13 results on '"Jia-Mei Wen"'
Search Results
2. Genetic Polymorphisms in theESR1Gene and Cerebral Infarction Risk: A Meta-Analysis
- Author
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Hong-hua Gao, Lian-bo Gao, and Jia-mei Wen
- Subjects
Subgroup analysis ,Single-nucleotide polymorphism ,Cochrane Library ,Biology ,Bioinformatics ,Polymorphism, Single Nucleotide ,Gene Frequency ,Risk Factors ,Genetics ,medicine ,Humans ,SNP ,Genetic Predisposition to Disease ,Sex Distribution ,Molecular Biology ,Allele frequency ,Genetic Association Studies ,Cerebral infarction ,Estrogen Receptor alpha ,Case-control study ,Cerebral Infarction ,Cell Biology ,General Medicine ,medicine.disease ,Case-Control Studies ,Meta-analysis ,Regression Analysis - Abstract
A number of studies have documented that estrogen receptor α (ESR1) may play an important role in the development and progression of cerebral infarction, but many existing studies have yielded inconclusive results. This meta-analysis was performed to evaluate the relationships between ESR1 genetic polymorphisms and cerebral infarction risk. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before October 1, 2013, without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Seven case-control studies were included with a total of 1471 patients with cerebral infarction and 4688 healthy control subjects. Two common single-nucleotide polymorphisms (SNPs) in the ESR1 gene (rs2234693 TC and rs9340799 AG) were assessed. Our meta-analysis results revealed that ESR1 genetic polymorphisms might increase the risk of cerebral infarction. Subgroup analysis by SNP type indicated that both rs2234693 and rs9340799 polymorphisms in the ESR1 gene were strongly associated with an increased risk of cerebral infarction. Further subgroup analysis by ethnicity showed significant associations between ESR1 genetic polymorphisms and increased risk of cerebral infarction among both Asians and Caucasians. In the stratified subgroup analysis by gender, the results suggested that ESR1 genetic polymorphisms were associated with an increased risk of cerebral infarction in the female population. However, there were no statistically significant associations between ESR1 genetic polymorphisms and cerebral infarction risk in the male population. Meta-regression analyses also confirmed that gender might be a main source of heterogeneity. Our findings indicate that ESR1 genetic polymorphisms may contribute to the development of cerebral infarction, especially in the female population.
- Published
- 2014
3. Correlations of MCP-1 −2518A>G Polymorphism and Serum Levels with Cerebral Infarction Risk: A Meta-Analysis
- Author
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Hong-hua Gao, Jia-mei Wen, and Lian-bo Gao
- Subjects
Risk ,medicine.medical_specialty ,Molecular Mechanisms of Disease ,Cochrane Library ,Biology ,Bioinformatics ,Polymorphism, Single Nucleotide ,Gastroenterology ,Internal medicine ,Odds Ratio ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Allele ,Molecular Biology ,Chemokine CCL2 ,Genetic Association Studies ,Cerebral infarction ,Case-control study ,Correction ,Cerebral Infarction ,Cell Biology ,General Medicine ,Odds ratio ,medicine.disease ,Confidence interval ,Strictly standardized mean difference ,Case-Control Studies ,Meta-analysis - Abstract
This meta-analysis was performed to evaluate the relationships between the monocyte chemoattractant protein-1 (MCP-1) −2518A>G (rs1024611 A>G) polymorphism and its serum levels, and the risk of cerebral infarction. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before October 1st, 2013 without language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Crude odds ratios (ORs) or standardized mean difference (SMD) with their 95% confidence intervals (95% CIs) were calculated. Twelve case–control studies that met all the inclusion criteria were included in this meta-analysis. A total of 1272 patients with cerebral infarction and 1210 healthy control subjects were involved in this meta-analysis. Our meta-analysis results reveal that the MCP-1 −2518A>G polymorphism might increase the risk of cerebral infarction (A allele vs. G allele: OR=1.37, 95% CI: 1.18–1.60, p0.05). Our findings indicate that the MCP-1 −2518A>G polymorphism and serum MCP-1 levels may contribute to the development of cerebral infarction. Thus, the MCP-1 −2518A>G polymorphism and serum MCP-1 levels could be potential biomarkers for the early detection of cerebral infarction.
- Published
- 2014
4. A fast emittance measurement unit for high intensity DC beam
- Author
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Jia Er Ceng, Tao Zhang, Yuan Xu, Haitao Ren, Zhiyu Guo, Jing Feng Zhang, Shixiang Peng, A. L. Zhang, Jia Mei Wen, and Wen Bin Wu
- Subjects
010302 applied physics ,Materials science ,Ion beam ,Proton ,business.industry ,Direct current ,General Physics and Astronomy ,Faraday cup ,01 natural sciences ,010305 fluids & plasmas ,symbols.namesake ,Optics ,0103 physical sciences ,symbols ,Physics::Accelerator Physics ,Metre ,Thermal emittance ,Beam emittance ,business ,Beam (structure) - Abstract
A combined unit, which has the ability to measure the current and emittance of the high intensity direct current (DC) ion beam, is developed at Peking University (PKU). It is a multi-slit single-wire (MSSW)-type beam emittance meter combined with a water-cooled Faraday Cup, named high intensity beam emittance measurement unit-6 (HIBEMU-6). It takes about 15 seconds to complete one measurement of the beam current and its emittance. The emittance of a 50-mA@50-kV DC proton beam is measured.
- Published
- 2018
5. Surface enhancement of molecular ion ${{\rm{H}}}_{2}^{+}$ yield in a 2.45-GHz electron–cyclotron resonance ion source
- Author
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A. L. Zhang, Yuan Xu, Jia Mei Wen, Jing Feng Zhang, Tao Zhang, Shixiang Peng, J. E. Chen, Haitao Ren, Zhiyu Guo, and Wen Bin Wu
- Subjects
010302 applied physics ,Materials science ,Polyatomic ion ,Analytical chemistry ,General Physics and Astronomy ,02 engineering and technology ,Plasma ,021001 nanoscience & nanotechnology ,01 natural sciences ,Electron cyclotron resonance ,Ion source ,Yield (chemistry) ,0103 physical sciences ,0210 nano-technology - Published
- 2017
6. Instability, adiabaticity and controlling effects of external fields for the dark state in a heteronuclear atom–tetramer conversion system
- Author
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Jia-Mei Wen, Li-Bin Fu, Shao-Ying Meng, Xi-Hao Chen, and Shuang-Ning Ning
- Subjects
Physics ,Energy conversion efficiency ,Condensed Matter Physics ,Instability ,Atomic and Molecular Physics, and Optics ,symbols.namesake ,Dark state ,Heteronuclear molecule ,Ultracold atom ,Atom ,symbols ,Physics::Atomic Physics ,Atomic physics ,Adiabatic process ,Raman spectroscopy - Abstract
We study the formation of stable heteronuclear tetramers from ultracold atoms via two different paths by generalized Raman adiabatic passage. The dynamical instability and adiabaticity of the dark state are investigated. The regions for the appearance of dynamical instability are analytically obtained and the adiabatic evolution is studied by adiabatic fidelity. Moreover, the effects of the external field parameters on the conversion efficiency are investigated, and a comparison is also drawn between the two different paths.
- Published
- 2014
7. Practical 2.45-GHz microwave-driven Cs-free H− ion source developed at Peking University.
- Author
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Tao Zhang, Shi-Xiang Peng, Wen-Bin Wu, Hai-Tao Ren, Jing-Feng Zhang, Jia-Mei Wen, Teng-Hao Ma, Yao-Xiang Jiang, Jiang Sun, Zhi-Yu Guo, and Jia-Er Chen
- Subjects
MICROWAVES ,ION sources ,DUOPLASMATRONS ,ELECTRODES ,ELECTRICAL conductors - Abstract
A practical 2.45-GHz microwave-driven Cs-free H
− source was improved based on the experimental H− source at Peking University (PKU). Several structural improvements were implemented to meet the practical requirements of Xi’an Proton Application Facility (XiPaf). Firstly, the plasma chamber size was optimized to enhance the plasma intensity and stability. Secondly, the filter magnetic field and electron deflecting magnetic field were enhanced to reduce co-extracted electrons. Thirdly, a new two-electrode extraction system with farther electrode gap and enhanced water cooling ability to diminish spark and sputter during beam extraction was applied. At last, the direct H− current measuring method was adopted by the arrangement of a new pair of bending magnets before Faraday cup (FC) to remove residual electrons. With these improvements, electron cyclotron resonance (ECR) magnetic field optimization experiments and operation parameter variation experiments were carried out on the H− ion source and a maximum 8.5-mA pure H− beam was extracted at 50 kV with the time structure of 100 Hz/0.3 ms. The root-mean-square (RMS) emittance of the beam is 0.25π⋅mm⋅mrad. This improved H− source and extraction system were maintenance-free for more than 200 hours in operation. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
8. A miniaturized 2.45 GHz ECR ion source at Peking University.
- Author
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Jia-Mei Wen, Shi-Xiang Peng, Hai-Tao Ren, Tao Zhang, Jing-Feng Zhang, Wen-Bin Wu, Jiang Sun, Zhi-Yu Guo, and Jia-Er Chen
- Subjects
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ION sources , *MINIATURE electronic equipment , *PERMANENT magnets , *HYDROGEN ions , *CYCLOTRON resonance - Abstract
A miniaturized 2.45 GHz permanent magnet electron cyclotron resonance (PMECR) ion source, which has the ability of producing a tens-mA H+ beam, has been built and tested at Peking University (PKU). Its plasma chamber dimension is Φ30 mm × 40 mm and the whole size of the ion source is Φ180 mm × 130 mm. This source has a unique structure with the whole source body embedded into the extraction system. It can be operated in both continuous wave (CW) mode and pulse mode. In the CW mode, more than 20 mA hydrogen ion beam at 40 kV can be obtained with the microwave power of 180 W and about 1 mA hydrogen ion beam is produced with a microwave power of 10 W. In the pulse mode, more than 50 mA hydrogen ion beam with a duty factor of 10% can be extracted when the peak microwave power is 1800 W. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
9. A fast emittance measurement unit for high intensity DC beam.
- Author
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Ai-Lin Zhang, Hai-Tao Ren, Shi-Xiang Peng, Tao Zhang, Yuan Xu, Jing-Feng Zhang, Jia-Mei Wen, Wen-Bin Wu, Zhi-Yu Guo, and Jia-Er Ceng
- Subjects
BEAM emittance (Nuclear physics) ,ION beams ,SAMPLING methods ,PROTON beams ,PARTICLE beams - Abstract
A combined unit, which has the ability to measure the current and emittance of the high intensity direct current (DC) ion beam, is developed at Peking University (PKU). It is a multi-slit single-wire (MSSW)-type beam emittance meter combined with a water-cooled Faraday Cup, named high intensity beam emittance measurement unit-6 (HIBEMU-6). It takes about 15 seconds to complete one measurement of the beam current and its emittance. The emittance of a 50-mA@50-kV DC proton beam is measured. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
10. Understanding hydrogen plasma processes based on the diagnostic results of 2.45 GHz ECRIS at Peking University.
- Author
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Wen-Bin Wu, Hai-Tao Ren, Shi-Xiang Peng, Yuan Xu, Jia-Mei Wen, Jiang Sun, Ai-Lin Zhang, Tao Zhang, Jing-Feng Zhang, and Jia-Er Chen
- Subjects
EMISSION spectroscopy ,HYDROGEN plasmas ,CYCLOTRON resonance ,ELECTRON density ,TEMPERATURE measurements - Abstract
Optical emission spectroscopy (OES), as a simple in situ method without disturbing the plasma, has been performed for the plasma diagnosis of a 2.45 GHz permanent magnet electron cyclotron resonance (PMECR) ion source at Peking University (PKU). A spectrum measurement platform has been set up with the quartz-chamber electron cyclotron resonance (ECR) ion source [Patent Number: ZL 201110026605.4] and experiments were carried out recently. The electron temperature and electron density inside the ECR plasma chamber have been measured with the method of line intensity ratio of noble gas. Hydrogen plasma processes inside the discharge chamber are discussed based on the diagnostic results. What is more, the superiority of the method of line intensity ratio of noble gas is indicated with a comparison to line intensity ratio of hydrogen. Details will be presented in this paper. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
11. Surface enhancement of molecular ion yield in a 2.45-GHz electron–cyclotron resonance ion source.
- Author
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Yuan Xu, Shi-Xiang Peng, Hai-Tao Ren, Ai-Lin Zhang, Tao Zhang, Jing-Feng Zhang, Jia-Mei Wen, Wen-Bin Wu, Zhi-Yu Guo, and Jia-Er Chen
- Subjects
SURFACES (Technology) ,ELECTRON cyclotron resonance sources ,ION sources ,ION beams ,STAINLESS steel ,INTERSTITIAL hydrogen generation - Abstract
High current hydrogen molecular ion beam is obtained with a specially designed stainless steel liner permanent magnet 2.45-GHz electron–cyclotron resonance (ECR) ion source (PMECR II) at Peking University (PKU). To further understand the physics of the hydrogen generation process inside a plasma chamber, theoretical and experimental investigations on the liner material of the plasma chamber in different running conditions are carried out. Several kinds of materials, stainless steel (SS), tantalum (Ta), quartz, and aluminum (Al) are selected in our study. Experimental results show that stainless steel and tantalum are much better than others in generation. During the experiment, an increasing trend in fraction is observed with stainless steel liner after O
2 discharge inside the ion source. Surface analyses show that the roughness change on the surface after O2 discharge may be responsible for this phenomenon. After these studies, the pure current of ions can reach 42.3 mA with a fraction of 52.9%. More details are presented in this paper. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
12. New progress on beam availability and reliability of PKU high intensity CW proton ECR ion source.
- Author
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Shi-Xiang Peng, Ai-Lin Zhang, Hai-Tao Ren, Yuan Xu, Tao Zhang, Jing-Feng Zhang, Jia-Mei Wen, Zhi-Yu Guo, and Jia-Er Chen
- Subjects
ION sources ,NUCLEAR physics instruments ,PARTICLE beams ,PROTON sources ,DUOPLASMATRONS - Abstract
The stability and reliability of an ion source and its beam availability are extremely significant for any accelerator, especially for those high current long term CW operation ones like ADS. Although the first high quality 306-hours continuous wave (CW) operating curve at 50 mA@35 keV has been successfully obtained with a standard compact 2.45 GHz ECR ion source at Peking University (PKU), but the uncertainties that caused beam trips before are unacceptable during an accelerator real operation and should be eliminated. Meanwhile, no permission will be given when the beam power is upgraded from 50 mA@35 keV to 50 mA@50 keV. To improve the PKU CW proton source quality, several upgrades were done recently. After those improvements, a new long term CW proton beam experiment at 50 mA@50 keV was carried out in June 2016. The total running time is 300.5 hours, including near 6 hours ion source preparation and 294 hours non-disturb continuous operation. Within the continuous 13 days operation, no beam-off happened, no spark was observed, no beam drop appeared, no interrupting action was needed, and only a few beam fluctuations caused by the air conditional failure occurred. Beam availability and reliability within the 294 hours is 100%. The root-mean-square (RMS) emittance of this 50 mA@50 keV CW proton beam is about 0.186 π.mm.mrad. A careful inspection of the ion source was done after this long term operation and no obvious damage was found. The restart experimental results obtained after the ion source inspection prove the high repeatability of PKU PMECRIS. In addition, a 130-mA H
+ beam was obtained at 50 kV with duty factor of 10% (100 Hz/1 ms) with this source. Details will be presented in this paper. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
13. Instability, adiabaticity and controlling effects of external fields for the dark state in a heteronuclear atom–tetramer conversion system.
- Author
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Shao-Ying Meng, Xi-Hao Chen, Shuang-Ning Ning, Jia-Mei Wen, and Li-Bin Fu
- Subjects
DARK states (Quantum optics) ,ELECTRIC fields ,HETERONUCLEAR diatomic molecules ,ULTRACOLD molecules ,ADIABATIC quantum computation - Abstract
We study the formation of stable heteronuclear tetramers from ultracold atoms via two different paths by generalized Raman adiabatic passage. The dynamical instability and adiabaticity of the dark state are investigated. The regions for the appearance of dynamical instability are analytically obtained and the adiabatic evolution is studied by adiabatic fidelity. Moreover, the effects of the external field parameters on the conversion efficiency are investigated, and a comparison is also drawn between the two different paths. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
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