1. Rheumatoid arthritis and changes on spirometry by smoking status in two prospective longitudinal cohorts
- Author
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Gary M Hunninghake, Zachary S Wallace, Edwin K Silverman, George R Washko, Jeffrey A Sparks, Michael H Cho, Matthew Moll, Pierre-Antoine Juge, Elizabeth A Regan, Raul San Jose Estepar, Gregory L Kinney, Paul F Dellaripa, Samuel Y Ash, Keigo Hayashi, Tracy J Doyle, Xiaosong Wang, Misti L Paudel, Gregory C McDermott, Danielle Sansone-Poe, and Kendra Young
- Subjects
Medicine - Abstract
Objective To compare longitudinal changes in spirometric measures between patients with rheumatoid arthritis (RA) and non-RA comparators.Methods We analysed longitudinal data from two prospective cohorts: the UK Biobank and COPDGene. Spirometry was conducted at baseline and a second visit after 5–7 years. RA was identified based on self-report and disease-modifying antirheumatic drug use; non-RA comparators reported neither. The primary outcomes were annual changes in the per cent-predicted forced expiratory volume in 1 s (FEV1%) and per cent predicted forced vital capacity (FVC%). Statistical comparisons were performed using multivariable linear regression. The analysis was stratified based on baseline smoking status and the presence of obstructive pattern (FEV1/FVC
- Published
- 2024
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