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216 results on '"Jia, Z. J."'

8. Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein

Author

Cho, I., Prier, C. K., Jia, Z. -J, Zhang, R. K., Görbe, Tamás, Arnold, F. H., Cho, I., Prier, C. K., Jia, Z. -J, Zhang, R. K., Görbe, Tamás, and Arnold, F. H.

Abstract

Chiral 1,2-amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been developed for accessing amino alcohols, the direct aminohydroxylation of alkenes to unprotected, enantioenriched amino alcohols remains a challenge. Using directed evolution, we have engineered a hemoprotein biocatalyst based on a thermostable cytochrome c that directly transforms alkenes to amino alcohols with high enantioselectivity (up to 2500 TTN and 90 % ee) under anaerobic conditions with O-pivaloylhydroxylamine as an aminating reagent. The reaction is proposed to proceed via a reactive iron-nitrogen species generated in the enzyme active site, enabling tuning of the catalyst's activity and selectivity by protein engineering., QC 20190328

Published
2019
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14. Trienamines in Organocatalysis

Author

Chen, Y.-C., primary, Jørgensen, K., primary, Jia, Z.-J., additional, Jiang, H., additional, Li, J.-L., additional, Gschwend, B., additional, Li, Q.-Z., additional, Yin, X., additional, and Grouleff, J., additional

Published
2011
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45. ent-Kaurenoids from the roots of Cacalia pilgeriana.

Author

Li, E.-W., Gao, K., and Jia, Z.-J.

Subjects
ASTERACEAE, HYDROXIDES, SPECTRUM analysis, NUCLEAR magnetic resonance spectroscopy
Abstract

Two new ent-kaurenoids,19-acetoxyl-ent-3β,17-dihydroxykaur-15-ene (1), 19-acetoxyl-ent-3β-hydroxykaur-15-en-17-al (2), together with seven known ent-kaurenoids: ent-kaur-16-en-19-al (3), ent-kaur-16-en-19-oic acid (4), ent-kauran-16β,17-diol (5), ent-15β, 16β-epoxy-17-hydroxykauran-19-oic acid (6),19-acetyl-ent-3β-hydroxyl-kaur-16-ene (7), ent-3β,19-dihydroxykaur-16-ene (8), ent-17-hydroxykaur-15-ene (9), were isolated from Cacalia pilgeriana. Their structures were elucidated by spectroscopic methods including 2D NMR spectral analysis. [ABSTRACT FROM AUTHOR]

Published
2007
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49. Real-time application to multiprocessor-system-on-chip mapping strategy for system-level design tool.

Author

Jia, Z. J., Bautista, T., and Núñez, A.

Subjects
*EMBEDDED computer systems, *MULTIPROCESSORS, *COST effectiveness, *ARRAY processors, *APPLICATION-specific integrated circuits
Abstract

A new static mapping technique is presented that can be integrated in a system-level design tool for modelling and simulating real-time applications onto an embedded multiprocessor system. The results of preliminary experiments indicate that the proposed two-phase mapping approach can achieve a good trade-off between the efficiency in resource usage and processor load balancing, as well as the minimisation of the inter-processor communication cost. [ABSTRACT FROM AUTHOR]

Published
2009
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50. Novel Highly Oxygenated Bisabolane Sesquiterpenes from Cremanthodium discoideum

Author

Zhu, Y., Yang, L., and Jia, Z.-J.

Abstract

Five new highly oxygenated bisabolane sesquiterpenes (1−5) were isolated from Cremanthodium discoideum. Their structures were elucidated on the basis of spectroscopic analysis and chemical transformations. The structure and relative stereochemistry of 1 were determined by single-crystal X-ray crystallography on the acetate derivative, 1a. Compound 1 showed antibacterial activity against Bacillus acidilatici and Bacillus subtilis.

Published
1999

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