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17 results on '"Jerez, Alvaro"'

10. Fine‐mapping scan of bipolar disorder susceptibility loci in Latino pedigrees

Author

Gonzalez, Suzanne, primary, Villa, Erika, additional, Rodriguez, Marco, additional, Ramirez, Mercedes, additional, Zavala, Juan, additional, Armas, Regina, additional, Dassori, Albana, additional, Contreras, Javier, additional, Raventós, Henriette, additional, Flores, Deborah, additional, Jerez, Alvaro, additional, Ontiveros, Alfonso, additional, Nicolini, Humberto, additional, and Escamilla, Michael, additional

Published
2019
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11. 507. Association of NRXN3 Deletion with Schizophrenia and Bipolar Disorder

Author

Shavit, Ayal, primary, Gonzalez, Jessica, additional, Chavez, Maricela, additional, Rodriguez, Marco, additional, Camarillo, Cynthia, additional, Ramirez, Mercedez, additional, Zavala, Juan, additional, Contreras, Javier, additional, Raventós, Henriette, additional, Flores, Deborah, additional, Jerez, Alvaro, additional, Ontiveros, Alfonso, additional, Nicolini, Humberto, additional, Escamilla, Michael, additional, and Gonzalez, Suzanne, additional

Published
2017
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12. Replication of genome‐wide association study ( GWAS ) susceptibility loci in a Latino bipolar disorder cohort

Author

Gonzalez, Suzanne, primary, Gupta, Jayanta, additional, Villa, Erika, additional, Mallawaarachchi, Indika, additional, Rodriguez, Marco, additional, Ramirez, Mercedes, additional, Zavala, Juan, additional, Armas, Regina, additional, Dassori, Albana, additional, Contreras, Javier, additional, Flores, Deborah, additional, Jerez, Alvaro, additional, Ontiveros, Alfonso, additional, Nicolini, Humberto, additional, and Escamilla, Michael, additional

Published
2016
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13. Heritability of age of onset of psychosis in schizophrenia

Author

Hare, Elizabeth, primary, Glahn, David C., additional, Dassori, Albana, additional, Raventos, Henriette, additional, Nicolini, Humberto, additional, Ontiveros, Alfonso, additional, Medina, Rolando, additional, Mendoza, Rick, additional, Jerez, Alvaro, additional, Muñoz, Rodrigo, additional, Almasy, Laura, additional, and Escamilla, Michael A., additional

Published
2009
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14. Methionine sulfoxide reductase: A novel schizophrenia candidate gene

Author

Walss-Bass, Consuelo, primary, Soto-Bernardini, Maria Clara, additional, Johnson-Pais, Teresa, additional, Leach, Robin J., additional, Ontiveros, Alfonso, additional, Nicolini, Humberto, additional, Mendoza, Ricardo, additional, Jerez, Alvaro, additional, Dassori, Albana, additional, Chavarria-Siles, Ivan, additional, Escamilla, Michael A., additional, and Raventos, Henriette, additional

Published
2009
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15. Heritability of age of onset of psychosis in schizophrenia

Author

Hare, Elizabeth, Glahn, David C., Dassori, Albana, Raventos, Henriette, Nicolini, Humberto, Ontiveros, Alfonso, Medina, Rolando, Mendoza, Rick, Jerez, Alvaro, Muñoz, Rodrigo, Almasy, Laura, and Escamilla, Michael A.

Abstract

Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age of onset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due to genetic factors, was estimated using a maximum likelihood method. The subjects were 717 members of families with more than one member affected with schizophrenia from Mexican and Central American populations. Age of onset of psychosis was determined by bestestimate consensus diagnosis based on the Diagnostic Interview for Genetic Studies, Family Interview for Genetic Studies, and each subjects medical records. Mean age of onset was 21.44 years SD 8.07; 20.55 years for males SD 6.90, and 22.67 for females SD 9.34. Variance components were estimated using a polygenic model in the SOLAR software package. The sex of the participant was a significant covariate P  0.010 accounting for 0.02 of the total variance in age of onset. The heritability of age of onset of psychosis was 0.33 SE  0.09; P  0.00004. These findings suggest that genetic factors significantly contribute to the age of onset of psychotic symptoms in individuals with schizophrenia and that sex influences this trait as well. © 2009 WileyLiss, Inc.

Published
2010
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16. Methionine sulfoxide reductase: A novel schizophrenia candidate genePlease cite this article as follows: WalssBass C, SotoBernardini MC, JohnsonPais T, Leach RJ, Ontiveros A, Nicolini H, Mendoza R, Jerez A, Dassori A, ChavarriaSiles I, Escamilla MA, Raventos H. 2009. Methionine Sulfoxide Reductase: A Novel Schizophrenia Candidate Gene. Am J Med Genet Part B 150B:219–225.

Author

WalssBass, Consuelo, SotoBernardini, Maria Clara, JohnsonPais, Teresa, Leach, Robin J., Ontiveros, Alfonso, Nicolini, Humberto, Mendoza, Ricardo, Jerez, Alvaro, Dassori, Albana, ChavarriaSiles, Ivan, Escamilla, Michael A., and Raventos, Henriette

Abstract

Methionine sulfoxide reductase MSRA is an antioxidant enzyme implicated in protection against oxidative stress and protein maintenance. We have previously reported the association of marker D8S542, located within the MSRAgene, with schizophrenia in the Central Valley of Costa Rica CVCR. By performing fine mapping analysis, we have now identified a potential threemarker at risk haplotype within MSRAin the same CVCR sample, with a global Pvalue slightly above nominal significance P  0.0526. By sequencing the MSRAgene in individuals carrying this haplotype, we identified a novel 4base pair deletion 1,792 bases upstream of the MSRAtranscription start site. This deletion was significantly undertransmitted to schizophrenia patients in the CVCR sample P  0.0292 using FBAT, and this was replicated in a large independent sample of 321 schizophrenia families from the Hispanic population P  0.0367. These findings suggest a protective effect of the deletion against schizophrenia. Further, MSRAmRNA levels were significantly lower in lymphoblastoid cell lines of individuals homozygous for the deletion compared to carriers of the normal allele P  0.0135, although significance was only evident when genotypes were collapsed. This suggests that the deleted sequence may play a role in regulating MSRAexpression. In conclusion, this work points towards MSRAas a novel schizophrenia candidate gene. Further studies into the mechanisms by which MSRA is involved in schizophrenia pathophysiology may shed light into the biological underpinnings of this disorder. © 2008 WileyLiss, Inc.

Published
2009
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