1. Pretreatment diffusion-weighted imaging for prediction of relapsed and refractory primary central nervous system lymphoma
- Author
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Hsi-Cheng Chien, Lee-Ren Yeh, Kuo-Chuan Hung, Sher-Wei Lim, Chung-Yu Cheng, Yu-Chang Lee, Jeon-Hor Chen, and Ching-Chung Ko
- Subjects
CNS lymphoma ,relapse ,refractory ,ADC ,DWI ,MRI ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
ObjectivesA subset of primary central nervous system lymphoma (PCNSL) has been shown to undergo an early relapsed/refractory (R/R) period after first-line chemotherapy. This study investigated the pretreatment clinical and MRI features to predict R/R in PCNSL, emphasizing the apparent diffusion coefficient (ADC) values in diffusion-weighted imaging (DWI).MethodsThis retrospective study investigated the pretreatment MRI features for predicting R/R in PCNSL. Only patients who had undergone complete preoperative and postoperative MRI follow-up studies were included. From January 2006 to December 2021, 52 patients from two medical institutions with a diagnosis of PCNSL were included (median follow-up time, 26.3 months). Among these, 24 (46.2%) had developed R/R (median time to relapse, 13 months). Cox proportional hazard regression analyses were performed to determine hazard ratios for all parameters.ResultsSignificant predictors of R/R in PCNSL were female sex, complete response (CR) to first-line chemotherapy, and ADC value/ratio (p
- Published
- 2023
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