Search

This study aimed to compare the effects of an 8-week creatine (CR) or placebo (PL) supplementation on muscle strength, thickness, endurance, and body composition employing different training paradigms with blood flow restriction (BFR) vs. traditional resistance training (TRAD). Seventeen healthy males were randomized between the PL ( n = 9) and CR ( n = 8) groups. Participants were trained unilaterally utilizing a within-between subject bicep curl exercise where each arm was allocated to TRAD or BFR for 8 weeks. Muscular strength, thickness, endurance, and body composition were evaluated. Creatine supplementation promoted increases in muscle thickness in TRAD and BFR compared with their placebo counterparts, however, without a significant difference between treatments ( p = 0.349). TRAD training increased maximum strength (1 repetition maximum (1RM)) compared with BFR after 8 weeks of training ( p = 0.021). Repetitions to failure at 30% of 1RM were increased in the BFR-CR group compared with the TRAD-CR group ( p = 0.004). Repetitions to failure at 70% 1RM were increased from weeks 0–4 ( p

Context: Capsaicinoids and capsinoids (CAP) are natural substances found primarily in chili peppers and other spicy foods that agonize the transient receptor potential vanilloid-1 in the mouth, stomach, and small intestine. Several studies have shown CAP to be a potential antiobesity agent and to exhibit an analgesic effect in both rodents and humans. However, there is no scientific consensus about the effects of CAP on physical exercise performance and its physiological mechanisms of action. Purpose: This systematic review aimed to better elucidate the effects of CAP compounds as ergogenic aids and to discuss underlying mechanisms of action by which this supplement may potentially enhance endurance performance and muscular strength. Conclusions: Among 22 studies included in the review, 14 examined the effects of capsaicinoid or capsinoid compounds on endurance and resistance exercise performance in animals, with 9 studies showing benefits on performance. In humans, 8 studies were included: 3 demonstrated significant acute endurance benefits and 2 showed acute resistance exercise performance benefits compared with a placebo condition. Therefore, while more mechanistic studies are necessary to confirm these outcomes in humans, the available scientific literature appears to suggest that these compounds could be considered an effective nutritional strategy to improve exercise performance.

Lima-Soares, F, Pessoa, KA, Torres Cabido, CE, Lauver, J, Cholewa, J, Rossi, FE, and Zanchi, NE. Determining the arterial occlusion pressure for blood flow restriction: Pulse oximeter as a new method compared with a handheld Doppler. J Strength Cond Res 36(4): 1120-1124, 2022-In laboratorial and clinical settings, the use of Doppler ultrasound equipment has been considered the gold standard method to determine arterial occlusion pressure (AOP). However, the use of Doppler equipment is inherently limited to the technical expertise needed to perform AOP measurements. To overcome the technical difficulties of the use of Doppler equipment use in the determination of AOP, a simpler and less subjective methodology would be helpful for blood flow restriction (BFR) practitioners. In this regard, portable pulse oximetry has been largely used in clinical practice for measuring systolic pressures, as well as loss or recovery of pulse, with results similar to those observed with the use of Doppler equipment. For such purposes, the AOP from young male and female subjects was evaluated after different body positions (standing, seated, and supine positions). Loss of capillary blood flow or AOP was readily determined by simple visual inspection for the pulse oximeter and loss of sound for the Doppler equipment. The results presented herein strongly suggest the use of the portable pulse oximetry equipment as reliable, when compared with the handheld Doppler (seated k = 0.962, standing k = 0.845, and supine k = 0.963 and seated rs = 0.980, standing rs = 0.958, and supine rs = 0.955). Because AOP measurement by pulse oximetry is relatively easier to perform and financially more accessible than handheld Doppler equipment, BFR practitioners may benefit from this new methodology to measure AOP, thus determining individualized restriction pressures.

Made available in DSpace on 2022-04-28T19:49:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 We sought to investigate the acute effects of capsaicin supplementation on the rate of perceived exertion (RPE) and heart rate during high-intensity intermittent exercise (HIIE) and resistance exercise performance executed after HIIE in resistance-trained men. Eleven resistance-trained men completed 2 randomized, double-blind trials: capsaicin condition or a placebo condition. The concurrent exercise session was composed of a 5-km intermittent run (1:1 effort and passive recovery ratio) and subsequent resistance exercise (4 × 70% of 1RM until muscle failure in the half-squat exercise). Heart rate was recorded during HIIE and after the protocol RPE (0–10 scale) was accessed. The resistance exercise performance was analyzed by the maximum number of repetitions performed for each set and the total volume (repetitions 3 weight lifted). During HIIE, the RPE (capsaicin = 7 ± 1 vs. placebo = 8 ± 1 points, t = -3.674, p = 0.005) and mean heart rate (capsaicin = 153 ± 13 vs. placebo = 158 ± 12 bpm, t = -2.292, p = 0.048) were significantly lower in the capsaicin compared with placebo condition. For subsequent resistance exercise, there was a significant decrease in volume across time (F = 19.889, p< 0.001, η2 = 0.69) with maximal number of repetitions performed in capsaicin than placebo condition (2,077.6 ± 465.2 kg vs. 1,838.9 ± 624.1 kg, p = 0.028, d = 0.43), but the condition vs. set was not significant (F = 0.582, p = 0.632, η2 = 0.06). Acute capsaicin supplementation induced a lower mean heart rate and RPE during HIIE and improved subsequent resistance exercise performance in resistance-trained men. Skeletal Muscle Assessment Laboratory (LABSIM) Department of Physical Education School of Technology and Sciences São Paulo State University (UNESP) Department of Physical Education Center University of Adamantina (UNIFAI) Department of Nutrition University of Western São Paulo (UNOESTE) Department of Kinesiology Coastal Carolina University School of Physical Education and Sport University of São Paulo Exercise and Immunometabolism Research Group Department of Physical Education São Paulo State University (UNESP), SP Immunometabolism of Skeletal Muscle and Exercise Research Group Department of Physical Education Federal University of Piauí (UFPI), PI Associate Graduate Program in Health Science Federal University of Piauí (UFPI), PI Skeletal Muscle Assessment Laboratory (LABSIM) Department of Physical Education School of Technology and Sciences São Paulo State University (UNESP) Exercise and Immunometabolism Research Group Department of Physical Education São Paulo State University (UNESP), SP

Objective Various nutritional strategies are adopted for athletes to maintain and improve performance during the competition season. Betaine may enhance performance during a competitive season by increasing the testosterone to cortisol ratio and reducing systemic inflammation. The aim of this study was to investigate the effect of betaine supplementation on the bio-motor abilities in young soccer players. Methods Twenty-nine professional young soccer players (age, 15.5 ± 0.3 years) were matched by position and randomly assigned to one of two groups for 14 weeks: betaine (BG, 2 g/day; n = 14) or placebo (PG n = 15). Diet was standardized by a nutritionist, and measures of muscular power (countermovement jump: CMJ), change of direction (modified 5-0-5), acceleration (10 m sprint), sprint performance (30 m sprint time: SpT), muscular strength (leg press and bench press 1-RM), repeated sprint ability (running-based anaerobic sprint test: RAST), and aerobic capacity (30 − 15 intermittent fitness test) were assessed in the pre (P1), mid (P2), and post (P3) season over the course of 5 days. All subjects participated in one soccer match and five training sessions per week. Results Significant (p 2max), anaerobic peak power, and muscular strength favoring BG at P2 and P3 compared to P1. There were meaningful (p 2max, and repeated sprint ability performance in youth professional soccer players. Betaine supplementation seems to be a useful nutritional strategy to improve and maintain performance during a competitive soccer season.

The barbell deadlift is a popular exercise and one of the three lifts in competitive powerlifting. While muscle activation has been tested between the sumo (SDL) and conventional deadlift (CDL), the relationships between anthropometrics and deadlift performance in the two styles is not yet known. The purpose of this study was to investigate the relationships between anthropometrics and SDL versus CDL performance (SDL:CDL strength ratio). Forty-seven (n = 28 male, n = 19 female) deadlift naïve subjects participated in this study. Anthropometric measurements were arm and hand length, wrist and ankle girth, seated height, thigh length, and lower leg length. Deadlift instructions for the two styles were provided on day 1 and 2. On day 3 and 4, deadlift 1RM was tested for the SDL or CDL in random order, and then deadlift repetitions to volitional fatigue with 60% of 1RM were measured. No significant differences between CDL 1RM and SDL 1RM were found. The only significant correlation found between the anthropometric predictors and the SDL:CDL strength ratio was an inverse relationship with the sitting height to total height ratio (r = 0.297, p = 0.043). Total repetitions to volitional fatigue was higher in females compared to males for both lifts (p = 0.041). Our findings suggest that the sumo deadlift may be slightly mechanically advantageous for deadlift naïve individuals with longer torsos, while the conventional deadlift may be better suited for those with shorter torsos.

Increased blood flow via vasodilation, metabolite production, and venous pooling contribute to the hyperemia and cellular swelling experienced during resistance training. It has been suggested that these effects play a role in hypertrophic adaptations. Over the past 2 decades, sport supplement products have been marketed to promote exercise hyperemia and intracellular fluid storage, thereby enhancing hypertrophy via acute swelling of myocytes. The three main classes of supplements hypothesized to promote exercise-induced hyperemia include vasodilators, such as nitric oxide precursor supplements; anaerobic energy system ergogenic aids that increase metabolite production, such as β-alanine and creatine; and organic osmolytes, such as creatine and betaine. Previous studies indicated that these dietary supplements are able to improve muscle performance and thus enhance muscle hypertrophy; however, recent evidences also point to these three classes of supplements affecting "secondary" physiological determinants of muscle mass accretion such as vasodilation, metabolite accumulation, and muscle cellular swelling. Although we recognize that the literature is relatively scarce regarding these topics, a better comprehension and discussion of these determinants can lead to increased knowledge and might guide further research regarding the proposed mechanisms of action of the identified compounds. In this case, increased knowledge may contribute to the development of improved efficacy, new products, or direct new research to specifically investigate those secondary effects. The aim of this review was to bring into focus new perspectives associated with secondary physiological effects induced by supplementation and to determine their relevance.

Objective Betaine supplementation may enhance body composition outcomes when supplemented chronically during an exercise program. The purpose of this study was to evaluate the effect of betaine supplementation on development-related hormones, body composition, and anthropometrics in professional youth soccer players during a competitive season. Methods Twenty-nine players (age, 15.45 ± 0.25 years) were matched based upon position and then randomly assigned to a betaine group (2 g/day; n = 14, BG) or placebo group (PG, n = 15). All subjects participated in team practices, conditioning, and games. If a subject did not participate in a game, a conditioning protocol was used to ensure workload was standardized throughout the 14-week season. Growth hormone (GH), insulin-like growth factor-1 (IGF-1), testosterone, cortisol, height, weight, and body composition were assessed at pre-season (P1), mid-season (P2) and post-season (P3). Anthropometric variables were also measured following a one-year follow-up (F). Results Significant (p

Made available in DSpace on 2021-06-25T10:14:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-11-01 Lira, FS, Conrado de Freitas, M, Gerosa-Neto, J, Cholewa, JM, and Rossi, FE. Comparison between full-body vs. split-body resistance exercise on the brain-derived neurotrophic factor immunometabolic response. J Strength Cond Res 34(11): 3094-3102, 2020-Intense aerobic exercise seems to increase serum concentrations of brain-derived neurotrophic factor (BDNF) in conjunction with increasing lactate; however, less is known about the BDNF response to differing resistance exercise protocols. We hypothesized that full-body (FB) resistance exercise will elicit a greater increase in serum BDNF and lactate compared with split-body resistance exercise. Twelve recreationally resistance-trained men (age = 25.3 ± 5.9 years) performed 3 randomized trials of 18 sets of exercise: upper-body (UB), lower-body (LB), and FB conditions. Serum BDNF levels were assessed at rest, immediately Post-exercise, Post-1 hour, and Post-2 hours during recovery. Lactate concentration was evaluated at rest, after 9 sets, Post-exercise, Post-5, Post-10, and Post-30 minutes during recovery. In addition, interleukin (IL-6 and IL-10) and the IL-6/IL-10 ratio were calculated. Lactate concentration and total volume were greater in the FB condition compared with LB and UB (p < 0.05). For BDNF, effect sizes were largest in the LB (1.4), followed by the FB (0.75), and moderate to UB (0.33), although no significant differences were observed between conditions. There was a statistically significant relationship between lactate and BDNF only for LB condition (rho = 0.72; p = 0.013). There were a greater IL-10 Post-1 hour for FB condition compared with UB and LB (p < 0.001), and lower IL-6/IL-10 ratio in FB compared with UB (p < 0.001). Lower body induced a great BDNF response, and FB resistance exercise elicited a greater increase of serum cytokines than UB in trained men. We speculate that the volume of work performed by larger muscles has a larger influence on BDNF than overall volume. Department of Physical Education Exercise and Immunometabolism Research Group São Paulo State University (UNESP) Department of Physical Education Skeletal Muscle Assessment Laboratory School of Technology and Sciences São Paulo State University Department of Kinesiology Coastal Carolina University Department of Physical Education Immunometabolism of Skeletal Muscle and Exercise Research Group Federal University of Piauí (UFPI) Department of Physical Education Exercise and Immunometabolism Research Group São Paulo State University (UNESP) Department of Physical Education Skeletal Muscle Assessment Laboratory School of Technology and Sciences São Paulo State University

Purpose To screen for candidate hub genes associated with the effects of exercise on melanoma tumor tissues and to review the potential signaling pathways involved in this process using bioinformatics analysis. Methods The GSE62628 expression profile was downloaded from Gene Expression Omnibus database. This data set contains 10 melanoma tumor tissues from two groups of exercise and nonexercise mice. The R software was utilized to identify differentially expressed genes between samples, and functional annotation and pathway analysis were performed. Results were visualized using Cytoscape software. Results In total, 315 differentially expressed genes were obtained, including 294 upregulated and 21 downregulated genes. The functional analysis showed that these genes were mainly enriched in immune response, inflammatory response, and positive regulation of the ERK1/2 cascade in biological process functional groups. The top 10 candidate hub genes were C3, Kng1, C3ar1, Ptafr, Fgg, Alb, Pf4, Orm1, Aldh3b1, and Apob. The pathway analysis of the most significant module identified from the protein-protein interaction network revealed that the complement and coagulation cascades, Staphylococcus aureus infection, cytokine-cytokine receptor interaction, chemokine signaling pathway and phagosome were mainly involved. C3, C3ar1, Kng1, Ptafr, and Fgg may be the critical genes in the complement and coagulation cascades pathway, and S. aureus in the infection pathway. Conclusions Exercise may ameliorate the immune response and inflammatory response in melanoma tissue, and further studies exploring their relationships are warranted.

Made available in DSpace on 2020-12-12T01:18:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-03-01 BACKGROUND: The purpose of this study was to investigate if a post-activation potentiation (PAP) protocol may attenuate the acute interference induced by high-intensity intermittent exercise (HIIE) and on subsequent strength exercise performance in recreationally trained men. METHODS: Eleven resistance-trained men (age: 25.7±3.7 y) randomly completed three experimental trials: strength exercise (SE) only (4 sets of maximal number of repetitions at 70% on the 45° leg press); concurrent exercise (CE) comprised 5000-m of HIIEat maximal aerobic speed (1:1 effort and pause ratio) followed by SEprotocol; CE with post-activation potentiation (CE-PAP), comprised the same CEprotocol preceded by one set of 2 repetitions at 90% of 1RM on the 45° leg-press before strength exercise. The number of repetitions performed was recorded for each set and total weight lifted was calculated. RESULTS: The CEcondition induced a greater decrement in volume for the leg press compared to SE and CE-PAP in sets 1 (24±21%; 18±25%), 2 (20±21%; 22±22%), and 3 (19±20%; 25±15%), respectively. Total weight lifted was greater after SE(8,795±2,581 kg) and CE-PAP(8.809±2.655 kg) conditions compared to CE(7.049±2.822 kg) (SEvs. CE: P=0.020) and (CE-PAP vs. CE: P=0.010) but there was no significant difference between SE and CE-PAP(P=1.00). CONCLUSIONS: PAP using a heavy load attenuated acute interference (total volume during lower-body strength) generated by HIIEprotocol, but did not enhance volume compared to SEalone. Skeletal Muscle Assessment Laboratory (LABSIM) Department of Physical Education School of Technology and Sciences São Paulo State University (UNESP) Department of Nutrition University of Western São Paulo (UNOESTE) School of Physical Education and Sport University of São Paulo Department of Kinesiology Coastal Carolina University Conway Immunometabolism of Skeletal Muscle and Exercise Research Group Federal University of Piauí (UFPI) Skeletal Muscle Assessment Laboratory (LABSIM) Department of Physical Education School of Technology and Sciences São Paulo State University (UNESP)

Background Betaine supplementation has been shown to improve body composition and some metrics of muscular performance in young men; but, whether betaine enhances body composition or performance in female subjects is currently unknown. Therefore, the purpose of this study was to investigate the interaction between resistance training adaptation and chronic betaine supplementation in females. Methods Twenty-three young women (21.0 ± 1.4 years, 165.9 ± 6.4 cm, 68.6 ± 11.8 kg) without prior structured resistance training experience volunteered for this study. Body composition (BodPod), rectus femoris muscle thickness (B-mode Ultrasound), vertical jump, back squat 1RM and bench press 1RM were assessed pre- and post-training. Following 1 week of familiarization training, subjects were matched for body composition and squat strength, and randomly assigned to either a betaine (2.5 g/day; n = 11) or placebo (n = 12) group that completed 3 sets of 6–7 exercises per day performed to momentary muscular failure. Training was divided into two lower and one upper body training sessions per week performed on non-consecutive days for 8 weeks, and weekly volume load was used to analyze work capacity. Results Significant main effects of time were found for changes in lean mass (2.4 ± 1.8 kg), muscle thickness (0.13 ± 0.08 cm), vertical jump (1.8 ± 1.6 cm), squat 1RM (39.8 ± 14.0 kg), and bench press 1 RM (9.1 ± 7.3 kg); however, there were no significant interactions. A trend (p = .056) was found for greater weekly training volumes for betaine versus placebo. Significant interactions were found for changes in body fat percentage and fat mass: body fat percentage and fat mass decreased significantly more in betaine (− 3.3 ± 1.7%; − 2.0 ± 1.1 kg) compared to placebo (− 1.7 ± 1.6%; − 0.8 ± 1.3 kg), respectively. Conclusions The results of this study indicated that betaine supplementation may enhance reductions in fat mass, but not absolute strength, that accompany a resistance training program in untrained collegiate females.

The present study was designed to investigate the effects of chronic ingestion of a proprietary beta-alanine supplement on body composition, indices of strength and power performance, and markers of cardiovascular endurance in physically active, college-aged males commissioning within the armed services. Subjects (n = 30) participated in four separate testing sessions, both pre and post assessment consuming either 6.0 g/day beta-alanine or Placebo supplementation for 6 weeks. Parameters evaluated included body fat percentage (BF%), fat free mass (FFM), vertical jump (VJ), 1 repetition maximum back squat (SQ) and bench press (BP), and a repetition maximum bench press (RMBP) at 75% of the attained maximum, maximal oxygen consumption (VO2peak), respiratory exchange ratio (RER), lactate threshold (LT), and peak lactate concentration. For all variables, no significant interactions existed across condition and time (p > .05). In addition, for all variables, no significant differences existed between conditions (p > .05). Beta-alanine did not show any benefit for improving body composition or physical performance parameters in this group of individuals.

Women’s participation in soccer has increased rapidly. The purpose of this study was to evaluate the physiological demands imposed on women’s NCAA Division I soccer players across a season according to speed, total distance traveled, and numbers of sprints measured via GPS (Polar Team Pro®). Eighteen athletes (19.2 ± 1.1 years, 50.5 ± 6.5 mL/kg/min and 23.4 ± 3.6% fat) participated in this study. The analysis was obtained through 13 official matches. Speed zones were defined as Zone 1 (1.0 to 5.99 km·h−1), Zone 2 (6.0 to 10.99 km·h−1), Zone 3 (11.0 to 15.49 km·h−1), Zone 4 (15.5 to 19.9 km·h−1) and Zone 5 (sprint &gt, 20 km·h−1), with Zones 4–5 considered as high intensity running. Individual differences in playing time and total distance were highly variable due to substitutions. Average distance traveled per game in quartiles was 3.9 km, 5.6 km and 7.4 km in the 25th, 50th, and 75th quartiles, respectively. Relative to playing time, players travelled an average of 113.64 ± 17.12 m/min (range: 93.7 to 143.5 m/min) and ran one sprint every 4.12 ± 2.06 min. When distance was summated and analyzed for the entire team, significant difference between halves was found for speed Zones 2, 3 and 4, with greater values found in the first half. Total distance, high intensity running and sprint distance were significantly less than previously recorded in professional players. These findings suggest that coaches should consider the unique physiological demands and recovery opportunities present in NCAA play when constructing practices and conditioning programs.

Previous research has demonstrated the positive effects of concurrent/combined aerobic and resistance exercise or leucine supplementation on skeletal muscle protein synthesis (MPS) and hypertrophy in aging organisms. However, the effects of a multimodal intervention which combines both aerobic and resistance exercise and leucine supplementation has not been fully elucidated. Eighteen month old and 2 month old C57BL/6 mice were assigned to aging control (AC, n = 8), aging and multimodal intervention (AMI, n = 8) and young control (YC, n = 8). Mice in the YC and AC groups were fed an alanine-rich diet (3.4%), and mice in the AMI group received an isonitrogenous leucine-supplemented (5%) diet in combination with combined aerobic (30 minutes swimming) and resistance exercise training (incremental jumping submersed in water with overload corresponding to 40%-50% body weight) for a total of 4 weeks. The gastrocnemius muscles were dissected for western blotting detection (signaling proteins involved in MPS) and the ex vivo determination of protein synthesis and protein content. The muscle strength of the hind limbs was measured pre-experiment and repeated once per week on Sunday for 4 weeks. Mice in the AC and AMI groups showed lower ex vivo protein synthesis, protein content, expression of signaling proteins involved in MPS, maximal grip strength but higher plasma cortisol compared with the YC group post intervention. When compared to AC mice, the multimodal treatment led to lower activity of Sestrin2, higher expression of PI3K III and the phosphorylation of mTOR, p70S6K and 4E-BP1, as well as higher plasma leucine, wet gastrocnemius muscle weight and muscle weight to body weight ratio. Furthermore, the multimodal intervention induced more pronounced anabolic response such as higher ex vivo protein synthesis rate, total protein content, and myofibrillar fractions in gastrocnemius muscle, and greater maximum grip strength. The present research shows that a multimodal intervention including combined both aerobic and resistance exercise training and 5% leucine supplementation has the potential to maintain skeletal muscle protein synthesis and attenuate losses in muscular strength during the aging process.

(1) Background: We investigated the effects of 28 days of beta-alanine (&beta, alanine) supplementation on the acute interference effect of high-intensity intermittent exercise (HIIE) on lower-body resistance exercise performance, body composition, and strength when combined with a resistance training program. (2) Methods: Twenty-two males were randomized into: &beta, alanine supplementation (6.4 g/day) or placebo (6.4 g/day maltodextrin) during 28 days. Total body water, intracellular and extracellular water, fat-free mass (FFM), and fat mass were assessed using bioelectrical impedance. Participants performed 5000-m HIIE (1:1 effort and rest ratio) followed by resistance exercise (four sets of 80% at 45&deg, leg press until muscular failure) at baseline and after 28 days. The resistance training program consisted of three sets of 10 to 12 RM with 90 s of rest, four days per week. (3) Results: For the post-HIIE leg press volume, higher values were observed post-training than pre-training, but no group x time interaction was observed. There was a non-significant trend for an interaction in the FFM change (&beta, alanine = 2.8% versus placebo = 1.0%, p = 0.072). (4) Conclusion: Twenty-eight days of &beta, alanine supplementation did not prevent acute strength loss during resistance exercise after high-intensity interval exercise, nor increase strength or hypertrophic adaptations associated with resistance training.

In general, nutritional sports ergogenics are designed to enhance energy production and/or improve body composition, promoting muscle growth and decreasing body fat. Many of the nutritional supplements and pharmacological substances have been used during resistance training without knowledge about the effects on human metabolism caused by their chronic administration. Before the usage or prescription of any ergogenic aid, it is important to consider some questions about that substance: Is it effective? Is it safe? Is it legal and ethical? In this chapter we will discuss the most widely used drugs and supplements among individuals engaged in resistance training—testosterone, growth hormone and insulin growth factor-1, creatine, beta-hydroxy beta-methylbutyrate and caffeine—focusing on their effects on strength and body composition, the safety of their usage, and the mechanisms of action.

Made available in DSpace on 2021-06-25T10:29:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01 ABSTRACT: Conrado de Freitas, M, Rossi, FE, Colognesi, LA, de Oliveira, JVNS, Zanchi, NE, Lira, FS, Cholewa, JM, and Gobbo, LA. Postactivation potentiation improves acute resistance exercise performance and muscular force in trained men. J Strength Cond Res 35(5): 1357-1363, 2021-The purpose of this study was to investigate the effects of heavy back squat (90% one repetition maximum [1RM]) postactivation potentiation (PAP) on acute resistance exercise performance and force production in recreationally trained men, and to verify the relationship between maximal strength and the PAP response. Ten resistance-trained men randomly completed 4 experimental trials: (a) back squats without PAP (No-PAP), (b) back squats with PAP, (c) maximum voluntary isometric contraction (MVIC) of the quadriceps without PAP, and (d) MVIC with PAP. Back squats were performed with 4 sets at 70% of 1 RM with 2 minutes of rest interval. The number of squats repetitions performed was recorded for each set, and a total number of repetitions were calculated to analyze performance. Maximum voluntary isometric contraction was measured using electronic dynamometer, and the peak force and mean force were recorded. Blood lactate concentration was analyzed presquat and postsquat exercise. Repetitions performed in the first set was significantly (p < 0.001) greater in the PAP condition (22.00 ± 5.14) compared with No-PAP (15.50 ± 5.10), which resulted in significantly (p = 0.001) more total repetitions performed in the PAP (56.20 ± 17.3) condition compared with No-PAP (48.80 ± 14.5). Maximum voluntary isometric contraction peak was higher in PAP than in No-PAP (PAP = 765.7 ± 147.8 vs. No-PAP = 696.8 ± 131.5 N, p = 0.006). No significant correlations were observed between back squat 1RM relative to body mass and the PAP response in squat and MVIC. There were no significant differences in lactate concentration between conditions. In conclusion, PAP resulting from a heavy load prior back squat exercise improved total volume during resistance exercise. In addition, PAP was effective to increase force production during MVIC, but there was no relationship between relative 1RM values and the PAP response in trained men. Skeletal Muscle Assessment Laboratory (LABSIM) Department of Physical Education School of Technology and Sciences São Paulo State University (UNESP) Department of Physical Education School of Technology and Sciences São Paulo State University (UNESP), Post Graduation Program in Movement Sciences Department of Nutrition University of Western São Paulo (UNOESTE) Department of Physical Education Immunometabolism of Skeletal Muscle and Exercise Research Group Federal University of Piauí (UFPI) Exercise and Immunometabolism Research Group Department of Physical Education São Paulo State University (UNESP) Department of Physical Education, Laboratory of Cellular and Molecular Biology of Skeletal Muscle (LABCEMME), São Luis, Brazil; and Department of Kinesiology Coastal Carolina University Skeletal Muscle Assessment Laboratory (LABSIM) Department of Physical Education School of Technology and Sciences São Paulo State University (UNESP) Department of Physical Education School of Technology and Sciences São Paulo State University (UNESP), Post Graduation Program in Movement Sciences Exercise and Immunometabolism Research Group Department of Physical Education São Paulo State University (UNESP)

Purpose: To examine data reporting characteristics in sports nutrition. Methods: We examined 236 papers from ten journals published in 2016. The primary outcome was statistical variance associated with treatment (SD (correct) vs. SEM or CI). Secondary outcomes included the reporting of: (a) effect sizes (Y/N); (b) outcome prioritization (Y/N; primary, secondary, etc.) and (c) statistical variance relative to change from baseline (CI (correct) vs. SD or SEM). As tertiary/exploratory outcome, we examined whether authors stated a directed hypothesis. Statistical evaluation was performed using chi-square analyses. Results: We observed significant trends for all analyses (p < 0.001) and between category comparisons (p < 0.002). For the primary outcome, 128 (59%) articles correctly used SD to denote treatment variance, while 79 (36%) and 11 (5%) used SEM and CI, respectively. For secondary outcomes, 63 articles (29%) reported effect sizes, while 155 (71%) did not. Additionally, 188 articles (86%) did not prioritize outcomes, 134 articles (61%) stated no hypotheses and 40 (19%, out of 100) articles used CI to denote change scores vs. SD (19%, n = 41) and SEM (n = 10, 5%). Eight articles (4%) reported no variance terms. Conclusions: Overall, there are gaps regarding reporting in sports nutrition. Editors, journal publishers, and the field of exercise science alike should consider these outcomes and provide editorial staff, reviewers and authors with more concrete guidelines.

Background: Aging and low physical activity are associated with the development of diseases (hypertension, type 2 diabetes, dyslipidemia, obesity) marked by chronic low-grade inflammation. Cardiovascular disease is the most common cause of death worldwide, while exercising muscle tissue can increase the secretion of myokines that can reestablish a possible inflammatory process in virtue of the anti-inflammatory effect. Methods: The objective of this review is to focus on molecular mechanisms involved between different kinds of exercise and cellular oxidative stress, and the emerging therapeutic strategies which have the potential to promote benefits in vascular health. Results: Regular exercise increases shear stress, mitochondrial biogenesis, and upregulates mitochondrial antioxidant system, inducing anti-inflammatory actions, such as suppression of TNF-α which may offer protection against TNF-α-induced vascular impairment. Conclusion: Exercise training of various durations and intensities appears to prevent and restore the age-related impairment of endothelial function, likely through the restoration of NO availability, reduction in oxidative stress, and turnover of the apoptotic process in the endothelium, thus minimizing vascular inflammation and decreasing the formation of atherosclerotic plaques.

The aim of this study was to compare the effects of linear periodization (LP) versus nonperiodized (NP) resistance training on upper-body isometric force and skeletal muscle mass (SMM) in sarcopenic older adults. Twenty sarcopenic older adults were randomly assigned into the LP and NP groups and performed 16 weeks of resistance training. The SMM was measured by octopolar bioelectrical impedance. The isometric force for handgrip and trunk were assessed by dynamometer. Evaluations were performed at baseline, after 4, 8, 12, and 16 weeks of resistance training. For total weight lifted, there was a main effect for time (F=126.986, P0.05). The SMM increased across time (P0.05). There were strong and significant correlations between handgrip maximum force and SMM (LP: rho=0.79, P=0.004 vs. NP: rho=−0.43, P=0.244) and handgrip mean force and SMM (LP: rho=0.68, P=0.021 vs. NP: rho=−0.37, P=0.332) only for the LP group. In conclusion, LP and NP resistance training induced similar benefits on upper-body isometric force and SMM in sarcopenic older adults. However, LP presented lower total weight lifted, suggesting that it is possible to obtain similar gains in isometric force and SMM with less total work.

Blood flow restriction (BFR) combined with low-intensity strength training has been shown to increase skeletal muscle mass and strength in a variety of populations. BFR results in a robust metabolic stress which is hypothesized to induce muscle growth via increased recruitment of fast-twitch muscle fibers, a greater endocrine response, and/or enhancing the cellular swelling contribution to the hypertrophic process. Following exercise, neutrophils are the first immune cells to initiate the tissue remodeling process via several mechanisms including an increased production of cytokines and recruitment of monocytes/macrophages, which facilitate the phagocytosis of foreign particles, the differentiation of myoblasts, and the formation of new myotubes. Thus, the purpose of this review was to discuss the mechanisms through which metabolic stress and immune cell recruitment may induce skeletal muscle remodeling following BFR strength training.

It is commonly accepted that adequate carbohydrate availability is necessary for optimal endurance performance. However, for strength- and physique-based athletes, sports nutrition research and recommendations have focused on protein ingestion, with far less attention given to carbohydrates. Varying resistance exercise protocols, such as differences in intensity, volume, and intraset rest prescriptions between strength-training and physique-training goals elicit different metabolic responses, which may necessitate different carbohydrate needs. The results of several acute and chronic training studies suggest that although severe carbohydrate restriction may not impair strength adaptations during a resistance training program, consuming an adequate amount of carbohydrate in the days leading up to testing may enhance maximal strength and strength-endurance performance. Although several molecular studies demonstrate no additive increases in postexercise mammalian target of rapamycin 1 phosphorylation with carbohydrate and protein compared with protein ingestion alone, the effects of chronic resistance training with carbohydrate restriction on muscle hypertrophy are conflicting and require further research to determine a minimal carbohydrate threshold necessary to optimize muscle hypertrophy. This review summarizes the current knowledge regarding carbohydrate availability and resistance training outcomes and poses new research questions that will better help guide carbohydrate recommendations for strength and physique athletes. In addition, given that success in physique sports is based on subjective appearance, and not objective physical performance, we also review the effects of subchronic carbohydrate ingestion during contest preparation on aesthetic appearance.

The positive influence of animal-based protein supplementation during muscle-damaging exercise has been widely studied. However, the effects of plant-based proteins remain unclear and require further clarification. This study investigated the protective role of oat protein against exercise induced muscle damage (EIMD), subsequent inflammation, and loss of performance induced by downhill running. Subjects consumed either oat protein (25 g protein) or a placebo for 14 days prior to a downhill running test and then for 4 days thereafter. Treatments with oat protein for 19 days markedly alleviated eccentric exercise induced skeletal muscle soreness, and reduced the elevation of plasma IL-6 concentrations and serum creatine kinase, myoglobin and C reactive protein contents. In addition, oat protein supplementation significantly inhibited limb edema following damaging exercise, and the adverse effects on muscle strength, knee-joint range of motion, and vertical jump performance were lessened. Furthermore, the administration of oat protein facilitated recovery from exhaustive downhill running in this study. These findings demonstrated that oat protein supplementation has the potential to alleviate the negative effects of eccentric exercise in untrained young males.

de Freitas, MC, Cholewa, JM, Gobbo, LA, de Oliveira, JVNS, Lira, FS, and Rossi, FE. Acute capsaicin supplementation improves 1,500-m running time-trial performance and rate of perceived exertion in physically active adults. J Strength Cond Res 32(2): 572-577, 2018-The purpose of this study was to investigate the acute effect of capsaicin supplementation on performance, rate of perceived exertion (RPE), and blood lactate concentrations during short-duration running in physically active adults. Ten physically active men (age = 23.5 ± 1.9 years, mass = 78.3 ± 12.4 kg, and height = 177.9 ± 5.9 cm) completed 2 randomized, double-blind trials: Capsaicin condition (12 mg) or a placebo condition. Forty-five minutes after supplement consumption, the participants performed a 1,500-m running time trial. Time (in seconds) was recorded. Blood lactate concentration was analyzed at rest, immediately after exercise, after 5, 10, and 30 minutes during recovery and the RPE was collected after exercise. The time was significantly (t = 3.316, p = 0.009) lower in the capsaicin (371.6 ± 40.8 seconds) compared with placebo (376.7 ± 39 seconds). Rate of perceived exertion was significantly (t = 2.753, p = 0.022) less in the capsaicin (18.0 ± 1.9) compared with the placebo (18.8 ± 1.3). Lactate increased across time for both conditions without significant differences between (p > 0.05). In summary, acute capsaicin supplementation improves middle distance running (1,500 m) performance and reduced RPE in physically active adults.

Objectives: This study investigated the performance enhancing effects of bicarbonate ingestion on soccer specific performance. Design: A randomized and double-blinded study. Methods: Division III collegiate male soccer players (N = 7) participated in the study. Participants ingested either an alkaline treatment (.3 g/kg NaHCO3) or placebo (cornflower) 60 min prior to exercise on two separate testing sessions spaced 7 days apart. Distance to fatigue in the Yo-Yo Intermittent Recovery Test Level 2 was used to assess performance. Capillary blood was sampled pre-ingestion (PE), 60 min post ingestion (PI), exhaustion (EX), following 15 min of recovery (RC) and analyzed for lactate ([La–]) and pH. Results: No significant ( p > .05) differences between conditions existed for performance. A significant ( p .05) existed between time and condition. pH values at PE and PI were significantly greater than EX and RC in both conditions; however, pH was significantly ( p < .05) greater at PI than PE in treatment but not placebo. Conclusion: Bicarbonate ingestion increased extracellular buffering capacity but does not appear to enhance shuttle run performance in Division III soccer players. (Journal of Trainology 2015;4:19-24)

Made available in DSpace on 2020-12-12T01:06:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01 Freitas, MC, Cholewa, JM, Gerosa-Neto, J, Gonçalves, DC, Caperuto, EC, Lira, FS, and Rossi, FE. A single dose of oral ATP supplementation improves performance and physiological response during lower body resistance exercise in recreational resistance-trained males. J Strength Cond Res 33(12): 3345-3352, 2019-The aim of this study was to investigate the acute effect of adenosine-5'-triphosphate (ATP) supplementation on performance and physiological responses during resistance exercise in recreationally resistance-trained males. Eleven men (age = 27.5 ± 5.5 years, mass = 83.4 ± 9.8 kg, height = 182 ± 0.04 cm) completed 2 randomized, double-blind trials: ATP supplement condition (ATP = 400 mg) or a placebo condition. Thirty minutes after supplement consumption, subjects performed 4 sets of half-squats until momentary muscular failure at 80% of the 1 repetition maximum with 2 minutes of recovery between sets. The total number of repetitions, blood pressure, heart rate, blood lactate, and oxygen consumption were evaluated. The total weight lifted were higher for the ATP condition compared with placebo (Placebo = 3,995.7 ± 1,137.8, ATP = 4,967.4 ± 1,497.9 kg; p = 0.005). Heart rate was higher at set-4 for ATP compared with placebo (p < 0.001) and oxygen consumption during exercise was greater for ATP (p = 0.021). There were no differences between conditions for lactate and blood pressure. In summary, a single oral dose of ATP supplementation improved lower-body resistance training performance and energy expenditure in recreational resistance-trained males. Exercise and Immunometabolism Research Group Department of Physical Education São Paulo State University (UNESP) Department of Kinesiology Coastal Carolina University Biosciences Department Federal University of São Paulo UNIFESP Human Movement Laboratory University São Judas Tadeu Immunometabolism of Skeletal Muscle and Exercise Research Group Department of Physical Education Federal University of Piauí (UFPI) PI Exercise and Immunometabolism Research Group Department of Physical Education São Paulo State University (UNESP)

Made available in DSpace on 2018-12-11T16:46:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-02-25 The aim of this study was to investigate the physiological responses to moderate-intensity continuous and high-intensity intermittent exercise. Twelve physically active male subjects were recruited and completed a 5-km run on a treadmill in two experimental sessions in randomized order: continuously (70% sVO2max) and intermittently (1:1 min at sVO2max). Oxygen uptake, excess post-exercise oxygen consumption, lactate concentration, heart rate and rating of perceived exertion data were recorded during and after each session. The lactate levels exhibited higher values immediately post-exercise than at rest (High-Intensity: 1.43 ± 0.25 to 7.36 ± 2.78; Moderate-Intensity: 1.64 ± 1.01 to 4.05 ± 1.52 mmol·L-1, p = 0.0004), but High-Intensity promoted higher values (p = 0.001) than Moderate-Intensity. There was a difference across time on oxygen uptake at all moments tested in both groups (High-Intensity: 100.19 ± 8.15L; Moderate-Intensity: 88.35 ± 11.46, p < 0.001). Both exercise conditions promoted increases in excess postexercise oxygen consumption (High-Intensity: 6.61 ± 1.85 L; Moderate-Intensity: 5.32 ± 2.39 L, p < 0.005), but higher values were observed in the High-Intensity exercise protocol. High-Intensity was more effective at modifying the heart rate and rating of perceived exertion (High-Intensity: 183 ± 12.54 and 19; Moderate-Intensity: 172 ± 8.5 and 16, respectively, p < 0.05). In conclusion, over the same distance, Moderate-Intensity and High-Intensity exercise exhibited different lactate concentrations, heart rate and rating of perceived exertion. As expected, the metabolic contribution also differed, and High-Intensity induced higher energy expenditure, however, the total duration of the session may have to be taken into account. Moreover, when following moderate-intensity training, the percentage of sVO2max and the anaerobic threshold might influence exercise and training responses. Exercise and Immunometabolism Research Group Department of Physical Education Universidade Estadual Paulista (UNESP) Department of Kinesiology Coastal Carolina University Department of Physical Education Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, 1235 Department of Sports School of Physical Education and Sports University of São Paulo Exercise and Immunometabolism Research Group Department of Physical Education Universidade Estadual Paulista (UNESP)

The aim of the present study was to investigate the effects of caffeine (CAF) and carbohydrate (CHO) intake on strength performance and its metabolic and inflammatory responses during concurrent training. Seven active males ingested a double-placebo (P), CAF (capsule 5 mg/kg) or CHO (20% maltodextrin solution) supplementation before strength exercise. Participants performed three randomized sessions of 5,000-m high-intensity intermittent aerobic exercise at maximal intensity followed by strength exercise, performing after the P, CHO, and CAF intake. The blood samples were collected before (pre) and immediately after concurrent strength exercise (post). We found a similar number of repetitions and total volume in all supplementation groups. There was a main effect of time on glucose, lactate, and interleukin (IL)-6 (P

Dietary proteins/essential amino acids (EAAs) are nutrients with anabolic properties that may increase muscle mass or attenuate muscle loss during immobilization and aging via the stimulation of muscle protein synthesis (MPS). An EAA's anabolic threshold, capable to maximize the stimulation of MPS has been hypothesized, but during certain conditions associated with muscle loss, this anabolic threshold seems to increase which reduces the efficacy of dietary EAAs to stimulate MPS. Preliminary studies have demonstrated that acute ingestion of dietary proteins/EAA (with a sufficient amount of leucine) was capable to restore the postprandial MPS during bed rest, immobilization or aging; however, whether these improvements translate into chronic increases (or attenuates loss) of muscle mass is equivocal. For example, although free leucine supplementation acutely increases MPS and muscle mass in some chronic studies, other studies have reported no increases in muscle mass following chronic leucine supplementation. In contrast, chronically increasing leucine intake via the consumption of an overall increase in dietary protein appears to be the most effective dietary intervention toward increasing or attenuating lean mass during aging; however, more research investigating the optimal dose and timing of protein ingestion is necessary. Several studies have demonstrated that decreases in postprandial MPS as a result of increased circulating oxidative and inflammatory are more responsible than muscle protein breakdown for the decreases in muscle mass during disuse and health aging. Therefore, nutritional interventions that reduce oxidation or inflammation in conjunction with higher protein intakes that overcome the anabolic resistance may enhance the MPS response to feeding and either increase muscle mass or attenuate loss. In preliminary studies, antioxidant vitamins and amino acids with antioxidant or anti-inflammatory properties show potential to restore the anabolic response associated with protein ingestion. More research, however, is required to investigate if these nutrients translate to increases in MPS and, ultimately, increased lean mass in aging humans. The purpose of the present review is to discuss the role of protein/EAA intake to enhance postprandial MPS during conditions associated with muscle loss, and bring new perspectives and challenges associated nutritional interventions aimed to optimize the anabolic effects of dietary protein/EAAs ingestion.

β-Hydroxy-β-methylbutyrate (HMB) is a leucine-derived compound with anabolic and anticatabolic properties that may improve both clinical and performance outcomes. Clinically, HMB supplementation has been shown to decrease muscle proteolysis and spare muscle mass during catabolic states associated with muscle wasting syndromes. In resistance training studies, HMB may promote enhanced gains in muscle mass and strength. When evaluating the potential effects of HMB, dosage, form (calcium and the free acid form), and subject status (atrophic or anabolic states) must be taken into consideration. This chapter aims to describe general scientific evidence on HMB supplementation with regard to clinical outcomes, as well as their effects associated with resistance training and other sports. Possible mechanisms of action are also discussed in detail, based on the physiological, biochemical, and cellular/molecular literature.

Human muscle hypertrophy brought about by voluntary exercise in laboratorial conditions is the most common way to study resistance exercise training, especially because of its reliability, stimulus control and easy application to resistance training exercise sessions at fitness centers. However, because of the complexity of blood factors and organs involved, invasive data is difficult to obtain in human exercise training studies due to the integration of several organs, including adipose tissue, liver, brain and skeletal muscle. In contrast, studying skeletal muscle remodeling in animal models are easier to perform as the organs can be easily obtained after euthanasia; however, not all models of resistance training in animals displays a robust capacity to hypertrophy the desired muscle. Moreover, some models of resistance training rely on voluntary effort, which complicates the results observed when animal models are employed since voluntary capacity is something theoretically impossible to measure in rodents. With this information in mind, we will review the modalities used to simulate resistance training in animals in order to present to investigators the benefits and risks of different animal models capable to provoke skeletal muscle hypertrophy. Our second objective is to help investigators analyze and select the experimental resistance training model that best promotes the research question and desired endpoints. J. Cell. Physiol. 229: 1148–1156, 2014. © 2013 Wiley Periodicals, Inc.