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Background: The aim of this study was to evaluate the impact of maxillomandibular advancement (MMA) on oral health-related quality of life (OHRQoL) in obstructive sleep apnea (OSA) patients prior to, immediately after, and up to 1 year after surgery. Methods: In this prospective study, OHRQoL was measured with the use of the Dutch version of the Oral Health Impact Profile questionnaire (OHIP-14NL). A total of 19 patients were asked to complete the questionnaires prior to surgery (T0), on the first 7 days post-surgery (T1-T7), and 1 month (T8), 6 months (T9), and at least 1 year post surgery (T10). The baseline OHIP score was compared with the post-surgery scores using the Wilcoxon signed-rank test with Bonferroni correction (significance at P