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Your search keyword '"Jeroen D. E. van Suijlen"' showing total 4 results
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4 results on '"Jeroen D. E. van Suijlen"'

1. Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study

Author

Dorien M. Kimenai, Remy J. H. Martens, Jeroen P. Kooman, Coen D. A. Stehouwer, Frans E. S. Tan, Nicolaas C. Schaper, Pieter C. Dagnelie, Miranda T. Schram, Carla J. H. van der Kallen, Simone J. S. Sep, Jeroen D. E. van Suijlen, Abraham A. Kroon, Otto Bekers, Marja P. van Dieijen-Visser, Ronald M. A. Henry, and Steven J. R. Meex

Subjects
Medicine, Science
Abstract

Abstract Interest in high-sensitivity cardiac troponin I(hs-cTnI) and T(hs-cTnT) has expanded from acute cardiac care to cardiovascular disease(CVD) risk stratification. Whether hs-cTnI and hs-cTnT are interchangeable in the ambulant setting is largely unexplored. Cardiac injury is a mechanism that may underlie the associations between troponin levels and mortality in the general population. In the population-based Maastricht Study, we assessed the correlation and concordance between hs-cTnI and hs-cTnT. Multiple regression analyses were conducted to assess the association of hs-cTnI and hs-cTnT with electrocardiographic (ECG) changes indicative of cardiac abnormalities. In 3016 eligible individuals(mean age,60 ± 8years;50.6%,men) we found a modest correlation between hs-cTnI and hs-cTnT(r = 0.585). After multiple adjustment, the association with ECG changes indicative of cardiac abnormalities was similar for both hs-cTn assays(OR,hs-cTnI:1.72,95%CI:1.40-2.10;OR,hs-cTnT:1.60,95%CI:1.22–2.11). The concordance of dichotomized hs-cTnI and hs-cTnT was κ = 0.397(≥sex-specific 75th percentile). Isolated high levels of hs-cTnI were associated with ECG changes indicative of cardiac abnormalities(OR:1.93,95%CI:1.01–3.68), whereas isolated high levels of hs-cTnT were not(OR:1.07,95%CI:0.49–2.31). In conclusion, there is a moderate correlation and limited concordance between hs-cTnI and hs-cTnT under non-acute conditions. These data suggest that associations of hs-cTnI and hs-cTnT with cardiac injury detected by ECG are driven by different mechanisms. This information may benefit future development of CVD risk stratification algorithms.

Published
2017
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2. The value of clinical and laboratory diagnostics for chest pain patients at the emergency department

Author

A. Jacob Six, Björn E. Groenemeijer, Richard L. Braam, René A. Tio, Jeroen D. E. van Suijlen, Laurens-Jan C. Jellema, Barbra E. Backus, Hester J. van der Zaag-Loonen, and Vascular Ageing Programme (VAP)

Subjects
Male, Time Factors, Clinical Biochemistry, Chest pain, Severity of Illness Index, Risk Factors, Medicine, ST-SEGMENT ELEVATION, Myocardial infarction, TROPONIN-I ASSAY, CARDIOLOGY, Immunoassay, medicine.diagnostic_test, biology, troponin, General Medicine, Middle Aged, EUROPEAN-SOCIETY, clinical diagnosis, Area Under Curve, Cardiology, HEART, Female, medicine.symptom, Emergency Service, Hospital, Adult, Chest Pain, medicine.medical_specialty, Acute coronary syndrome, ACUTE MYOCARDIAL-INFARCTION, Physical examination, Internal medicine, Severity of illness, SCORE, Humans, Acute Coronary Syndrome, ROOM, Aged, business.industry, Biochemistry (medical), Emergency department, Laboratories, Hospital, medicine.disease, Troponin, ROC Curve, laboratory testing, biology.protein, business, Mace, Follow-Up Studies
Abstract

Background: The focus during the diagnostic process for patients with acute chest pain is to discriminate patients who can be safely discharged from those who are at risk for an acute coronary syndrome (ACS). In this study the diagnostic value of the clinical examination is compared with laboratory testing of troponin.Methods: This study included 710 chest pain patients who presented at the ED of two hospitals in the Netherlands. Clinical examination and laboratory testing were combined in the recently developed HEART-score. The diagnostic values of clinical presentation, troponin and the HEART-score for a major adverse coronary event (MACE) and an ACS within 6 weeks were assessed. Furthermore, the improvement of HEART with the second troponin measurement after 6 h was assessed using the net reclassification improvement (NRI).Results: The use of HEART (AUC(MACE) : 0.77; AUC(ACS) : 0.82) obtains a higher diagnostic value than troponin (AUC(MACE) : 0.72; AUC(ACS) : 0.74) or clinical evaluation (AUC(MACE) : 0.69; AUC(ACS) : 0.74). Statistical significant different AUCs were obtained when HEART is compared to troponin or clinical evaluation (p Conclusions: The HEART-score combines clinical evaluation and results from laboratory testing, which should be used together, to discriminate patients at risk of a cardiac event from patients who can be safely discharged. In addition, it is shown that a second troponin measurement slightly improves the discriminative ability of the HEART-score.

Published
2014
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4. Multicentre evaluation of the Boehringer Mannheim/Hitachi 917 analysis system

Author

Kurt Bauer, Pierangelo Bonini, Peter Degenhard, Jörg Hofmann, Wolfgang Bablok, Antonio Torralba, Wolfgang Stockmann, Margaret McGovern, Klaus Wielckens, Mary Martyn, Bert G. Blijenberg, Ferrucio Ceriotti, Anne Kelly, Jeroen D. E. van Suijlen, Zahur Zaman, Norbert Blanckaert, and Carmen Ferré

Subjects
Analyte, Digoxin, Digitoxin, Urine, Bioinformatics, Clinical chemistry, Analytical Chemistry, chemistry.chemical_compound, Química clínica, Chemical Engineering (miscellaneous), Medicine, Instrumentation, Hitachi 917, Creatinine, Chromatography, biology, business.industry, Albumin, Computer Science Applications, chemistry, Diagnòstic de laboratori, Laboratory diagnosis, biology.protein, Creatine kinase, business, medicine.drug, Research Article
Abstract

The new selective access analysis system BM/Hitachi 917 was evaluated in an international multicentre study, mainly according to the ECCLS protocol for the evaluation of analysers in clinical chemistry. Forty-three different analytes, covering 56 different methods enzymes, substrates, electrolytes, specific proteins, drugs and urine applications were tested in seven European clinical chemistry laboratories. Additionally, the practicability of the BM/ Hitachi 917 was tested according to a standardized questionnaire. Within-run CVs (median of 3 days) for enzymes, substrates and electrolytes were

Published
2008

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