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Your search keyword '"Jensen, Chantel N."' showing total 7 results
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7 results on '"Jensen, Chantel N."'

2. Biocatalytic Conversion of Cyclic Ketones Bearing α-Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium-Sized Carbocycles

Author

Morrill, Charlotte, Jensen, Chantel N, Just-Baringo, Xavier, Grogan, Gideon, Turner, Nicholas, and Procter, David John

Subjects
010405 organic chemistry, General Medicine, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences
Abstract

Cyclic ketones bearing alpha-quaternary stereocenters undergo efficient kinetic resolution using cyclohexanone monooxygenase (CHMO) from Acinetobacter calcoaceticus. Lactones possessing tetrasubstituted stereocenters are obtained with high enantioselectivity (up to >99% ee) and complete chemoselectivity. Preparative scale biotransformations were exploited in conjunction with a SmI2-mediated cyclization process to access complex, enantiomerically enriched cycloheptan- and cycloctan-1,4-diols. In a parallel approach to structurally distinct products, enantioenriched ketones from the resolution bearing an alpha- all carbon quaternary stereocenter were used in a SmI2-mediated cyclization process to give cyclobutanol products (up to >99% ee).

Published
2018

7. Genome Sequence of Stenotrophomonas maltophilia PML168, Which Displays Baeyer-Villiger Monooxygenase Activity.

Author

Allen, Michael J., Tait, Karen, Mühling, Martin, Weynberg, Karen, Bradley, Claire, Trivedi, Urmi, Gharbi, Karim, Nissimov, Jozef, Mavromatis, Konstantinos, Jensen, Chantel N., Grogan, Gideon, and Ali, Sohail T.

Subjects
*STENOTROPHOMONAS maltophilia, *BAEYER-Villiger rearrangement, *FLAVOPROTEINS, *GENOMES, *ENZYMES, *MONOOXYGENASES
Abstract

Stenotrophomonas maltophilia PML168 was isolated from Wembury Beach on the English Coast from a rock pool following growth and selection on agar plates. Here we present the permanent draft genome sequence, which has allowed prediction of function for several genes encoding enzymes relevant to industrial biotechnology, including a novel flavoprotein monooxygenase. [ABSTRACT FROM AUTHOR]

Published
2012
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