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22 results on '"Jena, Kautilya Kumar"'

1. Transgenic mouse models support a protective role of type I IFN response in SARS-CoV-2 infection-related lung immunopathology and neuroinvasion

Author

Chauhan, Nishant Ranjan, Kundu, Soumya, Bal, Ramyasingh, Chattopadhyay, Diya, Sahu, Rinku, Mehto, Subhash, Yadav, Rina, Krishna, Sivaram, Jena, Kautilya Kumar, Satapathy, Sameekshya, Pv, Anusha, Murmu, Krushna C., Singh, Bharati, Patnaik, Srinivas, Jena, Sarita, Harshan, Krishnan H., Syed, Gulam Hussain, Idris, Mohammed M., Prasad, Punit, and Chauhan, Santosh

Published
2023
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4. Contributors

Author

Abdellatif, Mahmoud, primary, Ahsan, Nuzhat, additional, Albornoz, Amelina, additional, Aman, Yahyah, additional, Andres, Allen, additional, Arden, Catherine, additional, Asa, Daniel, additional, Bellido, Belén, additional, Boudina, Sihem, additional, Briones-Herrera, Alfredo, additional, Budini, Mauricio, additional, Bueno, Elizabeth, additional, Camuzard, Olivier, additional, Carle, Georges F., additional, Chauhan, Santosh, additional, Corbalan, Ramon, additional, Criollo, Alfredo, additional, Dasanna, Srinivasulu, additional, De Meyer, Guido R.Y., additional, Diwan, Abhinav, additional, Donate-Lagartos, Maria Jose, additional, Duttenhefner, Robyn, additional, Eisenberg, Tobias, additional, Fang, Evandro F., additional, Frank, Johannes, additional, Garrido-Moreno, Valeria, additional, Garrido-Olivares, Luis, additional, Georgiou, Merilin, additional, Ghimire, Saurav, additional, Gómez-Sierra, Tania, additional, Gudmundsrud, Ruben, additional, Guenther, Andreas, additional, Guns, Pieter-Jan, additional, He, Congcong, additional, Helgason, G. Vignir, additional, Hermans, Nina, additional, Hernandez-Diaz, Sergio, additional, Ianniciello, Angela, additional, Islam, Moydul, additional, Jena, Kautilya Kumar, additional, Katsuki, Hiroshi, additional, Korfei, Martina, additional, Korolchuk, Viktor I., additional, Ktistakis, Nicholas T., additional, Lavandero, Sergio, additional, Li, Mark, additional, Ljubojević-Holzer, Senka, additional, Mahavadi, Poornima, additional, Main, Patrick, additional, Manifava, Maria, additional, Markby, Greg R., additional, Martinet, Wim, additional, Martínez-Klimova, Elena, additional, Mehto, Subhash, additional, Mills, Jason C., additional, Neutel, Cédric HG., additional, Nhi Nguyen, Ngoc Uyen, additional, Pedraza-Chaverri, José, additional, Peña-Oyarzún, Daniel, additional, Pierrefite-Carle, Valérie, additional, Pimentel-Muiños, Felipe X., additional, Pulinilkunnil, Thomas, additional, Rabanal-Ruiz, Yoana, additional, Radyk, Megan D., additional, Rodríguez, Christian, additional, Roth, Lynn, additional, Rothermel, Beverly A., additional, Sakamoto, Kei, additional, Sanchez-Mirasierra, Irene, additional, Sedej, Simon, additional, Seki, Takahiro, additional, Sequeida, Alvaro, additional, Shi, Liu, additional, Sinha, Sangita C., additional, Slade, Logan, additional, Soukup, Sandra-Fausia, additional, Spatz, Lillian B., additional, Steenput, Bieke, additional, Tatsumi, Takayuki, additional, Čechová, Kateřina, additional, Trojani, Marie-Charlotte, additional, Tsukamoto, Satoshi, additional, Vega-Rubín-de-Celis, Silvia, additional, Vinod, Vishaka, additional, Vyhnalek, Martin, additional, Williams, Amelia, additional, Wyatt, Samuel, additional, Xie, Chenglong, additional, and Yang, Ling, additional

Published
2022
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5. Transgenic Mouse Models Support a Protective Role of Type 1 IFN Response in SARS-CoV-2 Infection-Related Lung Immunopathology and Neuroinvasion

Author

Chauhan, Nishant Ranjan, primary, Kundu, Soumya, additional, Bal, Ramyasingh, additional, Chattopadhyay, Diya, additional, Mehto, Subhash, additional, Sahu, Rinku, additional, Yadav, Rina, additional, Krishna, Sivaram, additional, Jena, Kautilya Kumar, additional, Satapathy, Sameekshya, additional, Murmu, Krushna C., additional, Singh, Bharati, additional, Das, Saroj Kumar, additional, Jena, Sarita, additional, Harshan, Krishnan H., additional, Syed, Gulam Hussain, additional, Prasad, Punit, additional, and Chauhan, Santosh, additional

Published
2023
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7. Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology

Author

Chauhan, Nishant Ranjan, primary, Kundu, Soumya, additional, Bal, Ramyasingh, additional, Chattopadhyay, Diya, additional, Mehto, Subhash, additional, Sahu, Rinku, additional, Yadav, Rina, additional, Krishna, Sivaram, additional, Jena, Kautilya Kumar, additional, Satapathy, Sameekshya, additional, Murmu, Krushna C, additional, Singh, Bharati, additional, Das, Saroj Kumar, additional, Jena, Sarita, additional, Harshan, Krishnan H, additional, Syed, Gulam Hussain, additional, Prasad, Punit, additional, and Chauhan, Santosh, additional

Published
2022
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8. Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection

Author

Mehto, Subhash, primary, Jena, Kautilya Kumar, additional, Yadav, Rina, additional, Priyadarsini, Swatismita, additional, Samal, Pallavi, additional, Krishna, Sivaram, additional, Dhar, Kollori, additional, Jain, Ashish, additional, Chauhan, Nishant Ranjan, additional, Murmu, Krushna C, additional, Bal, Ramyasingh, additional, Sahu, Rinku, additional, Jaiswal, Pundrik, additional, Sahoo, Bhabani Sankar, additional, Patnaik, Srinivas, additional, Kufer, Thomas A, additional, Rusten, Tor Erik, additional, Chauhan, Swati, additional, Prasad, Punit, additional, and Chauhan, Santosh, additional

Published
2022
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11. Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses

Author

Nath, Parej, primary, Chauhan, Nishant Ranjan, additional, Jena, Kautilya Kumar, additional, Datey, Ankita, additional, Kumar, Nilima Dinesh, additional, Mehto, Subhash, additional, De, Saikat, additional, Nayak, Tapas Kumar, additional, Priyadarsini, Swatismita, additional, Rout, Kshitish, additional, Bal, Ramyasingh, additional, Murmu, Krushna C, additional, Kalia, Manjula, additional, Patnaik, Srinivas, additional, Prasad, Punit, additional, Reggiori, Fulvio, additional, Chattopadhyay, Soma, additional, and Chauhan, Santosh, additional

Published
2021
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12. Innate immunity and inflammophagy: balancing the defence and immune homeostasis.

Author

Chauhan, Swati, Jena, Kautilya Kumar, Mehto, Subhash, Chauhan, Nishant Ranjan, Sahu, Rinku, Dhar, Kollori, Yadav, Rina, Krishna, Sivaram, Jaiswal, Pundrik, and Chauhan, Santosh

Subjects
*NATURAL immunity, *PATTERN perception receptors, *HOMEOSTASIS, *CELLULAR signal transduction, *TRIM proteins
Abstract

Extensive crosstalk exists between autophagy and innate immune signalling pathways. The stimuli that induce pattern recognition receptor (PRR)‐mediated innate immune signalling pathways, also upregulate autophagy. The purpose of this increased autophagy is to eliminate the stimuli and/or suppress the inflammatory pathways by targeted degradation of PRRs or intermediary proteins (termed 'inflammophagy'). By executing these functions, autophagy dampens excess inflammation triggered by the innate immune signalling pathways. Thus, autophagy helps in the maintenance of the body's innate immune homeostasis to protect from inflammatory and autoimmune diseases. Many autophagy‐dependent mechanisms that could control innate immune signalling have been studied over the last few years. However, still, the understanding is incomplete, and studies that are more systematic should be undertaken to delineate the mechanisms of inflammophagy. Here, we discuss the available knowledge of crosstalk between autophagy and PRR signalling pathways. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Autoimmunity gene IRGM suppresses cGAS‐STING and RIG‐I‐MAVS signaling to control interferon response

Author

Jena, Kautilya Kumar, Mehto, Subhash, Nath, Parej, Chauhan, Nishant Ranjan, Sahu, Rinku, Dhar, Kollori, Das, Saroj Kumar, Kolapalli, Srinivasa Prasad, Murmu, Krushna C, Jain, Ashish, Krishna, Sivaram, Sahoo, Bhabani Sankar, Chattopadhyay, Soma, Rusten, Tor Erik, Prasad, Punit, Chauhan, Swati, and Chauhan, Santosh

Subjects
autophagy, Immunology, Autoimmunity, Articles, IRGM, RIG‐I‐MAVS, Nucleotidyltransferases, Article, Autoimmune Diseases, Mice, mitophagy, Animals, cGAS‐STING, Autophagy & Cell Death, Signal Transduction
Abstract

Activation of the type 1 interferon response is extensively connected to the pathogenesis of autoimmune diseases. Loss of function of Immunity Related GTPase M (IRGM) has also been associated to several autoimmune diseases, but its mechanism of action is unknown. Here, we found that IRGM is a master negative regulator of the interferon response. Several nucleic acid‐sensing pathways leading to interferon‐stimulated gene expression are highly activated in IRGM knockout mice and human cells. Mechanistically, we show that IRGM interacts with nucleic acid sensor proteins, including cGAS and RIG‐I, and mediates their p62‐dependent autophagic degradation to restrain interferon signaling. Further, IRGM deficiency results in defective mitophagy leading to the accumulation of defunct leaky mitochondria that release cytosolic DAMPs and mtROS. Hence, IRGM deficiency increases not only the levels of the sensors, but also those of the stimuli that trigger the activation of the cGAS‐STING and RIG‐I‐MAVS signaling axes, leading to robust induction of IFN responses. Taken together, this study defines the molecular mechanisms by which IRGM maintains interferon homeostasis and protects from autoimmune diseases., Loss of function of IRGM has been linked to the pathogenesis of several autoimmune diseases. This study shows that IRGM is a master repressor of interferon responses by controlling mitophagy and selective autophagy of nucleic acid sensors.

Published
2020

14. IRGM links autoimmunity to autophagy

Author

Nath, Parej, primary, Jena, Kautilya Kumar, additional, Mehto, Subhash, additional, Chauhan, Nishant Ranjan, additional, Sahu, Rinku, additional, Dhar, Kollori, additional, Srinivas, Kolapalli, additional, Chauhan, Swati, additional, and Chauhan, Santosh, additional

Published
2020
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15. Autoimmunity Risk Gene IRGM is a Master Negative Regulator of Interferon Response by Controlling the Activation of cGAS-STING and RIG-I-MAVS Signaling Pathways

Author

Jena, Kautilya Kumar, primary, Mehto, Subhash, additional, Nath, Parej, additional, Chauhan, Nishant Ranjan, additional, Sahu, Rinku, additional, Nayak, Tapas Kumar, additional, Das, Saroj Kumar, additional, Dhar, Kollori, additional, Sahoo, Pradyumna Kumar, additional, Murmu, Krushna C, additional, De, Saikat, additional, Datey, Ankita, additional, Prasad, Punit, additional, Chattopadhyay, Soma, additional, Chauhan, Swati, additional, and Chauhan, Santosh, additional

Published
2019
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17. TRIM16 governs the biogenesis and disposal of stress-induced protein aggregates to evade cytotoxicity: implication for neurodegeneration and cancer

Author

Jena, Kautilya Kumar, primary, Mehto, Subhash, additional, Kolapalli, Srinivasa Prasad, additional, Nath, Parej, additional, Sahu, Rinku, additional, Chauhan, Nishant Ranjan, additional, Sahoo, Pradyumna Kumar, additional, Dhar, Kollori, additional, Das, Saroj Kumar, additional, Chauhan, Swati, additional, and Chauhan, Santosh, additional

Published
2019
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18. The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

Author

Mehto, Subhash, primary, Jena, Kautilya Kumar, additional, Nath, Parej, additional, Chauhan, Swati, additional, Kolapalli, Srinivasa Prasad, additional, Das, Saroj Kumar, additional, Sahoo, Pradyumna Kumar, additional, Jain, Ashish, additional, Taylor, Gregory A., additional, and Chauhan, Santosh, additional

Published
2019
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21. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy

Author

Jena, Kautilya Kumar, primary, Kolapalli, Srinivasa Prasad, additional, Mehto, Subhash, additional, Nath, Parej, additional, Das, Biswajit, additional, Sahoo, Pradyumna Kumar, additional, Ahad, Abdul, additional, Syed, Gulam Hussain, additional, Raghav, Sunil K, additional, Senapati, Shantibhusan, additional, Chauhan, Swati, additional, and Chauhan, Santosh, additional

Published
2018
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