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160 results on '"Jensen, S.E."'

4. Applications of gene replacement technology to Streptocymes clavuligerus strain development for clavulanic acid production

Author

Paradkar, A.S., Mosher, R.H., Anders, C., Griffin, A., Griffin, J., Hughes, C., Greaves, P., Barton, B., and Jensen, S.E.

Subjects
Microbial genetic engineering -- Research, Streptomyces -- Research, Antibiotics -- Research, Biological sciences
Abstract

Researchers used genetic engineering to suppress the production of non-clavulanic acid clavams by Streptomyces clavuligerus. This bacterium is used to produce clavulanic acid, an antibiotic that can inhibit beta lactamases. It is used clinically in combination with beta lactam antibiotics.

Published
2001

5. Everolimus-Eluting Versus Biolimus-Eluting Stents With Biodegradable Polymers in Unselected Patients Undergoing Percutaneous Coronary Intervention:A Randomized Noninferiority Trial With 1-Year Follow-Up (SORT OUT VIII Trial)

Author

Maeng, M., Christiansen, Evald Høj, Raungaard, B., Kahlert, J., Terkelsen, C.J., Kristensen, S.D., Carstensen, S., Aarøe, J., Jensen, S.E., Villadsen, A.B., Lassen, J.F., Thim, T., Eftekhari, A., Veien, K.T., Hansen, K.N., Junker, A., Bøtker, H.E., Jensen, L.O., Raungaard, Bent, and Jensen, Svend Eggert

Subjects
biolimus, percutaneous coronary intervention, biodegradable polymer, drug-eluting stent(s), everolimus, randomized clinical trial
Abstract

Objectives: The aim of this study was to compare the thin-strut biodegradable-polymer everolimus-eluting platinum-chromium stent (EES) with the biodegradable-polymer biolimus-eluting stainless-steel stent (BES). Background: Currently available drug-eluting coronary stents have been refined to reduce the risk for coronary events following implantation. Methods: This randomized, multicenter, all-comers, noninferiority trial was undertaken at 3 sites in western Denmark. Patients with clinical indications for percutaneous coronary intervention were eligible for inclusion. Patients were randomly assigned (1:1) to either EES or BES. The primary endpoint, target lesion failure, was a composite of safety (cardiac death and myocardial infarction not clearly attributable to a nontarget lesion) and efficacy (target lesion revascularization) at 12 months, analyzed using intention-to-treat principles. The trial was powered to assess target lesion failure noninferiority of the EES compared with the BES with a predetermined noninferiority margin of 3%. Results: A total of 1,385 patients were assigned to treatment with EES and 1,369 patients to treatment with BES. The analysis showed that 55 patients (4.0%) assigned to the EES and 60 (4.4%) assigned to the BES met the primary endpoint (absolute risk difference 0.4%; upper limit of 1-sided 95% confidence interval: 1.7%; p < 0.001). Conclusions: At 1-year follow-up, the EES was found to be noninferior to the BES with respect to target lesion failure. (Everolimus-eluting SYNERGY Stent Versus Biolimus-Eluting Biomatrix NeoFlex Stent—SORT-OUT VIII; NCT02093845)

Published
2019
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6. A sorghum practical haplotype graph facilitates genome‐wide imputation and cost‐effective genomic prediction

Author

Jensen, S.E., Charles, J.R., Muleta, K., Bradbury, P. J., Casstevens, T., Deshpande, S.P., Gore, M.A., Gupta, R., Ilut, D.C., Johnson, L., Lozano, R., Miller, Z., Ramu, P., Rathore, A., Romay, M.C., Upadhyaya, H.D., Varshney, R.K., Morris, G.P., Pressoir, G., Buckler, E.S., Ramstein, G.P., Jensen, S.E., Charles, J.R., Muleta, K., Bradbury, P. J., Casstevens, T., Deshpande, S.P., Gore, M.A., Gupta, R., Ilut, D.C., Johnson, L., Lozano, R., Miller, Z., Ramu, P., Rathore, A., Romay, M.C., Upadhyaya, H.D., Varshney, R.K., Morris, G.P., Pressoir, G., Buckler, E.S., and Ramstein, G.P.

Abstract

Successful management and utilization of increasingly large genomic datasets is essential for breeding programs to accelerate cultivar development. To help with this, we developed a Sorghum bicolor Practical Haplotype Graph (PHG) pangenome database that stores haplotypes and variant information. We developed two PHGs in sorghum that were used to identify genome‐wide variants for 24 founders of the Chibas sorghum breeding program from 0.01x sequence coverage. The PHG called single nucleotide polymorphisms (SNPs) with 5.9% error at 0.01x coverage—only 3% higher than PHG error when calling SNPs from 8x coverage sequence. Additionally, 207 progenies from the Chibas genomic selection (GS) training population were sequenced and processed through the PHG. Missing genotypes were imputed from PHG parental haplotypes and used for genomic prediction. Mean prediction accuracies with PHG SNP calls range from .57–.73 and are similar to prediction accuracies obtained with genotyping‐by‐sequencing or targeted amplicon sequencing (rhAmpSeq) markers. This study demonstrates the use of a sorghum PHG to impute SNPs from low‐coverage sequence data and shows that the PHG can unify genotype calls across multiple sequencing platforms. By reducing input sequence requirements, the PHG can decrease the cost of genotyping, make GS more feasible, and facilitate larger breeding populations. Our results demonstrate that the PHG is a useful research and breeding tool that maintains variant information from a diverse group of taxa, stores sequence data in a condensed but readily accessible format, unifies genotypes across genotyping platforms, and provides a cost‐effective option for genomic selection.

Published
2020

7. Should denmark and sweden join the banking union?

Author

Hougaard Jensen, S.E. (Svend E.), Schoenmaker, D. (Dirk), Hougaard Jensen, S.E. (Svend E.), and Schoenmaker, D. (Dirk)

Abstract

An important policy discussion on joining the banking union is currently taking place in Denmark and Sweden. In this article we review the pros and cons of joining. The main rationale for joining the banking union is the importance of cross-border banking in the EU internal market. Reviewing the banking systems, we find that banks in Denmark and Sweden have the same cross-border characteristics as those in the euro area countries, suggesting a similar rationale for joining the banking union. Moreover, both countries have large banks which may be too big to save at country level, but not at the banking union level. Nevertheless, there are some governance concerns. While euro area countries have an automatic and full say in all banking union arrangements, the non-euro area countries (the ‘out’ countries) lack certain formal powers in ultimate decision-making; however, we find that this may be less of a problem in practice. If necessary, the ‘out’ countries would have the ‘nuclear option’ of leaving the banking union.

Published
2020
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8. De ribben van de grammatica

Author

Jensen, L.E., Jensen, S.E., Pas, N., Rovers, D., Gulik, K. van, Jensen, L.E., Pas, N., Rovers, D., and Gulik, K. van

Subjects
Europe in a Changing World, Transnational Europe
Abstract

Item does not contain fulltext

Published
2019

9. English please. I don't speak Dutch

Author

Jensen, L.E. and Jensen, S.E.

Subjects
Europe in a Changing World, Transnational Europe
Abstract

Item does not contain fulltext 16 november 2019

Published
2019

11. Inhibition of delta-protein kinase C by delcasertib as an adjunct to primary percutaneous coronary intervention for acute anterior ST-segment elevation myocardial infarction: results of the PROTECTION AMI Randomized Controlled Trial

Author

Lincoff, A.M., Roe, M., Aylward, P., Galla, J., Rynkiewicz, A., Guetta, V., Zelizko, M., Kleiman, N., White, H., McErlean, E., Erlinge, D., Laine, M., Ferreira, J.M. Dos Santos, Goodman, S., Mehta, S., Atar, D., Suryapranata, H., Jensen, S.E., Forster, T., Fernandez-Ortiz, A., Schoors, D., Radke, P., Belli, G., Brennan, D., Bell, G., and Krucoff, M.

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Population, Myocardial Infarction, Infarction, Pilot Projects, Drug Administration Schedule, Percutaneous Coronary Intervention, Reperfusion therapy, Double-Blind Method, Internal medicine, medicine, Creatine Kinase, MB Form, Humans, ST segment, cardiovascular diseases, Myocardial infarction, Infusions, Intravenous, education, Protein Kinase Inhibitors, Aged, education.field_of_study, Ejection fraction, business.industry, Troponin I, Percutaneous coronary intervention, Middle Aged, medicine.disease, Treatment Outcome, Chemotherapy, Adjuvant, Area Under Curve, Conventional PCI, Cardiology, Female, Peptides, Cardiology and Cardiovascular Medicine, business, Biomarkers
Abstract

Aims Delcasertib is a selective inhibitor of delta-protein kinase C (delta-PKC), which reduced infarct size during ischaemia/reperfusion in animal models and diminished myocardial necrosis and improved reperfusion in a pilot study during primary percutaneous coronary intervention (PCI) for ST elevation myocardial infarction (STEMI). Methods and results A multicentre, double-blind trial was performed in patients presenting within 6 h and undergoing primary PCI for anterior (the primary analysis cohort, n = 1010 patients) or inferior (an exploratory cohort, capped at 166 patients) STEMI. Patients with anterior STEMI were randomized to placebo or one of three doses of delcasertib (50, 150, or 450 mg/h) by intravenous infusion initiated before PCI and continued for ∼2.5 h. There were no differences between treatment groups in the primary efficacy endpoint of infarct size measured by creatine kinase MB fraction area under the curve (AUC) (median 5156, 5043, 4419, and 5253 ng h/mL in the placebo, delcasertib 50, 150, and 450 mg/mL groups, respectively) in the anterior STEMI cohort. No treatment-related differences were seen in secondary endpoints of infarct size, electrocardiographic ST-segment recovery AUC or time to stable ST recovery, or left ventricular ejection fraction at 3 months. No differences in rates of adjudicated clinical endpoints (death, heart failure, or serious ventricular arrhythmias) were observed. Conclusions Selective inhibition of delta-PKC with intravenous infusion of delcasertib during PCI for acute STEMI in a population of patients treated according to contemporary standard of care did not reduce biomarkers of myocardial injury. Clinical trial registration ClinicalTrials.gov Identifier: [NCT00785954][1]. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00785954&atom=%2Fehj%2Fearly%2F2014%2F05%2F05%2Feurheartj.ehu177.atom

Published
2014
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14. Adaptive control of force microscope cantilever dynamics

Author

Jensen, S.E., Dougherty, W.M., Garbini, J.L., and Sidles, J.A.

Subjects
Magnetic resonance -- Research, Oscillators (Electronics) -- Magnetic properties, Physics
Abstract

The formalism and design tools are described that are required for implementing a continuously adaptive controller for magnetic resonance force microscopy (MRFM). The adaptive algorithm has enabled narrow-band formally-optimal control over a wide range of resonance frequencies and has preserved the thermally-limited signal to noise ratio (SNR).

Published
2007

16. P1376Landmark analysis of clinical outcome following first-generation vs newer-generation coronary drug-eluting stent implantation: a pooled analysis of SORT OUT III-V studies

Author

Maeng, M., primary, Christiansen, E.H., additional, Raungaard, B., additional, Kristensen, S.D., additional, Terkelsen, C.J., additional, Jensen, S.E., additional, Ravkilde, J., additional, Junker, A., additional, Veien, K.T., additional, Madsen, M., additional, Boetker, H.E., additional, and Jensen, L.O., additional

Published
2017
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18. 31245-year clinical outcome following first-generation vs newer-generation coronary drug-eluting stent implantation: A pooled analysis of SORT OUT III, IV, and V studies

Author

Maeng, M., primary, Christiansen, E.H., additional, Raungaard, B., additional, Kristensen, S.D., additional, Terkelsen, C.J., additional, Jensen, S.E., additional, Ravkilde, J., additional, Junker, A., additional, Veien, K.T., additional, Madsen, M., additional, Boetker, H.E., additional, and Jensen, L.O., additional

Published
2017
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19. 2199Rate of very late stent thrombosis differs between drug-eluting stents: a 5-year pooled landmark analysis of the SORT OUT III, IV, and V trials

Author

Maeng, M., primary, Christiansen, E.H., additional, Raungaard, B., additional, Kristensen, S.D., additional, Terkelsen, C.J., additional, Jensen, S.E., additional, Ravkilde, J., additional, Junker, A., additional, Veien, K.T., additional, Madsen, M., additional, Boetker, H.E., additional, and Jensen, L.O., additional

Published
2017
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21. P5346Worst lead residual ST-deviation 60 minutes after primary PCI for STEMI is associated with infarct size and myocardial salvage on cardiac magnetic resonance imaging

Author

Hommerstad, A., primary, Halvorsen, S., additional, Arheden, H., additional, Carlsson, M., additional, Engblom, H., additional, Jensen, S.E., additional, Erlinge, D., additional, Larsen, A.I., additional, Nordrehaug, J.E., additional, Fakhri, Y., additional, Sejersten, M., additional, Clemmensen, P., additional, Hallen, J., additional, Atar, D., additional, and Hall, T.S., additional

Published
2017
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27. Dus ik ben weer

Author

Jensen, S.E., Literature, and Art and Culture, History, Antiquity

Published
2012

34. Minimum Information about a Biosynthetic Gene cluster

Author

Medema, M.H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J.B., Blin, K., de Bruijn, I., Chooi, Y.H., Claesen, J., Coates, R.C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D.J., Fewer, D.P., Garg, N., Geiger, C., Gomez-Escribano, J.P., Greule, A., Hadjithomas, M., Haines, A.S., Helfrich, E.J., Hillwig, M.L., Ishida, K., Jones, A.C., Jones, C.S., Jungmann, K., Kegler, C., Kim, H.U., Kötter, P., Krug, D., Masschelein, J., Melnik, A.V., Mantovani, S.M., Monroe, E.A., Moore, M., Moss, N., Nützmann, H.W., Pan, G., Pati, A., Petras, D., Reen, F.J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N.J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A.K., Balibar, C.J., Balskus, E.P., Barona-Gómez, F., Bechthold, A., Bode, H.B., Borriss, R., Brady, S.F., Brakhage, Axel A., Caffrey, P., Cheng, Yo, Clardy, J., Cox, R.J., De Mot, R., Donadio, S., Donia, M.S., van der Donk, W.A., Dorrestein, P.C., Doyle, Sean, Driessen, A.J., Ehling-Schulz, M., Entian, K.D., Fischbach, M.A., Gerwick, L., Gerwick, W.H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S.E., Ju, J., Katz, L., Kaysser, L., Klassen, J.L., Keller, N.P., Kormanec, J., Kuipers, O.P., Kuzuyama, T., Kyrpides, N.C., Kwon, H.J., Lautru, S., Lavigne, R., Lee, C.Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D.A., Moore, B.S., Moreira, L.M., Muller, R., Neilan, B.A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M.S., Ostash, B., Payne, S.M., Pernodet, J.L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J.M., Salas, J.A., Schmitt, E.K., Scott, B., Seipke, R.F., Shen, B., Sherman, D.H., Sivonen, K., Smanski, M.J., Sosio, M., Stegmann, E., Süssmuth, R.D., Tahlan, K., Thomas, C.M., Tang, Y., Truman, A.W., Viaud, M., Walton, J.D., Walsh, C.T., Weber, T., van Wezel, G.P., Wilkinson, B., Willey, J.M., Wohlleben, W., Wright, G.D., Ziemert, N., Zhang, C., Zotchev, S.B., Breitling, R., Takano, E., Glöckner, F.O., Medema, M.H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J.B., Blin, K., de Bruijn, I., Chooi, Y.H., Claesen, J., Coates, R.C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D.J., Fewer, D.P., Garg, N., Geiger, C., Gomez-Escribano, J.P., Greule, A., Hadjithomas, M., Haines, A.S., Helfrich, E.J., Hillwig, M.L., Ishida, K., Jones, A.C., Jones, C.S., Jungmann, K., Kegler, C., Kim, H.U., Kötter, P., Krug, D., Masschelein, J., Melnik, A.V., Mantovani, S.M., Monroe, E.A., Moore, M., Moss, N., Nützmann, H.W., Pan, G., Pati, A., Petras, D., Reen, F.J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N.J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A.K., Balibar, C.J., Balskus, E.P., Barona-Gómez, F., Bechthold, A., Bode, H.B., Borriss, R., Brady, S.F., Brakhage, Axel A., Caffrey, P., Cheng, Yo, Clardy, J., Cox, R.J., De Mot, R., Donadio, S., Donia, M.S., van der Donk, W.A., Dorrestein, P.C., Doyle, Sean, Driessen, A.J., Ehling-Schulz, M., Entian, K.D., Fischbach, M.A., Gerwick, L., Gerwick, W.H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S.E., Ju, J., Katz, L., Kaysser, L., Klassen, J.L., Keller, N.P., Kormanec, J., Kuipers, O.P., Kuzuyama, T., Kyrpides, N.C., Kwon, H.J., Lautru, S., Lavigne, R., Lee, C.Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D.A., Moore, B.S., Moreira, L.M., Muller, R., Neilan, B.A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M.S., Ostash, B., Payne, S.M., Pernodet, J.L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J.M., Salas, J.A., Schmitt, E.K., Scott, B., Seipke, R.F., Shen, B., Sherman, D.H., Sivonen, K., Smanski, M.J., Sosio, M., Stegmann, E., Süssmuth, R.D., Tahlan, K., Thomas, C.M., Tang, Y., Truman, A.W., Viaud, M., Walton, J.D., Walsh, C.T., Weber, T., van Wezel, G.P., Wilkinson, B., Willey, J.M., Wohlleben, W., Wright, G.D., Ziemert, N., Zhang, C., Zotchev, S.B., Breitling, R., Takano, E., and Glöckner, F.O.

Abstract

A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

Published
2015

41. Goddelijke brulapen

Author

Jensen, S.E., Literature, and Art and Culture, History, Antiquity

Published
2007

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