30 results on '"Jason Lerner"'
Search Results
2. BHV-7000, A Novel, Selective Kv7.2/7.3 Potassium Channel Activator, Demonstrates Dose-Dependent Pharmacodynamic Effects on EEG Parameters in Healthy Adults
- Author
-
Jason Lerner, M.D., Bharat Awsare, M.D., Heather Sevinsky, M.S., Eric Ashbrenner, M.S., Randall Killingsworth, B.A., Racheal Kendrick, PharmD, Emiel Vereycken, M.S., Nigel Colenbier, Ph.D., Caroline Neuray, M.D., Pieter van Mierlo, Ph.D., Jeremy Slater, M.D., David Wyatt, M.D., Irfan Qureshi, M.D., Steven Dworetzky, Ph.D., and Michael Bozik, M.D.
- Subjects
Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2024
- Full Text
- View/download PDF
3. Pathogenic Cav3.2 channel mutation in a child with primary generalized epilepsy
- Author
-
Ivana A. Souza, Maria A. Gandini, Fang-Xiong Zhang, Wendy G. Mitchell, Joyce Matsumoto, Jason Lerner, Tyler Mark Pierson, and Gerald W. Zamponi
- Subjects
Cav3.2 ,T-type ,Epilepsy ,Seizure ,Mutation ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Two paternally-inherited missense variants in CACNA1H were identified and characterized in a 6-year-old child with generalized epilepsy. Febrile and unprovoked seizures were present in this child. Both variants were expressed in cis or isolation using human recombinant Cav3.2 calcium channels in tsA-201 cells. Whole-cell patch-clamp recordings indicated that one variant (c.3844C > T; p.R1282W) caused a significant increase in current density consistent with a pathogenic gain-of-function phenotype; while the other cis-related variant (c.5294C > T; p.A1765V) had a benign profile.
- Published
- 2019
- Full Text
- View/download PDF
4. AR2, a novel automatic muscle artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available software [version 2; referees: 2 approved]
- Author
-
Shennan Aibel Weiss, Ali A Asadi-Pooya, Sitaram Vangala, Stephanie Moy, Dale H Wyeth, Iren Orosz, Michael Gibbs, Lara Schrader, Jason Lerner, Christopher K Cheng, Edward Chang, Rajsekar Rajaraman, Inna Keselman, Perdro Churchman, Christine Bower-Baca, Adam L Numis, Michael G Ho, Lekha Rao, Annapoorna Bhat, Joanna Suski, Marjan Asadollahi, Timothy Ambrose, Andres Fernandez, Maromi Nei, Christopher Skidmore, Scott Mintzer, Dawn S Eliashiv, Gary W Mathern, Marc R Nuwer, Michael Sperling, Jerome Engel Jr, and John M Stern
- Subjects
Neuroimaging ,Medicine ,Science - Abstract
Objective: To develop a novel software method (AR2) for reducing muscle contamination of ictal scalp electroencephalogram (EEG), and validate this method on the basis of its performance in comparison to a commercially available software method (AR1) to accurately depict seizure-onset location. Methods: A blinded investigation used 23 EEG recordings of seizures from 8 patients. Each recording was uninterpretable with digital filtering because of muscle artifact and processed using AR1 and AR2 and reviewed by 26 EEG specialists. EEG readers assessed seizure-onset time, lateralization, and region, and specified confidence for each determination. The two methods were validated on the basis of the number of readers able to render assignments, confidence, the intra-class correlation (ICC), and agreement with other clinical findings. Results: Among the 23 seizures, two-thirds of the readers were able to delineate seizure-onset time in 10 of 23 using AR1, and 15 of 23 using AR2 (p
- Published
- 2017
- Full Text
- View/download PDF
5. Can deterrence persist? Long‐term evidence from a randomized experiment in street lighting
- Author
-
David Mitre‐Becerril, Sarah Tahamont, Jason Lerner, and Aaron Chalfin
- Subjects
Public Administration ,Law - Published
- 2022
- Full Text
- View/download PDF
6. AR2, a novel automatic artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available software [version 1; referees: 2 approved with reservations]
- Author
-
Shennan Aibel Weiss, Ali A Asadi-Pooya, Sitaram Vangala, Stephanie Moy, Dale H Wyeth, Iren Orosz, Michael Gibbs, Lara Schrader, Jason Lerner, Christopher K Cheng, Edward Chang, Rajsekar Rajaraman, Inna Keselman, Perdro Churchman, Christine Bower-Baca, Adam L Numis, Michael G Ho, Lekha Rao, Annapoorna Bhat, Joanna Suski, Marjan Asadollahi, Timothy Ambrose, Andres Fernandez, Maromi Nei, Christopher Skidmore, Scott Mintzer, Dawn S Eliashiv, Gary W Mathern, Marc R Nuwer, Michael Sperling, Jerome Engel Jr, and John M Stern
- Subjects
Software Tool Article ,Articles ,Neuroimaging ,scalp EEG ,electroencephalogram ,muscle artifact ,independent component analysis ,seizure - Abstract
Objective: To develop a novel software method (AR2) for reducing muscle contamination of ictal scalp electroencephalogram (EEG), and validate this method on the basis of its performance in comparison to a commercially available software method (AR1) to accurately depict seizure-onset location. Methods: A blinded investigation used 23 EEG recordings of seizures from 8 patients. Each recording was uninterpretable with digital filtering because of muscle artifact and processed using AR1 and AR2 and reviewed by 26 EEG specialists. EEG readers assessed seizure-onset time, lateralization, and region, and specified confidence for each determination. The two methods were validated on the basis of the number of readers able to render assignments, confidence, the intra-class correlation (ICC), and agreement with other clinical findings. Results: Among the 23 seizures, two-thirds of the readers were able to delineate seizure-onset time in 10 of 23 using AR1, and 15 of 23 using AR2 (p Conclusions: EEG artifact reduction methods for localizing seizure-onset does not result in high rates of interpretability, reader confidence, and inter-reader agreement. However, the assignments by groups of readers are often congruent with other clinical data. Utilization of the AR2 software method may improve the validity of ictal EEG artifact reduction.
- Published
- 2017
- Full Text
- View/download PDF
7. Reducing Crime Through Environmental Design: Evidence from a Randomized Experiment of Street Lighting in New York City
- Author
-
Aaron Chalfin, Benjamin Hansen, Jason Lerner, and Lucie Parker
- Subjects
Law ,Pathology and Forensic Medicine - Published
- 2021
- Full Text
- View/download PDF
8. Medical resource utilization and costs for total hip arthroplasty: benchmarking an anterior approach technique in the Medicare population
- Author
-
Atul F. Kamath, Brian Curtin, Charles A. DeCook, Steve Lochow, Chantal E. Holy, Abhishek S Chitnis, Joel M. Matta, and Jason Lerner
- Subjects
Male ,musculoskeletal diseases ,medicine.medical_specialty ,Databases, Factual ,Arthroplasty, Replacement, Hip ,Cost-Benefit Analysis ,Medicare ,Statistics, Nonparametric ,Insurance Claim Review ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,medicine ,Humans ,030212 general & internal medicine ,Propensity Score ,Aged ,Retrospective Studies ,Aged, 80 and over ,030222 orthopedics ,business.industry ,Health Policy ,Health Care Costs ,Benchmarking ,Length of Stay ,United States ,Case-Control Studies ,Medicare population ,Benchmark (computing) ,Physical therapy ,Health Resources ,Female ,Anterior approach ,business ,Medical costs ,Resource utilization ,Total hip arthroplasty - Abstract
The anterior approach (AA) for total hip arthroplasty (THA) is associated with more rapid recovery when compared to traditional approaches. The purpose of this study was to benchmark healthcare resource utilization and costs for patients with THA via AA relative to matched patients.This study queried Medicare claims data (2012-2014) to identify patients who received THA via an AA from experienced surgeons, and matched these patients to a control cohort (all THA approaches). Direct and propensity-score matching were employed to maximize similarity between patients and hospitals in the two cohorts. Hospital length of stay (LOS), the proportion of patients discharged to home or home health, and post-acute claim payments during the 90-day episode were assessed. Generalized estimating equations were applied to control for imbalances between the cohorts and clustering of outcomes within hospitals.A total of 1,794 patients were included after patient matching. Patients who received AA had significantly lower mean hospital LOS vs patients in the control group (2.06 ± 1.36 vs 2.98 ± 1.58 days, p .0001). The adjusted proportion of patients discharged to home was nearly 20 percentage points higher in the AA cohort vs the control cohort (87.3% vs 68.7%, p .0001). Post-acute claim payments for AA patients were nearly 50% lower than those for control patients ($4,139 vs $7,465, p .0001).AA patients had significantly lower post-acute care resource use when compared to control patients. Further research is warranted to evaluate the cost effectiveness of AA among surgeons of varying experience levels.
- Published
- 2017
- Full Text
- View/download PDF
9. Preoperative Behavioral Health, Opioid, and Antidepressant Utilization and 2-year Costs After Spinal Fusion-Revelations From Cluster Analysis
- Author
-
John B. Pracyk, A.M. Menzie, Samir Bhattacharyya, Kevin J. McGuire, Jeffrey J. Headd, Jason Lerner, Katherine Etter, and Jill Ruppenkamp
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Behavioral Medicine ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Health care ,Medicine ,Cluster Analysis ,Humans ,Orthopedics and Sports Medicine ,Claims database ,Postoperative Period ,Retrospective Studies ,030222 orthopedics ,business.industry ,Evidence-based medicine ,Health Care Costs ,Middle Aged ,Patient Acceptance of Health Care ,Confidence interval ,Antidepressive Agents ,Analgesics, Opioid ,Spinal Fusion ,Opioid ,Spinal fusion ,Preoperative Period ,Antidepressant ,Health Resources ,Anticonvulsants ,Female ,Neurology (clinical) ,business ,Administrative Claims, Healthcare ,030217 neurology & neurosurgery ,Resource utilization ,medicine.drug ,Unsupervised Machine Learning - Abstract
STUDY DESIGN Retrospective administrative claims database analysis. OBJECTIVE Identify distinct presurgery health care resource utilization (HCRU) patterns among posterior lumbar spinal fusion patients and quantify their association with postsurgery costs. SUMMARY OF BACKGROUND DATA Presurgical HCRU may be predictive of postsurgical economic outcomes and help health care providers to identify patients who may benefit from innovation in care pathways and/or surgical approach. METHODS Privately insured patients who received one- to two-level posterior lumbar spinal fusion between 2007 and 2016 were identified from a claims database. Agglomerative hierarchical clustering (HC), an unsupervised machine learning technique, was used to cluster patients by presurgery HCRU across 90 resource categories. A generalized linear model was used to compare 2-year postoperative costs across clusters controlling for age, levels fused, spinal diagnosis, posterolateral/interbody approach, and Elixhauser Comorbidity Index. RESULTS Among 18,770 patients, 56.1% were female, mean age was 51.3, 79.4% had one-level fusion, and 89.6% had inpatient surgery. Three patient clusters were identified: Clust1 (n = 13,987 [74.5%]), Clust2 (n = 4270 [22.7%]), Clust3 (n = 513 [2.7%]). The largest between-cluster differences were found in mean days supplied for antidepressants (Clust1: 97.1 days, Clust2: 175.2 days, Clust3: 287.1 days), opioids (Clust1: 76.7 days, Clust2: 166.9 days, Clust3: 129.7 days), and anticonvulsants (Clust1: 35.1 days, Clust2: 67.8 days, Clust3: 98.7 days). For mean medical visits, the largest between-cluster differences were for behavioral health (Clust1: 0.14, Clust2: 0.88, Clust3: 16.3) and nonthoracolumbar office visits (Clust1: 7.8, Clust2: 13.4, Clust3: 13.8). Mean (95% confidence interval) adjusted 2-year all-cause postoperative costs were lower for Clust1 ($34,048 [$33,265-$34,84]) versus both Clust2 ($52,505 [$50,306-$54,800]) and Clust3 ($48,452 [$43,007-$54,790]), P
- Published
- 2019
10. Reducing Crime Through Environmental Design: Evidence from a Randomized Experiment of Street Lighting in New York City
- Author
-
Benjamin Hansen, Aaron Chalfin, Jason Lerner, and Lucie Parker
- Subjects
Public housing ,Randomized experiment ,05 social sciences ,Environmental design ,Criminology ,Intervention (law) ,Political science ,General partnership ,050501 criminology ,Deterrence (legal) ,0501 psychology and cognitive sciences ,Situational ethics ,050104 developmental & child psychology ,0505 law ,Criminal justice - Abstract
This paper offers novel experimental evidence that violent crimes can be successfully reduced by changing the situational environment that potential victims and offenders face. We focus on a ubiquitous but understudied feature of the urban landscape—street lighting—and report the first experimental evidence on the effect of street lighting on crime. Through a unique public partnership in New York City, temporary street lights were randomly allocated to 40 of the city’s public housing developments. We find evidence that communities that were assigned more lighting experienced sizable reductions in nighttime outdoor index crimes. We also observe a large decline in arrests indicating that deterrence is the most likely mechanism through which the intervention reduced crime. Results suggests that street lighting, when deployed tactically, may be a means through which policymakers can control crime without widening the net of the criminal justice system.
- Published
- 2019
- Full Text
- View/download PDF
11. Seven-year cost-effectiveness of ProDisc-C total disc replacement: results from investigational device exemption and post-approval studies
- Author
-
Thierry Bernard, Chao Yang, Jack E. Zigler, Jason Lerner, and Kris E. Radcliff
- Subjects
Male ,Total Disc Replacement ,medicine.medical_specialty ,Cost effectiveness ,Cost-Benefit Analysis ,Anterior cervical discectomy and fusion ,Intervertebral Disc Degeneration ,Investigational device exemption ,Degenerative disc disease ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Cost–benefit analysis ,United States Food and Drug Administration ,business.industry ,General Medicine ,medicine.disease ,United States ,Confidence interval ,Quality-adjusted life year ,Spinal Fusion ,Treatment Outcome ,Cervical Vertebrae ,Physical therapy ,Female ,Quality-Adjusted Life Years ,business ,030217 neurology & neurosurgery ,Diskectomy - Abstract
OBJECTIVE The purpose of this study was to evaluate the 7-year cost-effectiveness of cervical total disc replacement (CTDR) versus anterior cervical discectomy and fusion (ACDF) for the treatment of patients with single-level symptomatic degenerative disc disease. A change in the spending trajectory for spine care is to be achieved, in part, through the selection of interventions that have been proven effective yet cost less than other options. This analysis complements and builds upon findings from other cost-effectiveness evaluations of CTDR through the use of long-term, patient-level data from a randomized study. METHODS This was a 7-year health economic evaluation comparing CTDR versus ACDF from the US commercial payer perspective. Prospectively collected health care resource utilization and treatment effects (quality-adjusted life years [QALYs]) were obtained from individual patient-level adverse event reports and SF-36 data, respectively, from the randomized, multicenter ProDisc-C total disc replacement investigational device exemption (IDE) study and post-approval study. Statistical distributions for unit costs were derived from a commercial claims database and applied using Monte Carlo simulation. Patient-level costs and effects were modeled via multivariate probabilistic analysis. Confidence intervals for 7-year costs, effects, and net monetary benefit (NMB) were obtained using the nonparametric percentile method from results of 10,000 bootstrap simulations. The robustness of results was assessed through scenario analysis and within a parametric regression model controlling for baseline variables. RESULTS Seven-year follow-up data were available for more than 70% of the 209 randomized patients. In the base-case analysis, CTDR resulted in mean per-patient cost savings of $12,789 (95% CI $5362–$20,856) and per-patient QALY gains of 0.16 (95% CI −0.073 to 0.39) compared with ACDF over 7 years. CTDR was more effective and less costly in 90.8% of probabilistic simulations. CTDR was cost-effective in 99.8% of sensitivity analysis simulations and generated a mean incremental NMB of $20,679 (95% CI $6053–$35,377) per patient at a willingness-to-pay threshold of $50,000/QALY. CONCLUSIONS Based on this modeling evaluation, CTDR was found to be more effective and less costly over a 7-year time horizon for patients with single-level symptomatic degenerative disc disease. These results are robust across a range of scenarios and perspectives and are intended to support value-based decision making.
- Published
- 2016
- Full Text
- View/download PDF
12. Impact of patient comorbidities on surgical site infection within 90 days of primary and revision joint (hip and knee) replacement
- Author
-
Ekoue Folly, Charles E. Edmiston, Jason Lerner, David Leaper, Chantal E. Holy, and Abhishek S Chitnis
- Subjects
Male ,Reoperation ,medicine.medical_specialty ,Epidemiology ,medicine.medical_treatment ,Arthroplasty, Replacement, Hip ,Knee replacement ,Comorbidity ,Logistic regression ,Medicare ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Paralysis ,Coagulopathy ,Odds Ratio ,Humans ,Surgical Wound Infection ,030212 general & internal medicine ,Arthroplasty, Replacement, Knee ,Aged ,Retrospective Studies ,0303 health sciences ,030306 microbiology ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,United States ,Infectious Diseases ,Logistic Models ,Female ,medicine.symptom ,business ,Cohort study - Abstract
The frequency of primary and revision total knee and hip replacements (pTKRs, rTKRs, pTHRs, and rTHRs, respectively) is increasing in the United States due to demographic changes. This study evaluated the impact of preoperative patient and clinical factors on the risk of surgical site infection (SSI) within the 90-day period after primary and revision total joint replacements (TJR).A retrospective observational cohort study was designed using the IBM MarketScan and Medicare databases, 2009-2015. Thirty-four comorbidities were assessed for all patients, and multivariable logistic regression models were used to evaluate factors associated with higher odds of SSI after adjusting for other patient and clinical preoperative conditions.The study included a total of 335,134 TKRs and 163,547 THRs. SSI rates were 15.6% and 8.6% after rTKR and rTHR, respectively, compared with 2.1% and 2.1% for pTKR and pTHR, respectively. Comorbidities with the greatest adjusted effect on SSI across all TJRs were acquired immunodeficiency syndrome (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.06-2.34; P = .0232), paralysis (OR, 1.56; 95% CI, 1.26-1.94; P.0001), coagulopathy (OR, 1.48; 95% CI, 1.36-1.62; P.0001), metastatic cancer (1.48; 95% CI, 1.24-1.76; P.0001), and congestive heart failure (OR, 1.39; 95% CI, 1.30-1.49; P.0001).SSI occurred most commonly among patients after revision TJR and were related to many patient comorbidities, including diabetes, congestive heart failure, and coagulopathy, which were significantly associated with a higher risk of SSI after TJR.
- Published
- 2019
13. Comparative Analysis of Hospital Length of Stay and Discharge Status of Two Contemporary Primary Total Knee Systems
- Author
-
Carl de Moor, Iftekhar Kalsekar, Jason Lerner, Michael Swank, Andrew Yoo, and Katherine Etter
- Subjects
musculoskeletal diseases ,Male ,medicine.medical_specialty ,Databases, Factual ,medicine.medical_treatment ,Operative Time ,Length of hospitalization ,Osteoarthritis ,Gee ,Discharge status ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Hospital Costs ,Arthroplasty, Replacement, Knee ,Propensity Score ,Generalized estimating equation ,Aged ,Retrospective Studies ,Skilled Nursing Facilities ,030222 orthopedics ,business.industry ,Retrospective cohort study ,Length of Stay ,Middle Aged ,Osteoarthritis, Knee ,medicine.disease ,Arthroplasty ,Patient Discharge ,United States ,Surgery ,Propensity score matching ,Physical therapy ,Female ,business ,Knee Prosthesis - Abstract
This study compares the differences in hospital length of stay (LOS), operating room time (ORT), discharge status, and total hospital costs among primary total knee arthroplasty (TKA) patients implanted with one of two contemporary primary total knee systems. A retrospective cohort analysis of elective inpatient, primary, unilateral TKA patients in the United States from 2013 to 2014 was conducted using the Premier Perspective® hospital billing database. The included patients had a diagnosis for osteoarthritis and received an ATTUNE® Knee (Gradually Reducing Radius Knee) or Triathlon™ (Single Radius Knee) from a hospital where both devices were used. Patient, provider, and procedure characteristics were included in generalized estimating equation (GEE) models to explore the impact of device on LOS, ORT, discharge status, and costs accounting for clustering within hospitals. A 1:1 propensity score–matched sensitivity analysis was also conducted. There were 1,178 patients who received gradually reducing radius knee and 5,707 patients who received single radius knee. GEE models indicated that the adjusted mean LOS and ORT for patients who received gradually reducing radius knee were significantly shorter than those who received single radius knee (p
- Published
- 2017
14. PIT13 IMPACT OF REOPERATIONS ON ONE-YEAR HEALTH CARE RESOURCE UTILIZATION AND COSTS AFTER INTRAMEDULLARY FIXATION OF PERTROCHANTERIC HIP FRACTURES
- Author
-
Abhishek S Chitnis, Jason Lerner, M. Vanderkarr, Chantal E. Holy, J. Ruppenkamp, and C. Sparks
- Subjects
Intramedullary rod ,medicine.medical_specialty ,Fixation (surgical) ,business.industry ,law ,Health Policy ,Health care ,Public Health, Environmental and Occupational Health ,medicine ,business ,Resource utilization ,Surgery ,law.invention - Published
- 2019
- Full Text
- View/download PDF
15. Best Practices for Outpatient Anterior Cervical Surgery: Results From a Delphi Panel
- Author
-
Chris Summa, Kevin T. Foley, Anita Mohandas, W Bradley Worthington, Gregory B Lanford, Robert J. Bohinski, Jason Lerner, Richard N. W. Wohns, and Carol Holden
- Subjects
medicine.medical_specialty ,Total Disc Replacement ,Consensus ,Delphi Technique ,MEDLINE ,Delphi method ,03 medical and health sciences ,0302 clinical medicine ,Outpatients ,medicine ,Humans ,Orthopedics and Sports Medicine ,Protocol (science) ,030222 orthopedics ,business.industry ,Perioperative ,Evidence-based medicine ,Spinal Fusion ,Ambulatory Surgical Procedures ,Orthopedic surgery ,Ambulatory ,Physical therapy ,Cervical Vertebrae ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Patient education - Abstract
Study design Delphi Panel expert panel consensus and narrative literature review. Objective To obtain expert consensus on best practices for patient selection and perioperative decision making for outpatient anterior cervical surgery (anterior cervical disc fusion (ACDF) and cervical total disc replacement (CTDR)). Summary of background data Spine surgery in ambulatory settings is becoming a preferred option for both patients and providers. The transition from traditional inpatient environments has been enabled by innovation in anesthesia protocols and surgical technique, as well as favorable economics. Studies have demonstrated that anterior cervical surgery (ACDF and CTDR) can be performed safely on an outpatient basis. However, practice guidelines and evidence-based protocols to inform best practices for the safe and efficient performance of these procedures in same-day, ambulatory settings are lacking. Methods A panel of five neurosurgeons, three anesthesiologists, one orthopedic spine surgeon, and a registered nurse was convened to comprise a multidisciplinary expert panel. A three-round modified-Delphi method was used to generate best-practice statements. Predetermined consensus was set at 70% for each best-practice statement. Results A total of 94 consensus statements were reviewed by the panel. After three rounds of review, there was consensus for 83 best-practice statements, while 11 statements failed to achieve consensus. All statements within several perioperative categories (and subcategories) achieved consensus, including preoperative assessment (n = 8), home-care/follow-up (n = 2), second-stage recovery (n = 18), provider economics (n = 8), patient education (n = 14), discharge criteria (n = 4), and hypothermia prevention (n = 6). Conclusion This study obtained expert-panel consensus on best practices for patient selection and perioperative decision making for outpatient anterior cervical surgery (ACDF/CTDR). Given a paucity of guidelines and a lack of established care pathways for ACDF/CTDR in same-day, ambulatory settings, results from this study can supplement available evidence in support of local protocol development for providers considering a transition to the outpatient environment. Level of evidence 4.
- Published
- 2016
16. Effect of Minimally Invasive Technique on Return to Work and Narcotic Use Following Transforaminal Lumbar Inter-body Fusion
- Author
-
Jason Lerner, Matthew J. McGirt, and Scott L. Parker
- Subjects
medicine.medical_specialty ,Time Factors ,Leadership and Management ,Narcotic ,medicine.medical_treatment ,Decision Making ,MEDLINE ,Work Capacity Evaluation ,Assessment and Diagnosis ,Occupational safety and health ,Indirect costs ,Return to Work ,Lumbar ,medicine ,Humans ,Minimally Invasive Surgical Procedures ,Care Planning ,Occupational Health ,Pain, Postoperative ,Lumbar Vertebrae ,business.industry ,Health Policy ,Prognosis ,Low back pain ,Surgery ,Analgesics, Opioid ,Spinal Fusion ,Treatment Outcome ,Systematic review ,Spinal fusion ,Physical therapy ,medicine.symptom ,business ,Case Management ,Low Back Pain - Abstract
Purpose of study Low back pain is one of the most prevalent and disabling musculoskeletal conditions affecting the working population in the United States. Informed, shared decision making among patients, clinicians, and case managers about treatment options for chronic low back pain-including the role of spinal fusion where medically necessary-can have a meaningful impact on return to work, normal function, and economic outcomes. Minimally invasive techniques for lumbar spinal fusion, including transforaminal lumbar interbody fusion (MIS TLIF) have recently been introduced with the goal of smaller operative wounds, less tissue trauma, and faster postoperative recovery when compared with open fusion. Although similar long-term clinical outcomes have been reported for MIS TLIF and open TLIF, the relative merits with respect to workplace productivity have not been comprehensively investigated. Time to return to work and narcotic independence after MIS TLIF and open TLIF are important parameters that may affect overall workplace productivity, and as such are the focus of this study. Primary practice setting(s) This study was performed via a review of the literature. Methodology and sample We performed a systematic literature review to identify all published articles that reported on the postoperative outcomes of patients, as assessed by return to work or narcotic independence status or both, following MIS TLIF or open TLIF. A cumulative comparison was made for all included MIS TLIF versus open TLIF surgeries. Results Seventy-four published studies reported postoperative outcomes following MIS TLIF or open TLIF; only five (6.8%) studies directly described time to return to work or duration of narcotic use postoperatively or both, and were therefore included into the analysis of this review. Four studies in the published literature describe time to return to work following MIS TLIF or open TLIF, and two studies describe time to narcotic independence. Overall, the reviewed literature suggests that MIS TLIF may be associated with an accelerated time to narcotic independence and return to work versus open TLIF. Implications for case management practice There are limited data regarding time to return to work and duration of postoperative narcotic use following TLIF for low back pain. The available data appear to suggest that MIS TLIF may be associated with accelerated return to work and narcotic independence compared with open TLIF. Further analysis will be necessary to quantify the impact of MIS TLIF on workplace productivity and the indirect costs borne by patients and employers. Such information will be of value to case managers, disability managers, employers, patients, and clinicians aligned on reducing morbidity and hastening return to normal function.
- Published
- 2012
- Full Text
- View/download PDF
17. Acute Hospital Costs After Minimally Invasive Versus Open Lumbar Interbody Fusion
- Author
-
Jason Lerner, James Lesko, Michael Wang, and Matthew J. McGirt
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Databases, Factual ,Total cost ,MEDLINE ,Lumbar ,International Classification of Diseases ,Lumbar interbody fusion ,Deformity ,medicine ,Humans ,Minimally Invasive Surgical Procedures ,Orthopedics and Sports Medicine ,Hospital Costs ,Acute hospital ,Aged ,Retrospective Studies ,Aged, 80 and over ,Lumbar Vertebrae ,business.industry ,Retrospective cohort study ,Length of Stay ,Middle Aged ,United States ,Surgery ,Hospitalization ,Spinal Fusion ,Treatment Outcome ,Female ,National database ,Neurology (clinical) ,medicine.symptom ,business ,Low Back Pain - Abstract
Study design Retrospective multi-institutional database review. Objective To determine if minimally invasive interbody fusion is associated with cost savings when compared with open surgery. Summary of background data Minimally invasive spine (MIS) surgeries are increasingly recognized as equivalent to open procedures. Although these techniques have been advocated for reducing pain, disability, and length of hospitalization, to date there has been little data demonstrating these benefits. Methods This study analyzed inpatient hospital records from the Premier Perspective database (2002 to 2009), including patients who underwent a posterior lumbar fusion with interbody cage placement by ICD-9 code, and had implant charge codes that allowed determination if MIS pedicle screws were utilized. Exclusion criteria included a refusion surgery, deformity, >2 levels, and anterior fusion. Total costs were adjusted for covariates (age, sex, race, hospital geography and setting, payor, and comorbidities) using an analysis of covariance model. Results A total of 6106 patients were identified (1667 MIS and 4439 open). Length of stay (LOS) for 1-level MIS surgery averaged of 3.35 days versus 3.6 days for open surgery (P≤0.006). For 2-level MIS surgery LOS averaged of 3.4 days versus 4.03 days for open surgery (P≤0.001). Total inflation-adjusted acute hospitalization cost averaged $29,187 for 1-level MIS procedures versus $29,947 for open surgery, a nonsignificant difference (P=0.55). Total inflation-adjusted acute hospitalization cost averaged $2106 lower for 2-level MIS surgery (total costs of $33,879 for MIS vs. $35,984 for open surgery, P=0.0023). Cost savings were attributable primarily to lower room and board ($857), operating room ($359), pharmacy ($304), and laboratory ($166) costs in the MIS group. High variances in the 2-level open surgery with prolonged hospital stay also accounted for overall cost differences. Conclusions This data from a large nationwide sample of hospitalizations demonstrates that MIS lumbar interbody fusion results in a statistically significant reduction in hospital LOS and a reduction in total hospital costs with 2-level surgery after adjusting for significant covariates. The majority of cost savings from MIS surgery were due to more rapid mobilization and discharge, as well as a reduction in outliers with extended hospitalizations.
- Published
- 2012
- Full Text
- View/download PDF
18. Comparative analysis of perioperative surgical site infection after minimally invasive versus open posterior/transforaminal lumbar interbody fusion: analysis of hospital billing and discharge data from 5170 patients
- Author
-
Luella Engelhart, Jason Lerner, Tyler Knight, Michael Wang, Scott L. Parker, and Matthew J. McGirt
- Subjects
Adult ,Male ,medicine.medical_specialty ,Discharge data ,Lumbar ,Lumbar interbody fusion ,medicine ,Humans ,Surgical Wound Infection ,Aged ,Retrospective Studies ,business.industry ,Incidence (epidemiology) ,Surgical wound ,Retrospective cohort study ,General Medicine ,Perioperative ,Length of Stay ,Middle Aged ,Patient Discharge ,Surgery ,Spinal Fusion ,Treatment Outcome ,Fees and Charges ,Anesthesia ,Female ,business ,Surgical site infection - Abstract
Object Surgical site infection (SSI) after lumbar fusion results in significant patient morbidity and associated medical resource utilization. Minimally invasive (MI) techniques for posterior/transforaminal lumbar interbody fusion (P/TLIF) were introduced with the goals of smaller wounds, less tissue trauma, reduced blood loss, and quicker postoperative recovery, while maintaining comparable surgical results. Studies with sufficient power to directly compare the incidence of SSI following MI versus open P/TLIF procedures have been lacking. Furthermore, the direct medical cost associated with the treatment of SSI following the P/TLIF procedure is poorly understood and has not been adequately assessed. Thus, the aim in the present study was to determine the incidence of perioperative SSI in patients undergoing MI versus open P/TLIF and the direct hospital cost associated with the diagnosis and management of SSI after P/TLIF as reported in a large administrative database. Methods The authors retrospectively reviewed hospital discharge and billing records from the Premier Perspective Database for 2003 to 2009 to identify patients undergoing 1- or 2-level MI or open P/TLIF for lumbar spondylotic disease, disc degeneration, or spondylolisthesis. The ICD-9-CM procedure codes were used to identify patients undergoing P/TLIF and those experiencing SSI. Infection-related costs were obtained from the total costs incurred by the hospital for SSI-related care provided during inpatient or hospital outpatient encounters. Results Five thousand one hundred seventy patients undergoing P/TLIF were identified. Demographic profiles, including the Charlson Comorbidity Index, were similar between MI and open cohorts. Overall, 292 patients (5.6%) experienced an SSI with a mean direct cost of $15,817 per SSI. For 1-level MI versus open P/TLIF, the incidence of SSI (38 [4.5%] vs 77 [4.8%], p = 0.77) and the mean SSI-associated cost per P/TLIF ($684 vs $724, p = 0.680) were similar. For 2-level MI versus open P/TLIF, the incidence of SSI (27 [4.6%] vs 150 [7.0%], p = 0.037) and mean SSI-associated cost per P/TLIF ($756 vs $1140, p = 0.030) were both significantly lower among MI-treated patients. In a multivariate model that accounted for differences in demographics and patient severity, open fusion was associated with a strong trend of increased incidence of SSI as compared with MI fusion (OR 1.469, 95% CI 0.959–2.250). Conclusions In this multihospital study, the MI technique was associated with a decreased incidence of perioperative SSI and a direct cost savings of $38,400 per 100 P/TLIF procedure when used in 2-level fusion. There was no significant difference in the incidence of SSIs between the open and MI cohorts for 1-level fusion procedures. The results of this study provide further evidence of the reduced patient morbidity and health care costs associated with MI P/TLIF.
- Published
- 2011
- Full Text
- View/download PDF
19. PMD147 - CHARACTERIZING HEALTH CARE RESOURCE UTILIZATION AND COSTS FOLLOWING INTRAMEDULLARY FIXATION FOR PERTROCHANTERIC HIP FRACTURE IN A MEDICARE POPULATION
- Author
-
M. Vanderkarr, Jason Lerner, Chantal E. Holy, J. Ruppenkamp, and Abhishek S Chitnis
- Subjects
medicine.medical_specialty ,Hip fracture ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,medicine.disease ,law.invention ,Surgery ,Intramedullary rod ,Fixation (surgical) ,law ,Health care ,Medicare population ,Medicine ,business ,Resource utilization - Published
- 2018
- Full Text
- View/download PDF
20. PMD20 - COMPARATIVE STUDY OF SPINE ANTERIOR LUMBAR INTERBODY FUSION DEVICES
- Author
-
S Bhattacharyya, A.M. Menzie, K. Corso, J.B. Pracyk, Jason Lerner, and Katherine Etter
- Subjects
Spine (zoology) ,Orthodontics ,business.industry ,Lumbar interbody fusion ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine ,business - Published
- 2018
- Full Text
- View/download PDF
21. Septic Revision of All Knee Components Following Total Knee Arthroplasty: Type and Payments for Care, and Incidence of 1-Year Re-Infection and Amputation
- Author
-
Chantal E. Holy, Jason Lerner, and Abhishek S Chitnis
- Subjects
medicine.medical_specialty ,Amputation ,business.industry ,Health Policy ,Incidence (epidemiology) ,medicine.medical_treatment ,Public Health, Environmental and Occupational Health ,medicine ,Total knee arthroplasty ,business ,Surgery ,Re infection - Published
- 2018
- Full Text
- View/download PDF
22. LATERAL EPICONDYLITIS: PREVALENCE AND HEALTH CARE COSTS IN THE UNITED STATES
- Author
-
B. Roides, Chantal E. Holy, S. Bhattacharyya, and Jason Lerner
- Subjects
medicine.medical_specialty ,business.industry ,Health Policy ,Epicondylitis ,Public Health, Environmental and Occupational Health ,medicine.disease ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Health care ,medicine ,Physical therapy ,business - Published
- 2016
- Full Text
- View/download PDF
23. COST OF CARE ASSOCIATED WITH IMPLANTATION OF MULTIPLANE EXTERNAL FIXATION SYSTEM
- Author
-
Chantal E. Holy, A. Menzie, and Jason Lerner
- Subjects
medicine.medical_specialty ,External fixation ,business.industry ,Health Policy ,medicine.medical_treatment ,Public Health, Environmental and Occupational Health ,Medicine ,business ,Cost of care ,Surgery - Published
- 2016
- Full Text
- View/download PDF
24. Healthcare Resource Utilization And Costs For Total Hip Arthroplasty: Benchmarking The Anterior Approach In The Medicare Population
- Author
-
Atul F. Kamath, Jason Lerner, D Wei, Chantal E. Holy, and Abhishek S Chitnis
- Subjects
business.industry ,Health Policy ,Medicare population ,Health care ,Public Health, Environmental and Occupational Health ,Medicine ,Benchmarking ,Anterior approach ,Medical emergency ,business ,medicine.disease ,Resource utilization ,Total hip arthroplasty - Published
- 2017
- Full Text
- View/download PDF
25. Seven-Year Cost-Effectiveness of Cervical Disc Replacement versus Anterior Cervical Discectomy and Fusion: Results from Investigational Device Exemption and Post-Approval Studies of ProDisc®-C Total Disc Replacement
- Author
-
Jack E. Zigler, Chao Yang, Kris E. Radcliff, Thierry Bernard, and Jason Lerner
- Subjects
Cervical disc replacement ,medicine.medical_specialty ,Total disc replacement ,Cost effectiveness ,business.industry ,Medicine ,Surgery ,Orthopedics and Sports Medicine ,Anterior cervical discectomy and fusion ,Neurology (clinical) ,Investigational device exemption ,business - Published
- 2015
- Full Text
- View/download PDF
26. Direct Medical Resource Utilization For Reoperation After Intramedullary Fixation of Pertrochanteric HIP Fractures
- Author
-
C Sparks, Jason Lerner, and A Menzie
- Subjects
Intramedullary rod ,Fixation (surgical) ,medicine.medical_specialty ,business.industry ,law ,Health Policy ,Public Health, Environmental and Occupational Health ,medicine ,business ,Resource utilization ,Surgery ,law.invention - Published
- 2016
- Full Text
- View/download PDF
27. Comparative Effectiveness of Attune ® Versus Triathlon tm Total Knee Systems: Real-World Length of Stay And Discharge Status
- Author
-
Jason Lerner, Katherine Etter, Iftekhar Kalsekar, Andrew Yoo, and C. de Moor
- Subjects
medicine.medical_specialty ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,Physical therapy ,Medicine ,business ,Total knee ,Discharge status - Published
- 2016
- Full Text
- View/download PDF
28. Comparative Analysis of Surgical Site Infection After Minimally Invasive Versus Open Posterior/Transforaminal Lumbar Interbody Fusion
- Author
-
Scott L. Parker, Matthew J. McGirt, Jason Lerner, Luella Engelhart, and Michael Wang
- Subjects
medicine.medical_specialty ,Discharge data ,business.industry ,Lumbar interbody fusion ,Medicine ,Surgery ,Neurology (clinical) ,business ,Surgical site infection - Published
- 2010
- Full Text
- View/download PDF
29. 152 Minimally Invasive vs Open Posterior Interbody Lumbar Fusion
- Author
-
Matthew J. McGirt, Scott L. Parker, and Jason Lerner
- Subjects
medicine.medical_specialty ,Lumbar ,business.industry ,media_common.quotation_subject ,Propensity score matching ,medicine ,Surgery ,Quality (business) ,Neurology (clinical) ,business ,media_common - Published
- 2013
- Full Text
- View/download PDF
30. Acute Hospitalization Costs Following Minimally Invasive Versus Open Lumbar Interbody Fusion
- Author
-
Michael Wang, Matthew J. McGirt, Jason Lerner, and James Lesko
- Subjects
Acute hospitalization ,medicine.medical_specialty ,business.industry ,Lumbar interbody fusion ,medicine ,Surgery ,National database ,Neurology (clinical) ,business - Published
- 2010
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.