1. Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres
- Author
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Martin Appelfeller, Chow Saephanh, Divisha Raheja, Suma Babu, Timothée Lenglet, Colleen Newhard, Ira J. Goodman, Agessandro Abrahao, Eoin Finegan, Olga Kwast-Rabben, Mark B. Bromberg, Stephan Goedee, Muhammad Al-Lozi, Tuan Vu, Jonathan D. Glass, Andreas Funke, Annemarie Hübers, Jesper Raaijman, Raul Juntas-Morales, Esther Rosier, Anke Tümmler, Nazem Atassi, Christina Fournier, Shafeeq Ladha, Markus Weber, Takuya Ohkubo, Antonio Canosa, Marion Zakrzewski, Robert C. Bucelli, Amina Coffey, Ron Leppanen, Nancy Hamel, Christoph Neuwirth, Kristl G. Claeys, Nathalie Braun, Toby A. Ferguson, Vinay Chaudhry, and Susanne Petri
- Subjects
Dorsum ,Male ,Recruitment, Neurophysiological ,medicine.medical_specialty ,Drug trial ,Clinical Neurology ,Biceps ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Multicentre ,Neurophysiological ,Physiology (medical) ,Healthy volunteers ,Medicine ,Training ,Humans ,0501 psychology and cognitive sciences ,Longitudinal Studies ,Amyotrophic lateral sclerosis ,Variability ,business.industry ,05 social sciences ,Amyotrophic Lateral Sclerosis ,Outcome measures ,Motor unit number ,medicine.disease ,Implementation ,MUNIX ,Female ,Sensory Systems ,Clinical trial ,Neurology ,Neurology (clinical) ,Recruitment ,business ,030217 neurology & neurosurgery - Abstract
Objective: Motor Unit Number Index (MUNIX) is a quantitative neurophysiological method that reflects loss of motor neurons in Amyotrophic Lateral Sclerosis (ALS) in longitudinal studies. It has been utilized in one natural history ALS study and one drug trial (Biogen USA) after training and qualification of raters. Methods: Prior to testing patients, evaluators had to submit test-retest data of 4 healthy volunteers. Twenty-seven centres with 36 raters measured MUNIX in 4 sets of 6 different muscles twice. Coefficient of variation of all measurements had to be
- Published
- 2018