Search

Your search keyword '"Jia, Xiaoling"' showing total 210 results
Start Over Author "Jia, Xiaoling"
210 results on '"Jia, Xiaoling"'

1. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial

Author

Ai, Xinyue, An, Chun, An, Yuhong, Bai, Shiru, Bai, Xueke, Bi, Jingao, Bin, Xiaoling, Bu, Miaomiao, Bu, Peili, Bu, Wei, Cai, Lvping, Cai, Nana, Cai, Shuhui, Cai, Ting, Cai, Wenjing, Cao, Bin, Cao, Bingbing, Cao, Huaping, Cao, Libo, Cao, Xiancun, Chai, Hui, Chai, Yonggui, Chai, Zhiyong, Chang, Chunduo, Chang, Jianbao, Chang, Shuyue, Chang, Yunling, Chao, Huanhuan, Che, Hang, Che, Qianqiu, Chen, Danlin, Chen, Dongsheng, Chen, Faxiu, Chen, Guang, Chen, Hairong, Chen, Hao, Chen, Huahua, Chen, Huijun, Chen, Jiafu, Chen, Jian, Chen, Jiasen, Chen, Jing, Chen, Jinzi, Chen, Junrong, Chen, lichun, Chen, Lijuan, Chen, Liyuan, Chen, Qun, Chen, Run, Chen, Shaoxing, Chen, Song, Chen, Tieshuang, Chen, Xianghong, Chen, Xiaowu, Chen, Xudong, Chen, Xue, Chen, Xunchun, Chen, Yao, Chen, Yongli, Chen, Yuanyue, Chen, Yuhong, Chen, Yuyi, Chen, Zhangying, Chen, Zhidong, Chen, Zuyi, Cheng, Caiming, Cheng, Jianbin, Cheng, Xiaoxia, Chu, Junjie, Cui, Ruifeng, Cui, Xiaolin, Cui, Xuechen, Cui, Yang, Cui, Zhonghua, Dai, Wanhong, Dai, Xing, Ding, Chunxia, Ding, Huihong, Ding, Qiuhong, Ding, Yaozong, Ding, Yingjie, Dong, Jiajia, Dong, Lei, Dong, Qi, Dong, Yumei, Du, Bing, Du, Hong, Du, Jie, Du, Laijing, Du, Meiling, Du, Qiong, Du, Tianmin, Du, Xue, Duan, Ru, Duan, Xiaojing, Duan, Xiaoting, Fan, Dandan, Fan, Xiaohong, Fan, Xin, Fang, Fang, Fang, Jing, Fang, Xibo, Fang, Yang, Feng, Erke, Feng, Hejin, Feng, Ling, Feng, Rui, Feng, Zhaohui, Fu, Hongmei, Fu, Qiuai, Gao, Haofei, Gao, Li, Gao, Lina, Gao, Liwei, Gao, Lu, Gao, Min, Gao, Qian, Gao, Yan, Gao, Yuan, Ge, Jinzhuo, Geng, Hongxu, Geng, Hui, Geng, Leijun, Geng, Lianqing, Gou, Hongyan, Gu, Qin, Guan, Lili, Guan, Shuo, Guan, Wenchi, Guan, Zheng, Guang, Bin, Guo, Anran, Guo, Changhong, Guo, Gaofeng, Guo, Lizhi, Guo, Qing, Guo, Qiue, Guo, Ying, Guo, Zhihua, Han, Aihong, Han, Meihong, Han, Suhui, Han, Xinru, Han, Yajun, Hao, Feng, Hao, Jingmin, Hao, Shiguo, He, Chuanhui, He, Dejian, He, Mengyuan, He, Miaomiao, He, Shaojuan, He, Wenkai, He, Xiaoyu, He, Yuxiang, Hong, Jige, Hou, Chuanxing, Hou, Jing, Hu, Danli, Hu, Jian, Hu, Jun, Hu, Lingai, Hu, Mengying, Hu, Zhiyuan, Huang, Anhui, Huang, Chunxia, Huang, Haolin, Huang, Jianlan, Huang, Sha, Huang, Siqi, Huang, Weijun, Huang, Wenxiu, Huang, Xinghe, Huang, Xinsheng, Huang, Xinxin, Hui, Jiliang, Hui, Lijun, Hui, Zhongsheng, Huo, Fangjie, Ji, Runqing, Jia, Guojiong, Jia, Hao, Jia, Jingjing, Jia, Jingmei, Jia, Xiaoling, Jiang, Hua, Jiang, Jingcheng, Jiang, Qian, Jiang, Xianyan, Jiang, Xiaoyuan, Jiang, Yanxiang, Jiao, Yunhong, Jie, Liying, Jin, Binbin, Jin, Lingjiao, Jin, Renshu, Jin, Rong, Jin, Xiang, Jin, Xianping, Jin, Yongfan, Jin, Zepu, Jin, Zhenan, Jing, Chengrong, Jing, Jiajie, Jing, Ruiling, Kang, Liping, Kang, Yu, Kong, Jianqiong, Kou, Shijie, Kou, Xianli, Kulaxihan, Lai, Jijia, Lei, Lubi, Li, Baoxiang, Li, Bin, Li, Bing, Li, Chaohui, Li, Cheng, Li, Chunmei, Li, Chunyan, Li, Daqing, Li, Deen, Li, Di, Li, Feng, Li, Guanyi, Li, Haiyang, Li, Hongwei, Li, Jia, Li, Jialin, Li, Jianan, Li, Jianguang, Li, Jiaying, Li, Jing, Li, Jinmei, Li, Lala, Li, Li, Li, Lijun, Li, Liping, Li, Lize, Li, Mingju, Li, Minglan, Li, Mingyan, Li, Na, Li, Nan, Li, Nana, Li, Qiang, Li, Qianru, Li, Rui, Li, Ruihong, Li, Shanshan, Li, Shilin, Li, Si, Li, Suwen, Li, Tongshe, Li, Tongying, Li, Wanke, Li, Wei, Li, Wenbo, Li, Wenjuan, Li, Xi, Li, Xiangxia, Li, Xiao, Li, Xiaohui, Li, Xingyan, Li, Xiujuan, Li, Yan, Li, Yanfang, Li, Yang, Li, Yanxia, Li, Yaona, Li, Yichong, Li, Ying, Li, Yuqing, Li, Zheng, Li, Zhengye, Liang, Chuanliang, Liang, Jihua, Liang, Jin, Liang, Ke, Liang, Linju, Liang, Tingchen, Liang, Xia, Liang, Xianfeng, Liang, Yanli, Liang, Zhenye, Lie, Zhenbang, Lin, Qingfei, Lin, Ruifang, Lin, Xiao, Lin, Zhiqiang, Liu, Aijun, Liu, Chao, Liu, Chunxia, Liu, Cong, Liu, Fang, Liu, Guaiyan, Liu, Hongjun, Liu, Jiamin, Liu, Jiangling, Liu, Jianqi, Liu, Jieyun, Liu, Jihong, Liu, Jing, Liu, Jinsha, Liu, Juan, Liu, Junfang, Liu, Liming, Liu, Lin, Liu, Ling, Liu, Lu, Liu, Qiang, Liu, Qiaoling, Liu, Qiaoxia, Liu, Qiuxia, Liu, Shaobo, Liu, Xiaobao, Liu, Xiaocheng, Liu, Xiaoyuan, Liu, Xinbo, Liu, Xu, Liu, Yang, Liu, Yanhu, Liu, Yanming, Liu, Yaqin, Liu, Yong, Liu, Zhihong, Long, Jing, Lu, Futang, Lu, Huamei, Lu, Jiapeng, Lu, Junhong, Lu, Weibin, Lu, Yanrong, Lu, Yuchun, Luan, Tianwei, Luo, Qingwei, Luo, Qun, Luo, Tian, Luo, Xia, Luo, Yongmei, Lv, Jing, Lv, Jinhai, Lv, Lei, Lv, Lili, Lv, Meng, Ma, Aiqing, Ma, Huaimin, Ma, Huihuang, Ma, Jie, Ma, Jinbao, Ma, Li, Ma, Lingzhen, Ma, Nan, Ma, Qiaojuan, Ma, Shumei, Ma, Tengfei, Ma, Xiange, Ma, Xiaowen, Ma, Yuehua, Mai, Lanxian, Mei, Xiao, Meng, Gen, Miao, Ruichao, Miao, Xue, Miao, Xuyan, Min, Tingting, Mo, Shubing, Morigentu, Nan, Tingyan, Ni, Jinyang, Ni, Shuguo, Nie, Yu, Ning, Benxing, Ning, Xiaowei, Niu, Manman, Niu, Qingying, Niu, Wentang, Niu, Xiaoxia, Ou, Fang, Pan, Biyun, Pan, Chengjie, Pan, Congming, Pan, Jieli, Pan, Xiaowen, Pan, Ziying, Pei, Guangzhong, Pei, Lingyu, Pei, Min, Pei, Yanzhen, Peng, Yinyu, Peng, Yuming, Pu, Zhaokun, Qi, Fengjun, Qi, Liwei, Qi, Meiqiong, Qi, Yan, Qian, Jun, Qin, Lei, Qin, Zhonghua, Qing, Lan, Qiu, Lixia, Qiu, Weiyu, Qiu, Xiaoling, Qu, Yueli, Quan, Minghua, Ren, Dingping, Ren, Hong, Ren, Lingzhi, Ren, Tingting, Ren, Wei, Ren, Yihui, Rong, Yufang, Ruan, Jiahui, Shang, Peiqin, Shao, Minyan, Shao, Xuefeng, Shao, Yuling, Shen, Junrong, Shen, Rui, Sheng, Lin, Shi, Jiangjie, Shi, Xun, Shi, Yanhong, Shi, Yeju, Shi, Yujiao, Shu, Bo, Song, Bingchun, Song, Dan, Song, Jinhui, Song, Jinwang, Song, Jinxian, Song, Wei, Song, Xiaoping, Song, Yawen, Su, He, Su, Qinfeng, Su, Shuhong, Su, Xiaozhou, Sun, Chengxiang, Sun, Fangfang, Sun, Gongping, Sun, Jiangnan, Sun, Mengmeng, Sun, Rongrong, Sun, Shuting, Sun, Songtao, Sun, Ying, Sun, Yongmiao, Sun, Yunhong, Sun, Zhiqiang, Suo, Mengying, Tan, Binghu, Tang, Chunyan, Tang, Zhongli, Tao, Yu, Tian, Changming, Tian, Hongmei, Tian, Jian, Tian, Xiaomin, Wan, Huaibin, Wan, Qin, Wan, Rongjun, Wang, Bobin, Wang, Chao, Wang, Chaoqun, Wang, Chengliang, Wang, Di, Wang, Enfang, Wang, Feng, Wang, Gang, Wang, Guangqiang, Wang, Guixiang, Wang, Haifeng, Wang, Haijun, Wang, Haiyang, Wang, Jianfang, Wang, Jianfeng, Wang, Jing, Wang, Junping, Wang, Junying, Wang, Kang, Wang, Lei, Wang, Lin, Wang, Lize, Wang, Meng, Wang, Pan, Wang, Qi, Wang, Qiong, Wang, Qiuli, Wang, Qiuxue, Wang, Ran, Wang, Shaojin, Wang, Shuai, Wang, Tao, Wang, Tiantian, Wang, Tinghui, Wang, Tongyan, Wang, Wanhong, Wang, Wenjuan, Wang, Wenyan, Wang, Wenying, Wang, Wenzhuan, Wang, Xiaofei, Wang, Xiaoyan, Wang, Xitong, Wang, Xu, Wang, Yan, Wang, Yanfang, Wang, Yang, Wang, Yanping, Wang, Yanying, Wang, Yaoxin, Wang, Yingli, Wang, Yiting, Wang, Yue, Wang, Yumei, Wang, Yuzhuo, Wang, Zhenhua, Wang, Zhifang, Wang, Zhimin, Wei, Chunli, Wei, Lixia, Wei, Pei, Wei, Shuying, Wei, Xiqing, Wen, Hong, Wen, Yun, Wu, Chaoqun, Wu, Hairong, Wu, Lihua, Wu, Lingxiang, Wu, Qi, Wu, Shaorong, Wu, Wenting, Wu, Xueyi, Wu, Yongshuan, Wu, Zhihao, Wu, Zhuying, Wu, Zongyin, Wuhanbilige, Xia, Jun, Xia, Yang, Xiang, Jing, Xiao, Heliu, Xiao, Yaying, Xie, Meiling, Xie, Yinyan, Xin, Huiling, Xing, Jing, Xiu, Guoquan, Xu, Baohua, Xu, Chuangze, Xu, En, Xu, Jian, Xu, Shuli, Xu, Wei, Xu, Wen, Xue, Na, Xue, Tingting, Xue, Wei, Yan, Haiyan, Yan, Xiaofang, Yan, Yanqing, Yang, Bo, Yang, Hui, Yang, Huiyu, Yang, Jinhua, Yang, Kun, Yang, Man, Yang, Mengya, Yang, Ning, Yang, Ping, Yang, Xiajiao, Yang, Xiaomo, Yang, Xin, Yang, Xiujuan, Yang, Xuemei, Yang, Xuming, Yang, Yan, Yang, Yanhua, Yang, Yi, Yang, Yuanyuan, Yang, Zhimei, Yang, Zhiming, Yao, Hui, Yao, Lu, Ye, Jinling, Ye, Wenhua, Yi, Mingjiao, Yi, Shaowei, Yi, Wenyi, Yi, Zhimin, Yin, Guangxia, Yin, Guoyuan, Yu, Guibin, Yu, Hairong, Yu, Huaitao, Yu, Lijie, Yu, Lijun, Yu, Nana, Yu, Qin, Yu, Xinli, Yu, Yi, Yuan, Biao, Zeng, Chunmei, Zhai, Na, Zhai, Xiaojuan, Zhan, Hongju, Zhang, Aizhen, Zhang, Baohua, Zhang, Bin, Zhang, Caizhu, Zhang, Chaoying, Zhang, Chengbo, Zhang, Chunlai, Zhang, Churuo, Zhang, Fan, Zhang, Feiqin, Zhang, Ge, Zhang, Haibo, Zhang, Hailin, Zhang, Hanxue, Zhang, Huaixing, Zhang, Hui, Zhang, Huijuan, Zhang, Jinguo, Zhang, Jingyu, Zhang, Jinyun, Zhang, Jisheng, Zhang, Jun, Zhang, Lei, Zhang, Li, Zhang, Liang, Zhang, Lifeng, Zhang, Lina, Zhang, Liping, Zhang, Min, Zhang, Ping, Zhang, Qiang, Zhang, Rufang, Zhang, Ruifen, Zhang, Shengde, Zhang, Siqi, Zhang, Sufang, Zhang, Tingting, Zhang, Wanyue, Zhang, Weiliang, Zhang, Xiaohan, Zhang, Xiaohong, Zhang, Xiaojuan, Zhang, Xin, Zhang, Xue, Zhang, Xuewei, Zhang, Yachen, Zhang, Yang, Zhang, Yanyan, Zhang, Yaojie, Zhang, Yingyu, Zhang, Yuan, Zhang, Yun, Zhang, Yunfeng, Zhang, Zaozhang, Zhang, Zhichao, Zhao, Baihui, Zhao, Dan, Zhao, Fuxian, Zhao, Guizeng, Zhao, Haijie, Zhao, Honglei, Zhao, Huizhen, Zhao, Jindong, Zhao, Juan, Zhao, Liming, Zhao, Ling, Zhao, Lingshan, Zhao, Qingxia, Zhao, Qiuping, Zhao, Wanchen, Zhao, Wangxiu, Zhao, Weiyi, Zhao, Xiaodi, Zhao, Xiaojing, Zhao, Xiaoli, Zhao, Xiaoyan, Zhao, Xiling, Zhao, Yannan, Zhao, Yiyuan, Zheng, Shuzhen, Zheng, Xin, Zhi, Lixia, Zhong, Hui, Zhong, Qing, Zhong, Xin, Zhong, Yunzhi, Zhou, Jianfeng, Zhou, Jihu, Zhou, Ke, Zhou, Liangliang, Zhou, Ling, Zhou, Na, Zhou, Shengcheng, Zhou, Suyun, Zhou, Tao, Zhou, Wanren, Zhou, Weifeng, Zhou, Weijuan, Zhou, Xiaohong, Zhou, Yunke, Zhou, Yuquan, Zhou, Zhaohai, Zhou, Zhiming, Zhu, Bingpo, Zhu, Jifa, Zhu, Jing, Zhu, Mengnan, Zhu, Youcun, Zong, Dafei, Zuo, Hongbo, and Zuo, Zhaokai

Published
2024
Full Text
View/download PDF

5. NEDD4L inhibits cell viability, cell cycle progression, and glutamine metabolism in esophageal squamous cell carcinoma via ubiquitination of c-Myc

Author

Cheng Wei, Li Guiyuan, Ye Zhou, Hu Jun, Gao Lixia, Jia Xiaoling, Zhao Suping, Wang Yan, and Zhou Qin

Subjects
esophageal squamous cell carcinoma, glutamine metabolism, NEDD4L, ubiquitination, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Esophageal squamous cell carcinoma (ESCC) is a common subtype of esophageal cancer with high incidence. Surgery remains the main strategy for treatment of ESCC at early stage. However, the treatment outcome is unsatisfactory. Therefore, finding new therapeutics is of great importance. In the present study, we measured the level of NEDD4L, an ubiquitin protein ligase, in clinical samples and investigated the effects of NEDD4L on cell viability, cell cycle progression, and glutamine metabolism in TE14 cells determined by CCK-8 assay, flow cytometry and biochemical analysis, respectively. The results show that NEDD4L is significantly decreased in ESCC specimens, and its decreased expression is associated with a poor clinical outcome. Overexpression of NEDD4L significantly inhibits cell viability, cell cycle progression, and glutamine metabolism in TE14 cells. Mechanistic study indicates that NEDD4L regulates tumor progression through ubiquitination of c-Myc and modulation of glutamine metabolism. NEDD4L inhibits cell viability, cell cycle progression, and glutamine metabolism in ESCC by ubiquitination of c-Myc to decrease the expressions of GLS1 and SLC1A5. Our findings highlight the importance of NEDD4L/c-Myc signaling in ESCC.

Published
2022
Full Text
View/download PDF

7. A Multi-mode Coordinate Rotation Digital Computer (CORDIC)

Author

Niu, Lifan, Jia, Xiaoling, Wu, Jun, Zhang, Zhifeng, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin (Sherman), Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Chen, Qianbin, editor, Meng, Weixiao, editor, and Zhao, Liqiang, editor

Published
2018
Full Text
View/download PDF

10. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial

Author

Liu, Jiamin, Li, Yan, Ge, Jinzhuo, Yan, Xiaofang, Zhang, Haibo, Zheng, Xin, Lu, Jiapeng, Li, Xi, Gao, Yan, Lei, Lubi, Liu, Jing, Li, Jing, Ai, Xinyue, An, Chun, An, Yuhong, Bai, Shiru, Bai, Xueke, Bi, Jingao, Bin, Xiaoling, Bu, Miaomiao, Bu, Peili, Bu, Wei, Cai, Lvping, Cai, Nana, Cai, Shuhui, Cai, Ting, Cai, Wenjing, Cao, Bin, Cao, Bingbing, Cao, Huaping, Cao, Libo, Cao, Xiancun, Chai, Hui, Chai, Yonggui, Chai, Zhiyong, Chang, Chunduo, Chang, Jianbao, Chang, Shuyue, Chang, Yunling, Chao, Huanhuan, Che, Hang, Che, Qianqiu, Chen, Danlin, Chen, Dongsheng, Chen, Faxiu, Chen, Guang, Chen, Hairong, Chen, Hao, Chen, Huahua, Chen, Huijun, Chen, Jiafu, Chen, Jian, Chen, Jian, Chen, Jiasen, Chen, Jing, Chen, Jinzi, Chen, Junrong, Chen, lichun, Chen, Lijuan, Chen, Liyuan, Chen, Qun, Chen, Run, Chen, Shaoxing, Chen, Song, Chen, Tieshuang, Chen, Xianghong, Chen, Xiaowu, Chen, Xudong, Chen, Xue, Chen, Xunchun, Chen, Yao, Chen, Yongli, Chen, Yuanyue, Chen, Yuhong, Chen, Yuyi, Chen, Zhangying, Chen, Zhidong, Chen, Zuyi, Cheng, Caiming, Cheng, Jianbin, Cheng, Xiaoxia, Chu, Junjie, Cui, Ruifeng, Cui, Xiaolin, Cui, Xuechen, Cui, Yang, Cui, Zhonghua, Dai, Wanhong, Dai, Xing, Ding, Chunxia, Ding, Huihong, Ding, Qiuhong, Ding, Yaozong, Ding, Yingjie, Dong, Jiajia, Dong, Lei, Dong, Qi, Dong, Yumei, Du, Bing, Du, Hong, Du, Jie, Du, Laijing, Du, Meiling, Du, Qiong, Du, Tianmin, Du, Xue, Duan, Ru, Duan, Xiaojing, Duan, Xiaoting, Fan, Dandan, Fan, Xiaohong, Fan, Xin, Fang, Fang, Fang, Jing, Fang, Xibo, Fang, Yang, Feng, Erke, Feng, Hejin, Feng, Ling, Feng, Rui, Feng, Zhaohui, Fu, Hongmei, Fu, Qiuai, Gao, Haofei, Gao, Li, Gao, Lina, Gao, Liwei, Gao, Lu, Gao, Min, Gao, Min, Gao, Qian, Gao, Yan, Gao, Yuan, Ge, Jinzhuo, Geng, Hongxu, Geng, Hui, Geng, Leijun, Geng, Lianqing, Gou, Hongyan, Gu, Qin, Guan, Lili, Guan, Shuo, Guan, Wenchi, Guan, Zheng, Guang, Bin, Guo, Anran, Guo, Changhong, Guo, Gaofeng, Guo, Lizhi, Guo, Qing, Guo, Qiue, Guo, Ying, Guo, Zhihua, Han, Aihong, Han, Meihong, Han, Suhui, Han, Xinru, Han, Yajun, Hao, Feng, Hao, Jingmin, Hao, Shiguo, He, Chuanhui, He, Dejian, He, Mengyuan, He, Miaomiao, He, Shaojuan, He, Wenkai, He, Xiaoyu, He, Yuxiang, Hong, Jige, Hou, Chuanxing, Hou, Jing, Hu, Danli, Hu, Jian, Hu, Jun, Hu, Lingai, Hu, Mengying, Hu, Zhiyuan, Huang, Anhui, Huang, Chunxia, Huang, Haolin, Huang, Jianlan, Huang, Sha, Huang, Siqi, Huang, Weijun, Huang, Wenxiu, Huang, Xinghe, Huang, Xinsheng, Huang, Xinxin, Hui, Jiliang, Hui, Lijun, Hui, Zhongsheng, Huo, Fangjie, Ji, Runqing, Ji, Runqing, Jia, Guojiong, Jia, Hao, Jia, Jingjing, Jia, Jingmei, Jia, Xiaoling, Jiang, Hua, Jiang, Jingcheng, Jiang, Qian, Jiang, Xianyan, Jiang, Xiaoyuan, Jiang, Yanxiang, Jiao, Yunhong, Jie, Liying, Jin, Binbin, Jin, Lingjiao, Jin, Renshu, Jin, Rong, Jin, Xiang, Jin, Xianping, Jin, Yongfan, Jin, Zepu, Jin, Zhenan, Jing, Chengrong, Jing, Jiajie, Jing, Ruiling, Kang, Liping, Kang, Yu, Kong, Jianqiong, Kou, Shijie, Kou, Xianli, Kulaxihan, Lai, Jijia, Lei, Lubi, Li, Baoxiang, Li, Bin, Li, Bing, Li, Chaohui, Li, Cheng, Li, Chunmei, Li, Chunyan, Li, Daqing, Li, Deen, Li, Di, Li, Feng, Li, Guanyi, Li, Haiyang, Li, Hongwei, Li, Jia, Li, Jialin, Li, Jianan, Li, Jianguang, Li, Jiaying, Li, Jing, Li, Jing, Li, Jinmei, Li, Lala, Li, Li, Li, Lijun, Li, Liping, Li, Lize, Li, Mingju, Li, Minglan, Li, Mingyan, Li, Na, Li, Na, Li, Nan, Li, Nana, Li, Qiang, Li, Qianru, Li, Rui, Li, Ruihong, Li, Shanshan, Li, Shilin, Li, Si, Li, Suwen, Li, Tongshe, Li, Tongying, Li, Wanke, Li, Wei, Li, Wenbo, Li, Wenjuan, Li, Xi, Li, Xiangxia, Li, Xiao, Li, Xiaohui, Li, Xingyan, Li, Xiujuan, Li, Yan, Li, Yanfang, Li, Yang, Li, Yanxia, Li, Yaona, Li, Yichong, Li, Ying, Li, Yuqing, Li, Zheng, Li, Zhengye, Liang, Chuanliang, Liang, Jihua, Liang, Jin, Liang, Ke, Liang, Linju, Liang, Tingchen, Liang, Xia, Liang, Xianfeng, Liang, Yanli, Liang, Zhenye, Lie, Zhenbang, Lin, Qingfei, Lin, Ruifang, Lin, Xiao, Lin, Zhiqiang, Liu, Aijun, Liu, Chao, Liu, Chunxia, Liu, Cong, Liu, Fang, Liu, Fang, Liu, Guaiyan, Liu, Hongjun, Liu, Jiamin, Liu, Jiangling, Liu, Jianqi, Liu, Jieyun, Liu, Jihong, Liu, Jing, Liu, Jinsha, Liu, Juan, Liu, Junfang, Liu, Liming, Liu, Lin, Liu, Lin, Liu, Lin, Liu, Ling, Liu, Lu, Liu, Qiang, Liu, Qiaoling, Liu, Qiaoxia, Liu, Qiuxia, Liu, Shaobo, Liu, Xiaobao, Liu, Xiaocheng, Liu, Xiaoyuan, Liu, Xinbo, Liu, Xu, Liu, Yang, Liu, Yanhu, Liu, Yanming, Liu, Yaqin, Liu, Yong, Liu, Zhihong, Long, Jing, Lu, Futang, Lu, Huamei, Lu, Jiapeng, Lu, Junhong, Lu, Weibin, Lu, Yanrong, Lu, Yuchun, Luan, Tianwei, Luo, Qingwei, Luo, Qun, Luo, Tian, Luo, Xia, Luo, Yongmei, Lv, Jing, Lv, Jinhai, Lv, Lei, Lv, Lili, Lv, Meng, Ma, Aiqing, Ma, Huaimin, Ma, Huihuang, Ma, Jie, Ma, Jinbao, Ma, Li, Ma, Lingzhen, Ma, Nan, Ma, Qiaojuan, Ma, Shumei, Ma, Tengfei, Ma, Xiange, Ma, Xiaowen, Ma, Yuehua, Mai, Lanxian, Mei, Xiao, Meng, Gen, Miao, Ruichao, Miao, Xue, Miao, Xuyan, Min, Tingting, Mo, Shubing, Morigentu, Nan, Tingyan, Ni, Jinyang, Ni, Shuguo, Nie, Yu, Ning, Benxing, Ning, Xiaowei, Niu, Manman, Niu, Qingying, Niu, Wentang, Niu, Xiaoxia, Ou, Fang, Pan, Biyun, Pan, Chengjie, Pan, Congming, Pan, Jieli, Pan, Xiaowen, Pan, Ziying, Pei, Guangzhong, Pei, Lingyu, Pei, Min, Pei, Yanzhen, Peng, Yinyu, Peng, Yuming, Pu, Zhaokun, Qi, Fengjun, Qi, Liwei, Qi, Meiqiong, Qi, Yan, Qian, Jun, Qin, Lei, Qin, Zhonghua, Qing, Lan, Qiu, Lixia, Qiu, Weiyu, Qiu, Xiaoling, Qu, Yueli, Quan, Minghua, Ren, Dingping, Ren, Hong, Ren, Lingzhi, Ren, Tingting, Ren, Wei, Ren, Yihui, Rong, Yufang, Ruan, Jiahui, Shang, Peiqin, Shao, Minyan, Shao, Xuefeng, Shao, Yuling, Shen, Junrong, Shen, Rui, Sheng, Lin, Shi, Jiangjie, Shi, Xun, Shi, Yanhong, Shi, Yeju, Shi, Yujiao, Shu, Bo, Song, Bingchun, Song, Dan, Song, Jinhui, Song, Jinwang, Song, Jinxian, Song, Wei, Song, Xiaoping, Song, Yawen, Su, He, Su, Qinfeng, Su, Shuhong, Su, Xiaozhou, Sun, Chengxiang, Sun, Fangfang, Sun, Gongping, Sun, Jiangnan, Sun, Mengmeng, Sun, Rongrong, Sun, Shuting, Sun, Songtao, Sun, Ying, Sun, Yongmiao, Sun, Yunhong, Sun, Zhiqiang, Suo, Mengying, Tan, Binghu, Tang, Chunyan, Tang, Zhongli, Tao, Yu, Tian, Changming, Tian, Hongmei, Tian, Jian, Tian, Xiaomin, Wan, Huaibin, Wan, Qin, Wan, Rongjun, Wang, Bobin, Wang, Chao, Wang, Chaoqun, Wang, Chengliang, Wang, Di, Wang, Enfang, Wang, Feng, Wang, Gang, Wang, Guangqiang, Wang, Guixiang, Wang, Haifeng, Wang, Haijun, Wang, Haiyang, Wang, Jianfang, Wang, Jianfeng, Wang, Jing, Wang, Junping, Wang, Junying, Wang, Kang, Wang, Lei, Wang, Lei, Wang, Lin, Wang, Lize, Wang, Meng, Wang, Pan, Wang, Qi, Wang, Qiong, Wang, Qiuli, Wang, Qiuxue, Wang, Ran, Wang, Shaojin, Wang, Shuai, Wang, Tao, Wang, Tiantian, Wang, Tinghui, Wang, Tongyan, Wang, Wanhong, Wang, Wenjuan, Wang, Wenyan, Wang, Wenying, Wang, Wenzhuan, Wang, Xiaofei, Wang, Xiaoyan, Wang, Xitong, Wang, Xu, Wang, Yan, Wang, Yan, Wang, Yan, Wang, Yanfang, Wang, Yang, Wang, Yang, Wang, Yanping, Wang, Yanying, Wang, Yaoxin, Wang, Yingli, Wang, Yiting, Wang, Yue, Wang, Yumei, Wang, Yuzhuo, Wang, Zhenhua, Wang, Zhifang, Wang, Zhimin, Wei, Chunli, Wei, Lixia, Wei, Pei, Wei, Shuying, Wei, Xiqing, Wen, Hong, Wen, Yun, Wu, Chaoqun, Wu, Hairong, Wu, Lihua, Wu, Lingxiang, Wu, Qi, Wu, Shaorong, Wu, Wenting, Wu, Xueyi, Wu, Yongshuan, Wu, Zhihao, Wu, Zhuying, Wu, Zongyin, Wuhanbilige, Xia, Jun, Xia, Yang, Xiang, Jing, Xiao, Heliu, Xiao, Yaying, Xie, Meiling, Xie, Yinyan, Xin, Huiling, Xing, Jing, Xiu, Guoquan, Xu, Baohua, Xu, Chuangze, Xu, En, Xu, Jian, Xu, Shuli, Xu, Wei, Xu, Wen, Xue, Na, Xue, Tingting, Xue, Wei, Yan, Haiyan, Yan, Xiaofang, Yan, Yanqing, Yang, Bo, Yang, Hui, Yang, Huiyu, Yang, Jinhua, Yang, Kun, Yang, Man, Yang, Mengya, Yang, Ning, Yang, Ping, Yang, Xiajiao, Yang, Xiaomo, Yang, Xin, Yang, Xiujuan, Yang, Xuemei, Yang, Xuming, Yang, Yan, Yang, Yanhua, Yang, Yi, Yang, Yuanyuan, Yang, Zhimei, Yang, Zhiming, Yao, Hui, Yao, Lu, Ye, Jinling, Ye, Wenhua, Yi, Mingjiao, Yi, Shaowei, Yi, Wenyi, Yi, Zhimin, Yin, Guangxia, Yin, Guoyuan, Yu, Guibin, Yu, Hairong, Yu, Huaitao, Yu, Lijie, Yu, Lijun, Yu, Nana, Yu, Qin, Yu, Xinli, Yu, Yi, Yuan, Biao, Zeng, Chunmei, Zhai, Na, Zhai, Xiaojuan, Zhan, Hongju, Zhang, Aizhen, Zhang, Baohua, Zhang, Bin, Zhang, Caizhu, Zhang, Chaoying, Zhang, Chengbo, Zhang, Chunlai, Zhang, Churuo, Zhang, Fan, Zhang, Feiqin, Zhang, Ge, Zhang, Haibo, Zhang, Hailin, Zhang, Hanxue, Zhang, Huaixing, Zhang, Hui, Zhang, Huijuan, Zhang, Jinguo, Zhang, Jingyu, Zhang, Jinyun, Zhang, Jisheng, Zhang, Jun, Zhang, Lei, Zhang, Li, Zhang, Li, Zhang, Liang, Zhang, Lifeng, Zhang, Lina, Zhang, Liping, Zhang, Liping, Zhang, Min, Zhang, Ping, Zhang, Qiang, Zhang, Rufang, Zhang, Ruifen, Zhang, Shengde, Zhang, Siqi, Zhang, Sufang, Zhang, Tingting, Zhang, Wanyue, Zhang, Weiliang, Zhang, Xiaohan, Zhang, Xiaohong, Zhang, Xiaojuan, Zhang, Xin, Zhang, Xin, Zhang, Xue, Zhang, Xuewei, Zhang, Yachen, Zhang, Yang, Zhang, Yanyan, Zhang, Yaojie, Zhang, Yingyu, Zhang, Yuan, Zhang, Yun, Zhang, Yunfeng, Zhang, Zaozhang, Zhang, Zhichao, Zhao, Baihui, Zhao, Dan, Zhao, Fuxian, Zhao, Guizeng, Zhao, Haijie, Zhao, Honglei, Zhao, Huizhen, Zhao, Jindong, Zhao, Juan, Zhao, Liming, Zhao, Ling, Zhao, Lingshan, Zhao, Qingxia, Zhao, Qiuping, Zhao, Wanchen, Zhao, Wangxiu, Zhao, Weiyi, Zhao, Xiaodi, Zhao, Xiaojing, Zhao, Xiaoli, Zhao, Xiaoyan, Zhao, Xiling, Zhao, Yannan, Zhao, Yiyuan, Zheng, Shuzhen, Zheng, Xin, Zhi, Lixia, Zhong, Hui, Zhong, Qing, Zhong, Xin, Zhong, Yunzhi, Zhou, Jianfeng, Zhou, Jihu, Zhou, Ke, Zhou, Liangliang, Zhou, Ling, Zhou, Na, Zhou, Shengcheng, Zhou, Suyun, Zhou, Tao, Zhou, Wanren, Zhou, Weifeng, Zhou, Weijuan, Zhou, Xiaohong, Zhou, Yunke, Zhou, Yuquan, Zhou, Zhaohai, Zhou, Zhiming, Zhu, Bingpo, Zhu, Jifa, Zhu, Jing, Zhu, Mengnan, Zhu, Youcun, Zong, Dafei, Zuo, Hongbo, and Zuo, Zhaokai

Abstract

Uncertainty exists about whether lowering systolic blood pressure to less than 120 mm Hg is superior to that of less than 140 mm Hg, particularly in patients with diabetes and patients with previous stroke.

Published
2024
Full Text
View/download PDF

18. Advances in In vitro Models of Neuromuscular Junction: Focusing on Organ‐on‐a‐chip, Organoids and Biohybrid Robotics

Author

Leng, Yubing, primary, Li, Xiaorui, additional, Zheng, Fuyin, additional, Liu, Hui, additional, Wang, Chunyan, additional, Wang, Xudong, additional, Liao, Yulong, additional, Liu, Jiangyue, additional, Meng, Kaiqi, additional, Yu, Jiaheng, additional, Zhang, Jingyi, additional, Wang, Binyu, additional, Tan, Yingjun, additional, Liu, Meili, additional, Jia, Xiaoling, additional, Li, Deyu, additional, Li, Yinghui, additional, Gu, Zhongze, additional, and Fan, Yubo, additional

Published
2023
Full Text
View/download PDF

33. Functional cooperation between IKCa and TRPC1 channels regulates serum‐induced vascular smooth muscle cell proliferation via mediating Ca2+ influx and ERK1/2 activation.

Author

Jia, Xiaoling, Chen, Xinlan, Gao, Chao, Wang, Haikun, Yang, Chengxi, Jiang, Lin‐Hua, and Fan, Yubo

Subjects
*CALCIUM-dependent potassium channels, *VASCULAR smooth muscle, *INTRACELLULAR calcium, *CELL proliferation, *MUSCLE cells, *CALCIUM ions
Abstract

The increased proliferation of vascular smooth muscle cells (VSMCs) contributes to the pathogenesis of vascular diseases. The intermediate conductance calcium‐activated potassium (IKCa) channel plays a critical role in VSMC proliferation by raising the intracellular calcium concentration ([Ca2+]i), but the underlying mechanism is still not unclear. Here we investigated the cooperation between IKCa and transient receptor potential canonical 1 (TRPC1) channels in mediating extracellular Ca2+ entry, which in turn activates downstream Ca2+ signalling in the regulation of VSMC proliferation using serum‐induced cell proliferation model. Serum‐induced cell proliferation was accompanied with up‐regulation of IKCa expression and an increase in [Ca2+]i. Serum‐induced cell proliferation and increase in [Ca2+]i were suppressed by IKCa inhibition with TRAM‐34 or IKCa knockdown. Serum‐induced cell proliferation was strongly reduced by the removal of extracellular Ca2+ with EGTA or intracellular Ca2+ with BAPTA‐AM and, additionally, by TRPC1 knockdown. Moreover, the increase in [Ca2+]i induced by serum or by IKCa activation with 1‐EBIO was attenuated by TRPC1 knockdown. Finally, serum induced ERK1/2 activation, which was attenuated by treatment with TRAM‐34 or BAPTA‐AM, as well as TRPC1 knockdown. Consistently, serum‐induced cell proliferation was suppressed by ERK1/2 inhibition with PD98059. Taken together, these results suggest that the IKCa and TRPC1 channels cooperate in mediating Ca2+ influx that activates the ERK1/2 pathway to promote cell proliferation, thus providing new mechanistic insights into VSMC proliferation. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

47. Stimulation of vascular smooth muscle cell proliferation by stiff matrix via the IKCa channel‐dependent Ca2+ signaling

Author

Jia, Xiaoling, primary, Yang, Qingmao, additional, Gao, Chao, additional, Chen, Xinlan, additional, Li, Yanan, additional, Su, Hao, additional, Zheng, Yufan, additional, Zhang, Shuwen, additional, Wang, Ziyu, additional, Wang, Haikun, additional, Jiang, Lin‐Hua, additional, Sun, Yan, additional, and Fan, Yubo, additional

Published
2021
Full Text
View/download PDF

48. Stimulation of vascular smooth muscle cell proliferation by stiff matrix via the IKCa channel‐dependent Ca2+ signaling.

Author

Jia, Xiaoling, Yang, Qingmao, Gao, Chao, Chen, Xinlan, Li, Yanan, Su, Hao, Zheng, Yufan, Zhang, Shuwen, Wang, Ziyu, Wang, Haikun, Jiang, Lin‐Hua, Sun, Yan, and Fan, Yubo

Subjects
*VASCULAR smooth muscle, *CELL proliferation, *EXTRACELLULAR signal-regulated kinases, *MUSCLE cells, *EXTRACELLULAR matrix
Abstract

Vascular stiffening, an early and common characteristic of cardiovascular diseases (CVDs), stimulates vascular smooth muscle cell (VSMC) proliferation which reciprocally accelerates the progression of CVDs. However, the mechanisms by which extracellular matrix stiffness accompanying vascular stiffening regulates VSMC proliferation remain largely unknown. In the present study, we examined the role of the intermediate‐conductance Ca2+‐activated K+ (IKCa) channel in the matrix stiffness regulation of VSMC proliferation by growing A7r5 cells on soft and stiff polydimethylsiloxane substrates with stiffness close to these of arteries under physiological and pathological conditions, respectively. Stiff substrates stimulated cell proliferation and upregulated the expression of the IKCa channel. Stiff substrate‐induced cell proliferation was suppressed by pharmacological inhibition using TRAM34, an IKCa channel blocker, or genetic depletion of the IKCa channel. In addition, stiff substrate‐induced cell proliferation was also suppressed by reducing extracellular Ca2+ concentration using EGTA or intracellular Ca2+ concentration using BAPTA‐AM. Moreover, stiff substrate induced activation of extracellular signal‐regulated kinases (ERKs), which was inhibited by treatment with TRAM34 or BAPTA‐AM. Stiff substrate‐induced cell proliferation was suppressed by treatment with PD98059, an ERK inhibitor. Taken together, these results show that substrates with pathologically relevant stiffness upregulate the IKCa channel expression to enhance intracellular Ca2+ signaling and subsequent activation of the ERK signal pathway to drive cell proliferation. These findings provide a novel mechanism by which vascular stiffening regulates VSMC function. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results