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1. Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee

Author

van Ewijk, Roelof, Chatziantoniou, Cyrano, Adams, Madeleine, Bertolini, Patrizia, Bisogno, Gianni, Bouhamama, Amine, Caro-Dominguez, Pablo, Charon, Valerie, Coma, Ana, Dandis, Rana, Devalck, Christine, De Donno, Giulia, Ferrari, Andrea, Fiocco, Marta, Gallego, Soledad, Giraudo, Chiara, Glosli, Heidi, ter Horst, Simone A. J., Jenney, Meriel, Klein, Willemijn M., Leemans, Alexander, Leseur, Julie, Mandeville, Henry C., McHugh, Kieran, Merks, Johannes H. M., Minard-Colin, Veronique, Moalla, Salma, Morosi, Carlo, Orbach, Daniel, Ording Muller, Lil-Sofie, Pace, Erika, Di Paolo, Pier Luigi, Perruccio, Katia, Quaglietta, Lucia, Renard, Marleen, van Rijn, Rick R., Ruggiero, Antonio, Sirvent, Sara I., De Luca, Alberto, and Schoot, Reineke A.

Published
2023
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2. Outcomes in lung-only metastatic rhabdomyosarcoma: An analysis of data from the European paediatric Soft tissue sarcoma Study Group MTS 2008 study

Author

Chisholm, Julia C., Schoot, Reineke A., Cameron, Alison L., Casanova, Michela, Minard-Colin, Veronique, Coppadoro, Beatrice, Garrido, Marta, Rogers, Timothy, Orbach, Daniel, Glosli, Heidi, Ben-Arush, Miriam, Ferman, Sima, Scarzello, Giovanni, van Rijn, Rick R., Hladun, Raquel, Corradini, Nadege, Ferrari, Andrea, Jenney, Meriel, Bisogno, Gianni, and Merks, Johannes H.M.

Published
2023
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7. Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial.

Author

Mandeville, Henry C., Bisogno, Gianni, Minard‐Colin, Veronique, Alaggio, Rita, Ben‐Arush, Myriam, Chargari, Cyrus, Coppadoro, Beatrice, Craigie, Ross, Devalck, Christine, Ferman, Sima, Ferrari, Andrea, Glosli, Heidi, Alvaro, Raquel Hladun, Hol, Marinka, Mudry, Peter, Orbach, Daniel, Albiac, Monica Ramos, Merks, Johannes H. M., and Jenney, Meriel E. M.

Subjects
SARCOMA, EYE-socket tumors, RHABDOMYOSARCOMA, OVERALL survival, SURGICAL excision
Abstract

Background: The authors report the prospective evaluation of reduced dose alkylator chemotherapy combined with radiotherapy for European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) standard risk nonalveolar rhabdomyosarcoma (NA‐RMS). Patients and Methods: Localized node negative Intergroup Rhabdomyosarcoma Study (IRS) II/III NA‐RMS at favorable sites (subgroup C), <25 years old, received five cycles of ifosfamide, vincristine, and dactinomycin (IVA) chemotherapy (30 g/m2 ifosfamide) and four cycles of vincristine and dactinomycin (if receiving radiotherapy), or nine cycles of IVA (54 g/m2 ifosfamide) ± radiotherapy. Delayed primary tumor excision was considered for IRS III tumors. The primary end points were event‐free survival (EFS) and overall survival (OS). Results: From October 2005 to December 2016, 359 evaluable patients were recruited: orbit, 164 (45.7%); head and neck nonparameningeal, 77 (21.4%); and genitourinary non–bladder/prostate, 118 (32.9%). EFS and OS were 77.4% (95% confidence interval [CI], 72.5–81.6) and 93.5% (95% CI, 90.1–95.8), respectively. Lower dose alkylator chemotherapy and radiotherapy achieved 5‐year OS of 93.7% but the difference with higher dose alkylator chemotherapy +/‐ radiotherapy was not significant (p = 0.8003). Adjuvant radiotherapy improved EFS with 5‐year estimates of 84.7% versus 65.2% for nonirradiated (p <.0001), but not OS (p =.9298). Omitting radiotherapy for orbital tumors reduced OS (5‐year was 87.1% vs. 97.3% for irradiated, p =.0257). Following R0 resection (n = 60), radiotherapy did not significantly improve EFS or OS. Conclusions: Radiotherapy for local tumor control allows for reduction of cumulative dose of alkylators in EpSSG standard risk subgroup C RMS patients. The omission of radiotherapy did not affect OS in all patients except those with orbital RMS and was associated with inferior EFS. Radiotherapy allowed effective reduction in cumulative dose of alkylators for localized Intergroup Rhabdomyosarcoma Study II/III nonalveolar rhabdomyosarcoma (RMS) at favorable sites in the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 trial. The omission of radiotherapy is associated with inferior event‐free survival but not overall survival (OS), although inferior OS was observed for orbital RMS. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia

Author

Attarbaschi, Andishe, Adams, Madeline R, Andres-Jensen, Liv, Bardi, Edit, Barzilai-Birenboim, Shlomit, Baust, Katja, Bhojwani, Deepa, Boesten, Tineke, Calaminus, Gabriele, Conyers, Rachel, Darlington, Anne-Sophie, de Ville, Maëlle, Escherich, Gabriele, Hagleitner, Melanie, Halsey, Christina, Harila-Saari, Arja, Hou, Jen-Yin, Huang, Ting-Huan, Hudson, Melissa, Jeha, Sima, Jenney, Meriel, Kato, Motohiro, Krawczuk-Rybak, Maryna, Kremer, Leontine, Lautem, Melchior, Liu, Hse-Che, Lopez Lopez, Elixabet, Mateos, Marion, Mlynarski, Wojciech, Möricke, Anja, Muszynska-Roslan, Katarzyna, Niinimaki, Riitta, Pieters, Rob, Piette, Caroline, Raetz, Elizabeth, Ronceray, Leila, Schmiegelow, Kjeld, Toro, Claudia, Trahair, Toby, Valsecchi, Maria Grazia, van der Sluis, Inge, van Litsenburg, Raphaële, Vrooman, Lynda, Weinreb, Sigal, Wiener, Andreas, Winick, Naomi, Yano, Michihiro, Yeh, Ting-Chi, Zapotocka, Ester, Andrés-Jensen, Liv, Hagleitner, Melanie M, van Litsenburg, Raphaele R L, Hudson, Melissa M, Kremer, Leontien, Grazia Valsecchi, Maria, and Vrooman, Lynda M

Published
2021
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9. Non-parameningeal head and neck rhabdomyosarcoma in children, adolescents, and young adults: Experience of the European paediatric Soft tissue sarcoma Study Group (EpSSG) – RMS2005 study

Author

Glosli, Heidi, Bisogno, Gianni, Kelsey, Anna, Chisholm, Julia C., Gaze, Mark, Kolb, Frederic, McHugh, Kieran, Shipley, Janet, Gallego, Soledad, Merks, Johannes H.M., Smeele, Ludi E., Mandeville, Henry, Ferrari, Andrea, Minard-Colin, Veronique, Corradini, Nadege, Jenney, Meriel, Zanetti, Ilaria, De Salvo, Gian L., and Orbach, Daniel

Published
2021
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12. Embryonal rhabdomyosarcoma completely resected at diagnosis: The European paediatric Soft tissue sarcoma Study Group RMS2005 experience

Author

Rose, Adriana, Devalck, Christine, Ferman, Sima, Mudry, Peter, Bergeron, Christophe, Arush, Myriam Weyl Ben, Bisogno, Gianni, Glosli, Heidi, Sejnova, Daniela, Cesen, Maja, Gallego, Soledad, Merks, J. Hans, Jenney, Meriel, De Corti, Federica, Merks, Hans, Ferrari, Andrea, Ranchère-Vince, Dominique, De Salvo, Gian Luca, Zanetti, Ilaria, Chisholm, Julia, Minard-Colin, Véronique, and Rogers, Timothy

Published
2021
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13. Reappraisal of prognostic factors used in the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 study for localized rhabdomyosarcoma to optimize risk stratification and generate a prognostic nomogram

Author

Onderzoek Beeld, De Salvo, Gian Luca, Del Bianco, Paola, Minard-Colin, Veronique, Chisholm, Julia, Jenney, Meriel, Guillen, Gabriela, Devalck, Christine, Van Rijn, Rick, Shipley, Janet, Orbach, Daniel, Kelsey, Anna, Rogers, Timothy, Guerin, Florent, Scarzello, Giovanni, Ferrari, Andrea, Cesen Mazic, Maja, Merks, Johannes H.M., Bisogno, Gianni, Onderzoek Beeld, De Salvo, Gian Luca, Del Bianco, Paola, Minard-Colin, Veronique, Chisholm, Julia, Jenney, Meriel, Guillen, Gabriela, Devalck, Christine, Van Rijn, Rick, Shipley, Janet, Orbach, Daniel, Kelsey, Anna, Rogers, Timothy, Guerin, Florent, Scarzello, Giovanni, Ferrari, Andrea, Cesen Mazic, Maja, Merks, Johannes H.M., and Bisogno, Gianni

Published
2024

14. Reappraisal of prognostic factors used in the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 study for localized rhabdomyosarcoma to optimize risk stratification and generate a prognostic nomogram.

Author

De Salvo, Gian Luca, Del Bianco, Paola, Minard‐Colin, Veronique, Chisholm, Julia, Jenney, Meriel, Guillen, Gabriela, Devalck, Christine, Van Rijn, Rick, Shipley, Janet, Orbach, Daniel, Kelsey, Anna, Rogers, Timothy, Guerin, Florent, Scarzello, Giovanni, Ferrari, Andrea, Cesen Mazic, Maja, Merks, Johannes H. M., and Bisogno, Gianni

Subjects
SARCOMA, RHABDOMYOSARCOMA, PROGNOSIS, PROPORTIONAL hazards models, NOMOGRAPHY (Mathematics)
Abstract

Background: The objective of this study was to investigate the role of clinical factors together with FOXO1 fusion status in patients with nonmetastatic rhabdomyosarcoma (RMS) to develop a predictive model for event‐free survival and provide a rationale for risk stratification in future trials. Methods: The authors used data from patients enrolled in the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) RMS 2005 study (EpSSG RMS 2005; EudraCT number 2005‐000217‐35). The following baseline variables were considered for the multivariable model: age at diagnosis, sex, histology, primary tumor site, Intergroup Rhabdomyosarcoma Studies group, tumor size, nodal status, and FOXO1 fusion status. Main effects and significant second‐order interactions of candidate predictors were included in a multiple Cox proportional hazards regression model. A nomogram was generated for predicting 5‐year event‐free survival (EFS) probabilities. Results: The EFS and overall survival rates at 5 years were 70.9% (95% confidence interval, 68.6%–73.1%) and 81.0% (95% confidence interval, 78.9%–82.8%), respectively. The multivariable model retained five prognostic factors, including age at diagnosis interacting with tumor size, tumor primary site, Intergroup Rhabdomyosarcoma Studies clinical group, and FOXO1 fusion status. Based on each patient's total score in the nomogram, patients were stratified into four groups. The 5‐year EFS rates were 94.1%, 78.4%, 65.2%, and 52.1% in the low‐risk, intermediate‐risk, high‐risk, and very‐high‐risk groups, respectively, and the corresponding 5‐year overall survival rates were 97.2%, 91.5%, 74.3%, and 60.8%, respectively. Conclusions: The results presented here provide the rationale to modify the EpSSG stratification, with the most significant change represented by the replacement of histology with fusion status. This classification was adopted in the new international trial launched by the EpSSG. Traditional clinical factors, together with FOXO1 fusion status, in nonmetastatic rhabdomyosarcoma were investigated to develop a predictive model for event‐free survival and provide a rationale for risk stratification in future trials. The most important result was the replacement of histology with fusion status, and this model was used for patient stratification in the new European Pediatric Soft Tissue Sarcoma Study Group Frontline and Relapse Rhabdomyosarcoma trial (ClinicalTrials.gov identifier NCT04625907). [ABSTRACT FROM AUTHOR]

Published
2024
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15. Frontline and Relapsed Rhabdomyosarcoma (FAR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)

Author

Chisholm, Julia, primary, Mandeville, Henry, additional, Adams, Madeleine, additional, Minard-Collin, Veronique, additional, Rogers, Timothy, additional, Kelsey, Anna, additional, Shipley, Janet, additional, van Rijn, Rick R., additional, de Vries, Isabelle, additional, van Ewijk, Roelof, additional, de Keizer, Bart, additional, Gatz, Susanne A., additional, Casanova, Michela, additional, Hjalgrim, Lisa Lyngsie, additional, Firth, Charlotte, additional, Wheatley, Keith, additional, Kearns, Pamela, additional, Liu, Wenyu, additional, Kirkham, Amanda, additional, Rees, Helen, additional, Bisogno, Gianni, additional, Wasti, Ajla, additional, Wakeling, Sara, additional, Heenen, Delphine, additional, Tweddle, Deborah A., additional, Merks, Johannes H. M., additional, and Jenney, Meriel, additional

Published
2024
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16. Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial

Author

Bisogno, Gianni, De Salvo, Gian Luca, Bergeron, Christophe, Gallego Melcón, Soledad, Merks, Johannes H, Kelsey, Anna, Martelli, Helene, Minard-Colin, Veronique, Orbach, Daniel, Glosli, Heidi, Chisholm, Julia, Casanova, Michela, Zanetti, Ilaria, Devalck, Christine, Ben-Arush, Myriam, Mudry, Peter, Ferman, Sima, Jenney, Meriel, and Ferrari, Andrea

Published
2019
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17. Addition of dose-intensified doxorubicin to standard chemotherapy for rhabdomyosarcoma (EpSSG RMS 2005): a multicentre, open-label, randomised controlled, phase 3 trial

Author

Cesen, Maja, Rose, Adriana, Ferman, Sima, Mudry, Peter, Sejnova, Daniela, Dal Bianco, Paola, Zanetti, Ilaria, Niggli, Felix, Rogers, Timothy, Cecchetto, Giovanni, De Corti, Federica, Guerin, Florent, Terwisscha, Sheila, Ranchere, Dominique, Alaggio, Rita, Shipley, Janet, Rosolen, Angelo, Mandeville, Henry, Scarzello, Giovanni, Bernier, Valerie, McHugh, Kieran, Bisogno, Gianni, Jenney, Meriel, Bergeron, Christophe, Gallego Melcón, Soledad, Ferrari, Andrea, Oberlin, Odile, Carli, Modesto, Stevens, Michael, Kelsey, Anna, De Paoli, Angela, Gaze, Mark N, Martelli, Helene, Devalck, Christine, Merks, Johannes H, Ben-Arush, Myriam, Glosli, Heidi, Chisholm, Julia, Orbach, Daniel, Minard-Colin, Veronique, and De Salvo, Gian Luca

Published
2018
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19. Maintenance Chemotherapy for Patients with Rhabdomyosarcoma

Author

Bisogno, Gianni, primary, Minard-Colin, Veronique, additional, Jenney, Meriel., additional, Ferrari, Andrea, additional, Chisholm, Julia, additional, Di Carlo, Daniela, additional, Hjalgrim, Lisa Lyngsie, additional, Orbach, Daniel, additional, Merks, Johannes Hendrikus Maria, additional, and Casanova, Michela, additional

Published
2023
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20. Long-term survivors of childhood cancer: cure and care—the Erice Statement (2006) revised after 10 years (2016)

Author

Jankovic, Momcilo, Haupt, Riccardo, Spinetta, John J., Beck, Joern D., Byrne, Julianne, Calaminus, Gabriele, Lackner, Herwig, Biondi, Andrea, Oeffinger, Kevin, Hudson, Melissa, Skinner, Roderick, Reaman, Gregory, van der Pal, Helena, Kremer, Leontien, den Hartogh, Jaap, Michel, Gisela, Frey, Eva, Bardi, Edit, Hawkins, Michael, Rizvi, Katie, Terenziani, Monica, Valsecchi, Maria Grazia, Bode, Gerlind, Jenney, Meriel, de Vathaire, Florent, Garwicz, Stanislaw, Levitt, Gill A., Grabow, Desiree, Kuehni, Claudia E., Schrappe, Martin, Hjorth, Lars, and participants in PanCare

Published
2018
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21. Time to broaden the eligibility criteria in paediatric oncology trials? An analysis of patients with rhabdomyosarcoma non-eligible to the EpSSG RMS2005 trial

Author

MS Radiotherapie, Cancer, Onderzoek Beeld, Bisogno, Gianni, De Salvo, Gian Luca, Minard-Colin, Veronique, Fajardo, Raquel Davila, Coppadoro, Beatrice, Jenney, Meriel, Ferrari, Andrea, Alvaro, Raquel Hladun, Dall'Igna, Patrizia, Glosli, Heidi, Merks, Johannes H.M., MS Radiotherapie, Cancer, Onderzoek Beeld, Bisogno, Gianni, De Salvo, Gian Luca, Minard-Colin, Veronique, Fajardo, Raquel Davila, Coppadoro, Beatrice, Jenney, Meriel, Ferrari, Andrea, Alvaro, Raquel Hladun, Dall'Igna, Patrizia, Glosli, Heidi, and Merks, Johannes H.M.

Published
2023

22. Outcomes in lung-only metastatic rhabdomyosarcoma: An analysis of data from the European paediatric Soft tissue sarcoma Study Group MTS 2008 study

Author

Arts-assistenten Kinderen, Onderzoek Beeld, Chisholm, Julia C., Schoot, Reineke A., Cameron, Alison L., Casanova, Michela, Minard-Colin, Veronique, Coppadoro, Beatrice, Garrido, Marta, Rogers, Timothy, Orbach, Daniel, Glosli, Heidi, Ben-Arush, Miriam, Ferman, Sima, Scarzello, Giovanni, van Rijn, Rick R., Hladun, Raquel, Corradini, Nadege, Ferrari, Andrea, Jenney, Meriel, Bisogno, Gianni, Merks, Johannes H.M., Arts-assistenten Kinderen, Onderzoek Beeld, Chisholm, Julia C., Schoot, Reineke A., Cameron, Alison L., Casanova, Michela, Minard-Colin, Veronique, Coppadoro, Beatrice, Garrido, Marta, Rogers, Timothy, Orbach, Daniel, Glosli, Heidi, Ben-Arush, Miriam, Ferman, Sima, Scarzello, Giovanni, van Rijn, Rick R., Hladun, Raquel, Corradini, Nadege, Ferrari, Andrea, Jenney, Meriel, Bisogno, Gianni, and Merks, Johannes H.M.

Published
2023

23. Nonmetastatic Rhabdomyosarcoma in Children and Adolescents: Overall Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS2005 Study

Author

MS Radiotherapie, Cancer, PMC Medisch specialisten, Onderzoek Beeld, Bisogno, Gianni, Minard-Colin, Veronique, Zanetti, Ilaria, Ferrari, Andrea, Gallego, Soledad, Dávila Fajardo, Raquel, Mandeville, Henry, Kelsey, Anna, Alaggio, Rita, Orbach, Daniel, Terwisscha Van Scheltinga, Sheila, Guillén Burrieza, Gabriela, Ben-Arush, Myriam, Glosli, Heidi, Mudry, Peter, Ferman, Sima, Devalck, Christine, Defachelles, Anne Sophie, Merks, Johannes Hendrikus Maria, Jenney, Meriel, MS Radiotherapie, Cancer, PMC Medisch specialisten, Onderzoek Beeld, Bisogno, Gianni, Minard-Colin, Veronique, Zanetti, Ilaria, Ferrari, Andrea, Gallego, Soledad, Dávila Fajardo, Raquel, Mandeville, Henry, Kelsey, Anna, Alaggio, Rita, Orbach, Daniel, Terwisscha Van Scheltinga, Sheila, Guillén Burrieza, Gabriela, Ben-Arush, Myriam, Glosli, Heidi, Mudry, Peter, Ferman, Sima, Devalck, Christine, Defachelles, Anne Sophie, Merks, Johannes Hendrikus Maria, and Jenney, Meriel

Published
2023

24. Biological Role and Clinical Implications of MYOD1L122R Mutation in Rhabdomyosarcoma

Author

MS Radiotherapie, Cancer, Onderzoek Beeld, Di Carlo, Daniela, Chisholm, Julia, Kelsey, Anna, Alaggio, Rita, Bisogno, Gianni, Minard-Colin, Veronique, Jenney, Meriel, Dávila Fajardo, Raquel, Merks, Johannes H.M., Shipley, Janet M., Selfe, Joanna L., MS Radiotherapie, Cancer, Onderzoek Beeld, Di Carlo, Daniela, Chisholm, Julia, Kelsey, Anna, Alaggio, Rita, Bisogno, Gianni, Minard-Colin, Veronique, Jenney, Meriel, Dávila Fajardo, Raquel, Merks, Johannes H.M., Shipley, Janet M., and Selfe, Joanna L.

Published
2023

25. Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee

Author

Beeldverwerking ISI, Cancer, MS Radiologie, Brain, Onderzoek Beeld, Research UMC Utrecht, Arts-assistenten Kinderen, van Ewijk, Roelof, Chatziantoniou, Cyrano, Adams, Madeleine, Bertolini, Patrizia, Bisogno, Gianni, Bouhamama, Amine, Caro-Dominguez, Pablo, Charon, Valerie, Coma, Ana, Dandis, Rana, Devalck, Christine, De Donno, Giulia, Ferrari, Andrea, Fiocco, Marta, Gallego, Soledad, Giraudo, Chiara, Glosli, Heidi, ter Horst, Simone A.J., Jenney, Meriel, Klein, Willemijn M., Leemans, Alexander, Leseur, Julie, Mandeville, Henry C., McHugh, Kieran, Merks, Johannes H.M., Minard-Colin, Veronique, Moalla, Salma, Morosi, Carlo, Orbach, Daniel, Ording Muller, Lil Sofie, Pace, Erika, Di Paolo, Pier Luigi, Perruccio, Katia, Quaglietta, Lucia, Renard, Marleen, van Rijn, Rick R., Ruggiero, Antonio, Sirvent, Sara I., De Luca, Alberto, Schoot, Reineke A., Beeldverwerking ISI, Cancer, MS Radiologie, Brain, Onderzoek Beeld, Research UMC Utrecht, Arts-assistenten Kinderen, van Ewijk, Roelof, Chatziantoniou, Cyrano, Adams, Madeleine, Bertolini, Patrizia, Bisogno, Gianni, Bouhamama, Amine, Caro-Dominguez, Pablo, Charon, Valerie, Coma, Ana, Dandis, Rana, Devalck, Christine, De Donno, Giulia, Ferrari, Andrea, Fiocco, Marta, Gallego, Soledad, Giraudo, Chiara, Glosli, Heidi, ter Horst, Simone A.J., Jenney, Meriel, Klein, Willemijn M., Leemans, Alexander, Leseur, Julie, Mandeville, Henry C., McHugh, Kieran, Merks, Johannes H.M., Minard-Colin, Veronique, Moalla, Salma, Morosi, Carlo, Orbach, Daniel, Ording Muller, Lil Sofie, Pace, Erika, Di Paolo, Pier Luigi, Perruccio, Katia, Quaglietta, Lucia, Renard, Marleen, van Rijn, Rick R., Ruggiero, Antonio, Sirvent, Sara I., De Luca, Alberto, and Schoot, Reineke A.

Published
2023

26. Conservative strategy in infantile fibrosarcoma is possible: The European paediatric Soft tissue sarcoma Study Group experience

Author

Orbach, Daniel, Brennan, Bernadette, De Paoli, Angela, Gallego, Soledad, Mudry, Peter, Francotte, Nadine, van Noesel, Max, Kelsey, Anna, Alaggio, Rita, Ranchère, Dominique, De Salvo, Gian Luca, Casanova, Michela, Bergeron, Christophe, Merks, Johannes H.M., Jenney, Meriel, Stevens, Michael C.G., Bisogno, Gianni, and Ferrari, Andrea

Published
2016
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28. Nonmetastatic Rhabdomyosarcoma in Children and Adolescents: Overall Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS2005 Study

Author

Bisogno, Gianni, primary, Minard-Colin, Veronique, additional, Zanetti, Ilaria, additional, Ferrari, Andrea, additional, Gallego, Soledad, additional, Dávila Fajardo, Raquel, additional, Mandeville, Henry, additional, Kelsey, Anna, additional, Alaggio, Rita, additional, Orbach, Daniel, additional, Terwisscha van Scheltinga, Sheila, additional, Guillén Burrieza, Gabriela, additional, Ben-Arush, Myriam, additional, Glosli, Heidi, additional, Mudry, Peter, additional, Ferman, Sima, additional, Devalck, Christine, additional, Defachelles, Anne Sophie, additional, Merks, Johannes Hendrikus Maria, additional, and Jenney, Meriel, additional

Published
2023
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30. Shedding a Light on the Challenges of Adolescents and Young Adults with Rhabdomyosarcoma

Author

Ferrari, Andrea, primary, Gatz, Susanne Andrea, additional, Minard-Colin, Veronique, additional, Alaggio, Rita, additional, Hovsepyan, Shushan, additional, Orbach, Daniel, additional, Gasparini, Patrizia, additional, Defachelles, Anne-Sophie, additional, Casanova, Michela, additional, Milano, Giuseppe Maria, additional, Chisholm, Julia C., additional, Jenney, Meriel, additional, Bisogno, Gianni, additional, Rogers, Timothy, additional, Mandeville, Henry C., additional, Shipley, Janet, additional, Miah, Aisha B., additional, Merks, Johannes H. M., additional, and van der Graaf, Winette T. A., additional

Published
2022
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31. Erratum to ‘Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma’ [Eur J Cancer 170 (2022) 209-235]

Author

Budde, Axel, primary, Baust, Katja, additional, Weinhold, Leonie, additional, Bernstein, Mark, additional, Bielack, Stefan, additional, Dhooge, Catharina, additional, Hjorth, Lars, additional, Janeway, Katherine A., additional, Jenney, Meriel, additional, Krailo, Mark D., additional, Marina, Neyssa, additional, Nagarajan, Rajaram, additional, Smeland, Sigbjørn, additional, Sydes, Matthew R., additional, De Vos, Patricia, additional, Whelan, Jeremy, additional, Wiener, Andreas, additional, Calaminus, Gabriele, additional, and Schmid, Matthias, additional

Published
2022
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32. Metastatic Rhabdomyosarcoma: Results of the European Paediatric Soft Tissue Sarcoma Study Group MTS 2008 Study and Pooled Analysis With the Concurrent BERNIE Study

Author

Schoot, Reineke A., primary, Chisholm, Julia C., additional, Casanova, Michela, additional, Minard-Colin, Veronique, additional, Geoerger, Birgit, additional, Cameron, Alison L., additional, Coppadoro, Beatrice, additional, Zanetti, Ilaria, additional, Orbach, Daniel, additional, Kelsey, Anna, additional, Rogers, Timothy, additional, Guizani, Cecile, additional, Elze, Markus, additional, Ben-Arush, Myriam, additional, McHugh, Kieran, additional, van Rijn, Rick R., additional, Ferman, Sima, additional, Gallego, Soledad, additional, Ferrari, Andrea, additional, Jenney, Meriel, additional, Bisogno, Gianni, additional, and Merks, Johannes H.M., additional

Published
2022
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33. Paratesticular rhabdomyosarcoma in children and adolescents—Outcome and patterns of relapse when utilizing a nonsurgical strategy for lymph node staging: Report from the International Society of Paediatric Oncology (SIOP) Malignant Mesenchymal Tumour 89 and 95 studies

Author

Rogers, Timothy, Minard‐Colin, Veronique, Cozic, Nathalie, Jenney, Meriel, Merks, Johannes H. M., Gallego, Soledad, Devalck, Christine, Gaze, Mark N., Kelsey, Anna, Oberlin, Odile, Stevens, Mike, Spicer, Richard D., Bergeron, Christophe, and Martelli, Helene

Published
2017
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34. Prognostic relevance of early radiologic response to induction chemotherapy in pediatric rhabdomyosarcoma: A report from the International Society of Pediatric Oncology Malignant Mesenchymal Tumor 95 study

Author

Vaarwerk, Bas, van der Lee, Johanna H., Breunis, Willemijn B., Orbach, Daniel, Chisholm, Julia C., Cozic, Nathalie, Jenney, Meriel, van Rijn, Rick R., McHugh, Kieran, Gallego, Soledad, Glosli, Heidi, Devalck, Christine, Gaze, Mark N., Kelsey, Anna, Bergeron, Christophe, Stevens, Michael C. G., Oberlin, Odile, Minard‐Colin, Veronique, and Merks, Johannes H. M.

Published
2018
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35. Adolescents and young adults with rhabdomyosarcoma treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) protocols: a cohort study

Author

Ferrari, Andrea, primary, Chisholm, Julia C, additional, Jenney, Meriel, additional, Minard-Colin, Veronique, additional, Orbach, Daniel, additional, Casanova, Michela, additional, Guillen, Gabriela, additional, Glosli, Heidi, additional, van Rijn, Rick R, additional, Schoot, Reineke A, additional, Cameron, Alison L, additional, Rogers, Timothy, additional, Alaggio, Rita, additional, Ben-Arush, Myriam, additional, Mandeville, Henry C, additional, Devalck, Christine, additional, Defachelles, Anne-Sophie, additional, Coppadoro, Beatrice, additional, Bisogno, Gianni, additional, and Merks, Johannes H M, additional

Published
2022
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36. Adolescents and young adults with rhabdomyosarcoma treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) protocols: a cohort study

Author

Ferrari, Andrea, Chisholm, Julia, Jenney, Meriel, Minard-Colin, Véronique, Orbach, Daniel, Casanova, Michela, Guillen, Gabriela, Glosli, Heidi, Van Rijn, Rick Robert, Schoot, Reineke R.A., Cameron, Alison, Rogers, Timothy, Alaggio, Rita, Ben-Arush, Myriam, Mandeville, Henry H.C., Devalck, Christine, Defachelles, Anne Sophie, Coppadoro, Beatrice, Bisogno, Gianni, Merks, Johannes H M, Ferrari, Andrea, Chisholm, Julia, Jenney, Meriel, Minard-Colin, Véronique, Orbach, Daniel, Casanova, Michela, Guillen, Gabriela, Glosli, Heidi, Van Rijn, Rick Robert, Schoot, Reineke R.A., Cameron, Alison, Rogers, Timothy, Alaggio, Rita, Ben-Arush, Myriam, Mandeville, Henry H.C., Devalck, Christine, Defachelles, Anne Sophie, Coppadoro, Beatrice, Bisogno, Gianni, and Merks, Johannes H M

Abstract

Background: Adolescent and young adult patients with rhabdomyosarcoma often have poorer outcomes than do children. We aimed to compare the findings of adolescent and young adult patients with children enrolled in two prospective clinical protocols. Methods: This retrospective observational analysis was based on data from the European paediatric Soft tissue sarcoma Study Group (EpSSG) rhabdomyosarcoma 2005 trial (phase 3 randomised trial for localised rhabdomyosarcoma, open from April, 2006, to December, 2016) and the EpSSG MTS 2008 protocol (prospective, observational, single-arm study for metastatic rhabdomyosarcoma, open from June, 2010, to December, 2016), which involved 108 centres from 14 different countries in total. For this analysis, patients were categorised according to their age into children (age 0–14 years) and adolescents and young adults (age 15–21 years). For the analysis of adherence to treatment and toxicity, only patients with high-risk localised rhabdomyosarcoma included in the randomised part of the rhabdomyosarcoma 2005 study were considered. The primary outcome of event-free survival (assessed in all participants) was defined as the time from diagnosis to the first event (eg, tumour progression, relapse) or to the latest follow-up. Secondary outcomes were overall survival, response to chemotherapy, and toxicity. Findings: Our analysis included 1977 patients, 1720 children (median age 4·7 years; IQR 2·6–8·4) and 257 adolescents and young adults (16·6 years; 15·8–18·0). 1719 patients were from the EpSSG rhabdomyosarcoma 2005 study (1523 aged <15 years and 196 aged 15–21 years) and 258 patients were from the EPSSG MTS 2008 study (197 aged <15 years and 61 aged 15–21 years). Adolescent and young adult patients were more likely than were children to have metastatic tumours (61 [23·7%] of 257 vs 197 [11·5%] of 1720; p<0·0001), unfavourable histological subtypes (119 [46·3%] vs 451 [26·2%]; p<0·0001), tumours larger than 5 cm (177 [68·9%] vs 891 [51·, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

37. Shedding a Light on the Challenges of Adolescents and Young Adults with Rhabdomyosarcoma

Author

Ferrari, Andrea, Gatz, Susanne Andrea, Minard-Colin, Veronique, Alaggio, Rita, Hovsepyan, Shushan, Orbach, Daniel, Gasparini, Patrizia, Defachelles, Anne Sophie, Casanova, Michela, Milano, Giuseppe Maria, Chisholm, Julia C., Jenney, Meriel, Bisogno, Gianni, Rogers, Timothy, Mandeville, Henry C., Shipley, Janet, Miah, Aisha B., Merks, Johannes H.M., van der Graaf, Winette T.A., Ferrari, Andrea, Gatz, Susanne Andrea, Minard-Colin, Veronique, Alaggio, Rita, Hovsepyan, Shushan, Orbach, Daniel, Gasparini, Patrizia, Defachelles, Anne Sophie, Casanova, Michela, Milano, Giuseppe Maria, Chisholm, Julia C., Jenney, Meriel, Bisogno, Gianni, Rogers, Timothy, Mandeville, Henry C., Shipley, Janet, Miah, Aisha B., Merks, Johannes H.M., and van der Graaf, Winette T.A.

Abstract

Rhabdomyosarcoma (RMS) is a typical tumour of childhood but can occur at any age. Several studies have reported that adolescent and young adult (AYA) patients with RMS have poorer survival than do younger patients. This review discusses the specific challenges in AYA patients with pediatric-type RMS, exploring possible underlying factors which may influence different outcomes. Reasons for AYA survival gap are likely multifactorial, and might be related to differences in tumor biology and intrinsic aggressiveness, or differences in clinical management (that could include patient referral patterns, time to diagnosis, enrolment into clinical trials, the adequacy and intensity of treatment), as well as patient factors (including physiology and comorbidity that may influence treatment tolerability, drug pharmacokinetics and efficacy). However, improved survival has been reported in the most recent studies for AYA patients treated on pediatric RMS protocols. Different strategies may help to further improve outcome, such as supporting trans-age academic societies and national/international collaborations; developing specific clinical trials without upper age limit; defining integrated and comprehensive approach to AYA patients, including the genomic aspects; establishing multidisciplinary tumor boards with involvement of both pediatric and adult oncologists to discuss all pediatric-type RMS patients; developing dedicated projects with specific treatment recommendations and registry/database.

Published
2022

38. Perianal/perineal rhabdomyosarcoma: Results of the SIOP MMT 95, Italian RMS 96, and EpSSG RMS 2005 studies

Author

MS Radiotherapie, Cancer, Rogers, Timothy, Zanetti, Ilaria, Coppadoro, Beatrice, Martelli, Hélène, Jenney, Meriel, Minard-Colin, Veronique, Terwisscha van Scheltinga, Sheila E.J., Skerritt, Clare, Fajardo, Raquel Dávila, Guérin, Florent, Kelsey, Anna, Merks, Johannes H.M., Mandeville, Henry, Guillén, Gabriela, Glosli, Heidi, De Corti, Federica, Bisogno, Gianni, MS Radiotherapie, Cancer, Rogers, Timothy, Zanetti, Ilaria, Coppadoro, Beatrice, Martelli, Hélène, Jenney, Meriel, Minard-Colin, Veronique, Terwisscha van Scheltinga, Sheila E.J., Skerritt, Clare, Fajardo, Raquel Dávila, Guérin, Florent, Kelsey, Anna, Merks, Johannes H.M., Mandeville, Henry, Guillén, Gabriela, Glosli, Heidi, De Corti, Federica, and Bisogno, Gianni

Published
2022

39. Therapy and prognostic significance of regional lymph node involvement in embryonal rhabdomyosarcoma: a report from the European paediatric Soft tissue sarcoma Study Group

Author

MS Radiotherapie, Cancer, Ben-Arush, Myriam, Minard-Colin, Veronique, Scarzello, Giovanni, Fajardo, Raquel D., Terwisscha Van Scheltinga, Sheila, Bernier, Valérie, Jenney, Meriel, Gallego, Soledad, Zanetti, Ilaria, Cesen, Maja, Merks, Johannes H.M., Bisogno, Gianni, MS Radiotherapie, Cancer, Ben-Arush, Myriam, Minard-Colin, Veronique, Scarzello, Giovanni, Fajardo, Raquel D., Terwisscha Van Scheltinga, Sheila, Bernier, Valérie, Jenney, Meriel, Gallego, Soledad, Zanetti, Ilaria, Cesen, Maja, Merks, Johannes H.M., and Bisogno, Gianni

Published
2022

40. Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies

Author

Orbach, Daniel, Mosseri, Veronique, Gallego, Soledad, Kelsey, Anna, Devalck, Christine, Brenann, Bernadette, van Noesel, Max M., Bergeron, Christophe, Merks, Johannes H. M., Rechnitzer, Catherine, Jenney, Meriel, Minard–Colin, Veronique, and Stevens, Michael

Published
2017
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41. Perianal/perineal rhabdomyosarcoma: Results of the SIOP MMT 95, Italian RMS 96, and EpSSG RMS 2005 studies

Author

Rogers, Timothy, primary, Zanetti, Ilaria, additional, Coppadoro, Beatrice, additional, Martelli, Hélène, additional, Jenney, Meriel, additional, Minard‐Colin, Veronique, additional, Terwisscha van Scheltinga, Sheila E. J., additional, Skerritt, Clare, additional, Fajardo, Raquel Dávila, additional, Guérin, Florent, additional, Kelsey, Anna, additional, Merks, Johannes H. M., additional, Mandeville, Henry, additional, Guillén, Gabriela, additional, Glosli, Heidi, additional, De Corti, Federica, additional, and Bisogno, Gianni, additional

Published
2022
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42. Erratum to ‘Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma’ [Eur J Cancer 170 (2022) 209-235, (S0959804922001629), (10.1016/j.ejca.2022.03.018)]

Author

Budde, Axel, Baust, Katja, Weinhold, Leonie, Bernstein, Mark, Bielack, Stefan, Dhooge, Catharina, Hjorth, Lars, Janeway, Katherine A., Jenney, Meriel, Krailo, Mark D., Marina, Neyssa, Nagarajan, Rajaram, Smeland, Sigbjørn, Sydes, Matthew R., De Vos, Patricia, Whelan, Jeremy, Wiener, Andreas, Calaminus, Gabriele, and Schmid, Matthias

Subjects
Medizin
Abstract

The publisher regrets that errors appear in Table 2a in the printed article. These errors have now been corrected online, and the correct version of Table 2a is given here.[Formula presented] We also note that a Multimedia component was included with the online article in error. This has now been removed from the online article. We can confirm that there are no additional Supplementary Data files to appear with this article. The publisher would like to apologise for any inconvenience caused.

Published
2022

45. Localised rhabdomyosarcoma in infants (<12 months) and young children (12–36 months of age) treated on the EpSSG RMS 2005 study

Author

Slater, Olga, primary, Gains, Jennifer E., additional, Kelsey, Anna M., additional, De Corti, Federica, additional, Zanetti, Ilaria, additional, Coppadoro, Beatrice, additional, Jorgensen, Mette, additional, Gallego, Soledad, additional, Orbach, Daniel H., additional, Glosli, Heidi, additional, Cesen, Maja, additional, Gaze, Mark N., additional, Smeulders, Naima, additional, Ferrari, Andrea, additional, Jenney, Meriel, additional, Minard-Colin, Veronique, additional, Bisogno, Gianni, additional, and Merks, Johannes H.M., additional

Published
2022
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46. Therapy and Prognostic Significance of Regional Lymph Node Involvement in Embryonal Rhabdomyosarcoma: A Report from the European Paediatric Soft Tissue Sarcoma Study Group

Author

Ben Arush, Myriam, primary, Minard, Véronique, additional, Scarzello, Giovanni, additional, Fajardo, Raquel Dávila, additional, Van Scheltinga, Sheila Terwisscha, additional, Bernier, Valérie, additional, Jenney, Meriel, additional, Gallego, Soledad, additional, Zanetti, Ilaria, additional, Cesen, Maja, additional, Merks, Johannes H. M., additional, and Bisogno, Gianni, additional

Published
2022
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47. Biological Role and Clinical Implications of MYOD1 L122R Mutation in Rhabdomyosarcoma.

Author

Di Carlo, Daniela, Chisholm, Julia, Kelsey, Anna, Alaggio, Rita, Bisogno, Gianni, Minard-Colin, Veronique, Jenney, Meriel, Dávila Fajardo, Raquel, Merks, Johannes H. M., Shipley, Janet M., and Selfe, Joanna L.

Subjects
CELL differentiation, GENETIC mutation, RHABDOMYOSARCOMA, PHOSPHOTRANSFERASES, CARCINOGENESIS, CELLS, PHENOTYPES
Abstract

Simple Summary: The myogenic differentiation 1 gene (MYOD1) p.L122R mutation was first discovered in a subset of clinically aggressive rhabdomyosarcomas in both adults and children. It occurs most frequently in spindle cell (Sp) or sclerosing (Sc) RMS, but also occasionally in ERMS, including 3% of all PAX fusion-negative RMS. The presence of the MYOD1L122R mutation seems to be associated with a very poor prognosis, especially when it occurs concomitantly with other mutations such as PIK3CA. In this review, we consider the known biological effects of MYOD1 mutations and present a review of published cases of RMS with MYOD1 mutations. Together, the reviewed biological characteristics and the clinical features focus attention on this specific subgroup of patients with poor outcome and highlight the need to identify an optimal therapeutic strategy. Major progress in recent decades has furthered our clinical and biological understanding of rhabdomyosarcoma (RMS) with improved stratification for treatment based on risk factors. Clinical risk factors alone were used to stratify patients for treatment in the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) RMS 2005 protocol. The current EpSSG overarching study for children and adults with frontline and relapsed rhabdomyosarcoma (FaR-RMS NCT04625907) includes FOXO1 fusion gene status in place of histology as a risk factor. Additional molecular features of significance have recently been recognized, including the MYOD1L122R gene mutation. Here, we review biological information showing that MYOD1L122R blocks cell differentiation and has a MYC-like activity that enhances tumorigenesis and is linked to an aggressive cellular phenotype. MYOD1L122R mutations can be found together with mutations in other genes, such as PIK3CA, as potentially cooperating events. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, ten publications in the clinical literature involving 72 cases were reviewed. MYOD1L122R mutation in RMS can occur in both adults and children and is frequent in sclerosing/spindle cell histology, although it is also significantly reported in a subset of embryonal RMS. MYOD1L122R mutated tumors most frequently arise in the head and neck and extremities and are associated with poor outcome, raising the issue of how to use MYOD1L122R in risk stratification and how to treat these patients most effectively. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Metastatic Rhabdomyosarcoma: Results of the European Soft Tissue Sarcoma Study Group MTS 2008 Study and Pooled Analysis With the Concurrent BERNIE Study.

Author

Schoot, Reineke A., Chisholm, Julia C., Casanova, Michela, Minard-Colin, Veronique, Geoerger, Birgit, Cameron, Alison L., Coppadoro, Beatrice, Zanetti, Ilaria, Orbach, Daniel, Kelsey, Anna, Rogers, Timothy, Guizani, Cecile, Elze, Markus, Ben-Arush, Myriam, McHugh, Kieran, van Rijn, Rick R., Ferman, Sima, Gallego, Soledad, Ferrari, Andrea, and Jenney, Meriel

Published
2022
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50. Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium

Author

Shern, Jack F., primary, Selfe, Joanna, additional, Izquierdo, Elisa, additional, Patidar, Rajesh, additional, Chou, Hsien-Chao, additional, Song, Young K., additional, Yohe, Marielle E., additional, Sindiri, Sivasish, additional, Wei, Jun, additional, Wen, Xinyu, additional, Rudzinski, Erin R., additional, Barkauskas, Donald A., additional, Lo, Tammy, additional, Hall, David, additional, Linardic, Corinne M., additional, Hughes, Debbie, additional, Jamal, Sabri, additional, Jenney, Meriel, additional, Chisholm, Julia, additional, Brown, Rebecca, additional, Jones, Kristine, additional, Hicks, Belynda, additional, Angelini, Paola, additional, George, Sally, additional, Chesler, Louis, additional, Hubank, Michael, additional, Kelsey, Anna, additional, Gatz, Susanne A., additional, Skapek, Stephen X., additional, Hawkins, Douglas S., additional, Shipley, Janet M., additional, and Khan, Javed, additional

Published
2021
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