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Your search keyword '"Ji, Shuangshuang"' showing total 27 results
Start Over Author "Ji, Shuangshuang"
27 results on '"Ji, Shuangshuang"'

6. Network pharmacology and in vivo experiment-based strategy to investigate mechanisms of JingFangFuZiLiZhong formula for ulcerative colitis

Author

Wang, Mengyuan, primary, Li, Jianan, additional, Yin, Yuzhang, additional, Liu, Liying, additional, Wang, Yifei, additional, Qu, Ying, additional, Hong, Yanqiu, additional, Ji, Shuangshuang, additional, Zhang, Tao, additional, Wang, Nan, additional, Liu, Jinlong, additional, Cao, Xu, additional, Zao, Xiaobin, additional, and Zhang, Shuxin, additional

Published
2022
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24. Bifunctional Platinated Nanoparticles for Photoinduced Tumor Ablation

Author

Guo, Zhengqing, primary, Zou, Yelin, additional, He, Hui, additional, Rao, Jiaming, additional, Ji, Shuangshuang, additional, Cui, Xiaoneng, additional, Ke, Hengte, additional, Deng, Yibin, additional, Yang, Hong, additional, Chen, Chunying, additional, Zhao, Yuliang, additional, and Chen, Huabing, additional

Published
2016
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26. Radical Hydro-Fluorosulfonylation of Unactivated Alkenes and Alkynes.

Author

Wang P, Zhang H, Zhao M, Ji S, Lin L, Yang N, Nie X, Song J, and Liao S

Subjects
Alkenes, Click Chemistry, Fluorides, Sulfinic Acids, Alkynes, Biological Products
Abstract

Recently, radical fluorosulfonylation is emerging as an appealing approach for the synthesis of sulfonyl fluorides, which are highly in demand in various disciplines, particularly in chemical biology and drug discovery. Here, we report the first establishment of radical hydro-fluorosulfonylation of alkenes, which is enabled by using 1-fluorosulfonyl 2-aryl benzoimidazolium (FABI) as an effective redox-active radical precursor. This method provides a new and facile approach for the synthesis of aliphatic sulfonyl fluorides from unactivated alkenes, and can be further applied to the late-stage modifications of natural products and peptides, as well as ligation of drugs in combination with click chemistry. Remarkably, this system could enable the radical hydro-fluorosulfonylation of alkynes, affording valuable alkenylsulfonyl fluoride products with a rare, high Z-selectivity, which are normally less stable and more challenging to synthesize in comparison with the E-configured products., (© 2022 Wiley-VCH GmbH.)

Published
2022
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27. Prognostic and immunological value of LTB4R in pan-cancer.

Author

Long S, Ji S, Xiao K, Xue P, and Zhu S

Subjects
Biomarkers, Tumor, Humans, Kaplan-Meier Estimate, Lymphocytes, Tumor-Infiltrating, Prognosis, Receptors, Leukotriene B4 genetics, Tumor Microenvironment, Carcinoma, Hepatocellular, Liver Neoplasms
Abstract

Background: LTB4 receptor 1 (LTB4R), as the high affinity leukotriene B4 receptor, is rapidly revealing its function in malignancies. However, it is still uncertain., Methods: We investigated the expression pattern and prognostic significance of LTB4R in pan-cancer across different databases, including ONCOMINE, PrognoScan, GEPIA, and Kaplan-Meier Plotter, in this study. Meanwhile, we explored the significance of LTB4R in tumor metastasis by HCMDB. Then functional enrichment analysis of related genes was performed using GeneMANIA and DAVID. Lastly, utilizing the TIMER datasets, we looked into the links between LTB4R expression and immune infiltration in malignancies., Results: In general, tumor tissue displayed higher levels of LTB4R expression than normal tissue. Although LTB4R had a negative influence on pan-cancer, a high expression level of LTB4R was protective of LIHC (liver hepatocellular carcinoma) patients' survival. There was no significant difference in the distribution of LTB4R between non-metastatic and metastatic tumors. Based on Gene Set Enrichment Analysis, LTB4R was implicated in pathways involved in inflammation, immunity, metabolism, and cancer diseases. The correlation between immune cells and LTB4R was found to be distinct across cancer types. Furthermore, markers of infiltrating immune cells, such as Treg, T cell exhaustion and T helper cells, exhibited different LTB4R-related immune infiltration patterns., Conclusion: The LTB4R is associated with immune infiltrates and can be used as a prognostic biomarker in pan-cancer.

Published
2021
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