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6 results on '"Jia, Ye-Lin"'

5. Fabrication of paclitaxel hybrid nanomicelles to treat resistant breast cancer via oral administration

Author

Wan-Liang Lu, Jing-Ying Zhang, Ying-Jie Hu, Jia-Ye Lin, Ling-Hui Dian, Yi-Nuo Cui, Zhan-Bo Su, and Yan Yan

Subjects
0301 basic medicine, Administration, Oral, Pharmaceutical Science, Apoptosis, 02 engineering and technology, Polyethylene Glycols, oral, chemistry.chemical_compound, International Journal of Nanomedicine, Oral administration, Drug Discovery, Micelles, Original Research, Caspase-9, Mice, Inbred BALB C, biology, Cytochromes c, General Medicine, 021001 nanoscience & nanotechnology, Mitochondria, Dequalinium, Paclitaxel, MCF-7 Cells, Female, Polyvinyls, drug-resistant breast cancer, 0210 nano-technology, mice, Biophysics, Life quality, Mice, Nude, Breast Neoplasms, Bioengineering, Biomaterials, 03 medical and health sciences, Breast cancer, medicine, Animals, Humans, nanomicelles, business.industry, Organic Chemistry, Cancer, medicine.disease, Antineoplastic Agents, Phytogenic, Xenograft Model Antitumor Assays, Nanostructures, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, biology.protein, Cancer research, business
Abstract

Ling-Hui Dian,1,2,* Ying-Jie Hu,1,* Jia-Ye Lin,1 Jing-Ying Zhang,1 Yan Yan,1 Yi-Nuo Cui,1 Zhan-Bo Su,1 Wan-Liang Lu1 1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 2School of Pharmaceutical Sciences, Guangdong Medical University, Dongguan, China *These authors contributed equally to this work Aim: Oral chemotherapy using anticancer drugs would improve the clinical practice and the life quality of patients. The aim of the present study was to develop paclitaxel hybrid nanomicelles for oral administration to treat resistant breast cancer. Methods: Evaluations were performed on human breast cancer MCF-7 cells, drug-resistant breast cancer MCF-7/Adr cells, and in MCF-7/Adr-xenografted BALB/c nude mice. The nanomicelles were composed of the polymer soluplus, d-α-tocopheryl polyethyleneglycol 1000 succinate (TPGS1000), and dequalinium (DQA). The constructed paclitaxel hybrid nanomicelles were ~65 nm in size. Results: The nanomicelles improved cellular uptake and anticancer efficacy in the resistant breast cancer cells and induced mitochondria-mediated apoptosis. The mechanism of the apoptosis-inducing effect was related to the co-localization of the nanomicelles with mitochondria; the activation of pro-apoptotic protein Bax, cytochrome C, and apoptotic enzymes caspase 9 and 3; and the inhibition of anti-apoptotic proteins Bcl-2 and Mcl-1. Oral administration of paclitaxel hybrid nanomicelles had the same anticancer efficacy as the intravenous injection of taxol in resistant breast cancer-bearing mice. The oral suitability of this formulation was associated with the nanostructure and the actions of TPGS1000 and DQA. Conclusion: The fabricated paclitaxel hybrid nanomicelles could provide a promising oral formulation to treat drug-resistant breast cancer. Keywords: paclitaxel, nanomicelles, oral, drug-resistant breast cancer, mice

Published
2018

6. Normal sperm head morphometric reference values in fertile Asian males.

Author

Jia YL, Wu YB, Yu L, Zheng Y, Yang TT, Wang YY, Zhou B, Zhang L, and Li FP

Subjects
Humans, Male, Reference Values, Semen Analysis methods, Adult, Fertility physiology, Spermatozoa, Acrosome, Sperm Head, Asian People
Abstract

Sperm head morphology is crucial for male factor infertility diagnosis and assessment of male reproductive potential. Several criteria are available to analyze sperm head morphology, but they are limited by poor methodology comparability and population applicability. This study aimed to explore comprehensive and new normal morphometric reference values for spermatozoa heads in fertile Asian males. An automated sperm morphology analysis system captured 23 152 stained spermatozoa from confirmed fertile males. Of these samples, 1856 sperm head images were annotated by three experienced laboratory technicians as "normal". We employed 14 novel morphometric features to describe sperm head size (head length, head width, length/width ratio, and girth), shape (ellipse intersection over union, girth intersection over union, short-axis symmetry, and long-axis symmetry), area (head, acrosome, postacrosomal areas, and acrosome area ratio), and degrees of acrosome and nuclear uniformity. This straight-forward method for the morphometric analysis of sperm by accurate visual measurements is clinically applicable. The measured parameters present valuable information to establish morphometric reference intervals for normal sperm heads in fertile Asian males. The presented detailed measurement data will be valuable for interlaboratory comparisons and technician training. In vitro fertilization and andrology laboratory technicians can use these parameters to perform objective morphology evaluation when assessing male fertilization potential., (Copyright © 2023 Copyright: © The Author(s)(2023).)

Published
2024
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