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Background and objectives: Since the beginning of the COVID-19 pandemic, the young popula- tion has been suffering from an accumulation of psychological symptoms in northern Spain. The main objectives of this study were (1) to assess whether psychological symptoms persisted after one year and a half of the COVID-19 pandemic in northern Spain sample of young people, and (2) to analyze whether pandemic-specific variables (having a chronic illness, living with a person who has a chronic illness, having been infected with COVID-19, having a close person who has died or believing that people are respecting the measures imposed) are related to psychological symptomatology. Methods: Symptoms of stress, anxiety, and depression were measured using the Depression and Stress Anxiety Scale-21 (DASS-21). An ad hoc online questionnaire was used to collect socio- demographical information related to chronic illnesses of the participants, living with a chroni- cally ill person, contact with a person diagnosed with COVID-19, having people close to them who have died of COVID-19, and their perception of whether or not people respect the health measures. Results: Young people have suffered higher stress, anxiety, and depression levels than at the beginning of the pandemic. Conclusions: The present study highlights the importance of addressing young people’s mental health, and ensure that future adults emerge from the COVID-19 pandemic in a psychologically strong state. This research was funded by KideOn Research Group of the Basque Government, Reference IT1342-19 (A category).

El objetivo de este trabajo fue calcular la proporción global de ansiedad de estudiantes de medicina durante la pandemia de COVID-19. Se realizó una búsqueda sistemática de artículos publicados hasta el 6 de enero de 2021 en Medline que reportaran prevalencia de ansiedad (según GAD-7) en estudiantes de medicina durante la pandemia de COVID-19. Diez estudios fueron incluidos en el meta-análisis, arrojando una prevalencia global estimada de ansiedad en estudiantes de medicina del 42. Este hallazgo sugiere la necesidad de evaluar sintomatología ansiosa entre los estudiantes de medicina durante la pandemia de COVID-19 y establecer programas de apoyo psicológico adecuados.

Vascular dementia (DV) is the second cause of dementia with 15.8-20% of cases. Previous studies of the effect of occupation in DV do not show conclusive results, therefore, the objective was to analyze if the type of occupation can vary the risk of developing DV in those older than 55 years.In the ZARADEMP project, a community sample of 4,803 individuals were followed longitudinally in four waves. The occupation was classified following the National Classification of Occupations (CNO-11) and the International Standard Classification of Occupations (ISCO-08). Different standardized instruments were used: the medical and psychiatric histories (History and Aetiology Schedule) and other risk factors (Mini-Mental Status Examination, Geriatric Mental State-AGECAT). For this study, we calculated incidence rates, incidence rate ratios and hazard ratios in multivariate Cox regression models, stratified by gender. For this study, we included 3,883 participants.In women, the risk of DV was doubled in Blue-collar workers, with a moderate effect (Cohen's d=0.54) and multiplying by 2.7 in Homeworks respect to White Collar with a moderate effect (Cohen's d=0.77), although they did not reach statistical significance. We did not observe the effect of occupation on the risk of DV in men.We have found a moderate but non-significant effect between occupation and DV risk in women. We found no effect of occupation on the risk of VD in males while other clinical factors (age, diabetes or body mass index) presented a clearer effect than the occupation.

Resumen Introduccion La demencia vascular (DV) representa la segunda causa de demencia, con el 15,8-20% de los casos. Dado que los estudios previos del efecto de la ocupacion en DV no muestran resultados concluyentes, nuestro objetivo fue analizar si el tipo de ocupacion varia el riesgo de desarrollar DV en mayores de 55 anos. Material y metodos El proyecto ZARADEMP evaluo inicialmente una muestra comunitaria de 4.803 individuos seguidos durante 4 olas. La ocupacion se clasifico siguiendo la Clasificacion Nacional de Ocupaciones de 2011 y la Clasificacion Internacional Uniforme de Ocupaciones de 2008. Se utilizaron diferentes instrumentos estandarizados: las historias medicas y psiquiatricas (History and Aetiology Schedule) y otros factores de riesgo (Mini-Mental Status Examination, Geriatric Mental State-AGECAT). Para este estudio, se calcularon tasas de incidencia, razon de tasas de incidencia y hazard ratio en modelos multivariados de regresion de Cox, estratificados por sexo. Han sido incluidos 3.883 participantes Resultados En mujeres, el riesgo de DV se duplico en trabajadoras de cuello azul, con un efecto moderado (d de Cohen = 0,54), y se multiplico por 2,7 en labores del hogar respecto a cuello blanco, con un efecto moderado (d de Cohen = 0,77), aunque sin significacion estadistica. No observamos efecto de la ocupacion en el riesgo de DV en varones. Conclusiones Hemos encontrado un efecto moderado, pero no significativo, entre la ocupacion y el riesgo de DV en mujeres. No hallamos efecto de la ocupacion en el riesgo de DV en varones, donde otros factores de riesgo (la edad, tener diabetes o el indice de masa corporal) tienen un efecto mas claro que la ocupacion laboral.

Background: Since the World Health Organization (WHO) declared the COVID-19 pandemic in March 2020, many measures have been taken to prevent the spread of the virus. Consequently, many minors have been confined to their homes and have had to subsequently adapt to countless protocol changes. These factors appear to have contributed to post-traumatic stress disorder (PTSD) in many children. Materials and Methods: The authors searched Medline through PubMed and other databases for studies published from 1 December 2019 to 31 December 2021 on the prevalence of PTSD in schoolchildren. The authors used a random-effects model to calculate the pooled prevalence of PTSD. Results: A total of six studies were included in this review. Our results show a pooled prevalence of PTSD of 14% in children and adolescents. Subgroup analyses identify a significantly higher prevalence of PTSD for studies conducted in China and a higher prevalence in boys. The prevalence of PTSD appeared independent of child age or the methodological rigor of the study. Conclusions: Our results suggest that a large number of children may be suffering from PTSD (post-traumatic stress disorder). Public health measures are thus needed to improve children’s mental health during and after the pandemic, so that the suffering is mitigated to prevent long-lasting effects.

Background: Education and occupational complexity are main sources of mental engagement during early life and adulthood respectively, but research findings are not conclusive regarding protective effects of these factors against late-life dementia. Objective: This project aimed to examine the unique contributions of education and occupational complexity to incident dementia, and to assess the mediating effects of occupational complexity on the association between education and dementia across diverse cohorts. Method: We used data from 10,195 participants (median baseline age = 74.1, range = 58∼103), representing 9 international datasets from 6 countries over 4 continents. Using a coordinated analysis approach, the accelerated failure time model was applied to each dataset, followed by meta-analysis. In addition, causal mediation analyses were performed. Result: The meta-analytic results indicated that both education and occupational complexity were independently associated with increased dementia-free survival time, with 28%of the effect of education mediated by occupational complexity. There was evidence of threshold effects for education, with increased dementia-free survival time associated with ‘high school completion’ or ‘above high school’ compared to ‘middle school completion or below’. Conclusion: Using datasets from a wide range of geographical regions, we found that both early life education and adulthood occupational complexity were independently predictive of dementia. Education and occupational experiences occur during early life and adulthood respectively, and dementia prevention efforts could thus be made at different stages of the life course.

Background: Since March 2020, when the World Health Organization (WHO) declared the COVID-19 pandemic, in order to stop the spread of the virus, unprecedented measures were taken worldwide. One of the most important measures was the closure of schools and educational centers around the world in 2020, and very extreme health protocols have been in place in educational centers since they were reopened. From early childhood education to universities, teachers first had to adapt in a short period time to online classes and then continuously readapt to new protocols according to the pandemic situation. This academic environment, in addition to the pandemic situation itself, has favored the emergence of mental disorders such as Post-Traumatic Stress Disorder (PTSD). Materials and Methods: Medline via PubMed and other databases were searched for studies on the prevalence of PTSD in teachers from 1 December 2019 to 1 October 2022. A total of five studies were included in this review. Our results show a prevalence of PTSD of 11% reported by teachers. No subgroups nor meta-regression analyses were performed due to the insufficient number of studies available. Conclusions: The results suggest that teachers are suffering from PTSD, so it is important to carry out more studies worldwide. Similarly, measures to improve the mental health and well-being of teachers during the pandemic and post-pandemic periods are needed.

Medical students frequently have depressive symptoms. Thus, the psychological impact of COVID-19 on them should be high.To conduct a systematic review and meta-analysis on the prevalence of depression in medical students during the COVID-19 pandemic.MEDLINE via PubMed, Embase and Web of Science were searched for studies reporting the prevalence of depression in medical students, published from December 1, 2019 to December 27, 2020.Eleven studies were included, most of them from Asia. The estimated overall prevalence of depression in medical students was 31% (95% CI: 23%-40%), with lower prevalence rates reported in studies from Asia in general, and China in particular.Our findings indicate that the proportion of medical students with depression during the pandemic was high, and comparable with that reported in other university students.

Background and objectives The identification of findings that suggest a unique dysbiotic microbial signature in Autism Spectrum Disorders (ASD), has drawn the attention towards promising therapies for ASD targeting gut-microbiota. In order to help physicians to make clinical decisions based on significant evidence, this work offers a systematic review of original peer-reviewed studies focused on microbiota-targeted treatments in ASD children. Methods The systematic review was conducted following the PRISMA guidelines. Quality of research was assessed using the National Health and Medical Research Council (NHMRC). Of 110 potential records initially identified, only 9 articles accomplished our inclusion criteria. Results A decrease in specific Clostridiales species and/or an increase in Bacillales was consistent in several studies after the microbiota-targeted interventions, whereas mixed results were seen in other phyla, congruent with different baseline trends in their ASD samples. Behavioral and GI function responses varied across interventions. Conclusion Preliminary data show microbiota-based therapies to have a positive effect on ASD patients. However, further well-designed, large-scale randomized controlled trials with standardized protocols are needed to support the effectiveness and safety of these treatments.

Energy Drink (ED)-associated cardiovascular emergency visits have increased in recent years. Although a toxicity threshold has been established for caffeine, the safety profile of whole ED consumption has not yet been defined.This systematic review was conducted following the PRISMA guidelines. Three reviewers conducted two separate systematic searches on PubMed on October 24 and December 3, 2019. Out of 250 potential records, 43 prospective clinical studies assessing the effects of ED on heart rate (HR) and/or any electrocardiographic (ECG) parameters were included. A meta-analysis was conducted to estimate pooled p-values using metap command for STATA 10.0.After ED consumption, resting HR increased in 71.1% of studies (pooled p-value0.001) but was only significant in 38%; HR during and after exercise increased in 55.5% (pooled p-value0.001) and 71.4% of studies, respectively; QRS increased in all but two protocols; evidence on PR interval was contradictory, and corrected QT interval (QTc) increased compared to baseline in all but one study, exceeding the pathological limit value in two of them. T wave changes were seen in two studies, and one study reported a ratio of 5 to 1 in the number of ectopic beats.Acute consumption of ED can alter the ECG in certain risk populations, posing a risk whose magnitude is yet to be determined. Caution should be exercised among at-risk and underage individuals but further research in these populations is warranted before restrictions are made.

Since the start of the COVID-19 pandemic, many studies have found that there has been a lot of teacher overload. One of the additional burdens has been that they have had to teach online. In addition, when they returned to face-to-face classes, they had to follow all the hygiene rules so that the COVID-19 virus would not spread. It is therefore not surprising that, during this pandemic period, high levels of psychological symptoms have been reported among teachers. Among this symptomatology, burnout has been very frequent among teachers. Therefore, the aim of this study is to conduct a meta-analysis to determine the overall prevalence of burnout among teachers during the COVID-19 pandemic. For this purpose, a search was conducted for cross-sectional studies listed in PubMed from 1 December 2019 to 14 February 2022 that reported on the prevalence of burnout among teachers. A total of nine studies from eight different countries in Africa, Asia, Europe, and North and South America, were included in this study. The pooled prevalence of burnout among teachers was 52% (95% CI 33–71%), which is higher than burnout rates reported for health professionals. There was significant heterogeneity between studies (I2 = 99%, p-value < 0.001), and the prevalence of burnout was higher in women and school teachers (compared to university educators), and lower in American studies. This meta-analysis concludes that teachers worldwide experienced a high rate of burnout during the COVID-19 pandemic. This has implications not only for the teachers themselves, but also for the quality of the education they were able to provide. This education has an influence on the student population. The possible long-term effects are yet to be determined.

This study was aimed to compare the recurrence-free survival rate among patients with Stage I or II of squamous carcinoma of the glottis treated with transoral laser microsurgery or radiotherapy, at a Spanish tertiary hospital. Between January 2004 and December 2016, data were collected from 120 patients diagnosed with stages I or II of squamous cell carcinoma of the larynx located in the glottis. Ninety-one patients were treated with transoral laser microsurgery and 29 patients received radiotherapy. The recurrence-free survival was studied during the first five years after the primary treatment. Kaplan-Meier survival curves and Cox regression models were performed. The cumulative incidence of glottis cancer recurrence was 62.6% in those treated with transoral laser microsurgery and 65.5% in those treated with radiotherapy. This led to an absolute risk reduction of 2.9% (95% CI: -17.1 to 22.8), and a number needed to treat of 35 patients. Those patients who received transoral laser microsurgery had a 17% lower risk of recurrence of glottis cancer than those treated with radiotherapy (hazard ratio, HR = 0.83; 95% CI 0.42 to 1.64; Cohen’s d = 0.65). In the initial stages of glottis squamous cell carcinoma, treatment with transoral laser microsurgery shows a tendency for higher re¬currence-free survival than treatment with radical radiotherapy in the first five years of intervention. Patients were not assigned randomly to the treatment, which might influence the generalization of our findings.

Objective: There is growing evidence for an association between anxiety and an increased risk of dementia, but it is not clear whether anxiety is a risk factor or a prodromic symptom. In this study, we investigated if clinically significant anxiety increases the risk of developing Alzheimer's disease (AD) up to 10 years later. Methods: We used data from the longitudinal Zaragoza Dementia and Depression (ZARADEMP) Project. Excluding subjects with dementia at baseline left us with 3044 individuals aged >65 years. The Geriatric Mental State-Automated Geriatric Examination for Computer Assisted Taxonomy (GMS-AGECAT) package was used to identify cases and subcases of anxiety. AD was diagnosed by a panel of research psychiatrists according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. Multivariate survival analysis with a competing risk regression model was performed. Results: We observed a significant association between clinically significant anxiety at baseline and AD risk within a 10-year follow-up (SHR 2.82 [95% CI 1.21–6.58]), after controlling for confounders including depression. In contrast, isolated symptoms of anxiety were not significantly associated with an increased incidence of AD. Conclusion: Our results support the hypothesis that clinically significant anxiety is an independent risk factor for AD and not just a prodromic symptom. Future studies should clarify if treating anxiety reduces the incidence of AD.

Objetivo: Determinar el nivel de satisfacción de los asistentes a un curso taller sobre revisiones sistemáticas y metaanálisis en ciencias biomédicas. Metodología: Estudio de corte transversal y descriptivo, en el que se administró una encuesta semi-estructurada de satisfacción a los asistentes al curso celebrado en julio de 2019. Resultados: El 73% de los alumnos que asistieron al curso provenían de Grado o Postgrado en Medicina. Sobre una escala de valoración de 5 puntos, los asistentes valoraron positivamente la actualidad del tema impartido, así como métodos docentes adecuados y una combinación adecuada de teoría y práctica. También destacaron la actitud positiva del profesorado y la amenidad del curso, considerando su recomendación. Conclusiones: El nivel de satisfacción de los asistentes al curso fue bueno (significativamente superior al valor neutral de 3) y ha intentado dotar a los asistentes de las herramientas necesarias para realizar una revisión sistemática y metaanálisis.

Objetivo: Determinar la percepción que los residentes en medicina que cursan estudios de postgrado tienen hacia el uso de software estadístico libre como jamovi frente a uno comercial como IBM SPSS. Metodología: Estudio observacional, de corte transversal y descriptivo, en el que se administró una encuesta a los asistentes a un taller de uso de jamovi. Resultados: Sobre una escala de valoración de 5 puntos, los asistentes valoraron positivamente la utilización de jamovi, ya que, frente a IBM SPSS, les permitía ahorrar tiempo (Media = 3,90; p=0,001) a la vez que se sienten más confiados en los resultados que éste ofrece (Media = 3,76; p = 0,002), aunque advierten que aún quedan muchas rutinas por implementar (Media = 3,31; p=0,080). Adicionalmente, los residentes se encuentran motivados en el uso presente de jamovi (Media=4,34; p

Background: Since the WHO declared the COVID-19 crisis a pandemic in March 2020, the young population is suffering from a range of psychological symptoms. The present study measured symptoms of stress, anxiety and depression in university students of Saltillo, Mexico, using the Depression and Anxiety Stress Scale-21 (DASS-21). Methods. The DASS-21 scale and an ad hoc questionnaire were used to collect sociodemographic information. Results: The results show that the students who participated in this study suffer from high levels of stress, anxiety and depression. In terms of sociodemographic variables, women, people suffering from a chronic disease and people living with a chronic disease had the highest levels of stress, anxiety and depression, and people who live with a chronically ill person, people who have had the COVID-19 disease and those who have had someone close to them fall sick have had more stress, anxiety and depression than the rest. Another finding of the present study is that university students who believe that others comply with COVID-19 safety measures have significantly lower anxiety and depression than those who believe that others do not comply. Conclusions: It is concluded that university students are a psychologically vulnerable group in the face of the pandemic. This research was funded by KideOn Research Group of the Basque Government, Reference IT1342-19 (A category).

Background: Most universities around the world have been heavily affected by the COVID-19 pandemic, as declared by the World Health Organization (WHO) in March 2020. Many students were isolated at home and underwent a forced transition from face-to-face learning to e-learning, at least in the first few months. The subsequent months and years were typically characterised by a slow return to normal learning under COVID-19 protocols and restrictions. A potential consequence of the lockdowns, social restrictions and changes to learning is the development of PTSD (post-traumatic stress disorder) in university students, affecting their health and well-being (SDG3) and quality of education (SDG4). Materials and Methods: Medline was searched through PubMed for studies on the prevalence of PTSD in university students from 1 December 2019 to 31 December 2021. The pooled prevalence of PTSD was calculated with random-effects models. Results: A total of six studies were included, across which the prevalence of PTSD among university students was 23%. Meta-regression showed that the prevalence of PTSD was significantly higher with older age, but independent of the percentage of women in a study or its methodological quality. Conclusions: Our results suggest that students suffer from PTSD at a moderate rate. Measures are needed to address the mental health issues of university students that have arisen during COVID-19 all around the world. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Background: Since the onset of the COVID-19 pandemic, the psychological state of university students has been a cause for concern. In particular, odontology students have experienced symptoms of anxiety due to the closure of universities and the suspension of clinical training. Methods: Medline via PubMed was searched for studies on the prevalence of anxiety in dental undergraduates, published from 1 December 2019 to 1 August 2021. Results: A total of fifteen studies were included in this review. Our results show a prevalence of anxiety of 35% reported by dental students, which was independent of gender, response rate or methodological quality. The only significant finding was a lower prevalence of anxiety in studies located in Europe compared to those located in other continents. Conclusions: The results suggest dental students are experiencing significant levels of anxiety during this COVID-19 pandemic and that there seem to be differences between students from different regions of the world. Therefore, it is important to help dental students psychologically as the pandemic situation continues.

INTRODUCCIÓN. El estudio de la asociación entre dos variables se expresa de forma analítica con el estadístico denominado coeficiente de correlación. Con frecuencia, encontramos asociaciones de magnitud relevante pero que no alcanzan la significación estadística, planteándonos entonces si el contraste de hipótesis tiene la suficiente potencia estadística para detectar diferencias cuando realmente existen. Desafortunadamente, SPSS no ofrece el cálculo de la potencia estadística para los estudios de asociación de variables cuantitativas. Por ello, se plantea el cálculo de la potencia estadística mediante sintaxis de SPSS en el escenario de estudios de asociación a través de un caso práctico. MÉTODO. Se proporciona un fichero de sintaxis de SPSS para calcular la potencia estadística en estudios de asociación. DISCUSIÓN. El uso del fichero de sintaxis será de utilidad para aquellos investigadores familiarizados con SPSS que necesiten realizar el cálculo de la potencia estadística en estudios de asociación.

The objective of the study was to examine the cognitive profile of Spanish patients with a first episode of schizophrenia (FESz) and to compare that to the profile of patients with a chronic schizophrenia (CSz) and non-psychiatric (NP) control subjects. The study included 106 FESz, 293 CSz, and 210 NP, assessed with the Spanish version of the MATRICS Consensus Cognitive Battery (MCCB). The MCCB cognitive profile in a Spanish sample of FESz was similar to the cognitive profile of CSz with some discrepancies in select domains. The scores of both patient samples were about 1-2 SD below the scores of non-psychiatric control subjects.

Background: Since the beginning of the COVID-19 pandemic, teachers have been accumulating adverse psychological symptoms due to the closure of educational centers and the need to adapt to different teaching modalities. Methods: Medline and PubMed were searched for studies on the prevalence of depression, anxiety, stress, and burn-out in teachers, published from 1 December 2019 to 15 June 2021. Results: In total, eight studies were included in this study. The results show that teachers report levels of anxiety (17%), depression (19%), and stress (30%). In Asia, there has been more anxiety compared to other continents. Overall, anxiety has been higher among teachers in schools compared to universities. However, stress levels have been higher among teachers in universities compared to schools. Statistically, there were no significant differences regarding gender and age in any of the symptoms. Conclusions: The results suggest that teachers at different educational levels are experiencing adverse psychological symptomatology during the COVID-19 pandemic, and that anxiety levels vary between different countries. However, more international studies are needed to fully understand the impact of the pandemic on teachers’ mental health. This research was funded by KideOn Research Group of the Basque Government, Reference IT1342-19 (A category); and R + d + i Projects Research Challenges of the Ministry of Economy, Science and Innovation, grant number PID2020-119011RB-100 EDU.

Ministerio de Ciencia e Innovacion, Grant/Award Number: FJCI-2017-34967; Sixth Framework Programme, Grant/Award Number: 016181 (FOOD), Background Metabolic risk and inflammatory state have an early life onset and are associated with future diseases. Objectives To assess the association between metabolic syndrome (MetS) and metabolic health with high-sensitive C-reactive protein (hsCRP), cross-sectionally and longitudinally, in children. Methods 2913 European children (2-10 years) from eight countries from the IDEFICS study were investigated. Data were collected at baseline and 2 years later (follow-up). A MetS z-score was computed with waist circumference (WC), insulin resistance index, blood pressure, high-density lipoprotein cholesterol and triglycerides. Metabolically unhealthy (MU) status was assessed. Multi-level linear and logistic regressions were performed. Results Among the MetS markers, WC was more consistently associated with hsCRP cross-sectional and prospectively. Baseline MetS score was significantly associated with greater risk of high hsCRP at follow-up and with prevalence and incidence of hsCRP. Those children who became MU overtime were significantly (P < .05) associated with future higher levels of hsCRP, independently of weight status at baseline. Conclusions Transition over time to a MU state was associated with higher levels of hsCRP at follow-up, independent of weight status at baseline. Screening of metabolic factors and routine measurement of WC are needed to prevent inflammatory status and related chronic diseases in children., Instituto de Salud Carlos III Spanish Government European Commission FJCI-2017-34967, European Commission 016181

With the increasing size of the aging population, dementia risk reduction has become a main public health concern. Dementia risk models or indices may help to identify individuals in the community at high risk to develop dementia. We have aimed to develop a novel dementia risk index focused on the late-life (65 years or more) population, that addresses risk factors for Alzheimer’s disease (AD) easily identifiable at primary care settings. These risk factors include some shown to be associated with the risk of AD but not featured in existing indices, such as hearing loss and anxiety. Our index is also the first to account for the competing risk of death. The Zaragoza Dementia and Depression Project (ZARADEMP) Alzheimer Dementia Risk Score predicts an individual´s risk of developing AD within 5 years. The probability of late onset AD significantly increases in those with risk scores between 21 and 28 and, furthermore, is almost 4-fold higher for those with risk scores of 29 or higher. Our index may provide a practical instrument to identify subjects at high risk of AD and to design preventive strategies targeting the contributing risk factors.

Introduction: COVID-19 pandemic, declared on March 11, 2020, constitute an extraordinary health, social and economic global challenge. The impact on people''s mental health is expected to be high. This paper sought to systematically review community-based studies on depression conducted during the COVID-19 and estimate the pooled prevalence of depression. Method: We searched for cross-sectional, community-based studies listed on PubMed or Web of Science from January 1, 2020 to May 8, 2020 that reported prevalence of depression. A random effect model was used to estimate the pooled proportion of depression. Results: A total of 12 studies were included in the meta-analysis, with prevalence rates of depression ranging from 7.45% to 48.30%. The pooled prevalence of depression was 25% (95% CI: 18% - 33%), with significant heterogeneity between studies (I2 = 99.60%, p < .001). Conclusions: Compared with a global estimated prevalence of depression of 3.44% in 2017, our pooled prevalence of 25% appears to be 7 times higher, thus suggesting an important impact of the COVID-19 outbreak on people's mental health. Addressing mental health during and after this global health crisis should be placed into the international and national public health agenda to improve citizens’ wellbeing.

Alzheimer’s disease (AD) is the most frequent cause of dementia, linked to morbidity and mortality among elderly patients. Recently, several clinical studies suggested that depression is a potential risk factor for cognitive decline and AD. A review of meta-analyses was performed, calculating pooled odds ratios to estimate the risk of AD in people with a prior diagnosis (or clinically significant symptoms) of depression. A total of six meta-analyses which represented 28 individual studies were analyzed. A significant association between depression and AD was found (OR = 1.54, 95% CI [1.02–2.31]; p = 0.038). The results showed that heterogeneity across studies was substantial. We found a significant positive effect size for clinical measures of depression, but not for symptomatic rating scales, in the association of depression with risk of AD. The type of rating scale used to assess depression and the cut-off criteria selected also moderated the relationship between depression and AD risk. We found that studies that used clinically significant criteria for diagnosis of depression had more consistent and significant results than studies that used symptomatic scales.

Objective This systematic review and meta-analysis aimed to summarize the available evidence regarding circulating kisspeptin and anti-mullerian hormone (AMH) and the homeostasis model assessment of insulin resistance (HOMA-IR) index in adolescents and women with and without polycystic ovary syndrome (PCOS). Method We performed a comprehensive literature search in Medline, Embase, Cochrane, Scopus, and Web of Science for studies evaluating circulating kisspeptin levels in women with and without PCOS published until September 24th, 2020. Co-primary outcomes were the HOMA-IR index and AMH. The quality of included studies was assessed using the Newcastle-Ottawa Scale. Random-effects models were used to estimate outcomes, and effects reported as mean difference (MD) or standardized MD (SMD) and their 95 % confidence interval (CI). The systematic review and meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO) as number CRD42020205030. Results We evaluated 18 studies including, 1282 PCOS cases and 977 controls. Participants with PCOS were younger (MD = −2.38 years, 95 %CI -4.32 to -0.44), with higher BMI (MD = 1.16, 95 % CI 0.54–1.78), waist-to-hip ratio (MD = 0.04, 95 %CI 0.02 to 0.05), circulating kisspeptin (SMD = 1.15, 95 %CI 0.68–1.62), luteinizing hormone (SMD = 1.29, 95 %CI 0.76–1.83), AMH (SMD = 0.97, 95 %CI 0.60–1,34), total testosterone (SMD = 2.48, 95 %CI 1.73–3.23), free testosterone (SMD = 1.37, 95 %CI 0.56–2.17), and dehydroepiandrosterone sulphate (SMD = 0.72, 95 %CI 0.32–1.13) levels, and Ferriman-Gallwey score (SMD = 5.08, 95 %CI 2.76–7.39), and lower sex hormone-binding globulin level (SMD = −1.34, 95 %CI −2.15 to −0.52). Besides, participants with PCOS had higher HOMA-IR index (SMD = 0.76, 95 %CI 0.35–1.17), and circulating insulin (SMD = 0.75, 95 %CI 0.30–1.19), leptin (SMD = 2.82, 95 %CI 1.35–4.29), and triglycerides (SMD = 2.15, 95 %CI 1.08–3.23) levels than participants without the syndrome. The meta-regression did not identify significant factors influencing circulating kisspeptin. Conclusion Patients with PCOS showed higher kisspeptin, LH, insulin, AMH, and androgen levels and HOMA-IR index, and lower sex hormone-binding globulin levels than those without the syndrome.