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Abstract: Bell palsy is a non-progressive neurological condition characterized by the acute onset of ipsilateral seventh cranial nerve paralysis. People who suffer from this type of facial paralysis develop a droop on one side of their face, or sometimes both. This condition is distinguished by a sudden onset of facial paralysis accompanied by clinical features such as mild fever, postauricular pain, dysgeusia, hyperacusis, facial changes, and drooling or dry eyes. Epidemiological evidence suggests that 15 to 23 people per 100,000 are affected each year, with a recurrence rate of 12%. It could be caused by ischaemic compression of the seventh cranial nerve, which could be caused by viral inflammation. Pregnant women, people with diabetes, and people with respiratory infections are more likely to have facial paralysis than the general population. Immune, viral, and ischemic pathways are all thought to play a role in the development of Bell paralysis, but the exact cause is unknown. However, there is evidence that Bell's hereditary proclivity to cause paralysis is a public health issue that has a greater impact on patients and their families. Delay or untreated Bell paralysis may contribute to an increased risk of facial impairment, as well as a negative impact on the patient's quality of life. For management, antiviral agents such as acyclovir and valacyclovir, and steroid treatment are recommended. Thus, early diagnosis accompanied by treatment of the uncertain etiology of the disorder is crucial. This paper reviews mechanistic approaches, and emerging medical perspectives on recent developments that encounter Bell palsy disorder.

OBJECTIVES: The study aimed to explore the in vivo protective potential of rosuvastatin (ROSS), an oral antihyperlipidemic drug against doxorubicin (DOXO) induced cardio toxicity in rats. MATERIALS AND METHODS: Cardiac toxicity was induced by DOXO injection (10 mg/kg, i.p.), once on the 20(th) day of the experiment. Except for the control rats, all were received DOXO and the study was continued for up to 21 days. The influence of ROSS on acute treatment was analyzed by quantification of cardiac marker enzymes such as creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and liver marker enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT) along with the measurement of in vivo antioxidants like superoxide dismutase and catalase. To observe histological changes of myocardial tissue hematoxylin and eosin staining were used. RESULTS: Acute administration of DOXO resulted in a marked rise of cardiac marker enzymes that confirms the myocardial damage compared to control animals whereas administration of ROSS (10 mg/kg, p.o.) resulted in the significant reduction of CK-MB, LDH levels (p

In recent decades, usage of biofuels as fossil fuel substitutes has increased. One method for lowering both crude oil use and environmental pollution is the production of ethanol (bioethanol) from biomass. This report offers an examination of the existing state of affairs and future prospects for biomass-to-ethanol. We examine different conversion routes from a technological, economic, and environmental standpoint. The main focus of this study is on the yield of ethanol from molasses in relation to the dilution ratio and the quantity of yeast used for fermentation while maintaining a constant fermentation temperature and time. In this investigation, the feedstock is sugarcane molasses. A thick by-product of turning sugar cane into sugar is sugarcane molasses. Consequently, sugarcane molasses and other agricultural byproducts are desirable feedstock for the manufacture of bioethanol. Agricultural wastes are cheap, abundant, and renewable. The least expensive strain for the conversion of biomass substrate is Saccharomyces cerevisiae. As a conclusion, it was found that the ethanol yield increased with an increase in yeast quantity, reaching an optimal yeast quantity before ethanol yield started to drop. The ideal ratio of molasses to water was found to be 1:2. The amount of fermentable sugars contained in the biomass has a significant impact on the output of ethanol.

Background: Depression or Major depressive disorder (MDD) is a prolonged condition of sadness. MDD is the most common mental disorder that affects more than 264 million people worldwide. According to the monoamine hypothesis, serotonin (5-hydroxy tryptamine, 5-HT), dopamine (DA) and norepinephrine (NE) are the major neurotransmitters (NTs) involved in depression. Methods: The methodology adopted for writing this review article is essentially based on the secondary literature search through a systematic literature review. This review mainly focussed on the role of 5-HT3 receptor antagonists (5-HT3RA) in depression and comorbid disorders like anxiety. Results: Out of three major NTs mentioned above, serotonin has a predominant role in the pathophysiology of depression. The serotonin type-3 receptors (5-HT3R) are well renowned to be expressed in the central nervous system (CNS) in regions which have significance in the vomiting reflex, perception of pain, the reward system, cognition, depression and anxiety control. 5-HT3R are the receptors of serotonergic family that belong to ligand-gated ion channel. 5-HT3RA inhibit the binding of serotonin to postsynaptic 5-HT3R and increases its availability to other receptors like 5- HT1A, 1B and 1D as well as 5-HT2 receptors and produces anti-depressant-like effect. 5-HT3RA also have an important role in mood and stress disorders. Some of the studies have shown the effectiveness of these agents in stress disorder. Conclusion: The present article focussed on the role of 5-HT3R and their antagonists in the treatment of depression and anxiety. Further studies are warranted to prove their efficacy with respect to other standard anti-depressants.

Background and Aims: The study was designed to evaluate the anti-fertility effect of methanolic extract of Clerodendrum serratum (MECS) on mature male rats. Methods: The vehicles and MECS were administered orally to four groups of forty male albino rats on consecutive days for 30 days. At the end of the experimental period, five animals from both the control and experimental groups were given anesthesia and the animal reproductive organs were collected and anti-fertility effect evaluated by studying the following parameters (i) Body and reproductive organ weight (ii) Biochemical estimation (iii) Reproductive hormone analysis (iv) Abnor malities in reproductive organ histology. Another five rats in each group were subjected to fertility testing. Results: This study shows that female rats which mated with MECS treated male rats delivered fewer pups than those which mated with the control rats. An antisteroidogenic effect was revealed through the increased concentration of testicular cho lesterol and ascorbic acid in MECS treated rats. However, testicular Δ5 -3β-hydroxysteroid dehydrogenase (Δ5 -3β-HSD), glucose-6-phosphate dehydrogenase (G-6-PD); serum reproductive hormones testosterone, FSH and LH were significantly reduced. Conclusion: The present investigation discovered the antisteroidogenic effect of MECS, which confirms the male antifertility effect of this plant. This encourages the traditional use of this plant in the Indian subcontinent as a male contraceptive.

Brain tumors arise from an uncontrolled proliferation of neural tissue cells or supportive glial tissue cells within the brain. The diagnosis and therapy of brain tumor is an extremely challenging task. Moreover, absence of early stage symptoms and consequently delays in diagnosis and therapy worsen its severity. Though in the present days, chemotherapeutic approach is the most common therapeutic approach; still it is linked with several precincts. The blood-brain barrier (BBB) is the main hurdle in delivering most of the chemotherapeutic agents as well as imaging agent that leads to insufficient accumulation of therapeutic / imaging agents at tumor site, and prevents adequate destruction of malignant cells. Recently, lipid based nanoparticles are gaining much more interest and are preferred over polymeric nanoparticles owing to their biodegradability, non-toxicity, excellent tumortargeting ability and ease of surface modification. Certain receptors are over expressed in brain tumor cells which confer an opportunity to the researchers for delivering the chemotherapeutic as well as imaging agent particularly to the tumor cells through the surface modification approach of nanoparticles. Ligands like proteins/peptides, carbohydrates, aptamers, antibodies, and antibody fragments are generally conjugated to the surface of the nanoparticles that bind specifically to an over expressed target on the brain tumor cell surface. In the present review, we discuss the diagnostic and therapeutic application of various types of lipid based nanoparticles such as liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carrier, lipid nanocapsule, and lipid polymer hybrid nanocarriers along with their various surface modified forms for targeting brain tumor.

Depression or Major depressive disorder (MDD) is a prolonged condition of sadness. MDD is the most common mental disorder that affects more than 264 million people worldwide. According to the monoamine hypothesis, serotonin (5-hydroxy tryptamine, 5-HT), dopamine (DA) and norepinephrine (NE) are the major neurotransmitters (NTs) involved in depression.The methodology adopted for writing this review article is essentially based on the secondary literature search through a systematic literature review. This review mainly focussed on the role of 5-HTOut of three major NTs mentioned above, serotonin has a predominant role in the pathophysiology of depression. The serotonin type-3 receptors (5-HTThe present article focussed on the role of 5-HT

The aim of the present study was to investigate the behavioral influence of atorvastatin alone and in combination with antiepileptics like lacosamide and levetiracetam in the mouse after the experimental convulsions induced by maximal electroshock method. The maximal seizure pattern was induced in mice in alternative days for upto 9 days by giving an alternating current of 45 mA for 0.2 Sec. Atorvastatin (10mg/ kg i.p) were administered intraperitoneally 30 min before the electrical induction of seizures in alone and in combination with lacosamide (10mg/kg i.p) and levetiracetam (10mg/kg i.p). Rota rod, hole board, tail suspension and were used to record behavioral effects periodically. Additionally, the effects of administration of atorvastatin on the adverse effect potential of an lacosamide and levetiracetam were assessed in the chimney test for its motor performance. The results shows that, there is a gradual significant increase of muscle grip strength (p

The present study was to extract the mucilage from the Okra plant (Abelmoschus esculentus) and to study the effect of mucilage concentration on in vitro release of lamivudine from sustained release matrix tablets. Mucilage was extracted from the fruits of Abelmoschus esclentus using organic solvent Acetone. The extracted mucilage was subjected to various physiological properties for its suitability as an excipient in the formulation of tablet preparation. Lamivudine sustained release tablets were prepared using different concentration of okra mucilage as a sustained release matrix excipient. The formulated tablets were evaluated for post compression parameters such as weight variation, hardness, friability, wetting time, water absorption ratio, and in vitro drug release studies. Stability studies of optimized formulation were carried out for three months. The results of in vitro release revealed that the release rate decreased with increase in the concentration of mucilage. The release kinetics indicated that the nature of drug release from the matrix tablets was dependent on drug diffusion and polymer relaxation and therefore followed non-fickian or anomalous release. No incompatibility was observed between the drug and excipients used in the formulation of matrix tablets. The okra mucilage showed promising results in terms of sustaining the release behavior of lamivudine from the matrix. The developed sustained release tablet of lamivudine, with extension of release up to 12 hours, can overcome the disadvantages of conventional tablets of lamivudine.