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3. Molecular Investigation of Occult Hepatitis B Virus Infection Among Patients with Liver Cancers

Author

Javanmard, Davod, primary, Marjani, Arezoo, additional, Karbalaie Niya, Mohammad Hadi, additional, Tavakoli, Ahmad, additional, Kiani, Seyed Jalal, additional, Fatemipour, Maryam, additional, Hoseyni, Mahdieh, additional, Bokharaei-Salim, Farah, additional, Panahi, Mahshid, additional, Alborzi, Ehsan, additional, Hosseini Fakhr, Somayeh Sadat, additional, and Monavari, Seyed Hamidreza, additional

Published
2023
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7. Implementation of an In-House Platform for Rapid Screening of SARS-CoV-2 Genome Variations

Author

Zare Ashrafi, Farzane, primary, Mohseni, Marzieh, additional, Beheshtian, Maryam, additional, Fattahi, Zohreh, additional, Ghodratpour, Fatemeh, additional, Keshavarzi, Fatemeh, additional, Behravan, Hanieh, additional, Kalhor, Marzieh, additional, Jalalvand, Khadijeh, additional, Azad, Maryam, additional, Koshki, Mahdieh, additional, Jafarpour, Ali, additional, Ghaziasadi, Azam, additional, Abdollahi, Alireza, additional, Kiani, Seyed Jalal, additional, Ataei-Pirkooh, Angila, additional, Rezaei Azhar, Iman, additional, Bokharaei-Salim, Farah, additional, Haghshenas, Mohammad Reza, additional, Babamahmoodi, Farhang, additional, Mokhames, Zakiye, additional, Soleimani, Alireza, additional, Ziaee, Masood, additional, Javanmard, Davod, additional, Ghafari, Shokouh, additional, Ezani, Akram, additional, Ansari Moghaddam, Alireza, additional, Shahraki-Sanavi, Fariba, additional, Hashemi Shahri, Seyed Mohammad, additional, Azaran, Azarakhsh, additional, Yousefi, Farid, additional, Moattari, Afagh, additional, Moghadami, Mohsen, additional, Fakhim, Hamed, additional, Ataei, Behrooz, additional, Nasri, Elahe, additional, Poortahmasebi, Vahdat, additional, Varshochi, Mojtaba, additional, Mojtahedi, Ali, additional, Jalilian, Farid, additional, Khazeni, Mohammad, additional, Moradi, Abdolvahab, additional, Tabarraei, Alijan, additional, Piroozmand, Ahmad, additional, Yahyapour, Yousef, additional, Bayani, Masoumeh, additional, Aboofazeli, Amir, additional, Ghafari, Parsa, additional, Keramat, Fariba, additional, Tavakoli, Mahsa, additional, Jalali, Tahmineh, additional, Pouriayevali, Mohammad Hassan, additional, Salehi-Vaziri, Mostafa, additional, Khorram Khorshid, Hamid Reza, additional, Najafipour, Reza, additional, Malekzadeh, Reza, additional, Kahrizi, Kimia, additional, Jazayeri, Seyed Mohammad, additional, and Najmabadi, Hossein, additional

Published
2023
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8. Evaluation of Cellular miR-122 Expression in Association with the Presence of Varicella-Zoster Virus among Central Nervous System Tumors

Author

Abbasi, Aida, primary, Sadri Nahand, Javid, additional, Moghoofei, Mohsen, additional, Esghaei, Maryam, additional, Javanmard, Davod, additional, Karbalaie Niya, Mohammad Hadi, additional, Sadeghi, Farzin, additional, Bokharaei-Salim, Farah, additional, Karimzadeh, Mohammad, additional, Khodayari, Amirhossein, additional, and Keyvani, Hossein, additional

Published
2022
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9. Prevalence of Human Cytomegalovirus Infection in Iranian Prostate Cancer Patients.

Author

Alborzi, Ehsan, Tavakoli, Ahmad, Kiani, Seyed Jalal, Ghorbani, Saied, Javanmard, Davod, Sabaei, Milad, Fatemipour, Maryam, and Monavari, Seyed Hamidreza

Subjects
PHYLOGENY, CYTOMEGALOVIRUS diseases, CASE-control method, TUMOR classification, COMPARATIVE studies, GENOMICS, DISEASE prevalence, GENOTYPES, DESCRIPTIVE statistics, RESEARCH funding, POLYMERASE chain reaction, DATA analysis software, PROSTATE-specific antigen, PROSTATE tumors
Abstract

Background and Aim: Human cytomegalovirus (HCMV) has the potential for oncogenicity and has been associated with many malignancies, including prostate cancer. This study aimed to investigate the genomic prevalence of HCMV in prostate cancer tumors. Materials and Methods: In this case-control study, 31 patients with prostate cancer were enrolled along with 31 patients with benign prostate cancer as the control group. The presence of the HCMV genome was assessed using real-time polymerase chain reaction (PCR). The nested PCR test was also used to detect the UL55 virus gene. Purified PCR products were sequenced using the Sanger method by a commercial service provider (Pishgam Co.), and the results were analyzed using Chromase software. Results: The overall mean (±SD) prostate-specific antigen (PSA) value was 9 (±7.8) ng/Ml in patients with different stages of prostate cancer, and 9 (±3) ng/Ml in the control group (P=0.09). The prevalence of HCMV DNA was 19.3% (n=6) in the case group, and 6.5% (n=2) in the control group (P=0.14). The highest prevalence was observed in stage IIA (33.3%), followed by stages III (25%), and IIB (12.5%) (P=0.016). There were close phylogenetic relationships between Iranian HCMV isolates and several reference genotypes - the closest genetic relationship was observed with the KR 534207 genotype. Conclusion: The prevalence of HCMV in the prostate cancer group was markedly higher than that of the control group, although this difference was not significant. However, the higher prevalence of HCMV in prostate cancer patients compared to the control group is indicative of the possible role of HCMV in the development of prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Disease Waves of SARS-CoV-2 in Iran Closely Mirror Global Pandemic Trends

Author

Fattahi, Zohreh, primary, Mohseni, Marzieh, additional, Beheshtian, Maryam, additional, Jafarpour, Ali, additional, Jalalvand, Khadijeh, additional, Keshavarzi, Fatemeh, additional, Behravan, Hanieh, additional, Ghodratpour, Fatemeh, additional, Zare Ashrafi, Farzane, additional, Kalhor, Marzieh, additional, Azad, Maryam, additional, Koshki, Mahdieh, additional, Ghaziasadi, Azam, additional, Soveyzi, Mohamad, additional, Abdollahi, Alireza, additional, Kiani, Seyed Jalal, additional, Ataei-Pirkooh, Angila, additional, Rezaeiazhar, Iman, additional, Bokharaei-Salim, Farah, additional, Haghshenas, Mohammad Reza, additional, Babamahmoodi, Farhang, additional, Mokhames, Zakiye, additional, Soleimani, Alireza, additional, Elahi, Zohreh, additional, Ziaee, Masood, additional, Javanmard, Davod, additional, Ghafari, Shokouh, additional, Ezani, Akram, additional, Ansari Moghaddam, Alireza, additional, Shahraki-Sanavi, Fariba, additional, Hashemi Shahri, Seyed Mohammad, additional, Azaran, Azarakhsh, additional, Yousefi, Farid, additional, Moattari, Afagh, additional, Moghadami, Mohsen, additional, Fakhim, Hamed, additional, Ataei, Behrooz, additional, Nasri, Elahe, additional, Poortahmasebi, Vahdat, additional, Varshochi, Mojtaba, additional, Mojtahedi, Ali, additional, Jalilian, Farid, additional, Khazeni, Mohammad, additional, Moradi, Abdolvahab, additional, Tabarraei, Alijan, additional, Piroozmand, Ahmad, additional, Yahyapour, Yousef, additional, Bayani, Masoumeh, additional, Tavangar, Fatemeh, additional, Yaghoubi, Mahmood, additional, Keramat, Fariba, additional, Tavakoli, Mahsa, additional, Jalali, Tahmineh, additional, Pouriayevali, Mohammad Hassan, additional, Salehi-Vaziri, Mostafa, additional, Khorram Khorshid, Hamid Reza, additional, Najafipour, Reza, additional, Malekzadeh, Reza, additional, Kahrizi, Kimia, additional, Jazayeri, Seyed Mohammad, additional, and Najmabadi, Hossein, additional

Published
2022
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11. Disease waves of SARS-CoV-2 in Iran closely mirror global pandemic trends

Author

Fattahi, Zohreh, primary, Mohseni, Marzieh, additional, Beheshtian, Maryam, additional, Jafarpour, Ali, additional, Jalalvand, Khadijeh, additional, Keshavarzi, Fatemeh, additional, Behravan, Hanieh, additional, Ghodratpour, Fatemeh, additional, Ashrafi, Farzane Zare, additional, Kalhor, Marzieh, additional, Azad, Maryam, additional, Koshki, Mahdieh, additional, Ghaziasadi, Azam, additional, Soveyzi, Mohamad, additional, Abdollahi, Alireza, additional, Kiani, Seyed Jalal, additional, Ataei-Pirkooh, Angila, additional, Rezaeiazhar, Iman, additional, Bokharaei-Salim, Farah, additional, Haghshenas, Mohammad Reza, additional, Babamahmoodi, Farhang, additional, Mokhames, Zakiye, additional, Soleimani, Alireza, additional, Elahi, Zohreh, additional, Ziaee, Masood, additional, Javanmard, Davod, additional, Ghafari, Shokouh, additional, Ezani, Akram, additional, AnsariMoghaddam, Alireza, additional, Shahraki-Sanavi, Fariba, additional, HashemiShahri, Seyed Mohammad, additional, Azaran, Azarakhsh, additional, Yousefi, Farid, additional, Moattari, Afagh, additional, Moghadami, Mohsen, additional, Fakhim, Hamed, additional, Ataei, Behrooz, additional, Nasri, Elahe, additional, Poortahmasebi, Vahdat, additional, Varshochi, Mojtaba, additional, Mojtahedi, Ali, additional, Jalilian, Farid, additional, khazeni, Mohammad, additional, Moradi, Abdolvahab, additional, Tabarraei, Alijan, additional, Piroozmand, Ahmad, additional, Yahyapour, Yousef, additional, Bayani, Masoumeh, additional, Tavangar, Fatemeh, additional, Yaghoubi, Mahmood, additional, Keramat, Fariba, additional, Tavakoli, Mahsa, additional, Jalali, Tahmineh, additional, Pouriayevali, Mohammad Hassan, additional, Salehi-Vaziri, Mostafa, additional, Khorram Khorshid, Hamid Reza, additional, Najafipour, Reza, additional, Malekzadeh, Reza, additional, Kahrizi, Kimia, additional, Jazayeri, Seyed Mohammad, additional, and Najmabadi, Hossein, additional

Published
2021
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13. Expression levels of miR-22, miR-30c, miR-145, and miR-519d and their possible associations with inflammatory markers among patients with coronary artery disease.

Author

Ghorbani, Saied, Sezavar, Seyed Hashem, Bokharaei-Salim, Farah, Ataei-Pirkooh, Angila, Tavakoli, Ahmad, Javanmard, Davod, Sadri-Nahand, Javid, Kiani, Seyed Jalal, Ghaffari, Hadi, Beikzadeh, Leila, Hamidpoor, Latif, and Monavari, Seyed Hamidreza

Subjects
CORONARY artery disease, MICRORNA, ATHEROSCLEROTIC plaque, TRANSFORMING growth factors-beta, MONONUCLEAR leukocytes
Abstract

BACKGROUND: Coronary artery disease (CAD) is a leading cause of death around the world. Micro-ribonucleic acid (miRNA) can be involved in forming of atherosclerotic plaques, inflammation, cholesterol metabolism, and other mechanisms involved in CAD development. This study aimed to evaluate the expression level of miR-22, miR-30c, miR-145, and miR-519d and their possible association with inflammatory markers among patients with CAD. METHODS: The expression level of miR-22, miR-30c, miR-145, miR-519d, interleukin 6 (IL-6), and transforming growth factor beta (TGF-β) was determined in peripheral blood mononuclear cells (PBMCs) from 46 patients with CAD and 39 healthy controls using real-time quantitative polymerase chain reaction (qPCR) assay. RESULTS: 53.8% (n = 21) and 52.2% (n = 24) of controls and cases were men, respectively; the mean age was 59.8 ± 7.4 and 57.0 ± 9.8 years, respectively. The miRNA expression pattern of each group showed significantly different expression profiles. In the CAD patients group, miR-22, miR-30c, and miR-145 were down-regulated compared to the control group. On the opposite, miR-519d was up-regulated in patients with CAD compared to the control group. Our results also showed that the expression levels of IL-6 and TGF-β were up-regulated among patients with CAD compared to the control group. In addition, the expression of miR-145 and miR-519d had a significantly negative and positive correlation with TGF-β and IL-6, respectively. CONCLUSION: The change in expression levels of miR-22, miR-30c, miR-145, and miR-519d in PBMCs of patients with CAD could be considered as a potential biomarker for CAD. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Downregulation of GSK3β and Upregulation of URG7 in Hepatitis B-Related Hepatocellular Carcinoma

Author

Javanmard, Davod, primary, Karbalaie Niya, Mohammad Hadi, additional, Khalafkhany, Davod, additional, Najafi, Mohammad, additional, Ziaee, Masood, additional, Babaei, Mohammad Reza, additional, Kiani, Seyed Jalal, additional, Esghaei, Maryam, additional, Jazayeri, Seyed Mohammad, additional, Panahi, Mahshid, additional, Safarnezhad Tameshkel, Fahimeh, additional, Mehrabi, Maryam, additional, Monavari, Seyed Hamidreza, additional, and Bokharaei-Salim, Farah, additional

Published
2020
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27. microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients

Author

Moghoofei, Mohsen, primary, Bokharaei-Salim, Farah, additional, Esghaei, Maryam, additional, Keyvani, Hossein, additional, Honardoost, Maryam, additional, Mostafaei, Shayan, additional, Ghasemi, Amir, additional, Tavakoli, Ahmad, additional, Javanmard, Davod, additional, Babaei, Farhad, additional, Garshasbi, Saba, additional, and Monavari, Seyed Hamidreza, additional

Published
2018
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33. The Frequency and Typing of Human Papilloma Virus Among Women with Normal and Abnormal Cytology in Southern Khorasan, Eastern Iran

Author

Javanmard, Davod, primary, Namaei, Mohammad Hasan, additional, Haghighi, Fatemeh, additional, Ziaee, Masood, additional, Behravan, Mahmoodreza, additional, Mirzaei, Jamal, additional, Ghanbarzadeh, Nahid, additional, Khazaei, Zohreh, additional, Zangoie, Mahboobeh, additional, Naseh, Narges, additional, Ataei, Marzieh, additional, Sharifzadeh, Gholamreza, additional, Salehabadi, Alireza, additional, and Ghannadkafi, Malaknaz, additional

Published
2017
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35. Epidemiology, risk factors, and molecular characterization of occult hepatitis B infection among anti‐hepatitis B core antigen alone subjects.

Author

Azarkar, Zohreh, Ziaee, Masood, Ebrahimzadeh, Azadeh, Sharifzadeh, Gholamreza, and Javanmard, Davod

Abstract

Objectives: Features of occult hepatitis B virus (HBV) infection among the anti‐hepatitis B core antigen (anti‐HBc) positives have yet to be described in more details. This study aimed to determine the molecular prevalence of occult HBV infection (OBI), and association to risk factors among seropositives for anti‐HBc. Methods: This was part of a community‐based screening project that included 5234 cases. All participants completed a questionnaire on demographic and socio‐epidemiological information. Then, the blood samples were collected and tested for anti‐HBc and HBsAg using ELISA method. To identify OBI, nested‐polymerase chain reaction (PCR) assays were performed for HBV‐S and X genes, and viral load was determined using an in‐house real‐time PCR. Sequencing and phylogenetic analysis have been implemented for genotyping. Results: Overall, 596 cases, positive only for anti‐HBc were included in the study. OBI was detected among 61 cases (10.2%). The genotype and subgenotype of HBV among all of them was D1, except one that was D4. Most of them had low viral loads ranged from 1.2 × 102 to 1.34 × 10 3 copies/mL; 19.6% had undetectable viral loads. Important mutations in surface protein and reverse transcriptase were sI92T, sQ129H, rtL80I, rtS85F, rtL91I. The prevalence of OBI was related to some risk factors, such as tattooing (P = 0.02), sexual activities (P = 0.009), and diabetes (P = 0.031). Conclusion: Our study suggests that OBI should be considered among anti‐HBc seropositive subjects. This form of HBV infection was accompanied with some mutations, risk factors, and diseases. However, further investigations are needed to determine virological importance of documented mutations. [ABSTRACT FROM AUTHOR]

Published
2019
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36. Hepatitis G virus and its prevalence and genotypes in patients with hepatitis B and C in Ahvaz, southwestern Iran

Author

Javanmard Davod, Makvandi Manoochehr, Hajiani Eskandar, and Khalafkhany Davod

Subjects
Hepatitis B virus, biology, business.industry, Hepatitis C virus, virus diseases, General Medicine, Hepatitis B, biology.organism_classification, medicine.disease, medicine.disease_cause, GB virus C, Virology, Virus, digestive system diseases, Reverse transcription polymerase chain reaction, Key words: Hepatitis G virus,hepatitis B virus,hepatitis C virus,prevalence,genotype,reverse transcription polymerase chain reaction, Genotype, biology.protein, medicine, Antibody, business
Abstract

The aim of this study was to determine the prevalence and genotype distribution of hepatitis G virus (HGV, or GB virus C) in patients with hepatitis B and C in Ahvaz, southeastern Iran. Materials and methods: A total of 100 patients were selected; 50 were positive for hepatitis C virus (HCV) and 50 for hepatitis B virus (HBV). HGV status was examined among the HCV- and HBV-positive patients. An enzyme-linked immunosorbent assay (ELISA) kit was used to detect anti-E2 antibody. Nested reverse transcription polymerase chain reaction (RT-PCR) was used for RNA detection from serum samples of chronic hepatitis patients. Sequencing was done to determine genotypes Results: Using the ELISA method, co-infection of HGV with HCV and HBV was determined at 6% and 8%, respectively. RT-PCR showed that co-infection of HGV with HCV and HBV was 22% and 10%, respectively. Based on nucleotide sequencing of PCR products, the predominant genotype of HGV among the samples was 2a. Conclusion: Our study showed that the co-infection rate of HGV in patients with hepatitis B and C was somewhat high and was higher in HCV- than in HBV-infected patients. As our findings and other reports from Iran and neighboring countries indicate, genotype 2 of HGV may be the most common genotype of HGV in Middle Eastern countries.

Published
2014

38. Detection of Chlamydia trachomatis in Pap Smear Samples from South Khorasan Province of Iran.

Author

Javanmard, Davod, Behravan, Mahmoodreza, Ghannadkafi, Malaknaz, Salehabadi, Alireza, Ziaee, Masood, and Namaei, Mohammad Hasan

Subjects
*FEMALE reproductive organ diseases, *CHLAMYDIA trachomatis, *CYTOLOGY, *GYNECOLOGIC examination, *PAP test, *PAPILLOMAVIRUSES, *POLYMERASE chain reaction, *SEXUALLY transmitted diseases, *CROSS-sectional method, *SEQUENCE analysis, *GENOTYPES, *MIXED infections, *DIAGNOSIS
Abstract

Background: Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection (STI), leads to pelvic inflammatory disease, infertility and chronic pelvic pain in women as well as an increased risk of vertical transmission, conjunctivitis and pneumonitis in infants. It may also be a co-factor along with human papillomavirus (HPV) in cervical cancer progression. We aimed to determine the prevalence of CT genotypes in genital specimens of women from South Khorasan, Iran and to test the association between CT and cytology statistics. Materials and Methods: This was a cross-sectional study on 248 Pap smear samples from women who visited a gynecologist for routine Pap smear testing in South Khorasan province. Nested polymerase chain reaction (PCR) was used to test the residual fluids of Pap smears for CT-DNA after cytological examination. Direct sequencing, alignment and phylogenic analyses were performed on eight samples to identify their genotypes. Results: The mean age of patients was 37.54 ± 5.21 years. Most samples had a normal cytology (214 cases, 86.29%). Overall, 31 samples were positive for CT infection (12.5%) of which 20 (9.34%) were normal and 11 (32.35%) were abnormal, with the frequency difference being significant (P=0.022). The co-infection of CT/HPV in total was identified in 14 cases (5.6%). The results of sequencing eight samples out of the 31 CT positive samples revealed the detection of genotypes D and E, each with four cases. Conclusion: We show that a high prevalence of genital CT infection is present in women with both normal and abnormal cytology; however, the higher prevalence among women in the abnormal group may indicate its involvement in cervical neoplasia. [ABSTRACT FROM AUTHOR]

Published
2018
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39. Molecular Epidemiology of Anellovirus Infection in Children's Urine: A Cross-sectional Study.

Author

Mortazkar P, Karbalaie Niya MH, Javanmard D, Esghaei M, and Keyvani H

Abstract

Background: Anelloviridae is a viral family which is considered as a constant component of human virome. Given the ubiquitous nature of the virus infection and the long-standing relationship between the virus and the host, in the present study, we aimed at investigating the presence of Anelloviruses in the urine samples of children in a cross-sectional study., Materials and Methods: The urine samples of 50 children who were referred to Hazrat Ali Asghar Children's Hospital, affiliated to Iran University of Medical Sciences, Tehran, Iran, were obtained. Three TaqMan real-time polymerase chain reactions (PCRs) were carried out for Anellovirus detection. A phylogenetic tree was drawn for positive products after PCR amplification, purification, and nucleotide sequencing. SPSS, version 20, was used for statistical analyses., Results: Children's mean age ± standard deviation was 4.30 ± 1.47 years and 56% (28/50) were female. Real-time PCR revealed that Anellovirus was positive in 12% (6/50). Furthermore, PCR-sequencing results showed that torque teno virus was detected in 83.3% (5/6) and SEN virus in 16.6% (1/6) of the Anellovirus positive samples. In addition, 86% (5/6) of the children with positive samples were female. No significant difference was detected between any of the demographic characteristics and Anellovirus positivity ( P > 0.05)., Conclusion: According to our preliminary study, the presence of Anelloviruses in the urine samples of asymptomatic children in Iran is striking, although limited sample size and age range limitations might have affected the comprehensive results of our study., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Advanced Biomedical Research.)

Published
2020
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