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Your search keyword '"Jason W. Wang"' showing total 3 results
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3 results on '"Jason W. Wang"'

1. An enantioselective and modular platform for C4ʹ-modified nucleoside analogue synthesis enabled by intramolecular trans-acetalizations

Author

Thirupathi Nuligonda, Gautam Kumar, Jason W. Wang, Dinithi Rajapaksha, Ismael A. Elayan, Ramiz Demir, Neil J. Meanwell, Sherrie F. Wang, Lara K. Mahal, Alex Brown, and Michael W. Meanwell

Subjects
Science
Abstract

Abstract C4ʹ-modified nucleoside analogues continue to attract global attention for their use in antiviral drug development and oligonucleotide-based therapeutics. However, current approaches to C4ʹ-modified nucleoside analogues still involve lengthy (9–16 steps), non-modular routes that are unamenable to library synthesis. Towards addressing the challenges associated with their syntheses, we report a modular 5-step process to a diverse collection of C4ʹ-modified nucleoside analogues through a sequence of intramolecular trans-acetalizations of readily assembled polyhydroxylated frameworks. Overall, the 2–3 fold reduction in step-count compares favorably to even recently reported biocatalytic approaches and should ultimately enable new opportunities in drug design around this popular chemotype.

Published
2024
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2. Electrochemical C–F bond activation of trifluoromethylarenes using silylium ions

Author

Subhojit Mondal, Boris Stevanovic, Eric Butler, Jason W. Wang, and Michael W. Meanwell

Subjects
Materials Chemistry, Metals and Alloys, Ceramics and Composites, General Chemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials
Abstract

We report a mild, electrochemical trihydrodefluorination (e-THDF) for breaking highly stable C–F bonds in trifluoromethyl arenes to form the corresponding methyl arene products.

Published
2023
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3. HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing

Author

Somik Chatterjee, John R. Bower, Jason W. Wang, Kenneth Steven Rosenthal, and Mary J. Cismowski

Subjects
Herpesvirus 2, Human, viruses, Gene Expression, Herpesvirus 1, Human, medicine.disease_cause, Virus, Herpesviridae, Viral Proteins, Viral Envelope Proteins, Virology, Alphaherpesvirinae, Chlorocebus aethiops, medicine, Animals, Cloning, Molecular, Vero Cells, Gene, chemistry.chemical_classification, biology, General Medicine, biology.organism_classification, Herpesvirus glycoprotein B, Molecular biology, Herpes simplex virus, chemistry, Vero cell, Glycoprotein, Protein Processing, Post-Translational
Abstract

The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.

Published
2009
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