9 results on '"Jesse, Columbo"'
Search Results
2. Excess mortality in the general population versus Veterans Healthcare System during the first year of the COVID-19 pandemic in the United States
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Daniel M. Weinberger, Liam Rose, Christopher Rentsch, Steven M. Asch, Jesse Columbo, Joseph King, Caroline Korves, Brian P. Lucas, Cynthia Taub, Yinong Young-Xu, Anita Vashi, Louise Davies, and Amy C. Justice
- Abstract
ImportanceThe COVID-19 pandemic had a substantial impact on the overall rate of death in the United States during the first year. It is unclear whether access to comprehensive medical care, such as through the VA healthcare system, altered death rates compared to the US population.ObjectiveQuantify the increase in death rates during the first year of the COVID-19 pandemic in the general US population and among individuals who receive comprehensive medical care through the Department of Veterans Affairs (VA).DesignAnalysis of changes in all-cause death rates by quarter, stratified by age, sex race/ethnicity, and region, based on individual-level data. Hierarchical regression models were fit in a Bayesian setting. Standardized rates were used for comparison between populations.Setting and participantsGeneral population of the United States, enrollees in the VA, and active users of VA healthcare.Exposure and main outcomeChanges in rates of death from any cause during the COVID-19 pandemic in 2020 compared to previous years.ResultsSharp increases were apparent across all of the adult age groups (25 years and older) in both the general US population and the VA populations. Across all of 2020, the relative increase in death rates was similar in the general US population (RR: 1.20 (95% CI: 1.17, 1.22)), VA enrollees (RR: 1.20 (95% CI: 1.14, 1.29)), and VA active users (RR: 1.19 (95% CI: 1.14, 1.26)). Because the pre-pandemic standardized mortality rates were higher in the VA populations prior to the pandemic, the absolute rates of excess mortality were higher in the VA populations.Conclusions and RelevanceDespite access to comprehensive medical care, active users of the VA had similar relative mortality increases from all causes compared with the general US population. Factors that influenced baseline rates of death and that mitigated viral transmission in the community are more likely to have influenced the impact of the pandemic.
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- 2022
3. The Impact of Clostridium difficile Infection in Contemporary Vascular Surgery
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Morgan Cox, Salvatore Scali, Jesse Columbo, Thomas Huber, Dan Neal, and David Stone
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Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2022
4. Factors associated with preference of choice of aortic aneurysm repair in the PReference for Open Versus Endovascular repair of AAA (PROVE-AAA) study
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Mark A. Eid, Jonathan A. Barnes, Kunal Mehta, Zachary Wanken, Jesse Columbo, Ravinder Kang, Karina Newhall, Vivienne Halpern, Joseph Raffetto, Panos Kougias, Peter Henke, Gale Tang, Leila Mureebe, Jason Johanning, Edith Tzeng, Salvatore Scali, David Stone, Bjoern Suckow, Eugeen Lee, Shipra Arya, Kristine Orion, Jessica O’Connell, Benjamin Brooke, Daniel Ihnat, Hasan Dosluoglu, Wei Zhou, Peter Nelson, Emily Spangler, Michael Barry, Brenda Sirovich, and Philip Goodney
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Blood Vessel Prosthesis Implantation ,Treatment Outcome ,Risk Factors ,Patient Selection ,Endovascular Procedures ,Odds Ratio ,Humans ,Surgery ,Cardiology and Cardiovascular Medicine ,Aortic Aneurysm, Abdominal ,Retrospective Studies - Abstract
Patients can choose between open repair and endovascular repair (EVAR) of abdominal aortic aneurysm (AAA). However, the factors associated with patient preference for one repair type over another are not well-characterized. Here we assess the factors associated with preference of choice for open or endovascular AAA repair among veterans exposed to a decision aid to help with choosing surgical treatment.Across 12 Veterans Affairs hospitals, veterans received a decision aid covering domains including patient information sources and understanding preference. Veterans were then given a series of surveys at different timepoints examining their preferences for open versus endovascular AAA repair. Questions from the preference survey were used in analyses of patient preference. Results were analyzed using χA total of 126 veterans received a decision aid informing them of their treatment choices, after which 121 completed all preference survey questions; five veterans completed only part of the instruments. Overall, veterans who preferred open repair were typically younger (70 years vs 73 years; P = .02), with similar rates of common comorbidities (coronary disease 16% vs 28%; P = .21), and similar aneurysms compared with those who preferred EVAR (6.0 cm vs 5.7 cm; P = .50). Veterans in both preference categories (28% of veterans preferring EVAR, 48% of veterans preferring open repair) reported taking their doctor's advice as the top box response for the single most important factor influencing their decision. When comparing the tradeoff between less invasive surgery and higher risk of long-term complications, more than one-half of veterans preferring EVAR reported invasiveness as more important compared with approximately 1 in 10 of those preferring open repair (53% vs 12%; P .001). Shorter recovery was an important factor for the EVAR group (74%) and not important in the open repair group (76%) (P = .5). In multivariable analyses, valuing a short hospital stay (odds ratio, 12.4; 95% confidence interval, 1.13-135.70) and valuing a shorter recovery (odds ratio, 15.72; 95% confidence interval, 1.03-240.20) were associated with a greater odds of preference for EVAR, whereas finding these characteristics not important was associated with a greater odds of preference for open repair.When faced with the decision of open repair versus EVAR, veterans who valued a shorter hospital stay and a shorter recovery were more likely to prefer EVAR, whereas those more concerned about long-term complications preferred an open repair. Veterans typically value the advice of their surgeon over their own beliefs and preferences. These findings need to be considered by surgeons as they guide their patients to a shared decision.
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- 2022
5. Abstract 10214: Stress Testing Prior to Abdominal Aortic Aneurysm Repair: What is Our Return on Investment?
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Jesse Columbo, Aravind S Ponukumati, Stanislav Henkin, Salvatore T Scali, Mark A Creager, Richard J Powell, and David Stone
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Introduction: The use of stress testing prior to abdominal aortic aneurysm (AAA) repair is highly variable. We examined the financial implications of this variation and its impact on postoperative cardiac events. Methods: We studied patients who underwent elective endovascular (EVAR) or open AAA repair at Vascular Quality Initiative participating centers from 2015–2019. We grouped centers into quintiles by their frequency of preoperative stress testing. We calculated rates of major adverse cardiovascular events (MACE), a composite of in-hospital myocardial infarction, stroke, heart failure, or death, for each quintile. We applied the charges for electrocardiographic, echocardiographic, and nuclear stress tests at our institution in 2019 to the study population to calculate expected charges per 1,000 patients. Results: We studied 27,978 patients who underwent EVAR (mean age: 73.5 ±8.5 years, 81.7% male) and 4,481 who underwent open AAA repair (mean age: 69.5 ±8.1 years, 75.1% male). Stratifying by quintile, stress test frequency ranged from 13.0% to 68.6% (mean: 37.9%) among EVAR patients and 15.9% to 85.0% (mean: 52.8%) among open AAA repair (Figure). The rate of MACE was 1.4% after EVAR and 10.2% after open AAA repair. MACE after EVAR increased with the frequency of stress testing and was 0.9% at 1 st quintile centers vs 1.7% at 5 th quintile centers (p-trend=0.033). There was no association between MACE and stress testing for open AAA repair (p-trend=0.192). The estimated charges for stress testing prior to EVAR was $125,806 per 1,000 patients at 1 st quintile centers, and $664,975 at 5 th quintile centers, while charges prior to open AAA repair were $153,861 per 1,000 patients at 1 st quintile centers, and $825,473 at 5 th quintile centers. Conclusions: More frequent stress testing is associated with high cost without a reduction in MACE. This lack of return on investment highlights the need for more judicious stress test use prior to AAA surgery.
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- 2021
6. Abstract 14085: Evaluating the Geographical Dispersion and Outcomes of Carotid Artery Revascularization in the United States: A Report From the Vascular Quality Initiative
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Michael N Young, Stanislav Henkin, Stephen Kearing, Alexander Iribarne, Philip P Goodney, and Jesse Columbo
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Introduction: Carotid artery revascularization - including endarterectomy (CEA) and stenting (CAS) - is the standard of care for severe carotid stenosis. The contemporary geographic dispersion of CAS relative to CEA is not well described and has implications on access-to-care in the United States. Methods: We identified 83,825 patients undergoing CEA and CAS between 2015-2019 among participating centers in the Vascular Quality Initiative. Patients were stratified according to type of revascularization and by urban vs. rural geographical designation based on Rural Urban Commuting Area coding. For CEA and CAS cohorts, demographic profiles and clinical outcomes were compared between urban vs. rural patients. Multivariable logistic regression was performed to estimate the association of geographical locale with 30-day and 1-year outcomes. Results: There was a progressive annual increase in CAS, CEA, and the relative ratio of CAS/CEA performed throughout the study period. (Figure 1) The proportion of carotid stents increased from 25.1% in 2015 to 48.7% in 2019. This finding was consistent in both rural (28.7% to 51.4%) and urban areas (23.9% to 47.7%). In both CEA and CAS cohorts, demographic characteristics, medical profiles, and in-hospital outcomes were overall comparable between rural and urban subgroups. For CAS, geographic locale was not associated with 30-day or 1-year mortality (OR 1.12, 95% CI 0.89-1.41; p=0.34 and OR 1.11, 95% CI 0.97-1.28; p=0.13, respectively). Similarly for CEA, 30-day and 1-year mortality were not significantly different between rural vs. urban subgroups (OR 1.04, 95% CI 0.84-1.29; p=0.72 and OR 1.05, 95% CI 0.94-1.17; p=0.40). Conclusions: Over a short time period, there has been progressive uptake in the relative use of CAS and CEA across the United States. There were no significant differences in either short- or long-term outcomes of carotid revascularization based on rurality.
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- 2021
7. Use of linked registry claims data for long term surveillance of devices after endovascular abdominal aortic aneurysm repair: observational surveillance study
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Philip, Goodney, Jialin, Mao, Jesse, Columbo, Bjoern, Suckow, Marc, Schermerhorn, Mahmoud, Malas, Benjamin, Brooke, Andrew, Hoel, Salvatore, Scali, Shipra, Arya, Emily, Spangler, Olamide, Alabi, Adam, Beck, Barbara, Gladders, Kayla, Moore, Xinyan, Zheng, Jens, Eldrup-Jorgensen, Art, Sedrakyan, and Jack, Cronenwett
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Male ,Aged, 80 and over ,Endovascular Procedures ,General Medicine ,Medicare ,United States ,Blood Vessel Prosthesis ,Blood Vessel Prosthesis Implantation ,Treatment Outcome ,Risk Factors ,Humans ,Female ,Stents ,Registries ,Aged ,Aortic Aneurysm, Abdominal ,Retrospective Studies - Abstract
ObjectiveTo evaluate long term outcomes (reintervention and late rupture of abdominal aortic aneurysm) of aortic endografts in real world practice using linked registry claims data.DesignObservational surveillance study.Setting282 centers in the Vascular Quality Initiative Registry linked to United States Medicare claims (2003-18).Participants20 489 patients treated with four device types used for endovascular abdominal aortic aneurysm repair (EVAR): 40.6% (n=8310) received the Excluder (Gore), 32.2% (n=6606) the Endurant (Medtronic), 16.0% (n=3281) the Zenith (Cook Medical), and 11.2% (n=2292) the AFX (Endologix). Given modifications to AFX in late 2014, patients who received the AFX device were categorized into two groups: the early AFX group (n=942) and late AFX group (n=1350) and compared with patients who received the other devices, using propensity matched Cox models.Main outcome measuresReintervention and rupture of abdominal aortic aneurysm post-EVAR; all patients (100%) had complete follow-up via the registry or claims based outcome assessment, or both.ResultsMedian age was 76 years (interquartile range (IQR) 70-82 years), 80.0% (16 386/20 489) of patients were men, and median follow-up was 2.3 years (IQR 0.9-4.1 years). Crude five year reintervention rates were significantly higher for patients who received the early AFX device compared with the other devices: 14.9% (95% confidence interval 13.7% to 16.2%) for Excluder, 19.5% (18.1% to 21.1%) for Endurant, 16.7% (15.0% to 18.6%) for Zenith, and early 27.0% (23.7% to 30.6%) for the early AFX. The risk of reintervention for patients who received the early AFX device was higher compared with the other devices in propensity matched Cox models (hazard ratio 1.61, 95% confidence interval 1.29 to 2.02) and analyses using a surgeon level instrumental variable of >33% AFX grafts used in their practice (1.75, 1.19 to 2.59). The linked registry claims surveillance data identified the increased risk of reintervention with the early AFX device as early as mid-2013, well before the first regulatory warnings were issued in the US in 2017.ConclusionsThe linked registry claims surveillance data identified a device specific risk in long term reintervention after EVAR of abdominal aortic aneurysm. Device manufacturers and regulators can leverage linked data sources to actively monitor long term outcomes in real world practice after cardiovascular interventions.
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- 2022
8. Patients with Chronic Limb Threatening Ischemia Prioritize Mobility over Pain, Support Systems, Wounds, or Mental Health
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Bjoern Suckow, Sarah Bessen, Dorothy Hebb, Glyn Elwyn, David Stone, Jesse Columbo, and Philip Goodney
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Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2021
9. Influence of Low-Dose Aspirin (81 mg) on the Incidence of Definite Stent Thrombosis in Patients Receiving Bare-Metal and Drug-Eluting Stents
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Jiang Cui, Siddharth Wartak, Gregory R. Giugliano, Amir Lotfi, Marc J. Schweiger, Mary E. Davis, Scott Mulvey, and Jesse Columbo
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Male ,medicine.medical_specialty ,Ticlopidine ,Paclitaxel ,medicine.medical_treatment ,Statistics as Topic ,Clinical Investigations ,Risk Assessment ,Coronary Restenosis ,medicine ,Humans ,Cumulative incidence ,cardiovascular diseases ,Retrospective Studies ,Sirolimus ,Aspirin ,business.industry ,Coronary Thrombosis ,Incidence ,Percutaneous coronary intervention ,Stent ,Drug-Eluting Stents ,Retrospective cohort study ,General Medicine ,Middle Aged ,Clopidogrel ,Surgery ,Cohort ,Conventional PCI ,Drug Therapy, Combination ,Female ,Cardiology and Cardiovascular Medicine ,business ,Immunosuppressive Agents ,Platelet Aggregation Inhibitors ,medicine.drug - Abstract
Background: Dual antiplatelet therapy with aspirin plus clopidogrel is the mainstay of therapy in patients undergoing percutaneous coronary intervention (PCI). However, the optimal dose of aspirin following PCI has not been established. Hypothesis: There is no difference for definite stent thrombosis in patients taking low dose versus standard aspirin. Methods: Low-dose (81 mg) aspirin was used as part of a standard dual antiplatelet therapy in patients receiving bare-metal stents (BMS) or drug-eluting stents (DES) at a large tertiary medical center. We retrospectively analyzed 5368 consecutive cases treated with stent placement and dual antiplatelet therapy. The incidence of definite stent thrombosis (DST) at our institution was compared to DST as reported in a large, published cohort of 24 trials and 12973 patients. We stratified DST events into early ( 30 days) timing and also stratified by stent type. The effect of aspirin dosing was evaluated using χ2, Cochran-Mantel-Haenszel, and homogeneity testing. Results: A total of 5187 patients underwent 7604 stent implantations during the study period. The cumulative incidence of DST was 0.60% (95% confidence interval [CI], 0.42%–0.84%) at 30 days and 0.76% (95% CI, 0.56%–1.03%) at 1 year. The overall incidence of DST during the study period was not different based on type of stent (0.53% for DES and 0.75% for BMS, P = 0.36). Compared to the historic, standard-dose aspirin (162–325 mg) cohort, DST in our low-dose aspirin (81 mg) cohort was not significantly different at either 30 days (0.72% vs 0.60%, P = 0.39) or at 1 year (1.08% vs 0.76%, P = 0.07). There was no appreciable interaction of aspirin dose on the incidence of DST, controlling for stent type, or timing of the event. Conclusions: Low-dose aspirin therapy in combination with clopidogrel following implantation of either BMS or DES in our cohort does not appear to increase the risk of DST compared to a higher-dose aspirin regimen. © 2011 Wiley Periodicals, Inc. The authors have no funding, financial relationships, or conflicts of interest to disclose.
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- 2011
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