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1. Confidence Intervals for the Mutual Information

Author

Stefani, A. G., Huber, J. B., Jardin, C., and Sticht, H.

Subjects
Computer Science - Information Theory
Abstract

By combining a bound on the absolute value of the difference of mutual information between two joint probablity distributions with a fixed variational distance, and a bound on the probability of a maximal deviation in variational distance between a true joint probability distribution and an empirical joint probability distribution, confidence intervals for the mutual information of two random variables with finite alphabets are established. Different from previous results, these intervals do not need any assumptions on the distribution and the sample size., Comment: 5 pages, 2 figure

Published
2013

2. A Tight Lower Bound on the Mutual Information of a Binary and an Arbitrary Finite Random Variable in Dependence of the Variational Distance

Author

Stefani, A. G., Huber, J. B., Jardin, C., and Sticht, H.

Subjects
Computer Science - Information Theory
Abstract

In this paper a numerical method is presented, which finds a lower bound for the mutual information between a binary and an arbitrary finite random variable with joint distributions that have a variational distance not greater than a known value to a known joint distribution. This lower bound can be applied to mutual information estimation with confidence intervals., Comment: 4 pages, 3 figures

Published
2013

28. Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-alpha binding

Author

Webel, R., Solbak, S.M.O., Held, C., Milbradt, J., Gross, A., Eichler, J., Wittenberg, T., Jardin, C., Sticht, H., Fossen, T., Marschall, M., and Publica

Abstract

The multifunctional protein kinase pUL97 of human cytomegalovirus (HCMV) strongly determines the efficiency of virus replication. Previously, the existence of two pUL97 isoforms that arise from alternative translational initiation and show a predominant nuclear localization was described. Two bipartite nuclear localization sequences, NLS1 and NLS2, were identified in the N terminus of the large isoform, whilst the small isoform exclusively contained NLS2. The current study found the following: (i) pUL97 nuclear localization in HCMV-infected primary fibroblasts showed accumulations in virus replication centres and other nuclear sections; (ii) in a quantitative evaluation system for NLS activity, the large isoform showed higher efficiency of nuclear translocation than the small isoform; (iii) NLS1 was mapped to aa 6-35 and NLS2 to aa 190-213; (iv) using surface plasmon resonance spectroscopy, the binding of both NLS1 and NLS2 to human importin-a was demonstrated, stressing the importance of individual arginine residues in the bipartite consensus motifs; (v) nuclear magnetic resonance spectroscopy of pUL97 peptides confirmed an earlier statement about the functional requirement of NLS1 embedding into an intact a-helical structure; and (vi) a bioinformatics investigation of the solvent-accessible surface suggested a high accessibility of NLS1 and an isoform-specific, variable accessibility of NLS2 for interaction with importin-a. Thus, the nucleocytoplasmic transport mechanism of the isoforms appeared to be differentially regulated, and this may have consequences for isoform-dependent functions of pUL97 during virus replication.

Published
2012

30. Crystalline effects in elastic peak electron spectroscopy

Author

Robert-Goumet, Christine, Gergely, G., Barna, A., Sulyok, A., Jardin, C., Gruzza, B., Bideux, L., Robert, Cédric, Toth, J., Varga, D., Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences et matériaux pour l'électronique et d'automatique (LASMEA), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
010302 applied physics, Elastic scattering, Diffraction, Chemistry, Electron energy loss spectroscopy, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Inelastic mean free path, 01 natural sciences, Electron spectroscopy, Surfaces, Coatings and Films, Ion, Condensed Matter::Materials Science, X-ray photoelectron spectroscopy, Sputtering, 0103 physical sciences, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Atomic physics, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, 0210 nano-technology, Instrumentation, ComputingMilieux_MISCELLANEOUS
Abstract

Elastic peak electron spectroscopy (EPES) is confined to incoherent elastic scattering, appearing in the elastic peak intensity I e . Ion bombardment cleaning disorganizes the surface layer and might produce a component enrichment. EPES was used for the experimental determination of the inelastic mean free path of electrons on ion bombarded Si, GaAs, InP, InSb and GaSb crystals. Imperfect amorphization can produce diffraction or directional elastic peak electron spectroscopy (DEPES) effects influencing the elastic peak intensity. They appear in the Renninger plots of I e rotating the sample around its azimuthal axis. The problem was met with the inelastic mean free path studies on InSb and GaSb crystalline samples working with a hemispherical analyser. The surface composition after Ar bombardment was checked by in situ X-ray photoelectron spectroscopy and electron energy loss spectroscopy. Using 2 keV Ar + sputtering, the enrichment of In or Ga was avoided, whereas In metallic phase was formed by 10 keV ions. The energy values of diffraction on Si(1 1 1), and III–V (1 0 0) crystals was calculated for a cylindrical mirror analyser and for a hemispherical analyser. Incoherent elastic scattering occurs in the minima of Renninger plots. The goal is to avoid diffraction and DEPES effects. They are eliminated by Ar + ion bombardment. The thickness of the amorphized layer was controlled by the Ar + ion energy and dose.

Published
1999

32. Neurological disorders in essential thrombocythemia

Author

Billot, S., primary, Kouroupi, E. G., additional, Le Guilloux, J., additional, Cassinat, B., additional, Jardin, C., additional, Laperche, T., additional, Fenaux, P., additional, Carpentier, A. F., additional, and Kiladjian, J.-J., additional

Published
2011
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