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268 results on '"Ji, Wenliang"'

45. Single-Atom Co–N4 Electrocatalyst Enabling Four-Electron Oxygen Reduction with Enhanced Hydrogen Peroxide Tolerance for Selective Sensing

Author

Wu, Fei, primary, Pan, Cong, additional, He, Chun-Ting, additional, Han, Yunhu, additional, Ma, Wenjie, additional, Wei, Huan, additional, Ji, Wenliang, additional, Chen, Wenxing, additional, Mao, Junjie, additional, Yu, Ping, additional, Wang, Dingsheng, additional, Mao, Lanqun, additional, and Li, Yadong, additional

Published
2020
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46. Highly Stable and Selective Sensing of Hydrogen Sulfide in Living Mouse Brain with NiN4Single-Atom Catalyst-Based Galvanic Redox Potentiometry

Author

Pan, Cong, Wu, Fei, Mao, Junjie, Wu, Wenjie, Zhao, Gang, Ji, Wenliang, Ma, Wenjie, Yu, Ping, and Mao, Lanqun

Abstract

Hydrogen sulfide (H2S) is recognized as a gasotransmitter and multifunctional signaling molecule in the central nervous system. Despite its essential neurofunctions, the chemical dynamics of H2S during physiological and pathological processes remains poorly understood, emphasizing the significance of H2S sensor development. However, the broadly utilized electrochemical H2S sensors suffer from low stability and sensitivity loss in vivo due to sulfur poisoning-caused electrode passivation. Herein, we report a high-performance H2S sensor that combines single-atom catalyst strategy and galvanic redox potentiometry to overcome the issue. Atomically dispersed NiN4active sites on the sensing interface promote electrochemical H2S oxidation at an extremely low potential to drive spontaneous bipolarization of a single carbon fiber. Bias-free potentiometric sensing at open-circuit condition minimizes sulfur accumulation on the electrode surface, thus significantly enhancing the stability and sensitivity. The resulting sensor displays high selectivity to H2S against physiological interferents and enables real-time accurate quantification of H2S-releasing behavior in the living mouse brain.

Published
2022
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47. Vitamin D Inhibits the Early Aggregation of α‐Synuclein and Modulates Exocytosis Revealed by Electrochemical Measurements.

Author

Zhang, Yue, Ji, Wenliang, Zhang, Shuai, Gao, Nan, Xu, Tianci, Wang, Xiaofang, and Zhang, Meining

Subjects
*EXOCYTOSIS, *VITAMIN D, *VITAMINS, *NEURODEGENERATION, *OLIGOMERS, *BRAIN diseases
Abstract

Alpha‐synuclein (α‐Syn) localizes at presynaptic terminal and modulates synaptic functions. Increasing evidence demonstrate that α‐Syn oligomers, forming at the early of aggregation, are cytotoxic and is thus related to brain neurodegenerative diseases. Herein, we find that vitamin D (VD) can reduce neurocytotoxicity. The reduced neurocytotoxicity might be attributed to the less amount of large‐sized α‐Syn oligomers inhibited by VD, measured by electrochemical collision at single particle level, which are not observable with traditionally ensembled method. Single‐cell amperometry (SCA) results show that VD can recover the amount of neurotransmitter release during exocytosis induced by α‐Syn oligomers, further verifying the neuroprotection of VD. Our study reveals the neuroprotective role of VD through inhibiting α‐Syn aggregation, which is envisioned to be of great importance in treatment and prevention of the neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2022
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