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32 results on '"Ji, Zhejun"'

1. Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

Author

Ma, Shuai, Ji, Zhejun, Zhang, Bin, Geng, Lingling, Cai, Yusheng, Nie, Chao, Li, Jiaming, Zuo, Yuesheng, Sun, Yuzhe, Xu, Gang, Liu, Beibei, Ai, Jiaqi, Liu, Feifei, Zhao, Liyun, Zhang, Jiachen, Zhang, Hui, Sun, Shuhui, Huang, Haoyan, Zhang, Yiyuan, Ye, Yanxia, Fan, Yanling, Zheng, Fangshuo, Hu, Jinghao, Zhang, Baohu, Li, Jingyi, Feng, Xin, Zhang, Feng, Zhuang, Yuan, Li, Tianjie, Yu, Yang, Bao, Zhaoshi, Pan, Sipei, Rodriguez Esteban, Concepcion, Liu, Zhili, Deng, Haohao, Wen, Feng, Song, Moshi, Wang, Si, Zhu, Guodong, Yang, Jiayin, Jiang, Tao, Song, Weihong, Izpisua Belmonte, Juan Carlos, Qu, Jing, Zhang, Weiqi, Gu, Ying, and Liu, Guang-Hui

Published
2024
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2. Resurrection of endogenous retroviruses during aging reinforces senescence

Author

Liu, Xiaoqian, Liu, Zunpeng, Wu, Zeming, Ren, Jie, Fan, Yanling, Sun, Liang, Cao, Gang, Niu, Yuyu, Zhang, Baohu, Ji, Qianzhao, Jiang, Xiaoyu, Wang, Cui, Wang, Qiaoran, Ji, Zhejun, Li, Lanzhu, Esteban, Concepcion Rodriguez, Yan, Kaowen, Li, Wei, Cai, Yusheng, Wang, Si, Zheng, Aihua, Zhang, Yong E., Tan, Shengjun, Cai, Yingao, Song, Moshi, Lu, Falong, Tang, Fuchou, Ji, Weizhi, Zhou, Qi, Belmonte, Juan Carlos Izpisua, Zhang, Weiqi, Qu, Jing, and Liu, Guang-Hui

Published
2023
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7. Destabilizing heterochromatin by APOE mediates senescence

Author

Zhao, Hongkai, Ji, Qianzhao, Wu, Zeming, Wang, Si, Ren, Jie, Yan, Kaowen, Wang, Zehua, Hu, Jianli, Chu, Qun, Hu, Huifang, Cai, Yusheng, Wang, Qiaoran, Huang, Daoyuan, Ji, Zhejun, Li, Jingyi, Belmonte, Juan Carlos Izpisua, Song, Moshi, Zhang, Weiqi, Qu, Jing, and Liu, Guang-Hui

Published
2022
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11. Nuclear pore complex and stem cell homeostasis

Author

Li Lanzhu, Ji Zhejun, Zhang Weiqi, Qu Jing, and Liu Guanghui

Subjects
nuclear pore complex, nucleoporin, stem cell, Medicine, Biotechnology, TP248.13-248.65
Abstract

As a channel for mediating exchange between the nucleus and cytoplasm, the nuclear pore complex (NPC) is a macromolecular complex composed of about 30 nucleoporins. In addition to mediating nucleocytoplasmic transport, NPC can also regulate chromatin organization and gene expression. The maintenance of stemcell homeostasis plays an essential role in the regeneration and repair of tissues, organs, and body homeostasis.More and more studies have shown that NPC and nucleoporins can regulate stem cell proliferation and differentiation, and affect stem cell homeostasis. This article reviews the related research on NPC and its influence on stemcell homeostasis, hoping to provide new ideas for the regulation and maintenance of stem cell homeostasis.

Published
2021
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15. Regeneration Roadmap: database resources for regenerative biology

Author

Kang, Wang, Jin, Tong, Zhang, Tao, Ma, Shuai, Yan, Haoteng, Liu, Zunpeng, Ji, Zhejun, Cai, Yusheng, Wang, Si, Song, Moshi, Ren, Jie, Hu, Baoyang, Zhou, Qi, Zhang, Weiqi, Qu, Jing, Bao, Yiming, and Liu, Guang-Hui

Subjects
Epigenomics, Aging, Databases, Factual, AcademicSubjects/SCI00010, Databases, Genetic, Database Issue, Animals, Humans, Regeneration, Transcriptome
Abstract

Regeneration plays an instrumental role in biological development and damage repair by constructing and replacing cells, tissues, and organs. Since regenerative capacity declines with age, promoting regeneration is heralded as a potential strategy for delaying aging. On this premise, mechanisms that regulate regeneration have been extensively studied across species and in different tissues. However, an open and comprehensive database collecting and standardizing the abundant data generated in regeneration research, such as high-throughput sequencing data, remains to be developed. In this work, we constructed Regeneration Roadmap to systematically and comprehensively collect such information over 2.38 million data entries across 11 species and 36 tissues, including regeneration-related genes, bulk and single-cell transcriptomics, epigenomics, and pharmacogenomics data. In this database, users can explore regulatory and expression changes of regeneration-associated genes in different species and tissues. Regeneration Roadmap provides the research community with a long-awaited and valuable data resource featuring convenient computing and visualizing tools, which is publicly available at https://ngdc.cncb.ac.cn/regeneration/index.

Published
2021

17. Single-cell transcriptomic Atlas of mouse cochlear aging

Author

Sun, Guoqiang, primary, Zheng, Yandong, additional, Fu, Xiaolong, additional, Zhang, Weiqi, additional, Ren, Jie, additional, Ma, Shuai, additional, Sun, Shuhui, additional, He, Xiaojuan, additional, Wang, Qiaoran, additional, Ji, Zhejun, additional, Cheng, Fang, additional, Yan, Kaowen, additional, Liu, Ziyi, additional, Izpisua Belmonte, Juan Carlos, additional, Qu, Jing, additional, Wang, Si, additional, Chai, Renjie, additional, and Liu, Guang-Hui, additional

Published
2022
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18. Single-cell transcriptomic atlas of mouse cochlear aging.

Author

Sun, Guoqiang, Zheng, Yandong, Fu, Xiaolong, Zhang, Weiqi, Ren, Jie, Ma, Shuai, Sun, Shuhui, He, Xiaojuan, Wang, Qiaoran, Ji, Zhejun, Cheng, Fang, Yan, Kaowen, Liu, Ziyi, Belmonte, Juan Carlos Izpisua, Qu, Jing, Wang, Si, Chai, Renjie, and Liu, Guang-Hui

Abstract

Progressive functional deterioration in the cochlea is associated with age-related hearing loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains largely unknown. Here, we established a dynamic single-cell transcriptomic landscape of mouse cochlear aging, in which we characterized aging-associated transcriptomic changes in 27 different cochlear cell types across five different time points. Overall, our analysis pinpoints loss of proteostasis and elevated apoptosis as the hallmark features of cochlear aging, highlights unexpected age-related transcriptional fluctuations in intermediate cells localized in the stria vascularis (SV) and demonstrates that upregulation of endoplasmic reticulum (ER) chaperon protein HSP90AA1 mitigates ER stress-induced damages associated with aging. Our work suggests that targeting unfolded protein response pathways may help alleviate aging-related SV atrophy and hence delay the progression of ARHL. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Hyperthermia differentially affects specific human stem cells and their differentiated derivatives

Author

Wang, Si, primary, Cheng, Fang, additional, Ji, Qianzhao, additional, Song, Moshi, additional, Wu, Zeming, additional, Zhang, Yiyuan, additional, Ji, Zhejun, additional, Feng, Huyi, additional, Belmonte, Juan Carlos Izpisua, additional, Zhou, Qi, additional, Qu, Jing, additional, Li, Wei, additional, Liu, Guang-Hui, additional, and Zhang, Weiqi, additional

Published
2021
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20. Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells

Author

Shan, Hezhen, primary, Geng, Lingling, additional, Jiang, Xiaoyu, additional, Song, Moshi, additional, Wang, Jianxun, additional, Liu, Zunpeng, additional, Zhuo, Xiao, additional, Wu, Zeming, additional, Hu, Jianli, additional, Ji, Zhejun, additional, Wang, Si, additional, Chan, Piu, additional, Qu, Jing, additional, Zhang, Weiqi, additional, and Liu, Guang-Hui, additional

Published
2021
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21. Correction to ‘SIRT3 consolidates heterochromatin and counteracts senescence’

Author

Diao, Zhiqing, primary, Ji, Qianzhao, additional, Wu, Zeming, additional, Zhang, Weiqi, additional, Cai, Yusheng, additional, Wang, Zehua, additional, Hu, Jianli, additional, Liu, Zunpeng, additional, Wang, Qiaoran, additional, Bi, Shijia, additional, Huang, Daoyuan, additional, Ji, Zhejun, additional, Liu, Guang-Hui, additional, Wang, Si, additional, Song, Moshi, additional, and Qu, Jing, additional

Published
2021
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22. Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

Author

Lei, Jinghui, primary, Jiang, Xiaoyu, additional, Li, Wei, additional, Ren, Jie, additional, Wang, Datao, additional, Ji, Zhejun, additional, Wu, Zeming, additional, Cheng, Fang, additional, Cai, Yusheng, additional, Yu, Zheng-Rong, additional, Belmonte, Juan Carlos Izpisua, additional, Li, Chunyi, additional, Liu, Guang-Hui, additional, Zhang, Weiqi, additional, Qu, Jing, additional, and Wang, Si, additional

Published
2021
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24. SIRT3 consolidates heterochromatin and counteracts senescence

Author

Diao, Zhiqing, primary, Ji, Qianzhao, additional, Wu, Zeming, additional, Zhang, Weiqi, additional, Cai, Yusheng, additional, Wang, Zehua, additional, Hu, Jianli, additional, Liu, Zunpeng, additional, Wang, Qiaoran, additional, Bi, Shijia, additional, Huang, Daoyuan, additional, Ji, Zhejun, additional, Liu, Guang-Hui, additional, Wang, Si, additional, Song, Moshi, additional, and Qu, Jing, additional

Published
2021
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26. Resurrection of endogenous retroviruses during aging reinforces senescence

Author

Liu, Xiaoqian, primary, Liu, Zunpeng, additional, Wu, Zeming, additional, Ren, Jie, additional, Fan, Yanling, additional, Sun, Liang, additional, Cao, Gang, additional, Niu, Yuyu, additional, Zhang, Baohu, additional, Ji, Qianzhao, additional, Jiang, Xiaoyu, additional, Wang, Cui, additional, Wang, Qiaoran, additional, Ji, Zhejun, additional, Li, Lanzhu, additional, Esteban, Concepcion Rodriguez, additional, Yan, Kaowen, additional, Li, Wei, additional, Cai, Yusheng, additional, Wang, Si, additional, Zheng, Aihua, additional, Zhang, Yong E., additional, Tan, Shengjun, additional, Cai, Yingao, additional, Song, Moshi, additional, Lu, Falong, additional, Tang, Fuchou, additional, Ji, Weizhi, additional, Zhou, Qi, additional, Belmonte, Juan Carlos Izpisua, additional, Zhang, Weiqi, additional, Qu, Jing, additional, and Liu, Guang-Hui, additional

Published
2021
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31. The effect of artificial selection for extended life span and late age fecundity on the age-specific phagocytic ability of blood cells in adult Drosophila melanogaster

Author

Ji, Zhejun

Subjects
immunosenescence, engulfment, aging, phagocytosis, Drosophila, innate immunity
Abstract

Immunosenescence is defined as the functional decline of the immune response with age and is found in most organisms. In mammals both the innate and adaptive components of the immune response decline with age, however, the cellular and genetic mechanisms of this phenomenon still remain unclear. Here, I use Drosophila melanogaster as our model to study the general effect of age on innate immunity. I studied the effect of age on phagocytic ability in six distinct Drosophila lations: three populations that had been artificially selected for extended life span and three unselected control populations. I measured phagocytic ability by injecting fluorescently-labeled heat killed E. coli flies at different ages and counted the number of E. coli lfed by the blood cells around the heart. Interestingly, I found that the average number of E. coli were engulfed by blood cells increased with age in all six fly populations. While there was no difference between the Selected and Control flies when data were combined across ages, I did find that the effect of age on phagocytic ability differed between the Control and Selected populations. The Control populations had a relatively larger number of engulfed bacteria at early age while populations selected for longer life span and increased late age fecundity had a higher engulfment at older age. To further test the efficiency of the phagocytic ability, I independently injected four of the populations with latex beads, which cannot be digested after engulfment by the blood cells. I found variable results with the beads but in general they were consistent with the bacteria data. In conclusion, our data indicates that life span extension is genetically correlated with phagocytosis ability and exhibits a trade-off with early age phagocytic efficiency. Understanding the genetic basis of this trade-off is an important topic for future study.

Published
2012
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32. Mitochondrial sirtuins, metabolism, and aging

Author

Ji, Zhejun, Liu, Guang-Hui, and Qu, Jing

Abstract

Maintaining metabolic homeostasis is essential for cellular and organismal health throughout life. Of the multiple signaling pathways that regulate metabolism, such as PI3K/AKT, mTOR, AMPK, and sirtuins, mammalian sirtuins also play unique roles in aging. By understanding how sirtuins regulate metabolic processes, we can start to understand how they slow down or accelerate biological aging. Here, we review the biology of SIRT3, SIRT4, and SIRT5, known as the mitochondrial sirtuins due to their localization in the mitochondrial matrix. First, we will focus on canonical pathways that regulate metabolism more broadly and how these are integrated with aging regulation. Then, we will summarize the current knowledge about functional differences between SIRT3, SIRT4, and SIRT5 in metabolic control and integration in signaling networks. Finally, we will discuss how mitochondrial sirtuins regulate processes associated with aging and oxidative stress, calorie restriction and disease.

Published
2021
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