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Malatya cheeses with different cow to goat milk ratios (1:0, 3:1, 1:1, 1:3 and 0:1) were prepared to investigate the effect of blend ratio between cow and goat milk on the yield, physicochemical properties, texture, color, melting temperature, sensory quality, protein hydrolysis and antioxidant properties of traditional Malatya cheese during the ripening process. The results showed that increasing the proportion of cow milk resulted in lower protein content, hardness, chewiness, brightness and whiteness values, and higher moisture content of Malatya cheese. As the ripening time increased, the degree of proteolysis gradually increased, and the antioxidant activity of cheese gradually increased until the 60th day, and then decreased. There was no significant difference in cheese yield between the 50% cow milk addition and the pure goat milk groups (P > 0.05), while the former had the highest sensory evaluation score. Malatya cheese prepared from 50% cow milk and 50% goat milk showed no significant difference in the degree of proteolysis compared with pure goat milk cheese, and in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity, superoxide anion radical scavenging capacity, reducing power, or total antioxidant capacity compared with traditional Malatya cheese (P > 0.05). From these results, it was found that the optimal addition level of cow milk in Malatya cheese was 50%, which imparted good quality and antioxidant properties to Malatya cheese.

The COG light board is prone to breakage during the stringent mechanical testing, which is a major pain point for COG light boards. In order to improve the adaptability to the back cover which is made by stamping, the elastic supporter solution is proposed and its feasibility is confirmed by the FEM simulation method and a series of tests. The pain point is solved successfully. [ABSTRACT FROM AUTHOR]

In this paper, the projective synchronization problem of nonautonomous neural networks with time delay and Caputo derivative is researched. First, by introducing time delay and variable coefficient into the known neural network model, the neural network that can more accurately describe the interaction between neurons is given. Second, based on the improved neural network model, two global synchronization schemes are achieved, respectively. Finally, by constructing two novel Lyapunov functions and utilizing the properties of delay fractional-order differential inequalities, the asymptotic stability of the zero equilibrium point of the error system obtained from the master–slave systems is proved by some new developing analysis methods, respectively, and some criteria for global projective synchronization of delayed nonautonomous neural networks with Caputo derivatives are obtained, respectively, under two new synchronous controllers. In addition, the correctness of the theoretical results obtained in this paper is verified by some numerical simulation. [ABSTRACT FROM AUTHOR]

Myocardial injury and cardiovascular dysfunction are the most common complications of sepsis, and effective therapeutic candidate is still lacking. This study aims to investigate the protective effect of oxycodone in myocardial injury of lipopolysaccharide‐induced sepsis and its related signalling pathways. Wild‐type and nuclear factor erythroid 2‐related factor 2 (Nrf2)‐knockout mice, as well as H9c2 cardiomyocytes cultures treated with lipopolysaccharide (LPS) were used as models of septic myocardial injury. H9c2 cardiomyocytes culture showed that oxycodone protected cells from pyroptosis induced by LPS. Mice model confirmed that oxycodone pretreatment significantly attenuated myocardial pathological damage and improved cardiac function demonstrated by increased ejection fraction (EF) and fractional shortening (FS), as well as decreased cardiac troponin I (cTnI) and creatine kinase isoenzymes MB (CK‐MB). Oxycodone also reduced the levels of inflammatory factors and oxidative stress damage induced by LPS, which involves pyroptosis‐related proteins including: Nod‐like receptor protein 3 (NLRP3), Caspase 1, Apoptosis‐associated speck‐like protein contain a CARD (ASC), and Gasdermin D (GSDMD). These changes were mediated by Nrf2 and heme oxygenase‐1 (HO‐1) because Nrf2‐knockout mice or Nrf2 knockdown in H9c2 cells significantly reversed the beneficial effect of oxycodone on oxidative stress, inflammatory responses and NLRP3‐mediated pyroptosis. Our findings yielded that oxycodone therapy reduces LPS‐induced myocardial injury by suppressing NLRP3‐mediated pyroptosis via the Nrf2/HO‐1 signalling pathway in vivo and in vitro. [ABSTRACT FROM AUTHOR]