1. Current practice in identifying and treating cardiovascular risk, with a focus on residual risk associated with atherogenic dyslipidaemia
- Author
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Ferrari, Roberto, Carlos, Aguiar2, Eduardo, Alegria3, Bonadonna4, Riccardo C., Francesco, Cosentino5, Moses, Elisaf6, Michel, Farnier7, Jean, Ferrie`res8, Pasquale Perrone Filardi9, Nicolae, Hancu10, Meral, Kayikcioglu11, Silva12, Alberto Mello e., Jesus, Millan14, Zˇeljko, Reiner15, Lale, Tokgozoglu16, Paul, Valensi17, Margus, Viigimaa18, Michal, Vrablik19, Alberto, Zambon20, Jose´ Luis Zamorano21, Catapano22, Alberico L., Kardiyoloji, Ege Üniversitesi, Ferrari, Roberto, Aguiar, Carlo, Alegria, Eduardo, Bonadonna, Riccardo C., Cosentino, Francesco, Elisaf, Mose, Farnier, Michel, Ferrières, Jean, Filardi, Pasquale Perrone, Hancu, Nicolae, Kayikcioglu, Meral, Mello E Silva, Alberto, Millan, Jesu, Reiner, Zeljko, Tokgozoglu, Lale, Valensi, Paul, Viigimaa, Margu, Vrablik, Michal, Zambon, Alberto, Zamorano, Jose Lui, and Catapano, Alberico L.
- Subjects
medicine.medical_specialty ,Statin ,medicine.drug_class ,Blood lipids ,Disease ,030204 cardiovascular system & hematology ,NO ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Fenofibrate ,cardiovascular disease ,atherogenic dyslipidemia ,Internal medicine ,Epidemiology ,fenofibrate-statin combination therapy ,medicine ,030212 general & internal medicine ,Atherogenic dyslipidaemia ,Cholesterol ,business.industry ,atherogenic dyslipidaemia ,cardiovascular risk ,residual cardiovascular risk ,statin ,fenofibrate ,Fenofibrate–statin combination therapy ,cholesterol ,Cardiovascular risk ,cardiovascular disease, cholesterol, atherogenic dyslipidemia ,Residual cardiovascular risk ,Residual risk ,Endocrinology ,chemistry ,Cardiovascular System & Cardiology ,lipids (amino acids, peptides, and proteins) ,Cardiology and Cardiovascular Medicine ,business ,Lipoprotein ,medicine.drug - Abstract
WOS: 000374478200002, PubMed ID: 28533705, A panel of European experts on lipids and cardiovascular disease discussed clinical approaches to managing cardiovascular risk in clinical practice, including residual cardiovascular risk associated with lipid abnormalities, such as atherogenic dyslipidaemia (AD). A simplified definition of AD was proposed to enhance understanding of this condition, its prevalence, and its impact on cardiovascular risk. Atherogenic dyslipidaemia can be defined by high fasting triglyceride levels (a parts per thousand yen2.3 mmol/L) and low high-density lipoprotein cholesterol (HDL-c) levels (a parts per thousand currency sign1.0 and a parts per thousand currency sign1.3 mmol/L in men and women, respectively) in statin-treated patients at high cardiovascular risk. The use of a single marker for the diagnosis and treatment of AD, such as non-HDL-c, was advocated. Interventions including lifestyle optimization and low-density lipoprotein (LDL)-lowering therapy with statins (+/- ezetimibe) are implemented by all experts. Treatment of residual AD can be performed with the addition of fenofibrate, since it can improve the complete lipoprotein profile and reduce the risk of cardiovascular events in patients with AD. Specific clinical scenarios in which fenofibrate may be prescribed are discussed, and include patients with very high triglycerides (a parts per thousand yen5.6 mmol/L), patients who are intolerant or resistant to statins, and patients with AD and at high cardiovascular risk. The fenofibrate-statin combination was considered by the experts to benefit from a favourable benefit-risk profile. Cardiovascular experts adopt a multifaceted approach to the prevention of atherosclerotic cardiovascular disease, with lifestyle optimization, LDL-lowering therapy, and treatment of AD with fenofibrate routinely used to help reduce a patient's overall cardiovascular risk., Mylan, This project was supported by Mylan. Medical writing support was provided by Dr Camille Bonomelli of Alphar-maxim Healthcare Communications and funded by Mylan.
- Published
- 2016