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CsPbBr3 quantum dots (CPB QDs) have great potential in photoreduction of CO2 to chemical fuels. However, the low charge transportation efficiency and chemical instability of CPB QDs presents a considerable challenge. Herein, we describe the electrostatic assemblies of negatively charged colloidal two dimensional (2D) Cu-Tetrakis(4-carboxyphenyl) porphyrins (Cu-TCPP) nanosheets and positively CPB QDs to construct the hydride heterojunction. The photogenerated electron migration from CPB QDs to Cu-TCPP nanosheets has been witnessed, providing the supply of long-lived electrons for the reduction of CO2 molecules adsorbed on Cu-TCPP matrix. As a direct result, The CPB@Cu-TCPP-x (x wt% of CPB QDs) photocatalysts exhibit significantly enhanced photocatalytic conversion of CO2, compared to the parent Cu-TCPP nanosheets or single CPB QDs. Especially, when with 20% CPB QDs, the heterostruture system achieves an evolution yield of 287.08 µmol g-1 in 4 h with highly CO selectivity (99%) under visible light irradiation, which is equivalent to a 3.87-fold improvement compared to the pristine CPB QDs. Meanwhile, the CH4 generation rate can be up to 3.25 µmol g-1. This optimized construction of heterostructure could provide a platform to funnel photoinduced electrons to the reaction center, which can both act as a crucial capture and the reaction actives of CO2.

Background: Dendrobium nobile Lindl. (DNL) is effective for the treatment of alcohol liver disease (ALD), but the underly mechanism is still unclear. Objectives: This research aimed to investigate the effects and mechanism of aqueous extract of Dendrobium nobile Lindl (AEDNL) in ALD rats based on a metabolomics approach. Materials and Methods: In this study, 18 Sprague-Dawley male rats were randomly divided into control, model, and AEDNL groups (n=six). Rats in the AEDNL group were given AEDNL (152 mg/kg) intragastric administration from the first day for 30 consecutive days. From day 15 to day 30, model and AEDNL groups were given 30% ethanol (10 ml/kg) after 4 h of daily administration. Then, serum and liver samples were collected for biochemical analysis, histopathological examination, and Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry (UPLC-Q-TOF/MS) determination for metabolomic analysis. Results: Compared with the model group, the liver/body weight index and serum levels of TC, LDL-C, and TBIL in the AEDNL group were significantly decreased. Hepatocyte cord arrangement, hepatocyte balloon, and fat vacuolization were significantly improved in the AEDNL group. Metabolism profiles were changed in the model and AEDNL groups. Seven and two common differential metabolites (Guanosine3',5'-cyclic monophosphate, and Glutaric acid) were found in serum and liver, respectively. In addition, the hepatoprotective effect of AEDNL on ALD was related to steroid hormone biosynthesis, riboflavin metabolism, and glycerophospholipid metabolism. Conclusion: The research could provide novel evidence of the protective effects of AEDNL on ALD.

Herein, the optional and controllable growth of Bi2S3 onto NH2-MIL-125 via covalent conjunction strategy was reported. The experimental results demonstrate that the obtained heterojunction exhibits boosting photocatalytic reduction CO2 and organic dye degradation. The 18-Bi2S3@NH2-MIL-125-SH displays the highest yield of 12.46 μmol g−1h−1 of CO, >13 times that of pure NH2-MIL-125. Meanwhile, the reaction kinetic of 18-Bi2S3@NH2-MIL-125-SH in the degradation of methylene blue is uppermost, which is 160 times than that of the commercial P25. The enhancement of photocatalytic performance could be ascribed to the covalent coordination-driven intimate interfacial interaction in n-scheme heterojunction. Meanwhile, the plausible mechanism was also investigated by UV–vis diffuse reflectance (UV–vis), photoluminescence (PL), electrochemical photocurrent, electron spin resonance (ESR) and electrochemical impedance spectroscopy (EIS).

Herein, the obtained Cu

Three new NiII/CoII-metal organic frameworks were self-assembled by the reaction of C3 symmetric 1,3,5-tribenzoic acid (H3BTC) and 2,4,6-tris(4-pyridyl)-1,3,5-triazine (4-TPT) ligands and NiII/CoII salts under solvothermal conditions. Isomorphous MOF1 and MOF2 exhibit a 3D pillar-layer framework based on binuclear M2(OH)(COO)2 units connected by tritopic BTC3- and 4-TPT ligands with a novel (3,5)-connected topology net. MOF3 displays a 3-fold interpenetrated 3D network exhibiting a (3,4)-connected topology net. The porous MOF3 can reversibly take up I2. The activated MOFs contain both Lewis acid (NiII center) and basic (uncoordinated pyridyl or carboxylic groups) sites, and act as bifunctional acid-base catalysts. The catalytic measurements demonstrate that the activated MOF3 exhibits good activities for benzyl alcohol oxidation and the Knoevenagel reaction and can be recycled and reused for at least four cycles without losing its structural integrity and high catalytic activity. Thus, the catalytic properties for the oxidation-Knoevenagel cascade reaction have also been studied.

In this paper, we present four Co-MOFs using R-substituted isophthalic acid (R-H2BDC, R = H, OH and COOH) along with trigonal n-TBT (n = 3 or 4) as organic ligands. These Co-MOFs are formulated as {[Co(1,3-BDC)(4-TBT)2/3]·(H2O)(DMF)1.5}n (Co-MOF-1), {[Co(HO-BDC)(4-TBT)]·(EtOH)2(DMF)2}n (Co-MOF-2), {[Co(HO-BDC)(4-TBT)2/3]·(H2O)3(MeOH)3(DMA)}n (Co-MOF-3) and {[Co3(BTC)2(3-TBT)2(H2O)2]·(H2O)2(EtOH)5(DMA)1.5}n (Co-MOF-4), where H2BDC = isophthalic acid, OH–H2BDC = 5-hydroxyisophthalic acid and H3BTC = 1,3,5-tricarboxybenzene, 4-TBT = 1,3,5- tris(4-pyridyl)benzene and 3-TBT = 1,3,5-tris(3-pyridyl)benzene. Co-MOF-1, 2 and 3 are constructed from the dimeric Co2(COO)2 unit and exhibit 3D frameworks. In Co-MOF-4, the dimeric Co2(COO)2 unit and single nuclear CoII center are connected by BTC3− and 3-TBT ligands into a 3D network. The catalytic experiments revealed that four Co-MOFs can catalyze the oxidative coupling reaction of benzyl alcohols and aniline to imines with good to excellent conversions under solvent-free conditions and an air atmosphere. Co-MOF-4 exhibited the best catalytic performance and the catalyst could be reused for at least five cycles without losing its structural integrity and catalytic activity.

High purity germanium detectors have important applications in many fields. Detector’s performance deteriorated significantly due to radiation of neutron. The annealing of damaged HPGe detector is expounded in this monograph. The experiment results indicate that raising the temperature to 70°C for five days, the restoration efficiency can reach 90%.

Three-dimensional (3D) hierarchical MnO2@NiCo2O4 core–shell nanoflower in situ grown on the Ni-foam substrate has successfully prepared via a two-step hydrothermal process and calcination treatment, and the related properties of electrode materials for supercapacitors have also been investigated. The prepared samples were characterized by scanning electron microscopy, transmission electron microscopy, powder X-ray diffraction, X-ray photoelectron spectroscopy, cyclic voltammetry, galvanostatic charge–discharge, and electrochemical impedance spectroscopy (EIS). When the current density was 0.25 A/g, the specific capacitance of the MnO2@NiCo2O4 composite material could reach 634.37 F/g. The specific capacitance was 83.1% retention after 3000 cycles at 1 A/g, and the initial capacitance retention rate was 96.3%, showing good capacitance stability. It opens up a new way for the development of high-performance supercapacitor electrode materials.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive impairment that currently is uncurable. Previous study shows that trilobatin (TLB), a naturally occurring food additive, exerts neuroprotective effect in experimental models of AD. In the present study we investigated the molecular mechanisms underlying the beneficial effect of TLB on experimental models of AD in vivo and in vitro. APP/PS1 transgenic mice were administered TLB (4, 8 mg· kg

CsPbBr

HPGe detector is used widely, its property is affected by neutron. Annealing to the germanium crystal is a good approach to recover the detector. To raise the temperature of germanium crystal to recover the resolution for the HPGe detector. A special copper ingot is designed and manufactured to increase the heating efficiency. Two temperature controlled power supplies are used to heat the germanium crystal and keep the temperature for cooling rod. The experiment results indicate that raising temperature to 70 $${}^\circ \hbox {C}$$ for five days, the restoration efficiency is better than 90%.

The self-assembly of 5-substituted isophthalic acid (R-H2BDC, R = H, NO2, Me, OH and tBu), CdII ions and 2,4,6-tris(3-pyridyl)-1,3,5-triazine (3-TPT) or 2,4,6-tris(4-pyridyl)-1,3,5-triazine (4-TPT) under solvothermal conditions yields six Cd-MOFs: {[Cd(BDC)(4-TPT)]·1.5H2O}n (Cd-MOF-1), {[Cd(NO2-BDC)(4-TPT)]·2H2O}n (Cd-MOF-2), {[Cd(Me-BDC)(4-TPT)]·2H2O}n (Cd-MOF-3),{[Cd(OH-BDC)(4-TPT)]·2.5H2O}n (Cd-MOF-4), {[Cd(tBu-BDC)(4-TPT)2/3]·DMF}n (Cd-MOF-5), and {[Cd(BDC)(3-TPT)2/3]·3H2O}n (Cd-MOF-6), (where H2BDC = isophthalic acid, NO2-BDC = 5-nitroisophthalic acid, Me-BDC = 5-methylisophthalic acid, OH-BDC = 5-hydroxyisophthalic acid, tBu-BDC = 5-tert-butylisophthalic acid, 3-TPT = 2,4,6-tris(3-pyridyl)-1,3,5-triazine and 4-TPT = 2,4,6-tris(4-pyridyl)-1,3,5-triazine). All the compounds are constructed from dimeric Cd2(OCO)2 units, connected by mixed R-H2BDC and n-TPT ligands into three-dimensional frameworks. Cd-MOF-1, 2 and 3 are isostructural, in which the Cd2(OCO)2 units are bridged into 1D chains extending along the [1 1 0] and [−1 1 0] directions, respectively, and are then further interlinked by 4-TPT ligands into three-dimensional networks with a CdS net topology. Cd-MOF-4 exhibits a three-dimensional framework with a pcu topology, in which the dimeric Cd2(OCO)2 units are firstly connected into two-dimensional Cd(OH-BDC)n sheets, and further “pillared” by 4-TPT into a three-dimensional network. In Cd-MOF-5 and 6, the Cd2(OCO)2 units are firstly linked into a three-dimensional NbO net by tBu-BDC/BDC ligands, which are further accommodated by the size-matching trigonal 3-TPT/4-TPT ligands into a novel (3,8)-connected three-dimensional net. Interestingly, via the synergistic effect of open hydroxyl and pyridyl groups, Cd-MOF-4 can be functionalized by Eu3+ ions by post-synthetic modification, and the resulting 0.001Eu3+@Cd-MOF-4 phosphor serves as a highly selective and sensitive probe for detection and recognition of Fe3+ ions through the luminescence quenching effect in aqueous solution.

A new Ni(II)-metal organic framework was self-assembled by the reaction of tripodal benzene-1,3,5-tribenzoic acid (H3BTB), 2,4,6-tris(4-pyridyl)-1,3,5-triazine (TPT) and NiII salts under solvothermal conditions. {[Ni3(OH)(BTB)2(TPT)[NH(CH3)2]}n•2nH2O (MOF1) exhibited two-fold interpenetrated three-dimensional (3D) framework, which was constructed from the Ni3(OH)(COO)6 trinuclear unit, connected by the mixed H3BTB and TPT ligands. In 1, the trinuclear Ni3(OH)(COO)6 units were firstly linked into 3D network by tripodal BTB3− ligands, which were further accommodated with another size-matched trigonal TPT ligands, and novel (3,8)-connected 3D net was created. The catalytic measurements showed that compound 1 was a good heterogeneous catalyst for the one-pot synthesis of imines from benzyl alcohols and aniline under solvent-free condition, and the catalyst could be recycled without losing its structural integrity and catalytic activity.

In this work, we employed solvethermal method to assemble highly crystalline NH2-MIL-125(Ti) nanocrystals on the CdS nanorods, forming CdS@NH2-MIL-125(Ti) (S@T-n) heterostructured photocatalyst. The photocatalytic activity, structures and morphology of the composites were characterized by UV–vis diffuse reflectance, powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer–Emmett-Teller (BET), photoluminescence (PL), X-ray photoelectron spectroscopy (XPS). Compared to pristine CdS, the S@T-n composites exhibited enhanced photo-degradation efficiencies for Rhodamine B (RhB), phenol and oxytetracycline (OTC) from aqueous solution under visible-light irradiation. Among them, the S@T-10 composite demonstrated the highest photocatalytic performance, and reached 361.4 times for phenol, and 236 times for OTC of Degussa P-25. The enhancement of photocatalytic activity could be described to the novel heterostructure, which can not only provide abundant surface area for the adsorption and diffusion of organic pollutants, but also efficient visible-light harvesting and interfacial charge separation. The possible photocatalytic mechanism of superoxide (O2 −) and holes (h+) by the electron-spin-resonance (ESR) was also investigated detailed.

The beam energy measurement system (BEMS) at the upgraded Beijing Electron-Positron Collider (BEPCII) is designed to provide beam energy value with the relative error at the level of 5×10−5. The obvious energy deviation found during J/ψ resonance scan in 2012 leads to great amount of investigations on both BEPCII and BEMS sides. The reasons causing such an unexpected difference are figured out, which include the neutron damage to HPGe detector, the leakage of RF cavity, and the background from Linac. Based on a series of measures, the ψ(3686) line shape scan is designed and performed, the experimental result indicates that BEMS can measure the beam energy with the claimed accuracy. The afterward performance of BEMS is smooth and stable, and BEMS will play a crucial role in the following high accurate experiments.

Chinese medicine (CM) has become a popular interventional treatment for rheumatoid arthritis (RA). However, limited knowledge about general characteristics and long-term clinical outcomes hampers the development of CM for RA.The main objectives of the China Rheumatoid Arthritis Registry of Patients with Chinese Medicine (CERTAIN) were to describe the population of RA patients receiving CM treatment in multiple centers in China using different variables and compare these findings with internationally reported data.The CERTAIN is a prospective, multicenter, observational disease registry.Adult RA patients who fulfilled the 2010 American College of Rheumatology/ European League Against Rheumatism classification criteria for RA and received CM treatment were recruited into the CERTAIN by rheumatologists from 145 hospitals across 30 provinces in China. Data on demographics, disease characteristics, comorbidities, treatments, and adverse events, with a 2-year follow-up, were collected and documented using a predefined protocol.In the 2 years since the study began in September 2019, 11,764 patients have been enrolled (enrolment is ongoing), and 13.10% of participants have completed the 6-month follow-up. We present the baseline characteristics of the first 11,764 enrollees.The CERTAIN is the first nationwide registry to document comprehensive data on CM treatment in patients with RA. The development of the CERTAIN resource is a significant step forward for Chinese RA patients, herbal medicine users, and research communities and will deepen our understanding of CM for RA.The study was registered at ClinicalTrials.gov (NCT05219214).

Herein, the optional and controllable growth of Bi

Three new NiII/CoII-metal organic frameworks were self-assembled by the reaction of C3 symmetric 1,3,5-tribenzoic acid (H3BTC) and 2,4,6-tris(4-pyridyl)-1,3,5-triazine (4-TPT) ligands and NiII/CoII salts under solvothermal conditions. Isomorphous MOF1 and MOF2 exhibit a 3D pillar-layer framework based on binuclear M2(OH)(COO)2 units connected by tritopic BTC3- and 4-TPT ligands with a novel (3,5)-connected topology net. MOF3 displays a 3-fold interpenetrated 3D network exhibiting a (3,4)-connected topology net. The porous MOF3 can reversibly take up I2. The activated MOFs contain both Lewis acid (NiII center) and basic (uncoordinated pyridyl or carboxylic groups) sites, and act as bifunctional acid-base catalysts. The catalytic measurements demonstrate that the activated MOF3 exhibits good activities for benzyl alcohol oxidation and the Knoevenagel reaction and can be recycled and reused for at least four cycles without losing its structural integrity and high catalytic activity. Thus, the catalytic properties for the oxidation-Knoevenagel cascade reaction have also been studied.

The highly emissive BODIPY （boron-dipyrromethene） have been grafted on the Eu-based metal-organic frameworks (Eu-MOFs) via the covalent F-B bonding using a facile one-pot solvothermal reaction. The fluorescence emission ratio of BODIPY@Eu-MOF has been applied to construct the ratiometric fluorescence sensor for the F-, H2O2 and glucose detection in water solution and living cells. The produced BODIPY@Eu-MOF probe provided enhanced sensitivity, higher selectivity and lower lower limits of detection (LOD) for the detection of F- (0.1737 μM), H2O2 (6.22 nM) and glucose (6.92 nM), and 5.96, 6.52 and 6.95 times lower than that for single Eu-MOF, respectively. More importantly, the probe also exhibited the lower biotoxic in living cells for bioimaging and the better visualization performance with multiplex channels. The results indicated the π-conjugated BODIPY derivative not only acted as the surfactant molecule or template agent for preferred growth, but also modulated the fluorescent emissions drastically, and thus induced excellent fluorescent detecting performances.

Biqi capsule is a Traditional Chinese Medicine preparation for treating rheumatoid arthritis (RA), and clinical studies have indicatedthat its effect may be more beneficial than that of Western medicine. The present study aimed to estimate the efficacy and safety of Biqi capsule alone or combined with methotrexate (MTX) compared with MTX alone for treating RA by performing a meta-analysis of randomized controlled trials and controlled clinical trials. A systematic literature search of studies published until March 2017 was performed. References from relevant studies were screened to obtain additional articles. The results were independently evaluated for relevance, and full-text studies were assessed for eligibility. The risk of bias was assessed using the Cochrane collaboration tool for assessing risk of bias. Out of 558 citations that were initially retrieved, a total of 5 studies comprising 522 patients met the inclusion criteria. The risk of bias of these trials was generally unclear or high. Meta-analysis indicated that Biqi capsule had better effects on C-reactive protein [standardized mean difference (SMD), -7.05; 95% CI -(10.77-3.33)] and tender joint count [SMD, -3.02; 95% CI, -(3.81-2.22)] and fewer adverse effects (AEs) than MTX [relative risk (RR), 0.19; 95% CI, 0.08-0.43]. Biqi capsule plus MTX was superior to MTX in terms of the total effect (RR, 1.17; 95% CI, 1.06-1.28), rheumatoid factor [SMD, -12.54; 95% CI, -(16.87-8.20)], swollen joint count [SMD, -1.50; 95% CI, -(1.99-1.01)], score of joint swelling [SMD -2.07; 95% CI, -(2.76-1.38)], tender joint count [SMD, -2.16; 95% CI, -(2.86-1.47)] and score of joint tenderness [SMD, -4.69; 95% CI, -(5.92-3.47)]. There was no difference in AEs between Biqi capsule plus MTX and MTX (RR, 0.71; 95% CI, 0.34-1.50). In conclusion, the present study indicated that compared with MTX, Biqi capsule plus MTX appeared to have more benefits but that Biqi capsule alone was not better for RA patients than MTX. In the other words, Biqi capsule plus MTX is more effective and has fewer AEs compared to MTX. However, the trials selected in the present meta-analysis have various limitations, including the lack of blinding and the short duration of the treatment; therefore, the conclusions are not sufficiently definitive. More randomized controlled trials are necessary to evaluate the use of Biqi capsule for managing RA.