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1. Upregulation of MCL-1 through MAPK Activation Maintaining Mitochondrial Oxidative Phosphorylation Confers Acquired Resistance to BCL-2 Inhibitor Venetoclax in AML

Author

Michael Andreeff, Stephen E. Kurtz, Vivian Ruvolo, Helen Ma, Marina Konopleva, Anthony Letai, Richard E. Davis, Qi Zhang, Ryan Jeremy, Joel D. Leverson, Rongqing Pan, Ma Man Chun John, Lina Han, Rodrigo Jacamo, Yingchang Mi, Hong Mu, Jeferrey Tyner, and Ce Shi

Subjects
Cancer Research, Venetoclax, business.industry, Hematology, Oxidative phosphorylation, Bcl-2 Inhibitor, MAPK activation, chemistry.chemical_compound, Acquired resistance, Oncology, chemistry, Downregulation and upregulation, Cancer research, Medicine, business
Published
2017
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