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Background: Dissimilar ventricular rhythms refer to the occurrence of different ventricular tachyarrhythmias in the right and left ventricles or different rates of the same tachyarrhythmia in the two ventricles.Objective: We investigated the inducibility of dissimilar ventricular rhythms, their underlying mechanisms, and the impact of anti-arrhythmic drugs (lidocaine and amiodarone) on their occurrence.Methods: Ventricular tachyarrhythmias were induced with burst pacing in 28 Langendorff-perfused Sprague Dawley rat hearts (14 control, 8 lidocaine, 6 amiodarone) and bipolar electrograms recorded from the right and left ventricles. Fourteen (6 control, 4 lidocaine, 4 amiodarone) further hearts underwent optical mapping of transmembrane voltage to study interventricular electrophysiological differences and mechanisms of dissimilar rhythms.Results: In control hearts, dissimilar ventricular rhythms developed in 8/14 hearts (57%). In lidocaine treated hearts, there was a lower cycle length threshold for developing dissimilar rhythms, with 8/8 (100%) hearts developing dissimilar rhythms in comparison to 0/6 in the amiodarone group. Dissimilar ventricular tachycardia (VT) rates occurred at longer cycle lengths with lidocaine vs. control (57.1 ± 7.9 vs. 36.6 ± 8.4 ms, p < 0.001). The ratio of LV:RV VT rate was greater in the lidocaine group than control (1.91 ± 0.30 vs. 1.76 ± 0.36, p < 0.001). The gradient of the action potential duration (APD) restitution curve was shallower in the RV compared with LV (Control - LV: 0.12 ± 0.03 vs RV: 0.002 ± 0.03, p = 0.015), leading to LV-to-RV conduction block during VT.Conclusion: Interventricular differences in APD restitution properties likely contribute to the occurrence of dissimilar rhythms. Sodium channel blockade with lidocaine increases the likelihood of dissimilar ventricular rhythms.

Este trabajo presenta un nuevo sistema teórico y metodológico así como un método arqueológico denominado "Sistema Analítico de Evaluación Habitacional" (S.A.E.H.) para evaluar la fuerza e intensidad de las ocupaciones prehistóricas a partir de los depósitos de las superficies líticas de los asentamientos. Nos referimos a un territorio situado al nordeste de España en la actual provin- cia de Zaragoza, denominada "Las Altas Cinco Villas". No obstante, el objetivo final es teorizar sobre la población prehistórica y su definición arqueológica en aquel tiempo (último periodo del Neolítico a la Edad del Bronce) y en una zona muy particular rodeada de pequeños ríos: Arba, Riguel y Onsella y sus afluentes (Busal, Orés, etc). Finalmente también se pretende dinamizar los debates entre los miembros de la comunidad científica que puedan estar interesados en esta problemática como tema de futuras investigaciones.