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1. The time of diagnosis impacts surgical management but not the outcome of patients with gallbladder Carcinoma

Author

Löhe F, Meimarakis G, Schauer C, Angele M, Jauch KW, and Schauer RJ

Subjects
Gallbladder cancer, Surgery, Follow up, Prognosis, Medicine
Abstract

Abstract Background Only 50% of gallbladder cancers (GBC) are recognized before operation and the remaining tumors are diagnosed during surgery or afterwards by the pathologist. These situations may demand substantial modifications of the proceeding during surgery as well as the need for reoperation in some cases. Therefore, the time of diagnosis may strongly influence the surgical management of GBC and the prognosis of the patients. Methods Records and follow-up of 152 patients with gallbladder carcinoma who underwent surgery between 1980 and 2004 were examined according to the time of diagnosis, TNM staging system, surgical procedures, morbidity and predictors of survival. There were 76 patients with preoperative diagnosis of GBC (50%; group1), 44 patients with intraoperative diagnosis (29%; group 2) and 32 patients (21%; group 3) with postoperatively incidental finding of GBC. In all cases radical resection of the GBC was intended, except in 5 patients from group 1. Surgical procedures comprised from simple cholecystectomy to multivisceral resections. Results Overall 5-year survival rate was 7% with a significantly better median survival in group 3 (53.2 month), when compared to only 6.1 month (group 2) and 5.4 month (group 1), respectively. Findings at operation forced significant modifications of the surgical strategy in 85%. Complete resection of GBC was achieved in 38% of the patients. Stage- dependent survival was comparable between the groups following R0 resection. Tumor stage, in particular the nodal status and radicality of the procedure, but not the time of diagnosis were the most powerful predictors of outcome. Conclusions Complete tumor resection may provide long-term survival even in locally advanced GBC. Although the time of diagnosis of GBC causes significant changes of the intended procedures during and after surgery, it has no influence on the prognosis provided that radical (R0) resection was accomplished.

Published
2009
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2. Surgical management of splenic echinococcal disease

Author

Meimarakis G, Grigolia G, Loehe F, Jauch KW, and Schauer RJ

Subjects
hydatid disease, spleen, surgical therapy, follow- up, Medicine
Abstract

Abstract Background Infection of the spleen with echinococcus is a rare clinical entity. Because the diagnosis of a splenic infestation with echinococcus is sometimes delayed, large hydatid cysts or pseudotumors may develop, demanding a differential surgical approach to cure the disease. Methods In a retrospective study 10 patients out of 250 with abdominal echinococcosis (4%) were identified to have splenic infestation, either limited to the spleen (n = 4) or with synchronous involvement of the liver (n = 4), major omentum (n = 1), or the liver and lung (n = 1). Only one patient had alveolar echinococcosis whereas the others showed hydatid cysts of the spleen. Surgical therapy included splenectomy in 7 patients or partial cyst excision combined with omentoplasty in 3 patients. In case of liver involvement, pericystectomy was carried out simultaneously. Results There was no mortality. Postoperative complications were observed in 4 patients. Hospital stay and morbidity were not influenced when splenic procedures were combined with pericystectomies of the liver. Mean follow- up was 8.8 years and all of the patients are free of recurrence at this time. Conclusions Splenectomy should be the preferred treatment of hydatid cysts but partial cystectomy is suitable when the cysts are located at the margins of the spleen. Due to low morbidity rates, simultaneous treatment of splenic and liver hydatid cysts is recom mended.

Published
2009
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3. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial

Author

Nordlinger, B, Sorbye, H, Glimelius, B, Poston, Gj, Schlag, Pm, Rougier, P, Bechstein, Wo, Primrose, Jn, Walpole, Et, FINCH JONES, M, Jaeck, D, Mirza, D, Parks, Rw, Collette, L, Praet, M, Bethe, U, VAN CUTSEM, E, Scheithauer, W, Gruenberger, T, Hohenberger, W, Iveson, T, Karner, J, Levi, J, Hugh, T, DE GREVE, J, Chan, A, Davidson, B, Lindner, P, Peeters, M, Stein, B, Diamond, T, Ducreux, M, Lasser, P, Graeven, U, Paillot, B, Doran, J, Gouillat, C, Iesalnieks, I, Jauch, Kw, JAGOT LACOUSSIERE, P, Jansen, Rl, Koehne, H, Konopke, R, Otto, F, Sherlock, D, VAN HAZEL, G, Ackland, S, Bedenne, L, Bories, E, CLAVERO FABRI MC, Conroy, T, KAMINSKY FORRETT MC, Husseini, F, Karapetis, C, Mãœller, L, Price, T, Rosenberg, R, Schott, J, Tschmelitsch, J, VAN LAETHEM JL, Wals, J, Weimann, A, Arnaud, Jp, Arsene, D, Auby, D, Bhattacharya, S, Cebon, E, Cherqui, D, Confente, C, Dousset, B, Frickhofen, N, Frilling, A, Evan, P, Ganju, V, Hã–ffken, K, Lazorthes, F, Letoublon, C, Madroszyk, A, Nitti, Donato, Orr, B, Pariente, Ea, Pector, Jc, Raoul, Jl, Rees, M, Ridwelski, K, Rouanet, P, Toogood, Gj, Vergauwe, P, Wilke, Hj, Kaplan, R, Horiot, Jc, Littbrand, B, Awada, A, Stenning, S, Lejeune, F., Haukeland University Hospital, University of Bergen (UiB), Uppsala Universitet [Uppsala], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre de Chirurgie Viscérale, Hépatique et de Transplantation Multiorganes, Université Louis Pasteur - Strasbourg I, European Organisation for Research and Treatment of Cancer [Bruxelles] (EORTC), European Cancer Organisation [Bruxelles] (ECCO), University Hospitals Leuven [Leuven], Centre Énergétique et Procédés (CEP), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), and Université d'Angers (UA)

Subjects
Adult, Male, medicine.medical_specialty, Organoplatinum Compounds, Colorectal cancer, [SDV]Life Sciences [q-bio], 030230 surgery, Perioperative Care, 03 medical and health sciences, 0302 clinical medicine, Hepatic arterial infusion, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Aged, business.industry, Liver Neoplasms, Hazard ratio, Cancer, General Medicine, Perioperative, Middle Aged, medicine.disease, Combined Modality Therapy, 3. Good health, Surgery, Oxaliplatin, Clinical trial, 030220 oncology & carcinogenesis, Female, Fluorouracil, Colorectal Neoplasms, Liver cancer, business, medicine.drug
Abstract

Summary Background Surgical resection alone is regarded as the standard of care for patients with liver metastases from colorectal cancer, but relapse is common. We assessed the combination of perioperative chemotherapy and surgery compared with surgery alone for patients with initially resectable liver metastases from colorectal cancer. Methods This parallel-group study reports the trial's final data for progression-free survival for a protocol unspecified interim time-point, while overall survival is still being monitored. 364 patients with histologically proven colorectal cancer and up to four liver metastases were randomly assigned to either six cycles of FOLFOX4 before and six cycles after surgery or to surgery alone (182 in perioperative chemotherapy group vs 182 in surgery group). Patients were centrally randomised by minimisation, adjusting for centre and risk score. The primary objective was to detect a hazard ratio (HR) of 0·71 or less for progression-free survival. Primary analysis was by intention to treat. Analyses were repeated for all eligible (171 vs 171) and resected patients (151 vs 152). This trial is registered with ClinicalTrials.gov, number NCT00006479. Findings In the perioperative chemotherapy group, 151 (83%) patients were resected after a median of six (range 1–6) preoperative cycles and 115 (63%) patients received a median six (1–8) postoperative cycles. 152 (84%) patients were resected in the surgery group. The absolute increase in rate of progression-free survival at 3 years was 7·3% (from 28·1% [95·66% CI 21·3–35·5] to 35·4% [28·1–42·7]; HR 0·79 [0·62–1·02]; p=0·058) in randomised patients; 8·1% (from 28·1% [21·2–36·6] to 36·2% [28·7–43·8]; HR 0·77 [0·60–1·00]; p=0·041) in eligible patients; and 9·2% (from 33·2% [25·3–41·2] to 42·4% [34·0–50·5]; HR 0·73 [0·55–0·97]; p=0·025) in patients undergoing resection. 139 patients died (64 in perioperative chemotherapy group vs 75 in surgery group). Reversible postoperative complications occurred more often after chemotherapy than after surgery (40/159 [25%] vs 27/170 [16%]; p=0·04). After surgery we recorded two deaths in the surgery alone group and one in the perioperative chemotherapy group. Interpretation Perioperative chemotherapy with FOLFOX4 is compatible with major liver surgery and reduces the risk of events of progression-free survival in eligible and resected patients. Funding Swedish Cancer Society, Cancer Research UK, Ligue Nationale Contre le Cancer, US National Cancer Institute, Sanofi-Aventis.

Published
2008
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4. Chirurgische Therapie des Pankreaskarzinoms

Author

Jauch Kw and Bruns Cj

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Splenectomy, Magnetic resonance imaging, General Medicine, Anastomosis, Pancreaticoduodenectomy, medicine.disease, Quality of life, Pancreatic cancer, medicine, Radiology, Surgical treatment, business, Survival rate
Published
2007
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5. Predictive value of early postoperative MELD scores on patient and graft survival after liver transplantation

Author

Khandoga, A, Iskandarov, E, Rentsch, M, Angele, M, Jauch, KW, Werner, J, and Guba, M

Subjects
body regions, ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Early allograft dysfunction after liver transplantation is not well defined. The aim of this study was to evaluate predictive value of early postoperative MELD scores on 3- and 12-months survival. Material and methods: In this single center retrospective study, 362 consecutive patients[for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2015
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6. Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial

Author

Geissler, E, Schnitzbauer, A, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, van Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, de Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Mirza, D, Otto, G, Mazzaferro, V, Neuhaus, P, Schlitt, H, Geissler EK, Schnitzbauer AA, Zulke C, Lamby PE, Proneth A, Duvoux C, Burra P, Jauch KW, Rentsch M, Ganten TM, Schmidt J, Settmacher U, Heise M, Rossi G, Cillo U, Kneteman N, Adam R, van Hoek B, Bachellier P, Wolf P, Rostaing L, Bechstein WO, Rizell M, Powell J, Hidalgo E, Gugenheim J, Wolters H, Brockmann J, Roy A, Mutzbauer I, Schlitt A, Beckebaum S, Graeb C, Nadalin S, Valente U, Turrion VS, Jamieson N, Scholz T, Colledan M, Fandrich F, Becker T, Soderdahl G, Chazouilleres O, Makisalo H, Pageaux GP, Steininger R, Soliman T, de Jong KP, Pirenne J, Margreiter R, Pratschke J, Pinna AD, Hauss J, Schreiber S, Strasser S, Klempnauer J, Troisi RI, Bhoori S, Lerut J, Bilbao I, Klein CG, Konigsrainer A, Mirza DF, Otto G, Mazzaferro V, Neuhaus P, Schlitt HJ, Geissler, E, Schnitzbauer, A, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, van Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, de Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Mirza, D, Otto, G, Mazzaferro, V, Neuhaus, P, Schlitt, H, Geissler EK, Schnitzbauer AA, Zulke C, Lamby PE, Proneth A, Duvoux C, Burra P, Jauch KW, Rentsch M, Ganten TM, Schmidt J, Settmacher U, Heise M, Rossi G, Cillo U, Kneteman N, Adam R, van Hoek B, Bachellier P, Wolf P, Rostaing L, Bechstein WO, Rizell M, Powell J, Hidalgo E, Gugenheim J, Wolters H, Brockmann J, Roy A, Mutzbauer I, Schlitt A, Beckebaum S, Graeb C, Nadalin S, Valente U, Turrion VS, Jamieson N, Scholz T, Colledan M, Fandrich F, Becker T, Soderdahl G, Chazouilleres O, Makisalo H, Pageaux GP, Steininger R, Soliman T, de Jong KP, Pirenne J, Margreiter R, Pratschke J, Pinna AD, Hauss J, Schreiber S, Strasser S, Klempnauer J, Troisi RI, Bhoori S, Lerut J, Bilbao I, Klein CG, Konigsrainer A, Mirza DF, Otto G, Mazzaferro V, Neuhaus P, and Schlitt HJ

Abstract

Background.We investigated whether sirolimus-based immunosuppression improves outcomes in liver transplantation (LTx) candidates with hepatocellular carcinoma (HCC). Methods. In a prospective-randomized open-label international trial, 525 LTx recipients with HCC initially receiving mammalian target of rapamycin inhibitor-free immunosuppression were randomized 4 to 6 weeks after transplantation into a group on mammalian target of rapamycin inhibitor-free immunosuppression (group A: 264 patients) or a group incorporating sirolimus (group B: 261). The primary endpoint was recurrence-free survival (RFS); intention-To-Treat (ITT) analysis was conducted after 8 years. Overall survival (OS) was a secondary endpoint. Results. Recurrence-free survival was 64.5% in group A and 70.2% in group B at study end, this difference was not significant (P = 0.28; hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.62; 1.15). In a planned analysis of RFS rates at yearly intervals, group B showed better outcomes 3 years after transplantation (HR, 0.7; 95% CI, 0.48-1.00). Similarly, OS (P = 0.21; HR, 0.81; 95% CI, 0.58-1.13) was not statistically better in group B at study end, but yearly analyses showed improvement out to 5 years (HR, 0.7; 95% CI, 0.49-1.00). Interestingly, subgroup (Milan Criteria-based) analyses revealed that low-risk, rather than high-risk, patients benefited most fromsirolimus; furthermore, younger recipients (age ≤60) also benefited, as well sirolimus monotherapy patients. Serious adverse event numbers were alike in groups A (860) and B (874). Conclusions. Sirolimus in LTx recipients with HCC does not improve long-Term RFS beyond 5 years. However, a RFS and OS benefit is evident in the first 3 to 5 years, especially in low-risk patients. This trial provides the first high-level evidence base for selecting immunosuppression in LTx recipients with HCC.

Published
2016

8. Aspirin targeting stem like side population cells in human esophageal cancer cells and its effect on chemoresistance

Author

Zhao, Y, Wang, Y, Schwarz, B, Zhao, L, Tichmacher, A, Mysliwietz, J, Ellwart, J, Bao, Q, Nieß, H, Modest, D, Camaj, P, Angele, MK, Jauch, KW, Nelson, P, and Bruns, CJ

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Taking aspirin was reported to prevent the development of both esophageal squamous cell cancer and adenocarcinoma. Some researchers indicated that aspirin could induce tumor cells apoptosis and might modulate cancer stem cells regulation through the Wnt/beta-catenin pathway. Previous[for full text, please go to the a.m. URL], 131. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2014
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9. Chirurgie und Pathologie: Gemeinsame Verantwortlichkeit im Biobanking für die translationale Forschung

Author

Thasler, W, Thasler, R, Schelcher, C, and Jauch, KW

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die biomedizinische Forschung ist in steigendem Maß von der Verfügbarkeit von bis auf molekularer Ebene möglichst intakte menschliche Bioproben in Verbindung mit für ihre wissenschaftliche Nutzung entsprechend aufbereiteten klinischen Daten angewiesen. Dies ist insbesondere[for full text, please go to the a.m. URL], 131. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2014
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10. Augmenter of Liver Regeneration attenuates CD4+ T cell recruitment and hepatocellular injury after ischemia-reperfusion of the liver

Author

Khandoga, A, Iskandarov, E, Mende, K, Rosentreter, D, Shelcher, C, Jauch, KW, Rentsch, M, and Thasler, W

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Augmenter of Liver Regeneration (ALR), a protein synthesized in the liver is suggested to be protective against oxidative stress-induced cell death. Hepatic ischemia-reperfusion (I/R) injury is triggered by reactive oxygen species. CD4+ T cells play a critical role during hepatic[for full text, please go to the a.m. URL], 131. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2014
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11. Multiviszerale Resektionen bei fortgeschrittenen Tumoren im Abdominalbereich – Risikofaktoren für Morbidität, Mortalität und Langzeitüberleben

Author

Nieß, H, Rolink, G, Angele, MK, Kleespies, A, Jauch, KW, and Bruns, CJ

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Multiviszerale Resektionen (MVR) können bei ausgewählten Patienten mit fortgeschrittenen Tumoren der Abdominalhöhle die einzig kurative Therapieoption darstellen. Allerdings gehen diese Eingriffe mit gesteigerter Morbidität und Mortalität einher und beinhalten in[for full text, please go to the a.m. URL], 131. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2014
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12. TOP-Studie: Keine Reduktion des Ischämie-Reperfusionsschadens nach Lebertransplantation marginaler Organe durch Tacrolimus Vorbehandlung

Author

Pratschke, S, Ott, M, Eder, M, Heise, M, Pascher, A, Schemmer, P, Scherer, M, Guba, M, Jauch, KW, and Angele, MK

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Experimentelle Studien im Rattenmodell zeigen eine Reduktion des Ischämie-Reperfusionsschadens nach Lebertransplantation durch eine Tacrolimus Vorbehandlung. Die Transplantation marginaler Organe ist mit einer Zunahme des Ischämie-Reperfusionsschadens verbunden. Basierend auf[for full text, please go to the a.m. URL], 131. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2014
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13. Leberresektionen bei Patienten älter als 70 Jahre: Risikofaktoren und Langzeit-Überleben

Author

Schiergens, TS, Schreiber, S, Müller, TH, Stielow, C, Rentsch, M, Jauch, KW, and Thasler, W

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die mit der steigenden Lebenserwartung einhergehende Alterung der Bevölkerung in den westlichen Nationen und die zunehmende Inzidenz hepatobiliärer Tumore sowie hepatischer Metastasen haben zu einem enormen Zuwachs älterer Patienten geführt, bei denen die Indikation zu[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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14. Frühpostoperative Ergebnisse nach laparoskopisch-assistierter Proktokolektomie und J-Pouch Rekonstruktion

Author

Kasparek, M, Dehos, S, Müller, M, Thasler, W, Jauch, KW, and Kreis, ME

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Proktokolektomie und J-Pouch-Anlage ist das Standardverfahren für Patienten bei operationsbedürftiger Colitis ulcerosa. Diese Operation kann in laparoskopischer und offener Technik erfolgen. Ziel unserer Untersuchung war es anhand der eigenen Patienten zu klären, ob diese[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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15. Surgical Decompression is a Prerequisite for the Beneficial Effect of Statin Therapy in Renal Ischemia-Reperfusion Injury

Author

Wagner, A, Schupp, N, Wang, H, Bartenstein, P, Hacker, M, Jauch, KW, Guba, M, and Herrler, T

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: The aim of this study is to determine the effect of statins alone and in combination with microcapsulotomy on renal ischemia-reperfusion (I/R) injury. As chronic inflammatory reactions predispose to fibrosis and dysfunction, the impact on macrophages as the characteristic cell type[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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16. Multiviszerale Resektionen in der onkologischen Chirurgie – Einfluss der Pankreasresektion auf die Morbidität

Author

Nieß, H, Rolink, G, Angele, M, Kleespies, A, Jauch, KW, and Bruns, CJ

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Bei lokal fortgeschrittenen Tumorerkrankungen stellen multiviszerale Resektionen (MVR) häufig die einzig kurative Therapieoption dar. In zunehmendem Maße beinhalten MVR Pankreasresektionen. Allerdings ist der Einfluss des Faktors "Pankreasresektion" auf die ohnehin schon[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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17. Resektion von Pankreassarkomen: Selten aber onkologisch sinnvoll

Author

Renz, BW, Mikhailov, M, Schiergens, T, Niess, H, Westphalen, CB, Jauch, KW, Bruns, CJ, Angele, M, and Kleespies, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Sowohl primäre als auch sekundäre Sarkome des Pankreas stellen äußerst seltene Weichgewebs-Neoplasien des Abdomens bzw. Retroperitoneums dar. Ziel der vorliegenden Studie war die Analyse des perioperativen Verlaufs und der Langzeit-Ergebnisse nach onkologischer Resektion[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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18. Platelet sequestration correlates with cold ischemia time and hepatocellular injury after liver transplantation

Author

Khandoga, A, Iskandarov, E, Mende, K, Jauch, KW, Rentsch, M, and Guba, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Experimental studies provide evidence that i) platelets accumulate in the postischemic liver and play a critical role for ischemia-reperfusion (I/R) injury, ii) interventions against platelet recruitment reduce hepatocellular damage and improve postoperative survival in various models[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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19. Augmenter of Liver Regeneration (ALR) expression in hepatocellular carcinomas may decrease the efficacy of chemotherapeutic treatment regimens

Author

Lee, S, Schelcher, C, Löwen, N, Jauch, KW, and Thasler, W

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Augmenter of Liver Regeneration (ALR) is a protein that carries out cytokine and enzymatic functions. Recently, it has been shown that ALR is expressed in hepatocellular carcinomas to a different extent depending on the grade and invasiveness. Since ALR has been shown to promote liver[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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20. Reduktion der Fistelrate nach Pankreaslinksresektion: das 'Blumgart-Prinzip'

Author

Kleespies, A, Löhe, F, Lowenthal, MM, Renz, B, Jauch, KW, Bruns, CJ, and Angele, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Pankreasfisteln gehören zu den häufigsten Komplikationen nach Pankreaslinksresektion. Unterschiedliche Verschlusstechniken des Pankreasstumpfes werden aktuell diskutiert. Die meißten Nahttechniken sind durch tangentiale Scherkräfte auf Kapsel und Parenchym gekennzeichnet.[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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21. Prätherapeutische Wirkstofftestung für den individuellen Magenkarzinompatienten in der neoadjuvanten Situation

Author

Ilmberger, C, Knäulein, A, Halfter, K, Schirra, J, Joka, M, Jauch, KW, and Mayer, B

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: In der neoadjuvanten Situation beim Magenkarzinom stehen gemäß der S3-Leitlinie eine Vielzahl verschiedener Therapieoptionen zur Verfügung. Hierzu gehören Capecitabin, 5-FU kombiniert mit Cisplatin oder Oxaliplatin, Irinotecan und zusätzlich Epirubicin. Dabei drängt[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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22. Pankreaskopfkarzinom im hohen Alter: Morbidität und Langzeitüberleben nach onkologischer Resektion

Author

Kleespies, A, Renz, BW, Khalil, PN, Nieß, H, Mikhailov, M, Jauch, KW, Angele, M, and Bruns, CJ

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die chirurgische Therapie älterer Patienten ist zur klinischen Routine geworden. Auch in Pankreaszentren werden zunehmend hochbetagte Patienten einer Operation zugeführt. Die spezifische Komplikationsrate, die Sterblichkeit und das Langzeitüberleben älterer Pat. nach [for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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23. Effects of hyperthermia and chemotherapy on colon cancer stem cells

Author

Zhao, L, Zhao, Y, Schwarz, B, Nieß, H, Jauch, KW, and Bruns, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Peritoneal carcinomatosis (PC) may arise from a variety of tumors but a significant proportion originates from colorectal cancer (CRC). The combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) has shown promising results for the treatment of PC of [for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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24. Perioperative Ergebnisse und Langzeit-Überleben von CED-assoziierten und sporadischen kolorektalen Karzinomen: Eine matched-pair Analyse

Author

Renz, B, Thasler, WE, Heide, T, Khalil, PN, Mikhailov, M, Kreis, ME, Jauch, KW, and Kleespies, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Das frühe und gehäufte Auftreten von kolorektalen Karzinomen (CRC) bei Patienten mit chronisch entzündlicher Darmerkrankung (CED) ist bekannt. Ziel unserer Studie war der direkte Vergleich des perioperativen- und Langzeit-Verlaufs von CED assoziierten (CED-CRC) und sporadischen[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012
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25. Perioperative transfusion requirements and graft survival in patients with pancreas retransplantation – a retrospective study

Author

Fertmann, JM, Arbogast, HP, Jauch, KW, and Hoffmann, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Blood transfusion has been characterised as a negative predictive factor for graft and patient survival in liver transplantation. Pancreas retransplantation is sometimes technically challenging due to retroperitoneal adhesions and iliac arteries compromised by arteriosclerosis, and can[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012
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26. Prädiktoren für das Überleben von Patienten mit pulmonalen Metastasen eines Weichgewebssarkoms

Author

Fertmann, J, Meimarakis, G, Angele, M, Spelsberg, F, Eichhorn, M, Jauch, KW, Hatz, R, and Winter, H

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Ziel der vorliegenden Studie war es, prognostische Faktoren bei Patienten mit pulmonalen Metastasen eines Weichgewebssarkoms zu identifizieren. Methoden: Zwischen 3/1980 und 07/2009 wurden in 95 Patienten mit primärem malignem Weichgewebstumor nach Resektion von pulmonalen[for full text, please go to the a.m. URL], 21. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie

Published
2012
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27. Einsatz des NO-Donors Nitroglycerin in der Transplantation marginaler Lebern: Verringerung des Ischämie-Reperfusionsschadens?

Author

Pratschke, S, Meimarakis, G, Guba, M, Jauch, KW, Löhe, F, and Angele, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Experimentelle Studien zeigen protektive Eigenschaften von NO-Donoren auf den Ischämie-Reperfusionsschaden nach Transplantation solider Organe. Aufgrund des herrschenden Organmangels werden in zunehmendem Maß marginale Organe transplantiert, die mit einem vermehrten Ischämie-Reperfusions[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012
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28. Spiegelmer based blockade of SDF1/CXCR4-interaction inhibits chronic transplant vasculopathy by inhibition of vascular smooth muscle cell proliferation

Author

Thomas, M, Kalnins, A, Andrassy, M, Tischer, A, Rentsch, M, Fischereder, M, Jauch, KW, Guba, M, and Andrassy, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Chronic transplant vasculopathy remains one of the major obstacles in transplant medicine. Efficient therapeutic strategies are lacking. Recent studies suggest a crucial role of the chemokine SDF-1 on neointima formation. Spiegelmers are mirror-image oligonucleotides that are able to bind[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012
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29. Bench to bedside: Zwischenbericht zur TOP-Studie bei Transplantation marginaler Lebern

Author

Angele, M, Pratschke, S, Eder, M, and Jauch, KW

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die zunehmende Transplantation marginaler Lebern auf Grund eines Organmangels ist mit einer Verschlechterung des Transplantationsergebnisses verbunden. Auf dem Boden eigener experimenteller Vorarbeiten zu einer ex vivo Tacrolimus Behandlung bei Lebertransplantation wurde die TOP-Studie (Tacrolimus[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012
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30. Anteil histologisch nachweisbarer IPMN bei Patienten mit der initialen Verdachtsdiagnose IPMN des Pankreas

Author

Rentsch, M, Oedekoven, R, Kleespies, A, Angele, M, Jauch, KW, and Bruns, CJ

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die intraduktale papillär-muzinöse Neoplasie (IPMN) stellt eine Form der selten auftretenden zystischen, intraduktalen Tumoren des Pankreas dar. Derzeit wird angenommen, dass etwa 50% der Tumore nach langem intraduktalem Wachstum invasiv werden können. Allerdings ist[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012
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48. Targeting tumor stroma and angiogenesis using suicide-gene carrying mesenchymal stem cells results in reduced tumor growth in hepatocellular carcinoma

Author

Nieß, H, Bao, Q, Schwarz, B, Jauch, KW, Nelson, P, and Bruns, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Mesenchymal stem cells (MSCs) are actively recruited to the stroma of some growing epithelial tumours and trans-differentiate into tumor-associated cells. MSC promote tumour growth and the formation of metastases in vivo by participating in angiogenesis and by expression of the chemotactic[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
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49. Hepatic protection of growth factors against ethanol toxicity

Author

Ilowski, M, Lee, S, Rentsch, M, Jauch, KW, and Thasler, W

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: The liver is a highly metabolic organ with a great potential of regeneration. Besides mitogenic signals via growth factors, liver regeneration is also triggered by metabolites and anti-apoptotic mechanisms. The aim of this study was to investigate a possible protective effect of growth[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
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50. VATS-Ösophagektomie

Author

Bruns, C, Winter, H, Wimmer, C, Angele, MK, Eichhorn, E, Fertmann, J, Hatz, R, and Jauch, KW

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die potentiell kurative Ösophagusresektion ist nur dann für den Patienten sinnvoll, wenn sie einerseits mit geringer Früh-Morbidität und Letalität verbunden ist (transhiatale Ösophagektomie, THE), andererseits die onkologische Radikalität bedingt durch [for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
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