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3 results on '"Jennifer O’shea"'

1. Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

Author

Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer O’shea, Michael J. Rau, Zachary Smith, Soumyo Sen, Brock Summers, John Smith, Owen A. Warmuth, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, and Paul T. Kotzbauer

Subjects
Article
Abstract

The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy neurites. We developed and validated a novel method to amplify Asyn fibrils extracted from LBD postmortem tissue samples and used solid state nuclear magnetic resonance (SSNMR) studies to determine atomic resolution structure. Amplified LBD Asyn fibrils comprise two protofilaments with pseudo-21helical screw symmetry, very low twist and an interface formed by antiparallel beta strands of residues 85-93. The fold is highly similar to the fold determined by a recent cryo-electron microscopy study for a minority population of twisted single protofilament fibrils extracted from LBD tissue. These results expand the structural landscape of LBD Asyn fibrils and inform further studies of disease mechanisms, imaging agents and therapeutics targeting Asyn.

Published
2023
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2. First 12 patients with coronavirus disease 2019 (COVID-19) in the United States

Author

Rebecca Sunenshine, Diane Buell, Martin Fenstersheib, Christopher Shepherd, Margie Morgan, Cheri Grigg, Rebecca Fisher, Marc Fischer, Isaac Benowitz, Rebecca C. Woodruff, Isaac Ghinai, Brandon Bonin, John T. Watson, Kelly Lo, Shifaq Kamili, Olivia Almendares, Glenn E. Mathisen, Catherine M. Brown, Lynn Mello, Ruth N. Moro, Matthew Westercamp, Hannah L Kirking, Brian Rha, Sara Cody, Alison M. Binder, Moon Kim, Dawn Terashita, Sarah Scott, Joana Y Lively, Lauren Epstein, Holly M. Biggs, Shanon Smith, Timothy M. Uyeki, Jan King, Manisha Patel, Marielle J Fricchione, Aron J. Hall, Alicia P. Budd, Krista Queen, Vaughn Barry, Lindsay Kim, Kevin Chatham-Stephens, Kathleen Harriman, Francisco N Alvarez, Melissa A Rolfes, Mark A. Pallansch, Karen K. Wong, Anna R Yousaf, Jennifer P Collins, Graham Gerrard, Chelsea Foo, Ying Tao, Jennifer O'Shea, Miwako Kobayashi, Elizabeth Traub, Jeffrey D. Gunzenhauser, Megan J. Wallace, Heather Reese, Stephanie A Kujawski, Elsa Villarino, Azaibi Tamin, Olivia L McGovern, Keith Erickson, Xiaoyan Lu, Michelle Livingston, Lawrence C. Madoff, Hollianne Bruce, Glen R. Abedi, N Seema Ahmed, Oren Friedman, Matthew Zahn, Nora Chea, Susan Robinson, Matthew Donahue, Bryan Stierman, Thomas Haupt, Sarah Wilkerson, Rachel Bystritsky, Melissa M. Garcia, Sarah L. Rudman, Kayla N. Anderson, Jonathan Bryant-Genevier, Suxiang Tong, Victoria T Chu, Jennifer R. Verani, Jennifer C. Hunter, Mariel Marlow, Satish K. Pillai, Massimo Pacilli, Janell Routh, Amy Xie, Kiran Joshi, Anna Uehara, Howard Chiou, Vishal Dasari, Nancy McClung, Regina Sy-Santos, Jonathan M. Wortham, Michael Ben-Aderet, Patrick Dawson, Meredith Haddix, Gary I. Gutkin, Claire M Midgley, Sung-Sil Moon, Ahmet Tural, Jeremy A. Falk, Shannon A. Novosad, William V. Stoecker, Lindsey M. Duca, Janna Murray, Isabel Pedraza, Rachel Rubin, Michael A. Jhung, Michelle Holshue, Anna Kocharian, Amber K. Haynes, Romeo R. Galang, Gregory Marks, Traci DeSalvo, Jennifer L Harcourt, Karri Bartlett, Lijuan Wang, Jennifer E Layden, Alicia M. Fry, Mathew D. Esona, Erin E. Conners, Philip Robinson, George A. Diaz, Susa I. Gerber, George S Han, Suzanne Evans, Prabhu Gounder, Audrey Meier, Brian Lynch, Senthilkumar K. Sakthivel, Tiffany Wu, Jordan Cates, Talia Pindyck, Yan Li, Kenneth Komatsu, Stephanie R. Black, Mitali Mehta, Varun Shetty, Claire Jarashow, Brett Whitaker, Max W. Jacobs, E. Matt Charles, Scott Lindquist, Clinton R. Paden, Amanda Kita-Yarbro, Max Cohen, Sharon Balter, Talar Kamali, Heather J. Rhodes, Ethan A. Smith, Ruth Link-Gelles, Jing Zhang, Sajan Patel, Rachel Klos, Marie E Killerby, Grace M Vahey, Natalie J. Thornburg, Suzanne Donovan, Cora Hoover, Tristan D. McPherson, Aaron T. Curns, Nichole Quick, Sara E. Oliver, Demian Christiansen, Ram Koppaka, Jonathan Grein, Rekha Murthy, Leora R. Feldstein, Karlyn D. Beer, Jennifer Lo, Stephen Lindstrom, Lakshmi Malapati, and Ian W. Pray

Subjects
medicine.medical_specialty, Viral culture, business.industry, Urine, Disease, medicine.disease_cause, medicine.disease, Virus, Pneumonia, Internal medicine, Epidemiology, medicine, Respiratory system, business, Coronavirus
Abstract

IntroductionMore than 93,000 cases of coronavirus disease (COVID-19) have been reported worldwide. We describe the epidemiology, clinical course, and virologic characteristics of the first 12 U.S. patients with COVID-19.MethodsWe collected demographic, exposure, and clinical information from 12 patients confirmed by CDC during January 20–February 5, 2020 to have COVID-19. Respiratory, stool, serum, and urine specimens were submitted for SARS-CoV-2 rRT-PCR testing, virus culture, and whole genome sequencing.ResultsAmong the 12 patients, median age was 53 years (range: 21–68); 8 were male, 10 had traveled to China, and two were contacts of patients in this series. Commonly reported signs and symptoms at illness onset were fever (n=7) and cough (n=8). Seven patients were hospitalized with radiographic evidence of pneumonia and demonstrated clinical or laboratory signs of worsening during the second week of illness. Three were treated with the investigational antiviral remdesivir. All patients had SARS-CoV-2 RNA detected in respiratory specimens, typically for 2–3 weeks after illness onset, with lowest rRT-PCR Ct values often detected in the first week. SARS-CoV-2 RNA was detected after reported symptom resolution in seven patients. SARS-CoV-2 was cultured from respiratory specimens, and SARS-CoV-2 RNA was detected in stool from 7/10 patients.ConclusionsIn 12 patients with mild to moderately severe illness, SARS-CoV-2 RNA and viable virus were detected early, and prolonged RNA detection suggests the window for diagnosis is long. Hospitalized patients showed signs of worsening in the second week after illness onset.

Published
2020
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3. Diagnosis and treatment of familial hypercholesterolemia: The impact of recent guidelines.

Author

Palma L, Welding M, and OʼShea J

Subjects
Humans, Risk Assessment, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Hyperlipoproteinemia Type II drug therapy
Abstract

Treatment of familial hypercholesterolemia can change the natural course of the disease to prevent premature atherosclerotic cardiovascular disease. New guidelines assist the clinician in the early identification of this common genetic disorder of lipid metabolism by placing individuals with elevated low-density lipoprotein cholesterol levels in high-risk groups who benefit from treatment with statins.

Published
2016
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