746 results on '"Ji, Bu‐Tian"'
Search Results
2. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
- Author
-
Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J., Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M., Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A., Kim, Jin Hee, Albanes, Demetrius, Wong, Jason Y. Y., Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E., Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H., Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J., Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Kun-Chieh, Gao, Yu-Tang, Qian, Biyun, Wu, Chen, Lu, Daru, Liu, Jianjun, Schwartz, Ann G., Houlston, Richard, Spitz, Margaret R., Gorlov, Ivan P., Wu, Xifeng, Yang, Ping, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Ji, Bu-Tian, Wichmann, H-Erich, Christiani, David C., Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James, Field, John K., Shete, Sanjay S., Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Zienolddiny-Narui, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Taylor, Fiona, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Jeon, Hyo-Sung, Jiang, Shih Sheng, Sung, Jae Sook, Chen, Chung-Hsing, Hsiao, Chin-Fu, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda, Liu, Jia, Zhu, Bin, Berndt, Sonja I., Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Wang, Wen-Chang, Xu, Jun, Guan, Peng, Tan, Wen, Yu, Chong-Jen, Yang, Gong, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Park, In Kyu, Xu, Ping, He, Qincheng, Wang, Chih-Liang, Hung, Hsiao-Han, Vermeulen, Roel C. H., Cheng, Iona, Wu, Junjie, Lim, Wei-Yen, Tsai, Fang-Yu, Chan, John K. C., Li, Jihua, Chen, Hongyan, Lin, Hsien-Chih, Jin, Li, Liu, Jie, Sawada, Norie, Yamaji, Taiki, Wyatt, Kathleen, Li, Shengchao A., Ma, Hongxia, Zhu, Meng, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Chao, Ann, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chen, Chih-Yi, Chen, Chien-Jen, Yang, Pan-Chyr, Yu, Jinming, Stevens, Victoria L., Fraumeni, Jr, Joseph F., Chatterjee, Nilanjan, Gorlova, Olga Y., Hsiung, Chao Agnes, Amos, Christopher I., Shen, Hongbing, Chanock, Stephen J., Rothman, Nathaniel, Kohno, Takashi, and Lan, Qing
- Published
- 2023
- Full Text
- View/download PDF
3. Household air pollution and epigenetic aging in Xuanwei, China
- Author
-
Blechter, Batel, Cardenas, Andres, Shi, Junming, Wong, Jason Y.Y., Hu, Wei, Rahman, Mohammad L., Breeze, Charles, Downward, George S., Portengen, Lützen, Zhang, Yongliang, Ning, Bofu, Ji, Bu-Tian, Cawthon, Richard, Li, Jihua, Yang, Kaiyun, Bozack, Anne, Dean Hosgood, H., Silverman, Debra T., Huang, Yunchao, Rothman, Nathaniel, Vermeulen, Roel, and Lan, Qing
- Published
- 2023
- Full Text
- View/download PDF
4. Methylated polycyclic aromatic hydrocarbons from household coal use across the life course and risk of lung cancer in a large cohort of 42,420 subjects in Xuanwei, China
- Author
-
Portengen, Lützen, Downward, George, Bassig, Bryan A., Blechter, Batel, Hu, Wei, Wong, Jason Y.Y., Ning, Bofu, Rahman, Mohammad L., Ji, Bu-Tian, Li, Jihua, Yang, Kaiyun, Hosgood, H. Dean, Silverman, Debra T., Rothman, Nathaniel, Huang, Yunchao, Vermeulen, Roel, and Lan, Qing
- Published
- 2023
- Full Text
- View/download PDF
5. A nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study
- Author
-
Rahman, Mohammad L., primary, Shu, Xiao‐Ou, additional, Jones, Dean P., additional, Hu, Wei, additional, Ji, Bu‐tian, additional, Blechter, Batel, additional, Wong, Jason Y. Y., additional, Cai, Qiuyin, additional, Yang, Gong, additional, Gao, Yu‐Tang, additional, Zheng, Wei, additional, Rothman, Nathaniel, additional, Walker, Douglas, additional, and Lan, Qing, additional
- Published
- 2024
- Full Text
- View/download PDF
6. Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility
- Author
-
Earp, Madalene, Tyrer, Jonathan P, Winham, Stacey J, Lin, Hui-Yi, Chornokur, Ganna, Dennis, Joe, Aben, Katja KH, Anton‐Culver, Hoda, Antonenkova, Natalia, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Despierre, Evelyn, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Høgdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Jung, Audrey Y, Karlan, Beth Y, Kellar, Melissa, Kiemeney, Lambertus A, Lim, Boon Kiong, Kjaer, Susanne K, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lele, Shashi, Lester, Jenny, Levine, Douglas A, Li, Zheng, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Odunsi, Kunle, Olson, Sara H, Orlow, Irene, Orsulic, Sandra, Paul, James, Pejovic, Tanja, Pelttari, Liisa M, Permuth, Jenny B, Pike, Malcolm C, Poole, Elizabeth M, Rosen, Barry, Rossing, Mary Anne, Rothstein, Joseph H, and Runnebaum, Ingo B
- Subjects
Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Genetics ,Oncology and Carcinogenesis ,Biotechnology ,Ovarian Cancer ,Cancer ,Human Genome ,Rare Diseases ,2.1 Biological and endogenous factors ,Aetiology ,A Kinase Anchor Proteins ,Carcinoma ,Ovarian Epithelial ,Female ,Genetic Association Studies ,Genetic Predisposition to Disease ,Genotype ,Humans ,Monomeric GTP-Binding Proteins ,Polymorphism ,Single Nucleotide ,Quantitative Trait Loci ,Rho Guanine Nucleotide Exchange Factors ,Risk Factors ,General Science & Technology - Abstract
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) which govern processes such as signal transduction, cell proliferation, cell motility, and vesicle transport. We hypothesized that common germline variation in genes encoding small GTPases is associated with EOC risk. We investigated 322 variants in 88 small GTPase genes in germline DNA of 18,736 EOC patients and 26,138 controls of European ancestry using a custom genotype array and logistic regression fitting log-additive models. Functional annotation was used to identify biofeatures and expression quantitative trait loci that intersect with risk variants. One variant, ARHGEF10L (Rho guanine nucleotide exchange factor 10 like) rs2256787, was associated with increased endometrioid EOC risk (OR = 1.33, p = 4.46 x 10-6). Other variants of interest included another in ARHGEF10L, rs10788679, which was associated with invasive serous EOC risk (OR = 1.07, p = 0.00026) and two variants in AKAP6 (A-kinase anchoring protein 6) which were associated with risk of invasive EOC (rs1955513, OR = 0.90, p = 0.00033; rs927062, OR = 0.94, p = 0.00059). Functional annotation revealed that the two ARHGEF10L variants were located in super-enhancer regions and that AKAP6 rs927062 was associated with expression of GTPase gene ARHGAP5 (Rho GTPase activating protein 5). Inherited variants in ARHGEF10L and AKAP6, with potential transcriptional regulatory function and association with EOC risk, warrant investigation in independent EOC study populations.
- Published
- 2018
7. A proteome‐wide analysis unveils a core Epstein–Barr virus antibody signature of classic Hodgkin lymphoma across ethnically diverse populations.
- Author
-
Sarathkumara, Yomani D., Xian, Rena R., Liu, Zhiwei, Yu, Kelly J., Chan, John K. C., Kwong, Yok‐Lam, Lam, Tai Hing, Liang, Raymond, Chiu, Brian, Xu, Jun, Hu, Wei, Ji, Bu‐Tian, Coghill, Anna E., Kelly, Ashton M., Pfeiffer, Ruth M., Rothman, Nathaniel, Ambinder, Richard F., Hildesheim, Allan, Lan, Qing, and Proietti, Carla
- Subjects
VIRAL antibodies ,HUMORAL immunity ,ANTIBODY formation ,HODGKIN'S disease ,ONCOGENIC viruses - Abstract
Epstein–Barr virus (EBV) is an oncogenic virus associated with various malignancies, including classical Hodgkin lymphoma (cHL). Despite its known association, the specific role of humoral immune response to EBV remains poorly characterized in cHL. To address this, we conducted a study using a custom protein microarray to measure the antibody responses in cHL patients and matched healthy controls recruited from an East‐Asian hospital‐based case–control study. We identified 16 IgG antibodies significantly elevated in EBV‐positive cHL compared with controls, defining an "East‐Asian antibody signature of EBV‐positive cHL." We evaluated responses against these 16 antibodies in a distinct European population, leveraging data from our previous European cHL case–control study from the UK, Denmark, and Sweden. A subset of antibodies (14/16, 87.5%) from the "East‐Asian antibody signature of EBV‐positive cHL" exhibited significant associations with cHL in the European population. Conversely, we assessed the "European antibody signature of EBV‐positive cHL" identified in our prior study which consisted of 18 EBV antibodies (2 IgA, 16 IgG), in the East‐Asian population. A subset of these antibodies (15/18, 83.3%) maintained significant associations with cHL in the East‐Asian population. This cross‐comparison of antibody signatures underscores the robust generalizability of EBV antibodies across populations. Five anti‐EBV IgG antibodies (LMP‐1, TK, BALF2, BDLF3, and BBLF1), found in both population‐specific antibody signatures, represent a "core signature of EBV‐positive cHL." Our findings suggest that the antibody responses targeting these core EBV proteins reflect a specific EBV gene expression pattern, serving as potential biomarkers for EBV‐positive cHL independent of population‐specific factors. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
8. Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer
- Author
-
Hampras, Shalaka S, Sucheston-Campbell, Lara E, Cannioto, Rikki, Chang-Claude, Jenny, Modugno, Francesmary, Dörk, Thilo, Hillemanns, Peter, Preus, Leah, Knutson, Keith L, Wallace, Paul K, Hong, Chi-Chen, Friel, Grace, Davis, Warren, Nesline, Mary, Pearce, Celeste L, Kelemen, Linda E, Goodman, Marc T, Bandera, Elisa V, Terry, Kathryn L, Schoof, Nils, Eng, Kevin H, Clay, Alyssa, Singh, Prashant K, Joseph, Janine M, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bean, Yukie, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Cook, Linda S, Cramer, Daniel W, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A, du Bois, Andreas, Dürst, Matthias, Easton, Doug, Eccles, Diana, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Gronwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hogdall, Claus, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Klapdor, Rüdiger, Kolomeyevskaya, Nonna, Krakstad, Camilla, Kjaer, Susanne K, Kruszka, Bridget, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashikant, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Liu, Song, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, and McGuire, Valeria
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Ovarian Cancer ,Rare Diseases ,Cancer ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Adenocarcinoma ,Clear Cell ,Adult ,Aged ,Carcinoma ,Ovarian Epithelial ,Female ,Gene Expression Regulation ,Neoplastic ,Gene Frequency ,Genetic Predisposition to Disease ,Genotype ,Humans ,Middle Aged ,Neoplasms ,Glandular and Epithelial ,Ovarian Neoplasms ,Polymorphism ,Single Nucleotide ,Protein Serine-Threonine Kinases ,Receptor ,Transforming Growth Factor-beta Type II ,Receptors ,Transforming Growth Factor beta ,Risk Factors ,T-Lymphocytes ,Regulatory ,ovarian cancer ,immunosuppression ,biomarkers ,genetic variation ,TGFBR2 ,TGFBR2 ,Oncology and carcinogenesis - Abstract
BackgroundRegulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.MethodsIn a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.ResultsThe most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively).ConclusionsCommon inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.
- Published
- 2016
9. Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.
- Author
-
Amankwah, Ernest K, Lin, Hui-Yi, Tyrer, Jonathan P, Lawrenson, Kate, Dennis, Joe, Chornokur, Ganna, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Bruinsma, Fiona, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chen, Zhihua, Chen, Y Ann, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis N, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Jim, Heather, Kellar, Melissa, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lim, Boon Kiong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Ian, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Eilber, Ursula, Odunsi, Kunle, Olson, Sara H, Orlow, Irene, Orsulic, Sandra, and Weber, Rachel Palmieri
- Subjects
Georgia Chenevix-Trench on behalf of the AOCS management group ,Humans ,Neoplasms ,Glandular and Epithelial ,Ovarian Neoplasms ,Genetic Predisposition to Disease ,Odds Ratio ,Risk ,Genotype ,Polymorphism ,Single Nucleotide ,Adult ,Aged ,Middle Aged ,European Continental Ancestry Group ,Female ,Genome-Wide Association Study ,Epithelial-Mesenchymal Transition ,Carcinoma ,Ovarian Epithelial ,epithelial-mesenchymal transition ,ovarian cancer ,single-nucleotide polymorphisms ,Neoplasms ,Glandular and Epithelial ,Polymorphism ,Single Nucleotide ,Carcinoma ,Ovarian Epithelial ,Epidemiology ,Public Health and Health Services ,Genetics - Abstract
Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene variants contribute to epithelial ovarian carcinoma (EOC) risk have been based on small sample sizes and none have sought replication in an independent population. We screened 15,816 single-nucleotide polymorphisms (SNPs) in 296 genes in a discovery phase using data from a genome-wide association study of EOC among women of European ancestry (1,947 cases and 2,009 controls) and identified 793 variants in 278 EMT-related genes that were nominally (P < 0.05) associated with invasive EOC. These SNPs were then genotyped in a larger study of 14,525 invasive-cancer patients and 23,447 controls. A P-value
- Published
- 2015
10. Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.
- Author
-
Kar, Siddhartha P, Tyrer, Jonathan P, Li, Qiyuan, Lawrenson, Kate, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Chenevix-Trench, Georgia, Australian Cancer Study, Australian Ovarian Cancer Study Group, Baker, Helen, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Berchuck, Andrew, Bisogna, Maria, Bjørge, Line, Bogdanova, Natalia, Brinton, Louise, Brooks-Wilson, Angela, Butzow, Ralf, Campbell, Ian, Carty, Karen, Chang-Claude, Jenny, Chen, Yian Ann, Chen, Zhihua, Cook, Linda S, Cramer, Daniel, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Easton, Douglas F, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus K, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Paul, James, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kjaer, Susanne K, Kelemen, Linda E, Kellar, Melissa, Kelley, Joseph, Kiemeney, Lambertus A, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain A, Menon, Usha, Modugno, Francesmary, Moysich, Kirsten B, Narod, Steven A, Nedergaard, Lotte, Ness, Roberta B, Nevanlinna, Heli, Odunsi, Kunle, Olson, Sara H, and Orlow, Irene
- Subjects
Australian Cancer Study ,Australian Ovarian Cancer Study Group ,Humans ,Cystadenocarcinoma ,Serous ,Ovarian Neoplasms ,Genetic Predisposition to Disease ,Nuclear Proteins ,Transcription Factors ,DNA ,Neoplasm ,Morbidity ,Risk Factors ,Gene Expression Regulation ,Neoplastic ,Genotype ,Female ,Genome-Wide Association Study ,Global Health ,Ovarian Cancer ,Biotechnology ,Cancer ,Genetics ,Rare Diseases ,Prevention ,Human Genome ,2.1 Biological and endogenous factors ,Epidemiology ,Medical and Health Sciences - Abstract
BackgroundGenome-wide association studies (GWAS) have so far reported 12 loci associated with serous epithelial ovarian cancer (EOC) risk. We hypothesized that some of these loci function through nearby transcription factor (TF) genes and that putative target genes of these TFs as identified by coexpression may also be enriched for additional EOC risk associations.MethodsWe selected TF genes within 1 Mb of the top signal at the 12 genome-wide significant risk loci. Mutual information, a form of correlation, was used to build networks of genes strongly coexpressed with each selected TF gene in the unified microarray dataset of 489 serous EOC tumors from The Cancer Genome Atlas. Genes represented in this dataset were subsequently ranked using a gene-level test based on results for germline SNPs from a serous EOC GWAS meta-analysis (2,196 cases/4,396 controls).ResultsGene set enrichment analysis identified six networks centered on TF genes (HOXB2, HOXB5, HOXB6, HOXB7 at 17q21.32 and HOXD1, HOXD3 at 2q31) that were significantly enriched for genes from the risk-associated end of the ranked list (P < 0.05 and FDR < 0.05). These results were replicated (P < 0.05) using an independent association study (7,035 cases/21,693 controls). Genes underlying enrichment in the six networks were pooled into a combined network.ConclusionWe identified a HOX-centric network associated with serous EOC risk containing several genes with known or emerging roles in serous EOC development.ImpactNetwork analysis integrating large, context-specific datasets has the potential to offer mechanistic insights into cancer susceptibility and prioritize genes for experimental characterization.
- Published
- 2015
11. Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma
- Author
-
Liu, Zhiwei, Sarathkumara, Yomani D., Chan, John K. C., Kwong, Yok-Lam, Lam, Tai Hing, Ip, Dennis Kai Ming, Chiu, Brian C.-H., Xu, Jun, Su, Yu-Chieh, Proietti, Carla, Cooper, Martha M., Yu, Kelly J., Bassig, Bryan, Liang, Raymond, Hu, Wei, Ji, Bu-Tian, Coghill, Anna E., Pfeiffer, Ruth M., Hildesheim, Allan, Rothman, Nathaniel, Doolan, Denise L., and Lan, Qing
- Published
- 2021
- Full Text
- View/download PDF
12. Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.
- Author
-
Lawrenson, Kate, Li, Qiyuan, Kar, Siddhartha, Seo, Ji-Heui, Tyrer, Jonathan, Spindler, Tassja J, Lee, Janet, Chen, Yibu, Karst, Alison, Drapkin, Ronny, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Australian Ovarian Cancer Study Group, Baker, Helen, Bandera, Elisa V, Bean, Yukie, Beckmann, Matthias W, Berchuck, Andrew, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Chen, Anne, Chen, Zhihua, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Easton, Douglas T, Edwards, Robert P, Eilber, Ursula, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, James, Paul, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kruger Kjaer, Susanne, Kelemen, Linda E, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, Nevanlinna, Heli, McNeish, Ian, and Menon, Usha
- Subjects
Australian Ovarian Cancer Study Group ,Cell Line ,Tumor ,Humans ,Neoplasms ,Glandular and Epithelial ,Ovarian Neoplasms ,Genetic Predisposition to Disease ,Homeodomain Proteins ,Neoplasm Proteins ,Gene Expression Regulation ,Neoplastic ,Protein Binding ,Quantitative Trait Loci ,Female ,Nuchal Cord ,Genetic Association Studies ,Carcinoma ,Ovarian Epithelial ,Cell Line ,Tumor ,Neoplasms ,Glandular and Epithelial ,Gene Expression Regulation ,Neoplastic ,Carcinoma ,Ovarian Epithelial ,Rare Diseases ,Prevention ,Ovarian Cancer ,Biotechnology ,Human Genome ,Cancer ,Genetics ,2.1 Biological and endogenous factors - Abstract
Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P≤10(-5)). For three cis-eQTL associations (P
- Published
- 2015
13. Dietary isoflavones, urinary isoflavonoids, and risk of ischemic stroke in women 1–3
- Author
-
Yu, Danxia, Shu, Xiao-Ou, Li, Honglan, Yang, Gong, Cai, Qiuyin, Xiang, Yong-Bing, Ji, Bu-Tian, Franke, Adrian A, Gao, Yu-Tang, Zheng, Wei, and Zhang, Xianglan
- Subjects
Aging ,Clinical Research ,Brain Disorders ,Prevention ,Nutrition ,Stroke ,Estrogen ,Complementary and Integrative Health ,Adult ,Aged ,Asian People ,Case-Control Studies ,Chromatography ,High Pressure Liquid ,Diet ,Female ,Follow-Up Studies ,Humans ,Isoflavones ,Middle Aged ,Multivariate Analysis ,Nutrition Assessment ,Prospective Studies ,Risk Factors ,Soybeans ,Surveys and Questionnaires ,ischemic stroke ,phytoestrogen ,prospective cohort study ,soy isoflavone ,women ,Engineering ,Medical and Health Sciences ,Nutrition & Dietetics - Abstract
BackgroundHormone therapy has been shown to increase risk of ischemic stroke in women. Plant-derived estrogens, particularly soy isoflavones, are known to have some estrogenic effects and have been marketed as natural alternatives to hormone therapy. Concerns have been raised about whether high isoflavone exposure may be related to ischemic stroke risk as well.ObjectiveWe examined the dietary intake of isoflavones and the urinary excretion of isoflavonoids in relation to risk of ischemic stroke in women.DesignA prospective cohort study was conducted in 66,832 Chinese women (aged 40-70 y) who had no cardiovascular disease or cancer at baseline. Usual dietary intakes were assessed via in-person interviews with the use of a validated food-frequency questionnaire. Incident strokes were ascertained during follow-up home visits and confirmed by medical records. We also conducted a nested case-control study in postmenopausal women who had never used hormone therapy, including 1422 incident ischemic stroke cases and 1422 controls individually matched by age, date and time of urine sample collection, time since last meal, and use of antibiotics. Urinary isoflavonoids were measured with the use of high-performance liquid chromatography coupled with mass spectrometry.ResultsDuring a mean follow-up of 10 y, 3110 incident ischemic strokes were verified. Dietary isoflavone intake was associated with increased risk of ischemic stroke; multivariable-adjusted HRs from lowest to highest quintiles were 1.00, 1.05, 1.10, 1.11, and 1.24, respectively (95% CI: 1.08, 1.42; P-trend = 0.002). In the case-control study, a similar positive association was observed for dietary isoflavones, but no significant associations were shown for the urinary isoflavonoid concentration [OR: 1.01 (95% CI: 0.77, 1.32) for comparison of extreme quintiles].ConclusionsA habitually high intake of soy isoflavones may be associated with a modest but significant increase in risk of ischemic stroke in women. However, no association was shown for the urinary excretion of isoflavonoids.
- Published
- 2015
14. Genome-wide significant risk associations for mucinous ovarian carcinoma (vol 47, pg 888, 2015)
- Author
-
Kelemen, Linda E, Lawrenson, Kate, Tyrer, Jonathan, Li, Qiyuan, Lee, Janet M, Seo, Ji-Heui, Phelan, Catherine M, Beesley, Jonathan, Chen, Xiaoqing, Spindler, Tassja J, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bandera, Elisa V, Bean, Yukie, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Chen, Y Ann, Chen, Zhihua, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Doerk, Thilo, du Bois, Andreas, Duerst, Matthias, Eccles, Diana, Easton, Douglas T, Edwards, Robert P, Eilber, Ursula, Ekici, Arif B, Engelholm, Svend Aage, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain, Menon, Usha, Modugno, Francesmary, Moes-Sosnowska, Joanna, Moysich, Kirsten B, Narod, Steven A, and Nedergaard, Lotte
- Subjects
Developmental Biology ,Medical and Health Sciences ,Biological Sciences - Published
- 2015
15. Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci
- Author
-
Coetzee, Simon G, Shen, Howard C, Hazelett, Dennis J, Lawrenson, Kate, Kuchenbaecker, Karoline, Tyrer, Jonathan, Rhie, Suhn K, Levanon, Keren, Karst, Alison, Drapkin, Ronny, Ramus, Susan J, Consortium, The Consortium of Investigators of Modifiers of BRCA1 2 The Ovarian Cancer Association, Couch, Fergus J, Offit, Kenneth, Chenevix-Trench, Georgia, Monteiro, Alvaro NA, Antoniou, Antonis, Freedman, Matthew, Coetzee, Gerhard A, Pharoah, Paul DP, Noushmehr, Houtan, Gayther, Simon A, Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bandera, Elisa V, Bean, Yukie, Beckmann, Matthias W, Berchuck, Andrew, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Chen, Ann, Chen, Zhihua, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Easton, Douglas F, Edwards, Robert P, Eilber, Ursula, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, James, Paul, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kjaer, Susanne Kruger, Kelemen, Linda E, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, and Lissowska, Jolanta
- Subjects
Biological Sciences ,Genetics ,Rare Diseases ,Prevention ,Human Genome ,Ovarian Cancer ,Biotechnology ,Cancer ,2.1 Biological and endogenous factors ,Underpinning research ,Aetiology ,1.1 Normal biological development and functioning ,Chromatin ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Histones ,Humans ,Organ Specificity ,Ovarian Neoplasms ,Polymorphism ,Single Nucleotide ,Regulatory Sequences ,Nucleic Acid ,Ovarian Cancer Association Consortium ,The Consortium of Investigators of Modifiers of BRCA1/2 ,Ovarian Cancer Association Consortium The Consortium of Investigators of Modifiers of BRCA1/2 ,Medical and Health Sciences ,Genetics & Heredity - Abstract
Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single-nucleotide polymorphisms (SNPs) associated with cancer risk lie in non-protein-coding regions, implicating regulatory DNA elements as functional targets of susceptibility variants. Here, we describe genome-wide annotation of regions of open chromatin and histone modification in fallopian tube and ovarian surface epithelial cells (FTSECs, OSECs), the debated cellular origins of high-grade serous ovarian cancers (HGSOCs) and in endometriosis epithelial cells (EECs), the likely precursor of clear cell ovarian carcinomas (CCOCs). The regulatory architecture of these cell types was compared with normal human mammary epithelial cells and LNCaP prostate cancer cells. We observed similar positional patterns of global enhancer signatures across the three different ovarian cancer precursor cell types, and evidence of tissue-specific regulatory signatures compared to non-gynecological cell types. We found significant enrichment for risk-associated SNPs intersecting regulatory biofeatures at 17 known HGSOC susceptibility loci in FTSECs (P = 3.8 × 10(-30)), OSECs (P = 2.4 × 10(-23)) and HMECs (P = 6.7 × 10(-15)) but not for EECs (P = 0.45) or LNCaP cells (P = 0.88). Hierarchical clustering of risk SNPs conditioned on the six different cell types indicates FTSECs and OSECs are highly related (96% of samples using multi-scale bootstrapping) suggesting both cell types may be precursors of HGSOC. These data represent the first description of regulatory catalogues of normal precursor cells for different ovarian cancer subtypes, and provide unique insights into the tissue specific regulatory variation with respect to the likely functional targets of germline genetic susceptibility variants for ovarian cancer.
- Published
- 2015
16. Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk
- Author
-
Chornokur, Ganna, Lin, Hui-Yi, Tyrer, Jonathan P, Lawrenson, Kate, Dennis, Joe, Amankwah, Ernest K, Qu, Xiaotao, Tsai, Ya-Yu, Jim, Heather SL, Chen, Zhihua, Chen, Ann Y, Permuth-Wey, Jennifer, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Bruinsma, Fiona, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harrington, Patricia, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Hogdall, Estrid, Hosono, Satoyo, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kelemen, Linda E, Kellar, Mellissa, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lim, Boon Kiong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Eilber, Ursula, Odunsi, Kunle, Olson, Sara H, and Orlow, Irene
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Genetics ,Cancer ,Ovarian Cancer ,Rare Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Black or African American ,Alleles ,Asian ,Biological Transport ,Carcinoma ,Ovarian Epithelial ,Carrier Proteins ,Case-Control Studies ,Female ,Genetic Association Studies ,Genetic Predisposition to Disease ,Genetic Variation ,Humans ,Neoplasms ,Glandular and Epithelial ,Odds Ratio ,Ovarian Neoplasms ,Polymorphism ,Single Nucleotide ,Risk ,Georgia Chenevix-Trench ,AOCS management group ,General Science & Technology - Abstract
BackgroundDefective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk.MethodsIn total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q
- Published
- 2015
17. Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC)
- Author
-
Jim, Heather SL, Lin, Hui-Yi, Tyrer, Jonathan P, Lawrenson, Kate, Dennis, Joe, Chornokur, Ganna, Chen, Zhihua, Chen, Ann Y, Permuth-Wey, Jennifer, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Bruinsma, Fiona, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Sieh, Weiva, Doherty, Jennifer A, Dörk, Thilo, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harter, Philipp, Hasmad, Hanis N, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kellar, Melissa, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Vierkant, Robert A, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lim, Boon Kiong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Ian, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Thomsen, Lotte, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Eilber, Ursula, Odunsi, Kunle, Olson, Sara H, Orlow, Irene, and Orsulic, Sandra
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Health Services and Systems ,Health Sciences ,Oncology and Carcinogenesis ,Cancer ,Orphan Drug ,Prevention ,Sleep Research ,Rare Diseases ,Ovarian Cancer ,Aetiology ,2.1 Biological and endogenous factors ,Georgia Chenevix-Trench on behalf of the AOCS management group 95 ,96 - Abstract
Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwork), is associated with increased incidence of breast, prostate, gastrointestinal and hematologic cancers and gliomas. Circadian genes are highly expressed in the ovaries where they regulate ovulation; circadian disruption is associated with several ovarian cancer risk factors (e.g., endometriosis). However, no studies have examined variation in germline circadian genes as predictors of ovarian cancer risk and invasiveness. The goal of the current study was to examine single nucleotide polymorphisms (SNPs) in circadian genes BMAL1, CRY2, CSNK1E, NPAS2, PER3, REV1 and TIMELESS and downstream transcription factors KLF10 and SENP3 as predictors of risk of epithelial ovarian cancer (EOC) and histopathologic subtypes. The study included a test set of 3,761 EOC cases and 2,722 controls and a validation set of 44,308 samples including 18,174 (10,316 serous) cases and 26,134 controls from 43 studies participating in the Ovarian Cancer Association Consortium (OCAC). Analysis of genotype data from 36 genotyped SNPs and 4600 imputed SNPs indicated that the most significant association was rs117104877 in BMAL1 (OR = 0.79, 95% CI = 0.68-0.90, p = 5.59 × 10-4]. Functional analysis revealed a significant down regulation of BMAL1 expression following cMYC overexpression and increasing transformation in ovarian surface epithelial (OSE) cells as well as alternative splicing of BMAL1 exons in ovarian and granulosa cells. These results suggest that variation in circadian genes, and specifically BMAL1, may be associated with risk of ovarian cancer, likely through disruption of hormonal pathways.
- Published
- 2015
18. Association between occupational exposure to trichloroethylene and serum levels of microRNAs: a cross-sectional molecular epidemiology study in China
- Author
-
Lee, Kyoung-Mu, Bassig, Bryan A., Zhang, Luoping, Vermeulen, Roel C., Hu, Wei, Wong, Jason Y. Y., Qiu, Chuangyi, Wen, Cuiju, Huang, Yongshun, Purdue, Mark P., Ji, Bu-Tian, Li, Laiyu, Tang, Xiaojiang, Rothman, Nathaniel, Smith, Martyn T., and Lan, Qing
- Published
- 2019
- Full Text
- View/download PDF
19. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
- Author
-
Wen, Wanqing, Zheng, Wei, Okada, Yukinori, Takeuchi, Fumihiko, Tabara, Yasuharu, Hwang, Joo-Yeon, Dorajoo, Rajkumar, Li, Huaixing, Tsai, Fuu-Jen, Yang, Xiaobo, He, Jiang, Wu, Ying, He, Meian, Zhang, Yi, Liang, Jun, Guo, Xiuqing, Sheu, Wayne Huey-Herng, Delahanty, Ryan, Guo, Xingyi, Kubo, Michiaki, Yamamoto, Ken, Ohkubo, Takayoshi, Go, Min Jin, Liu, Jian Jun, Gan, Wei, Chen, Ching-Chu, Gao, Yong, Li, Shengxu, Lee, Nanette R, Wu, Chen, Zhou, Xueya, Song, Huaidong, Yao, Jie, Lee, I-Te, Long, Jirong, Tsunoda, Tatsuhiko, Akiyama, Koichi, Takashima, Naoyuki, Cho, Yoon Shin, Ong, Rick TH, Lu, Ling, Chen, Chien-Hsiun, Tan, Aihua, Rice, Treva K, Adair, Linda S, Gui, Lixuan, Allison, Matthew, Lee, Wen-Jane, Cai, Qiuyin, Isomura, Minoru, Umemura, Satoshi, Kim, Young Jin, Seielstad, Mark, Hixson, James, Xiang, Yong-Bing, Isono, Masato, Kim, Bong-Jo, Sim, Xueling, Lu, Wei, Nabika, Toru, Lee, Juyoung, Lim, Wei-Yen, Gao, Yu-Tang, Takayanagi, Ryoichi, Kang, Dae-Hee, Wong, Tien Yin, Hsiung, Chao Agnes, Wu, I-Chien, Juang, Jyh-Ming Jimmy, Shi, Jiajun, Choi, Bo Youl, Aung, Tin, Hu, Frank, Kim, Mi Kyung, Lim, Wei Yen, Wang, Tzung-Dao, Shin, Min-Ho, Lee, Jeannette, Ji, Bu-Tian, Lee, Young-Hoon, Young, Terri L, Shin, Dong Hoon, Chun, Byung-Yeol, Cho, Myeong-Chan, Han, Bok-Ghee, Hwu, Chii-Min, Assimes, Themistocles L, Absher, Devin, Yan, Xiaofei, Kim, Eric, Kuo, Jane Z, Kwon, Soonil, Taylor, Kent D, Chen, Yii-Der I, Rotter, Jerome I, Qi, Lu, Zhu, Dingliang, Wu, Tangchun, Mohlke, Karen L, and Gu, Dongfeng
- Subjects
Biological Sciences ,Genetics ,Obesity ,Nutrition ,Human Genome ,Women's Health ,5'-Nucleotidase ,Aldehyde Dehydrogenase ,Aldehyde Dehydrogenase ,Mitochondrial ,Asian People ,Blood Proteins ,Body Mass Index ,Cardiac Myosins ,Asia ,Eastern ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Glycoproteins ,Humans ,KCNQ1 Potassium Channel ,Male ,Myosin Light Chains ,Polymorphism ,Single Nucleotide ,Proteinase Inhibitory Proteins ,Secretory ,Medical and Health Sciences ,Genetics & Heredity - Abstract
Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.
- Published
- 2014
20. Associations between Longer Leukocyte Telomere Length and Increased Lung Cancer Risk among Never Smokers in Urban China
- Author
-
Wong, Jason Y.Y., primary, Shu, Xiao-Ou, additional, Hu, Wei, additional, Blechter, Batel, additional, Shi, Jianxin, additional, Wang, Kevin, additional, Cawthon, Richard, additional, Cai, Qiuyin, additional, Yang, Gong, additional, Rahman, Mohammad L., additional, Ji, Bu-tian, additional, Gao, Yutang, additional, Zheng, Wei, additional, Rothman, Nathaniel, additional, and Lan, Qing, additional
- Published
- 2023
- Full Text
- View/download PDF
21. Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer
- Author
-
Shen, Hui, Fridley, Brooke L, Song, Honglin, Lawrenson, Kate, Cunningham, Julie M, Ramus, Susan J, Cicek, Mine S, Tyrer, Jonathan, Stram, Douglas, Larson, Melissa C, Köbel, Martin, Ziogas, Argyrios, Zheng, Wei, Yang, Hannah P, Wu, Anna H, Wozniak, Eva L, Ling Woo, Yin, Winterhoff, Boris, Wik, Elisabeth, Whittemore, Alice S, Wentzensen, Nicolas, Palmieri Weber, Rachel, Vitonis, Allison F, Vincent, Daniel, Vierkant, Robert A, Vergote, Ignace, Van Den Berg, David, Van Altena, Anne M, Tworoger, Shelley S, Thompson, Pamela J, Tessier, Daniel C, Terry, Kathryn L, Teo, Soo-Hwang, Templeman, Claire, Stram, Daniel O, Southey, Melissa C, Sieh, Weiva, Siddiqui, Nadeem, Shvetsov, Yurii B, Shu, Xiao-Ou, Shridhar, Viji, Wang-Gohrke, Shan, Severi, Gianluca, Schwaab, Ira, Salvesen, Helga B, Rzepecka, Iwona K, Runnebaum, Ingo B, Anne Rossing, Mary, Rodriguez-Rodriguez, Lorna, Risch, Harvey A, Renner, Stefan P, Poole, Elizabeth M, Pike, Malcolm C, Phelan, Catherine M, Pelttari, Liisa M, Pejovic, Tanja, Paul, James, Orlow, Irene, Zawiah Omar, Siti, Olson, Sara H, Odunsi, Kunle, Nickels, Stefan, Nevanlinna, Heli, Ness, Roberta B, Narod, Steven A, Nakanishi, Toru, Moysich, Kirsten B, Monteiro, Alvaro NA, Moes-Sosnowska, Joanna, Modugno, Francesmary, Menon, Usha, McLaughlin, John R, McGuire, Valerie, Matsuo, Keitaro, Mat Adenan, Noor Azmi, Massuger, Leon FAG, Lurie, Galina, Lundvall, Lene, Lubiński, Jan, Lissowska, Jolanta, Levine, Douglas A, Leminen, Arto, Lee, Alice W, Le, Nhu D, Lambrechts, Sandrina, Lambrechts, Diether, Kupryjanczyk, Jolanta, Krakstad, Camilla, Konecny, Gottfried E, Krüger Kjaer, Susanne, Kiemeney, Lambertus A, Kelemen, Linda E, Keeney, Gary L, Karlan, Beth Y, Karevan, Rod, Kalli, Kimberly R, Kajiyama, Hiroaki, Ji, Bu-Tian, Jensen, Allan, and Jakubowska, Anna
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Oncology and Carcinogenesis ,Ovarian Cancer ,Cancer ,Human Genome ,Rare Diseases ,Prevention ,Aetiology ,2.1 Biological and endogenous factors ,DNA Methylation ,Epigenesis ,Genetic ,Female ,Gene Expression Profiling ,Genetic Predisposition to Disease ,Hepatocyte Nuclear Factor 1-beta ,Humans ,Ovarian Neoplasms ,Polymorphism ,Single Nucleotide ,Promoter Regions ,Genetic ,PRACTICAL Consortium ,Australian Ovarian Cancer Study Group ,Australian Cancer Study - Abstract
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10(-10)) and clear cell (rs11651755 OR=0.77, P=1.6 × 10(-8)) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes.
- Published
- 2013
22. Association of sleep duration and incidence of diabetes modified by tea consumption: a report from the Shanghai men's health study
- Author
-
Dai, Fei, Cai, Hui, Li, Honglan, Yang, Gong, Ji, Bu-Tian, Zheng, Wei, Xiang, Yong-Bing, and Shu, Xiao-Ou
- Published
- 2017
- Full Text
- View/download PDF
23. Lung cancer risk in welders and foundry workers with a history of heavy smoking in the USA: The National Lung Screening Trial
- Author
-
Wong, Jason Y Y, Bassig, Bryan A, Seow, Wei Jie, Hu, Wei, Ji, Bu-Tian, Blair, Aaron, Silverman, Debra T, and Lan, Qing
- Published
- 2017
24. Exposure to smoky coal combustion emissions and leukocyte Alu retroelement copy number
- Author
-
Blechter, Batel, primary, Wong, Jason Y Y, additional, Hu, Wei, additional, Cawthon, Richard, additional, Downward, George S, additional, Portengen, Lützen, additional, Zhang, Yongliang, additional, Ning, Bofu, additional, Rahman, Mohammad L, additional, Ji, Bu-Tian, additional, Li, Jihua, additional, Yang, Kaiyun, additional, Hosgood, H Dean, additional, Silverman, Debra T, additional, Huang, Yunchao, additional, Rothman, Nathaniel, additional, Vermeulen, Roel, additional, and Lan, Qing, additional
- Published
- 2023
- Full Text
- View/download PDF
25. Abstract 6056: A nested case-control study of untargeted plasma metabolomics and lung cancer risk among never-smoking women in the prospective Shanghai Women’s Health Study
- Author
-
Rahman, Mohammad L., primary, Shu, Xiao-Ou, additional, Walker, Douglas, additional, Jones, Dean P., additional, Hu, Wei, additional, Ji, Bu-tian, additional, Blechter, Batel, additional, Wong, Jason YY, additional, Cai, Qiuyin, additional, Yang, Gong, additional, Gao, Tu-Tang, additional, Zheng, Wei, additional, Rothman, Nathaniel, additional, and Lan, Qing, additional
- Published
- 2023
- Full Text
- View/download PDF
26. Abstract 3483: Epigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai
- Author
-
Rahman, Mohammad L., primary, Breeze, Charles E., additional, Shu, Xiao-Ou, additional, Wong, Jason YY, additional, Cardenas, Andres, additional, Wang, Xuting, additional, Ji, Bu-Tian, additional, Hu, Wei, additional, Blechter, Batel, additional, Cai, Qiuyin, additional, Hosgood, H Dean, additional, Yang, Gong, additional, Shi, Jianxin, additional, Long, Jirong, additional, Gao, Yu-Tang, additional, Bell, Douglas, additional, Zheng, Wei, additional, Lan, Qing, additional, and Rothman, Nathaniel, additional
- Published
- 2023
- Full Text
- View/download PDF
27. Data from Sleep Duration across the Adult Lifecourse and Risk of Lung Cancer Mortality: A Cohort Study in Xuanwei, China
- Author
-
Wong, Jason Y., primary, Bassig, Bryan A., primary, Vermeulen, Roel, primary, Hu, Wei, primary, Ning, Bofu, primary, Seow, Wei Jie, primary, Ji, Bu-Tian, primary, Downward, George S., primary, Katki, Hormuzd A., primary, Barone-Adesi, Francesco, primary, Rothman, Nathaniel, primary, Chapman, Robert S., primary, and Lan, Qing, primary
- Published
- 2023
- Full Text
- View/download PDF
28. Supplementary Tables 1, 2, 3, 4 from Sleep Duration across the Adult Lifecourse and Risk of Lung Cancer Mortality: A Cohort Study in Xuanwei, China
- Author
-
Wong, Jason Y., primary, Bassig, Bryan A., primary, Vermeulen, Roel, primary, Hu, Wei, primary, Ning, Bofu, primary, Seow, Wei Jie, primary, Ji, Bu-Tian, primary, Downward, George S., primary, Katki, Hormuzd A., primary, Barone-Adesi, Francesco, primary, Rothman, Nathaniel, primary, Chapman, Robert S., primary, and Lan, Qing, primary
- Published
- 2023
- Full Text
- View/download PDF
29. Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China
- Author
-
Rahman, Mohammad L, Breeze, Charles E, Shu, Xiao-Ou, Wong, Jason Y Y, Blechter, Batel, Cardenas, Andres, Wang, Xuting, Ji, Bu-Tian, Hu, Wei, Cai, Qiuyin, Hosgood, H Dean, Yang, Gong, Shi, Jianxin, Long, Jirong, Gao, Yu-Tang, Bell, Douglas A, Zheng, Wei, Rothman, Nathaniel, and Lan, Qing
- Abstract
BackgroundThe aetiology of lung cancer among individuals who never smoked remains elusive, despite 15% of lung cancer cases in men and 53% in women worldwide being unrelated to smoking. Epigenetic alterations, particularly DNA methylation (DNAm) changes, have emerged as potential drivers. Yet, few prospective epigenome-wide association studies (EWAS), primarily focusing on peripheral blood DNAm with limited representation of never smokers, have been conducted.MethodsWe conducted a nested case-control study of 80 never-smoking incident lung cancer cases and 83 never-smoking controls within the Shanghai Women’s Health Study and Shanghai Men’s Health Study. DNAm was measured in prediagnostic oral rinse samples using Illumina MethylationEPIC array. Initially, we conducted an EWAS to identify differentially methylated positions (DMPs) associated with lung cancer in the discovery sample of 101 subjects. The top 50 DMPs were further evaluated in a replication sample of 62 subjects, and results were pooled using fixed-effect meta-analysis.ResultsOur study identified three DMPs significantly associated with lung cancer at the epigenome-wide significance level of p<8.22×10−8. These DMPs were identified as cg09198866 (MYH9; TXN2), cg01411366 (SLC9A10) and cg12787323. Furthermore, examination of the top 1000 DMPs indicated significant enrichment in epithelial regulatory regions and their involvement in small GTPase-mediated signal transduction pathways. Additionally, GrimAge acceleration was identified as a risk factor for lung cancer (OR=1.19 per year; 95% CI 1.06 to 1.34).ConclusionsWhile replication in a larger sample size is necessary, our findings suggest that DNAm patterns in prediagnostic oral rinse samples could provide novel insights into the underlying mechanisms of lung cancer in never smokers.
- Published
- 2024
- Full Text
- View/download PDF
30. Do Standing, Lifting, Climbing, or Long Hours of Work during Pregnancy Have an Effect on Fetal Growth?
- Author
-
Hatch, Maureen, Ji, Bu-Tian, Shu, Xiao Ou, and Susser, Mervyn
- Published
- 1997
31. Supplementary Figure 3 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
- Author
-
Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary
- Published
- 2023
- Full Text
- View/download PDF
32. Data from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
- Author
-
Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary
- Published
- 2023
- Full Text
- View/download PDF
33. Data from Pathway Analyses Identify TGFBR2 as Potential Breast Cancer Susceptibility Gene: Results from a Consortium Study among Asians
- Author
-
Ma, Xiangyu, primary, Beeghly-Fadiel, Alicia, primary, Lu, Wei, primary, Shi, Jiajun, primary, Xiang, Yong-Bing, primary, Cai, Qiuyin, primary, Shen, Hongbing, primary, Shen, Chen-Yang, primary, Ren, Zefang, primary, Matsuo, Keitaro, primary, Khoo, Ui Soon, primary, Iwasaki, Motoki, primary, Long, Jirong, primary, Zhang, Ben, primary, Ji, Bu-Tian, primary, Zheng, Ying, primary, Wang, Wenjing, primary, Hu, Zhibin, primary, Liu, Yao, primary, Wu, Pei-Ei, primary, Shieh, Ya-Lan, primary, Wang, Shenming, primary, Xie, Xiaoming, primary, Ito, Hidemi, primary, Kasuga, Yoshio, primary, Chan, Kelvin Y.K., primary, Iwata, Hiroji, primary, Tsugane, Shoichiro, primary, Gao, Yu-Tang, primary, Shu, Xiao Ou, primary, Moses, Harold L., primary, and Zheng, Wei, primary
- Published
- 2023
- Full Text
- View/download PDF
34. Supplementary Figure 2 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
- Author
-
Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary
- Published
- 2023
- Full Text
- View/download PDF
35. Supplementary Table 1 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
- Author
-
Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary
- Published
- 2023
- Full Text
- View/download PDF
36. Supplementary Tables 1 - 3 from Pathway Analyses Identify TGFBR2 as Potential Breast Cancer Susceptibility Gene: Results from a Consortium Study among Asians
- Author
-
Ma, Xiangyu, primary, Beeghly-Fadiel, Alicia, primary, Lu, Wei, primary, Shi, Jiajun, primary, Xiang, Yong-Bing, primary, Cai, Qiuyin, primary, Shen, Hongbing, primary, Shen, Chen-Yang, primary, Ren, Zefang, primary, Matsuo, Keitaro, primary, Khoo, Ui Soon, primary, Iwasaki, Motoki, primary, Long, Jirong, primary, Zhang, Ben, primary, Ji, Bu-Tian, primary, Zheng, Ying, primary, Wang, Wenjing, primary, Hu, Zhibin, primary, Liu, Yao, primary, Wu, Pei-Ei, primary, Shieh, Ya-Lan, primary, Wang, Shenming, primary, Xie, Xiaoming, primary, Ito, Hidemi, primary, Kasuga, Yoshio, primary, Chan, Kelvin Y.K., primary, Iwata, Hiroji, primary, Tsugane, Shoichiro, primary, Gao, Yu-Tang, primary, Shu, Xiao Ou, primary, Moses, Harold L., primary, and Zheng, Wei, primary
- Published
- 2023
- Full Text
- View/download PDF
37. Supplementary Figure 1 from Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer
- Author
-
Long, Jirong, primary, Zheng, Wei, primary, Xiang, Yong-Bing, primary, Lose, Felicity, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Dubrowinskaja, Natalia, primary, Goodman, Marc T., primary, Salvesen, Helga B., primary, Fasching, Peter A., primary, Scott, Rodney J., primary, Delahanty, Ryan, primary, Zheng, Ying, primary, O'Mara, Tracy, primary, Healey, Catherine S., primary, Hodgson, Shirley, primary, Risch, Harvey, primary, Yang, Hannah P., primary, Amant, Frederic, primary, Turmanov, Nurzhan, primary, Schwake, Anita, primary, Lurie, Galina, primary, Trovik, Jone, primary, Beckmann, Matthias W., primary, Ashton, Katie, primary, Ji, Bu-Tian, primary, Bao, Ping-Ping, primary, Howarth, Kimberly, primary, Lu, Lingeng, primary, Lissowska, Jolanta, primary, Coenegrachts, Lieve, primary, Kaidarova, Dilyara, primary, Dürst, Matthias, primary, Thompson, Pamela J., primary, Krakstad, Camilla, primary, Ekici, Arif B., primary, Otton, Geoffrey, primary, Shi, Jiajun, primary, Zhang, Ben, primary, Gorman, Maggie, primary, Brinton, Louise, primary, Coosemans, An, primary, Matsuno, Rayna K., primary, Halle, Mari K., primary, Hein, Alexander, primary, Proietto, Anthony, primary, Cai, Hui, primary, Lu, Wei, primary, Dunning, Alison, primary, Easton, Douglas, primary, Gao, Yu-Tang, primary, Cai, Qiuyin, primary, Spurdle, Amanda B., primary, and Shu, Xiao-Ou, primary
- Published
- 2023
- Full Text
- View/download PDF
38. Supplementary Figure 2 from Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer
- Author
-
Long, Jirong, primary, Zheng, Wei, primary, Xiang, Yong-Bing, primary, Lose, Felicity, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Dubrowinskaja, Natalia, primary, Goodman, Marc T., primary, Salvesen, Helga B., primary, Fasching, Peter A., primary, Scott, Rodney J., primary, Delahanty, Ryan, primary, Zheng, Ying, primary, O'Mara, Tracy, primary, Healey, Catherine S., primary, Hodgson, Shirley, primary, Risch, Harvey, primary, Yang, Hannah P., primary, Amant, Frederic, primary, Turmanov, Nurzhan, primary, Schwake, Anita, primary, Lurie, Galina, primary, Trovik, Jone, primary, Beckmann, Matthias W., primary, Ashton, Katie, primary, Ji, Bu-Tian, primary, Bao, Ping-Ping, primary, Howarth, Kimberly, primary, Lu, Lingeng, primary, Lissowska, Jolanta, primary, Coenegrachts, Lieve, primary, Kaidarova, Dilyara, primary, Dürst, Matthias, primary, Thompson, Pamela J., primary, Krakstad, Camilla, primary, Ekici, Arif B., primary, Otton, Geoffrey, primary, Shi, Jiajun, primary, Zhang, Ben, primary, Gorman, Maggie, primary, Brinton, Louise, primary, Coosemans, An, primary, Matsuno, Rayna K., primary, Halle, Mari K., primary, Hein, Alexander, primary, Proietto, Anthony, primary, Cai, Hui, primary, Lu, Wei, primary, Dunning, Alison, primary, Easton, Douglas, primary, Gao, Yu-Tang, primary, Cai, Qiuyin, primary, Spurdle, Amanda B., primary, and Shu, Xiao-Ou, primary
- Published
- 2023
- Full Text
- View/download PDF
39. Supplementary Methods and Figure Legend from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
- Author
-
Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary
- Published
- 2023
- Full Text
- View/download PDF
40. Supplemental Figure 1 from Association of Leukocyte Mitochondrial DNA Copy Number with Colorectal Cancer Risk: Results from the Shanghai Women's Health Study
- Author
-
Huang, Bo, primary, Gao, Yu-Tang, primary, Shu, Xiao-Ou, primary, Wen, Wanqing, primary, Yang, Gong, primary, Li, Guoliang, primary, Courtney, Regina, primary, Ji, Bu-Tian, primary, Li, Hong-Lan, primary, Purdue, Mark P., primary, Zheng, Wei, primary, and Cai, Qiuyin, primary
- Published
- 2023
- Full Text
- View/download PDF
41. Data from Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk
- Author
-
Kar, Siddhartha P., primary, Tyrer, Jonathan P., primary, Li, Qiyuan, primary, Lawrenson, Kate, primary, Aben, Katja K.H., primary, Anton-Culver, Hoda, primary, Antonenkova, Natalia, primary, Chenevix-Trench, Georgia, primary, Baker, Helen, primary, Bandera, Elisa V., primary, Bean, Yukie T., primary, Beckmann, Matthias W., primary, Berchuck, Andrew, primary, Bisogna, Maria, primary, Bjørge, Line, primary, Bogdanova, Natalia, primary, Brinton, Louise, primary, Brooks-Wilson, Angela, primary, Butzow, Ralf, primary, Campbell, Ian, primary, Carty, Karen, primary, Chang-Claude, Jenny, primary, Chen, Yian Ann, primary, Chen, Zhihua, primary, Cook, Linda S., primary, Cramer, Daniel, primary, Cunningham, Julie M., primary, Cybulski, Cezary, primary, Dansonka-Mieszkowska, Agnieszka, primary, Dennis, Joe, primary, Dicks, Ed, primary, Doherty, Jennifer A., primary, Dörk, Thilo, primary, du Bois, Andreas, primary, Dürst, Matthias, primary, Eccles, Diana, primary, Easton, Douglas F., primary, Edwards, Robert P., primary, Ekici, Arif B., primary, Fasching, Peter A., primary, Fridley, Brooke L., primary, Gao, Yu-Tang, primary, Gentry-Maharaj, Aleksandra, primary, Giles, Graham G., primary, Glasspool, Rosalind, primary, Goode, Ellen L., primary, Goodman, Marc T., primary, Grownwald, Jacek, primary, Harrington, Patricia, primary, Harter, Philipp, primary, Hein, Alexander, primary, Heitz, Florian, primary, Hildebrandt, Michelle A.T., primary, Hillemanns, Peter, primary, Hogdall, Estrid, primary, Hogdall, Claus K., primary, Hosono, Satoyo, primary, Iversen, Edwin S., primary, Jakubowska, Anna, primary, Paul, James, primary, Jensen, Allan, primary, Ji, Bu-Tian, primary, Karlan, Beth Y., primary, Kjaer, Susanne K., primary, Kelemen, Linda E., primary, Kellar, Melissa, primary, Kelley, Joseph, primary, Kiemeney, Lambertus A., primary, Krakstad, Camilla, primary, Kupryjanczyk, Jolanta, primary, Lambrechts, Diether, primary, Lambrechts, Sandrina, primary, Le, Nhu D., primary, Lee, Alice W., primary, Lele, Shashi, primary, Leminen, Arto, primary, Lester, Jenny, primary, Levine, Douglas A., primary, Liang, Dong, primary, Lissowska, Jolanta, primary, Lu, Karen, primary, Lubinski, Jan, primary, Lundvall, Lene, primary, Massuger, Leon, primary, Matsuo, Keitaro, primary, McGuire, Valerie, primary, McLaughlin, John R., primary, McNeish, Iain A., primary, Menon, Usha, primary, Modugno, Francesmary, primary, Moysich, Kirsten B., primary, Narod, Steven A., primary, Nedergaard, Lotte, primary, Ness, Roberta B., primary, Nevanlinna, Heli, primary, Odunsi, Kunle, primary, Olson, Sara H., primary, Orlow, Irene, primary, Orsulic, Sandra, primary, Weber, Rachel Palmieri, primary, Pearce, Celeste Leigh, primary, Pejovic, Tanja, primary, Pelttari, Liisa M., primary, Permuth-Wey, Jennifer, primary, Phelan, Catherine M., primary, Pike, Malcolm C., primary, Poole, Elizabeth M., primary, Ramus, Susan J., primary, Risch, Harvey A., primary, Rosen, Barry, primary, Rossing, Mary Anne, primary, Rothstein, Joseph H., primary, Rudolph, Anja, primary, Runnebaum, Ingo B., primary, Rzepecka, Iwona K., primary, Salvesen, Helga B., primary, Schildkraut, Joellen M., primary, Schwaab, Ira, primary, Shu, Xiao-Ou, primary, Shvetsov, Yurii B., primary, Siddiqui, Nadeem, primary, Sieh, Weiva, primary, Song, Honglin, primary, Southey, Melissa C., primary, Sucheston-Campbell, Lara E., primary, Tangen, Ingvild L., primary, Teo, Soo-Hwang, primary, Terry, Kathryn L., primary, Thompson, Pamela J., primary, Timorek, Agnieszka, primary, Tsai, Ya-Yu, primary, Tworoger, Shelley S., primary, van Altena, Anne M., primary, Van Nieuwenhuysen, Els, primary, Vergote, Ignace, primary, Vierkant, Robert A., primary, Wang-Gohrke, Shan, primary, Walsh, Christine, primary, Wentzensen, Nicolas, primary, Whittemore, Alice S., primary, Wicklund, Kristine G., primary, Wilkens, Lynne R., primary, Woo, Yin-Ling, primary, Wu, Xifeng, primary, Wu, Anna, primary, Yang, Hannah, primary, Zheng, Wei, primary, Ziogas, Argyrios, primary, Sellers, Thomas A., primary, Monteiro, Alvaro N.A., primary, Freedman, Matthew L., primary, Gayther, Simon A., primary, and Pharoah, Paul D.P., primary
- Published
- 2023
- Full Text
- View/download PDF
42. Supplementary Figure 4 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
- Author
-
Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary
- Published
- 2023
- Full Text
- View/download PDF
43. Supplementary Tables S1-6, Figures S1-2 from Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk
- Author
-
Kar, Siddhartha P., primary, Tyrer, Jonathan P., primary, Li, Qiyuan, primary, Lawrenson, Kate, primary, Aben, Katja K.H., primary, Anton-Culver, Hoda, primary, Antonenkova, Natalia, primary, Chenevix-Trench, Georgia, primary, Baker, Helen, primary, Bandera, Elisa V., primary, Bean, Yukie T., primary, Beckmann, Matthias W., primary, Berchuck, Andrew, primary, Bisogna, Maria, primary, Bjørge, Line, primary, Bogdanova, Natalia, primary, Brinton, Louise, primary, Brooks-Wilson, Angela, primary, Butzow, Ralf, primary, Campbell, Ian, primary, Carty, Karen, primary, Chang-Claude, Jenny, primary, Chen, Yian Ann, primary, Chen, Zhihua, primary, Cook, Linda S., primary, Cramer, Daniel, primary, Cunningham, Julie M., primary, Cybulski, Cezary, primary, Dansonka-Mieszkowska, Agnieszka, primary, Dennis, Joe, primary, Dicks, Ed, primary, Doherty, Jennifer A., primary, Dörk, Thilo, primary, du Bois, Andreas, primary, Dürst, Matthias, primary, Eccles, Diana, primary, Easton, Douglas F., primary, Edwards, Robert P., primary, Ekici, Arif B., primary, Fasching, Peter A., primary, Fridley, Brooke L., primary, Gao, Yu-Tang, primary, Gentry-Maharaj, Aleksandra, primary, Giles, Graham G., primary, Glasspool, Rosalind, primary, Goode, Ellen L., primary, Goodman, Marc T., primary, Grownwald, Jacek, primary, Harrington, Patricia, primary, Harter, Philipp, primary, Hein, Alexander, primary, Heitz, Florian, primary, Hildebrandt, Michelle A.T., primary, Hillemanns, Peter, primary, Hogdall, Estrid, primary, Hogdall, Claus K., primary, Hosono, Satoyo, primary, Iversen, Edwin S., primary, Jakubowska, Anna, primary, Paul, James, primary, Jensen, Allan, primary, Ji, Bu-Tian, primary, Karlan, Beth Y., primary, Kjaer, Susanne K., primary, Kelemen, Linda E., primary, Kellar, Melissa, primary, Kelley, Joseph, primary, Kiemeney, Lambertus A., primary, Krakstad, Camilla, primary, Kupryjanczyk, Jolanta, primary, Lambrechts, Diether, primary, Lambrechts, Sandrina, primary, Le, Nhu D., primary, Lee, Alice W., primary, Lele, Shashi, primary, Leminen, Arto, primary, Lester, Jenny, primary, Levine, Douglas A., primary, Liang, Dong, primary, Lissowska, Jolanta, primary, Lu, Karen, primary, Lubinski, Jan, primary, Lundvall, Lene, primary, Massuger, Leon, primary, Matsuo, Keitaro, primary, McGuire, Valerie, primary, McLaughlin, John R., primary, McNeish, Iain A., primary, Menon, Usha, primary, Modugno, Francesmary, primary, Moysich, Kirsten B., primary, Narod, Steven A., primary, Nedergaard, Lotte, primary, Ness, Roberta B., primary, Nevanlinna, Heli, primary, Odunsi, Kunle, primary, Olson, Sara H., primary, Orlow, Irene, primary, Orsulic, Sandra, primary, Weber, Rachel Palmieri, primary, Pearce, Celeste Leigh, primary, Pejovic, Tanja, primary, Pelttari, Liisa M., primary, Permuth-Wey, Jennifer, primary, Phelan, Catherine M., primary, Pike, Malcolm C., primary, Poole, Elizabeth M., primary, Ramus, Susan J., primary, Risch, Harvey A., primary, Rosen, Barry, primary, Rossing, Mary Anne, primary, Rothstein, Joseph H., primary, Rudolph, Anja, primary, Runnebaum, Ingo B., primary, Rzepecka, Iwona K., primary, Salvesen, Helga B., primary, Schildkraut, Joellen M., primary, Schwaab, Ira, primary, Shu, Xiao-Ou, primary, Shvetsov, Yurii B., primary, Siddiqui, Nadeem, primary, Sieh, Weiva, primary, Song, Honglin, primary, Southey, Melissa C., primary, Sucheston-Campbell, Lara E., primary, Tangen, Ingvild L., primary, Teo, Soo-Hwang, primary, Terry, Kathryn L., primary, Thompson, Pamela J., primary, Timorek, Agnieszka, primary, Tsai, Ya-Yu, primary, Tworoger, Shelley S., primary, van Altena, Anne M., primary, Van Nieuwenhuysen, Els, primary, Vergote, Ignace, primary, Vierkant, Robert A., primary, Wang-Gohrke, Shan, primary, Walsh, Christine, primary, Wentzensen, Nicolas, primary, Whittemore, Alice S., primary, Wicklund, Kristine G., primary, Wilkens, Lynne R., primary, Woo, Yin-Ling, primary, Wu, Xifeng, primary, Wu, Anna, primary, Yang, Hannah, primary, Zheng, Wei, primary, Ziogas, Argyrios, primary, Sellers, Thomas A., primary, Monteiro, Alvaro N.A., primary, Freedman, Matthew L., primary, Gayther, Simon A., primary, and Pharoah, Paul D.P., primary
- Published
- 2023
- Full Text
- View/download PDF
44. Supplementary Table 4 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
- Author
-
Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary
- Published
- 2023
- Full Text
- View/download PDF
45. Supplementary Figure 1 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
- Author
-
Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary
- Published
- 2023
- Full Text
- View/download PDF
46. Supplementary Table 2 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
- Author
-
Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary
- Published
- 2023
- Full Text
- View/download PDF
47. Supplementary Tables 1 - 4 from Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer
- Author
-
Long, Jirong, primary, Zheng, Wei, primary, Xiang, Yong-Bing, primary, Lose, Felicity, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Dubrowinskaja, Natalia, primary, Goodman, Marc T., primary, Salvesen, Helga B., primary, Fasching, Peter A., primary, Scott, Rodney J., primary, Delahanty, Ryan, primary, Zheng, Ying, primary, O'Mara, Tracy, primary, Healey, Catherine S., primary, Hodgson, Shirley, primary, Risch, Harvey, primary, Yang, Hannah P., primary, Amant, Frederic, primary, Turmanov, Nurzhan, primary, Schwake, Anita, primary, Lurie, Galina, primary, Trovik, Jone, primary, Beckmann, Matthias W., primary, Ashton, Katie, primary, Ji, Bu-Tian, primary, Bao, Ping-Ping, primary, Howarth, Kimberly, primary, Lu, Lingeng, primary, Lissowska, Jolanta, primary, Coenegrachts, Lieve, primary, Kaidarova, Dilyara, primary, Dürst, Matthias, primary, Thompson, Pamela J., primary, Krakstad, Camilla, primary, Ekici, Arif B., primary, Otton, Geoffrey, primary, Shi, Jiajun, primary, Zhang, Ben, primary, Gorman, Maggie, primary, Brinton, Louise, primary, Coosemans, An, primary, Matsuno, Rayna K., primary, Halle, Mari K., primary, Hein, Alexander, primary, Proietto, Anthony, primary, Cai, Hui, primary, Lu, Wei, primary, Dunning, Alison, primary, Easton, Douglas, primary, Gao, Yu-Tang, primary, Cai, Qiuyin, primary, Spurdle, Amanda B., primary, and Shu, Xiao-Ou, primary
- Published
- 2023
- Full Text
- View/download PDF
48. Supplementary Methods from Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer
- Author
-
Long, Jirong, primary, Zheng, Wei, primary, Xiang, Yong-Bing, primary, Lose, Felicity, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Dubrowinskaja, Natalia, primary, Goodman, Marc T., primary, Salvesen, Helga B., primary, Fasching, Peter A., primary, Scott, Rodney J., primary, Delahanty, Ryan, primary, Zheng, Ying, primary, O'Mara, Tracy, primary, Healey, Catherine S., primary, Hodgson, Shirley, primary, Risch, Harvey, primary, Yang, Hannah P., primary, Amant, Frederic, primary, Turmanov, Nurzhan, primary, Schwake, Anita, primary, Lurie, Galina, primary, Trovik, Jone, primary, Beckmann, Matthias W., primary, Ashton, Katie, primary, Ji, Bu-Tian, primary, Bao, Ping-Ping, primary, Howarth, Kimberly, primary, Lu, Lingeng, primary, Lissowska, Jolanta, primary, Coenegrachts, Lieve, primary, Kaidarova, Dilyara, primary, Dürst, Matthias, primary, Thompson, Pamela J., primary, Krakstad, Camilla, primary, Ekici, Arif B., primary, Otton, Geoffrey, primary, Shi, Jiajun, primary, Zhang, Ben, primary, Gorman, Maggie, primary, Brinton, Louise, primary, Coosemans, An, primary, Matsuno, Rayna K., primary, Halle, Mari K., primary, Hein, Alexander, primary, Proietto, Anthony, primary, Cai, Hui, primary, Lu, Wei, primary, Dunning, Alison, primary, Easton, Douglas, primary, Gao, Yu-Tang, primary, Cai, Qiuyin, primary, Spurdle, Amanda B., primary, and Shu, Xiao-Ou, primary
- Published
- 2023
- Full Text
- View/download PDF
49. Supplementary Table 3 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
- Author
-
Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary
- Published
- 2023
- Full Text
- View/download PDF
50. Alterations to biomarkers related to long-term exposure to diesel exhaust at concentrations below occupational exposure limits in the European Union and the USA
- Author
-
Wong, Jason YY, primary, Blechter, Batel, additional, Bassig, Bryan A, additional, Dai, Yufei, additional, Vermeulen, Roel, additional, Hu, Wei, additional, Rahman, Mohammad L, additional, Duan, Huawei, additional, Niu, Yong, additional, Downward, George S, additional, Leng, Shuguang, additional, Ji, Bu-Tian, additional, Fu, Wei, additional, Xu, Jun, additional, Meliefste, Kees, additional, Zhou, Baosen, additional, Yang, Jufang, additional, Ren, Dianzhi, additional, Ye, Meng, additional, Jia, Xiaowei, additional, Meng, Tao, additional, Bin, Ping, additional, Hosgood, H. Dean, additional, Rothman, Nathaniel, additional, Silverman, Debra T, additional, Zheng, Yuxin, additional, and Lan, Qing, additional
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.