, paving the way for the exploration of unconventional, non-diffusive heat transport phenomena., Comment: 8 pages, 4 figures + supplementary materials (8 pages, 7 figures)
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- 2024
30. Cultural Heritage 3D Reconstruction with Diffusion Networks
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Jaramillo, Pablo and Sipiran, Ivan
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Graphics - Abstract
This article explores the use of recent generative AI algorithms for repairing cultural heritage objects, leveraging a conditional diffusion model designed to reconstruct 3D point clouds effectively. Our study evaluates the model's performance across general and cultural heritage-specific settings. Results indicate that, with considerations for object variability, the diffusion model can accurately reproduce cultural heritage geometries. Despite encountering challenges like data diversity and outlier sensitivity, the model demonstrates significant potential in artifact restoration research. This work lays groundwork for advancing restoration methodologies for ancient artifacts using AI technologies., Comment: Accepted by the workshop VISART for ECCV 2024
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- 2024
31. Evaluación de dosis de extracto etanólico de canela más agua ozonificada en pudrición de corona de banano
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Sánchez Romero, Patricia Lizbeth, Jaramillo Aguilar, Edwin Edison, and García Batista, Rigoberto Miguel
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extracto etanólico ,ozono ,pudrición de corona ,canela ,agua ozonificada ,Special aspects of education ,LC8-6691 ,Social sciences (General) ,H1-99 - Abstract
La investigación se desarrolló en el laboratorio de fitopatología de la Facultad de Ciencias Agropecuarias (FCA), de la Universidad Técnica de Machala, con el objetivo de evaluar el comportamiento de distintas dosis de extracto etanólico de canela más agua ozonificada en la pudrición de banano, el diseño experimental fue bloque al azar con siete tratamientos y tres repeticiones, El T1 con dosis de 1 ml de extracto etanólico de canela y 99 ml de agua ozonificada, el T2 con dosis de 2 ml de EEC y 98 ml de O3, el T3 con dosis de 3 ml de EEC y 97 ml de O3, el T4 con dosis de 4 ml de EEC y 96 ml de O3, el T5 con dosis de 5 ml de EEC y 95 ml de O3, se tuvo en cuenta dos testigos absolutos, el primero con 100 ml de agua ozonificada y el segundo con 100 ml de agua pura. Los resultados indican que el tratamiento 4 posee una mejor acción antifúngica que permitió el desarrollo hasta un 36,17% de la enfermedad, seguido del tratamiento 5 con valores de eficiencia antifúngica de 51.33% de desarrollo de la enfermedad, se pudo observar que la eficiencia fue propia del extracto de canela, el testigo de Ozono puro (T6) no presentó resultados eficientes, dado por algún factor interviniente en la preparación.
- Published
- 2021
32. Role of thrombopoietin stimulating agents(Eltrombopag and Romiplostim) in immune thrombocytopenia secondary to SLE
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Toro Vélez, Esteban, Nova Escobar, Santiago, and Jaramillo Arroyave, Daniel
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lupus erythematosus systemic ,purpura thrombo-cytopenic idiopathic ,receptors thrombopoietin ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introduction: Immune thrombocytopenia is a frequent hematologic manifestation in systemic lupus erythematosus (SLE). Corticosteroids are the first line of treatment for moderate to severe thrombocytopenia in this disease, in conjunction with antimalarials or other immunosuppressants. In particular cases where the response to initial interventions is not achieved, secondline therapies with different mechanisms of action are available. Objective: This narrative review will focus on two thrombopoietin receptor agonist drugs (TPO-RA): eltrombopag and romiplostim, and their role in immune thrombocytopenia secondary to SLE. In addition, its pharmacological profile, dose and indications will be reviewed in the context of this disease. Methods: A literature search was conducted in different databases; scientific articles and guidelines were analyzed, both for SLE and immune thrombocytopenia. With the purpose of answering different clinical questions that constantly arise in the scene of daily practice. Results and conclusions: The use of TPO-RA stimulants is a therapeutic alternative for particular scenarios in patients with SLE and immune thrombocytopenia, however studies focused on this particular population are necessary to be able to make strong recommendations about its utility. Current data are extrapolated from primary immune thrombocytopenia.
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- 2021
- Full Text
- View/download PDF
33. Design and Evaluation of an Innovative Pedagogical Strategy for Undergraduate Medical Students Learning Chemistry
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Soraya Elena Layton Jaramillo, William Ani´bal Villamil Villar, Eva Aguaded Rami´rez, and Javier Carrillo Rosu´a
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Training in chemistry is essential for undergraduate medical students; however, at the National University of Colombia, basic chemistry courses are associated with high fail rates and low academic performance with regard to first semester students, especially in vulnerable special admission populations. A longitudinal study was carried out via program evaluation methodology using quantitative and qualitative techniques to assess an innovative pedagogical strategy founded on context-based learning and different didactic and evaluative strategies employing information and communication technologies (ICT), which was tested on students of medicine by an interdisciplinary team of teachers in a new course. With the pedagogical strategy, a statistically significant improvement was observed in the academic performance of the students, with an increase in the mean grades that went from 3.61/5.00 to 3.95/5.00, a decrease of the fail rate from 15.50% to 3.48%, and the development of useful chemistry knowledge for the students during their training and for their professional lives. Furthermore, the study became an opportunity for collaborative learning among colleagues, favoring ongoing training of teaching staff and pedagogical innovation in professional learning communities.
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- 2024
- Full Text
- View/download PDF
34. The Oral Health of Patients with DiGeorge Syndrome (22q11) Microdeletion: A Case Report
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Candelo E, Estrada-Mesa MA, Jaramillo A, Martinez-Cajas CH, Osorio JC, and Pachajoa H
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digeorge syndrome ,22q11.2 deletion ,oral manifestations ,facial dysmorphism ,case report ,Medicine (General) ,R5-920 ,Genetics ,QH426-470 - Abstract
Estephania Candelo,1– 3 Maria Alejandra Estrada-Mesa,4 Adriana Jaramillo,4 Carlos Humberto Martinez-Cajas,4 Julio Cesar Osorio,4 Harry Pachajoa1,2 1Congenital Abnormalities and Rare Disease Centre (CIACER), Cali, Colombia; 2Genetics Department, Fundacion Valle del Lili, Cali, Colombia; 3Centro de Investigaciones Clínicas, Fundacion Valle del Lili, Cali, Colombia; 4Institución Universitaria Colegios de Colombia (UNICOC), Cali, ColombiaCorrespondence: Estephania Candelo Email ecandelo@icesi.edu.coBackground: DiGeorge syndrome (DG) is a genetic disorder associated with 22q11 deletion. It involves various phenotypes, including craniofacial abnormalities, congenital heart disorders, endocrine dysfunction, cognitive deficits, and psychiatric disorders. Cases commonly involve multiple anomalies. However, little is known about the condition of the oral cavity in this disorder, although palate fissure, abnormal mandible, malocclusion, and tooth hypoplasia have been identified. We aimed to determine the odontological features of patients with 22q11.2 microdeletion, in relation to gingival health and oral hygiene. We report the systemic manifestations of nine patients and results of oral evaluation of two patients. In the oral examination, oral hygiene and gingivitis were evaluated.Case Presentation: In terms of the systemic manifestations, we found high frequencies of low weight and height at birth. In terms of the oral manifestations, both examined patients presented malocclusion, enamel hypoplasia, dental crowding, anodontia, and healthy periodontium.Conclusion: Although DG has been documented to involve periodontium disease, the patients in this study exhibited more dental manifestations such as enamel defects, misalignment between the teeth and the two dental arches, anodontia, and dental crowding. As such, a multidisciplinary approach combining dentistry and healthcare is recommended in this case.Keywords: DiGeorge syndrome 22q11.2 deletion, oral manifestations, facial dysmorphism, case report
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- 2021
35. Análisis multitemporal de cambios de cobertura y uso del suelo: cuenca del río jubones, Ecuador
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Cobos Anguisaca, Juan Diego, Luna Romero, Angel Eduardo, Barrezueta Unda, Salomón Alejandro, and Jaramillo Aguilar, Edwin Edison
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uso del suelo ,actividades antropogénicas ,índice kappa ,landsat. ,Special aspects of education ,LC8-6691 ,Social sciences (General) ,H1-99 - Abstract
La cuenca del río Jubones (CRJ) cuenta con una diversidad tanto de pisos ecológicos como climáticos; los cambios de cobertura y uso de suelo afectan las actividades que dependen del recurso hídrico. El objetivo fue analizar los cambios producidos en las distintas clases de cobertura y el uso del suelo en la CRJ. Se utilizó imágenes Landsat 5 (TM) y Landsat 8 (OLI-TIRS) para los años 1991 y 2016, respectivamente. La clasificación supervisada se realizó en 6 clases de acuerdo al nivel 1 propuesto en la cartografía temática del Ministerio del Ambiente del Ecuador, con el descarte de pixeles ocupados por nubes. En los mapas temáticos obtenidos de la clasificación, destaca una precisión general mínima del 0,93 y un índice Kappa de 0,90. En la evaluación de cambio de coberturas y uso de suelo se comparó los mapas temáticos en función de las tasas de cambio por clases de cobertura; se registró un aumento en las clases TA (0,76%) y AH (0,62%); y una disminución en BO (-2,05%) y OT (-1.79%). Estos cambios en un periodo de 25 años se pueden atribuir a la fuerte intervención antrópica sobre los recursos naturales
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- 2021
36. ¿Donde están? Hispanic/Latine inclusion, diversity and representation in the HEALthy Brain and Child Development Study (HBCD).
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Anunziata, Florencia, Cisneros, Cynthia, Natale Castillo, Maria, Perez, Alexandra, Rodriguez, Valeria, De La Cruz, Sheila, Estrada, Karla, Durbal, Abigaile, Jaramillo, Mishaska, Enriquez Marquez, Lidia, Nuñez, Janet, Peralta-Carcelen, Myriam, and Lee Wisnowski, Jessica
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Early childhood ,HBCD ,Health disparities ,Hispanic/Latine populations ,Longitudinal studies ,Spanish Language and Culture Committee ,Child ,Child ,Preschool ,Female ,Humans ,Brain ,Child Development ,Cultural Diversity ,Hispanic or Latino ,Longitudinal Studies ,Prospective Studies ,United States - Abstract
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. Central to its mission of reducing health disparities is the establishment of the Spanish Language and Culture Committee (SLCC) within the HBCD framework, a significant step towards demographic representation and inclusivity in research. By addressing linguistic and sociocultural barriers and embracing the diverse identities of Hispanic/Latine individuals nationwide, the SLCC aims to promote inclusion, equity, and representation of all Hispanic/Latine subgroups, a population that has been historically misrepresented in health research. In this paper we describe the role of the SLCC in advocating for Hispanic/Latine families within the study, ensuring their inclusion from inception. This report also provides an overview of the SLCC organization, workflow, challenges and lessons learned thus far to reduce stigma and improve study outcomes, highlighting recruitment and retention strategies for the Hispanic/Latine population, and expanding outreach to promote inclusion across diverse Hispanic/Latine subgroups in the United States.
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- 2024
37. Approximation of Smooth Numbers for Harmonic Samples A Stein method Approach
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Jaramillo, Arturo and Yang, Xiaochuan
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Mathematics - Probability ,Statistics - Other Statistics ,60F05, 11K65 - Abstract
We present a de Bruijn type approximation for quantifying the content of m smooth numbers, derived from samples obtained through a probability measure over the set of integers less than or equal to n, with point mass function at k inversely proportional to k. Our analysis is based on a stochastic representation of the measure of interest, utilizing weighted independent geometric random variables. This representation is analyzed through the lens of Stein method for the Dickman distribution. A pivotal element of our arguments relies on precise estimations concerning the regularity properties of the solution to the Dickman Stein equation for heaviside functions, recently developed by Bhattacharjee and Schulte. Remarkably, our arguments remain mostly in the realm of probability theory, with Mertens first and third theorems standing as the only number theory estimations required.
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- 2024
38. The overlooked need for Ethics in Complexity Science: Why it matters
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Adisa, Olumide, Blay, Enio Alterman, Asgari, Yasaman, Di Bona, Gabriele, Dies, Samantha, Jaramillo, Ana Maria, Resende, Paulo H., and Leitao, Ana Maria de Sousa
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Physics - Physics and Society ,Computer Science - Computers and Society - Abstract
Complexity science, despite its broad scope and potential impact, has not kept pace with fields like artificial intelligence, biotechnology and social sciences in addressing ethical concerns. The field lacks a comprehensive ethical framework, leaving us, as a community, vulnerable to ethical challenges and dilemmas. Other areas have gone through similar experiences and created, with discussions and working groups, their guides, policies and recommendations. Therefore, here we highlight the critical absence of formal guidelines, dedicated ethical committees, and widespread discussions on ethics within the complexity science community. Drawing on insights from the disciplines mentioned earlier, we propose a roadmap to enhance ethical awareness and action. Our recommendations include (i) initiating supportive mechanisms to develop ethical guidelines specific to complex systems research, (ii) creating open-access resources, and (iii) fostering inclusive dialogues to ensure that complexity science can responsibly tackle societal challenges and achieve a more inclusive environment. By initiating this dialogue, we aim to encourage a necessary shift in how ethics is integrated into complexity research, positioning the field to address contemporary challenges more effectively., Comment: 7 pages, 2 figures, 1 Annexus, 1 table
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- 2024
39. Virtual EVE: a Deep Learning Model for Solar Irradiance Prediction
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Indaco, Manuel, Gass, Daniel, Fawcett, William James, Galvez, Richard, Wright, Paul J., and Muñoz-Jaramillo, Andrés
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Understanding space weather is vital for the protection of our terrestrial and space infrastructure. In order to predict space weather accurately, large amounts of data are required, particularly in the extreme ultraviolet (EUV) spectrum. An exquisite source of information for such data is provided by the Solar Dynamic Observatory (SDO), which has been gathering solar measurements for the past 13 years. However, after a malfunction in 2014 affecting the onboard Multiple EUV Grating Spectrograph A (MEGS-A) instrument, the scientific output in terms of EUV measurements has been significantly degraded. Building upon existing research, we propose to utilize deep learning for the virtualization of the defective instrument. Our architecture features a linear component and a convolutional neural network (CNN) -- with EfficientNet as a backbone. The architecture utilizes as input grayscale images of the Sun at multiple frequencies -- provided by the Atmospheric Imaging Assembly (AIA) -- as well as solar magnetograms produced by the Helioseismic and Magnetic Imager (HMI). Our findings highlight how AIA data are all that is needed for accurate predictions of solar irradiance. Additionally, our model constitutes an improvement with respect to the state-of-the-art in the field, further promoting the idea of deep learning as a viable option for the virtualization of scientific instruments., Comment: Submission to Machine Learning and the Physical Sciences Workshop, NeurIPS 2023
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- 2024
40. BioBricks.ai: A Versioned Data Registry for Life Sciences Data Assets
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Gao, Yifan, Mughal, Zakariyya, Jaramillo-Villegas, Jose A., Corradi, Marie, Borrel, Alexandre, Lieberman, Ben, Sharif, Suliman, Shaffer, John, Fecho, Karamarie, Chatrath, Ajay, Maertens, Alexandra, Teunis, Marc A. T., Kleinstreuer, Nicole, Hartung, Thomas, and Luechtefeld, Thomas
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Computer Science - Databases ,Quantitative Biology - Quantitative Methods - Abstract
Researchers in biomedical research, public health, and the life sciences often spend weeks or months discovering, accessing, curating, and integrating data from disparate sources, significantly delaying the onset of actual analysis and innovation. Instead of countless developers creating redundant and inconsistent data pipelines, BioBricks.ai offers a centralized data repository and a suite of developer-friendly tools to simplify access to scientific data. Currently, BioBricks.ai delivers over ninety biological and chemical datasets. It provides a package manager-like system for installing and managing dependencies on data sources. Each 'brick' is a Data Version Control git repository that supports an updateable pipeline for extraction, transformation, and loading data into the BioBricks.ai backend at https://biobricks.ai. Use cases include accelerating data science workflows and facilitating the creation of novel data assets by integrating multiple datasets into unified, harmonized resources. In conclusion, BioBricks.ai offers an opportunity to accelerate access and use of public data through a single open platform., Comment: 23 pages, 2 figures
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- 2024
41. Atomic fluorescence collection into planar photonic devices
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Smedley, Orion, Natarajan, Vighnesh, Jaramillo, Oscar, Rivy, Hamim Mahmud, and Mehta, Karan K.
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Physics - Optics ,Physics - Atomic Physics ,Quantum Physics - Abstract
Fluorescence collection from individual emitters plays a key role in state detection and remote entanglement generation, fundamental functionalities in many quantum platforms. Planar photonics have been demonstrated for robust and scalable addressing of trapped-ion systems, motivating consideration of similar elements for the complementary challenge of photon collection. Here, using an argument from the reciprocity principle, we show that far-field photon collection efficiency can be simply expressed in terms of the fields associated with the collection optic at the emitter position alone. We calculate collection efficiencies into ideal paraxial and fully vectorial focused Gaussian modes parameterized in terms of focal waist, and further quantify the modest enhancements possible with more general beam profiles, establishing design requirements for efficient collection. Towards practical implementation, we design, fabricate, and characterize a diffractive collection element operating at $\lambda=397$ nm predicted to offer a total 0.25\% collection efficiency into a single waveguide mode. A more efficient design with more demanding fabrication requirements would offer $1.14\%$, and we indicate avenues to improved devices approaching the limits predicted for ideal beams. We point out a particularly simple integrated waveguide configuration for polarization-based remote entanglement generation enabled by integrated collection.
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- 2024
42. Atomic Structure of Self-Buffered BaZr(S,Se)$_3$ Epitaxial Thin Film Interfaces
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Xu, Michael, Ye, Kevin, Sadeghi, Ida, Jaramillo, Rafael, and LeBeau, James M.
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Condensed Matter - Materials Science - Abstract
Understanding and controlling the growth of chalcogenide perovskite thin films through interface design is important for tailoring film properties. Here, the film and interface structure of BaZr(S,Se)$_3$ thin films grown on LaAlO$_3$ by molecular beam epitaxy and post-growth anion exchange is resolved using aberration-corrected scanning transmission electron microscopy. Epitaxial films are achieved from self-assembly of an interface ``buffer'' layer, which accommodates the large film/substrate lattice mismatch of nearly 40\% for the alloy film studied here. The self-assembled buffer layer, occurring for both the as-grown sulfide and post-selenization alloy films, is shown to have rock-salt-like atomic stacking akin to a Ruddlesden-Popper phase. Above this buffer, the film quickly transitions to the perovskite structure. Overall, these results provide insights into oxide-chalcogenide heteroepitaxial film growth, illustrating a process that yields relaxed, crystalline, epitaxial chalcogenide perovskite films that support ongoing studies of optoelectronic and device properties.
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- 2024
43. Pointwise semi-Lipschitz functions and Banach-Stone theorems
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Durand-Cartagena, Estíbalitz, Jaramillo, Jesús Á., and M, Francisco Venegas
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Mathematics - Functional Analysis ,46T99, 30L99, 51F30 - Abstract
We study the fundamental properties of pointwise semi-Lipschitz functions between asymmetric spaces, which are the natural asymmetric counterpart of pointwise Lipschitz functions. We also study the influence that partial symmetries of a given space may have on the behavior of pointwise semi-Lipschitz functions defined on it. Furthermore, we are interested in characterizing the pointwise semi-Lipschitz structure of an asymmetric space in terms of real-valued pointwise semi-Lipschitz functions defined on it. By using two algebras of functions naturally associated to our spaces of pointwise real-valued semi-Lipschitz functions, we are able to provide two Banach-Stone type results in this context. In fact, these results are obtained as consequences of a general Banach-Stone type theorem of topological nature, stated for abstract functional spaces, which is quite flexible and can be applied to many spaces of continuous functions over metric and asymmetric spaces., Comment: No additional comments
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- 2024
44. Integrability in Perturbed Black Holes: Background Hidden Structures
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Jaramillo, José Luis, Lenzi, Michele, and Sopuerta, Carlos F.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
In this work we investigate the presence of integrable hidden structures in the dynamics of perturbed non-rotating black holes (BHs). This can also be considered as a first step in a wider program of an effective identification of ``slow'' and ``fast'' degrees of freedom (DoFs) in the (binary) BH dynamics, following a wave-mean flow perspective. The slow DoFs would be associated with a nonlinear integrable dynamics, on which the fast ones propagate following an effective linear dynamics. BH perturbation theory offers a natural ground to test these properties. Indeed, the decoupling of Einstein equations into wave master equations with a potential provides an instance of such splitting into (frozen) slow DoFs (background potential) over which the linear dynamics of the fast ones (perturbation master functions) evolve. It has been recently shown that these wave equations possess an infinite number of symmetries that correspond to the flow of the infinite hierarchy of Korteweg-de Vries (KdV) equations. Starting from these results, we systematically investigate the presence of integrable structures in BH perturbation theory. We first study them in Cauchy slices and then extend the analysis to hyperboloidal foliations. This second step introduces a splitting of the master equation into bulk and boundary contributions, unveiling an underlying structural relation with the slow and fast DoFs. This insight represents a first step to establish the integrable structures associated to the slow DoFs as bulk symmetries of the dynamics of perturbed BHs., Comment: 23 pages, to match with PRD published version
- Published
- 2024
- Full Text
- View/download PDF
45. Complex structures of boson stars and anisotropic distribution of satellite galaxies
- Author
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Jaramillo, Víctor and Zhou, Shuang-Yong
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General Relativity and Quantum Cosmology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Theory - Abstract
We construct and explore the complex structures of boson stars, drawing inspiration from similar configurations of non-topological solitons in Minkowski space. These "molecular states" of boson stars have a multipolar structure and both positive and negative Noether charges within one star, and the opposite charges swap with time. Thanks to the gravitational attraction, they exist even in the case of a free scalar field. We also explore the effects of scalar self-interactions on these complex structures. We propose to use galactic-scale charge-swapping boson stars as a potential solution to the problem of the observed anisotropic distribution of satellite galaxies., Comment: 27 pages, 23 figures. Matches published version
- Published
- 2024
46. Around Classical and Intuitionistic Linear Processes
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Jaramillo, Juan C., Frumin, Dan, and Pérez, Jorge A.
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Computer Science - Logic in Computer Science - Abstract
Curry-Howard correspondences between Linear Logic (LL) and session types provide a firm foundation for concurrent processes. As the correspondences hold for intuitionistic and classic versions of LL (ILL and CLL), we obtain two different families of type systems for concurrency. An open question remains: how do these two families exactly relate to each other? Based upon a translation from CLL to ILL due to Laurent (2018), we provide two complementary answers, in the form of full abstraction results based on a typed observational equivalence due to Atkey (2017). Our results elucidate hitherto missing formal links between seemingly related yet different type systems for concurrency., Comment: Full version, 19 pages + appendices
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- 2024
47. Facing the challenges to shorten the diagnostic odyssey: first Whole Genome Sequencing experience of a Colombian cohort with suspected rare diseases
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Velasco, Harvy Mauricio, Bertoli-Avella, Aida, Jaramillo, Carolina Jaramillo, Cardona, Danny Styvens, González, Leonel Andrés, Vanegas, Melisa Naranjo, Arango, Juan Pablo Valencia, Buitrago, Cesar Augusto, González, Jorge Alberto Gutiérrez, Marcello, Jonas, Bauer, Peter, and Moncada, Juliana Espinosa
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- 2024
- Full Text
- View/download PDF
48. A Prospective Examination of Mental Health Trajectories of Disaster-Exposed Young Adults in the COVID-19 Pandemic.
- Author
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Janson, Melissa, Felix, Erika, Jaramillo, Natalia, Sharkey, Jill, and Barnett, Miya
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COVID-19 pandemic ,collectively experienced traumas ,life stressors ,mental health trajectories ,natural disaster ,young adult mental health symptoms - Abstract
This longitudinal study examines young adult mental health (MH) trajectories after exposure to natural disasters (i.e., hurricanes, wildfires, mudslides) across four waves, two pre- and two during the COVID-19 pandemic. Participants (n = 205) answered questions about anxiety, depression, and post-traumatic stress symptoms (PTSSs) across Waves (Ws) s 1-4 and pre-pandemic factors (prior trauma history, disaster exposure, life stressors since disaster) at Wave (W) 1. Hierarchical linear modeling was conducted to examine MH trajectories and associations with pre-pandemic factors. Only the PTSS trajectory significantly differed across all Ws, with the largest increase between Ws 2 and 3 (pre- and during-pandemic time points). Prior trauma history and life stressors since the disaster were significantly associated with all MH trajectory intercepts but not growth rates.
- Published
- 2024
49. Modeling Diurnal and Annual Ethylene Generation from Solar-Driven Electrochemical CO2 Reduction Devices
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Yap, Kyra MK, Wei, William, Pabón, Melanie Rodríguez, Bui, Justin C, Wei, Lingze, Lee, Sang-Won, Weber, Adam Z, Bell, Alexis T, Nielander, Adam C, and Jaramillo, Thomas F
- Subjects
Engineering ,Materials Engineering - Abstract
Integrated solar fuels devices for CO2 reduction (CO2R) are a promising technology class towards achieving net-negative carbon emissions. Designing integrated CO2R solar fuels devices requires careful co-design of electrochemical and photovoltaic components as well as consideration of the diurnal and seasonal effects of solar irradiance, temperature, and other meteorological factors expected for ‘on-sun’ deployment. Using a photovoltaic-electrochemical (PV-EC) platform, we developed a temperature and potential-dependent diurnal and annual model using experimental CO2R performance of Cu-based electrocatalysts, local meteorological data from the National Solar Radiation Database (NSRD), and modeled performance of commercial c-Si PVs. We simulated diurnal product outputs with and without the effects of ambient temperature to determine gaseous product temperature sensitivity. From these outputs, we observed seasonal variation in gaseous product generation, with up to two-fold increases in ethylene productivity between the Winter and Summer, analyzed the consequences of dynamic cloud coverage, and identified periods where device cooling/heating mechanisms could be implemented to maximize ethylene generation. Finally, we modeled the annual ethylene generation for a scaled 1 MW solar farm at three different locations (Beijing, CN; Sydney, AUS; Barstow, CA) to determine the consequences of local meteorological climates on PV-EC CO2R product output, recording a maximum ethylene output of 18.5 tonne/yr at Barstow. Overall, this model presents a critical tool for streamlining the translation of experimental solar-driven electrochemical research to real-world implementation.
- Published
- 2024
50. Safety of the PCSK9 inhibitor alirocumab: insights from 47 296 patient-years of observation
- Author
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Goodman, Shaun G, Steg, Philippe Gabriel, Szarek, Michael, Bhatt, Deepak L, Bittner, Vera A, Diaz, Rafael, Harrington, Robert A, Jukema, J Wouter, White, Harvey D, Zeiher, Andreas M, Manvelian, Garen, Pordy, Robert, Poulouin, Yann, Stipek, Wanda, Garon, Genevieve, Schwartz, Gregory G, Steg, Ph Gabriel, Tricoci, Pierluigi, Roe, Matthew T, Mahaffey, Kenneth W, Edelberg, Jay M, Hanotin, Corinne, Lecorps, Guillaume, Moryusef, Angèle, Sasiela, William J, Tamby, Jean-François, Aylward, Philip E, Drexel, Heinz, Sinnaeve, Peter, Dilic, Mirza, Lopes, Renato D, Gotcheva, Nina N, Prieto, Juan-Carlos, Yong, Huo, López-Jaramillo, Patricio, Pećin, Ivan, Reiner, Zeljko, Ostadal, Petr, Poulsen, Steen Hvitfeldt, Viigimaa, Margus, Nieminen, Markku S, Danchin, Nicolas, Chumburidze, Vakhtang, Marx, Nikolaus, Liberopoulos, Evangelos, Valdovinos, Pablo Carlos Montenegro, Tse, Hung-Fat, Kiss, Robert Gabor, Xavier, Denis, Zahger, Doron, Valgimigli, Marco, Kimura, Takeshi, Kim, Hyo Soo, Kim, Sang-Hyun, Erglis, Andrejs, Laucevicius, Aleksandras, Kedev, Sasko, Yusoff, Khalid, López, Gabriel Arturo Ramos, Alings, Marco, Halvorsen, Sigrun, Flores, Roger M Correa, Sy, Rody G, Budaj, Andrzej, Morais, Joao, Dorobantu, Maria, Karpov, Yuri, Ristic, Arsen D, Chua, Terrance, Murin, Jan, Fras, Zlatko, Dalby, Anthony J, Tuñón, José, de Silva, H Asita, Hagström, Emil, Landmesser, Ulf, Chiang, Chern-En, Sritara, Piyamitr, Guneri, Sema, Parkhomenko, Alexander, Ray, Kausik K, Moriarty, Patrick M, Chaitman, Bernard, Kelsey, Sheryl F, Olsson, Anders G, and Rouleau, Jean-Lucien
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Trials and Supportive Activities ,Patient Safety ,Clinical Research ,6.1 Pharmaceuticals ,Good Health and Well Being ,Humans ,Antibodies ,Monoclonal ,Humanized ,Anticholesteremic Agents ,Biomarkers ,Cardiovascular Diseases ,Cholesterol ,LDL ,Dyslipidemias ,PCSK9 Inhibitors ,Proprotein Convertase 9 ,Randomized Controlled Trials as Topic ,Serine Proteinase Inhibitors ,Time Factors ,Treatment Outcome ,ODYSSEY OUTCOMES Investigators ,Alirocumab ,Cholesterol ,PCSK9 ,Safety ,Cardiorespiratory Medicine and Haematology ,Pharmacology and Pharmaceutical Sciences ,Cardiovascular medicine and haematology ,Pharmacology and pharmaceutical sciences - Abstract
The ODYSSEY OUTCOMES trial, comprising over 47 000 patient-years of placebo-controlled observation, demonstrated important reductions in the risk of recurrent ischaemic cardiovascular events with the monoclonal antibody to proprotein convertase subtilisin/kexin type 9 alirocumab, as well as lower all-cause death. These benefits were observed in the context of substantial and persistent lowering of low-density lipoprotein cholesterol with alirocumab compared with that achieved with placebo. The safety profile of alirocumab was indistinguishable from matching placebo except for a ∼1.7% absolute increase in local injection site reactions. Further, the safety of alirocumab compared with placebo was evident in vulnerable groups identified before randomization, such as the elderly and those with diabetes mellitus, previous ischaemic stroke, or chronic kidney disease. The frequency of adverse events and laboratory-based abnormalities was generally similar to that in placebo-treated patients. Thus, alirocumab appears to be a safe and effective lipid-modifying treatment over a duration of at least 5 years.
- Published
- 2024
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