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1,051 results on '"Jiang, Gening"'

3. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Author

Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J., Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M., Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A., Kim, Jin Hee, Albanes, Demetrius, Wong, Jason Y. Y., Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E., Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H., Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J., Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Kun-Chieh, Gao, Yu-Tang, Qian, Biyun, Wu, Chen, Lu, Daru, Liu, Jianjun, Schwartz, Ann G., Houlston, Richard, Spitz, Margaret R., Gorlov, Ivan P., Wu, Xifeng, Yang, Ping, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Ji, Bu-Tian, Wichmann, H-Erich, Christiani, David C., Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James, Field, John K., Shete, Sanjay S., Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Zienolddiny-Narui, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Taylor, Fiona, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Jeon, Hyo-Sung, Jiang, Shih Sheng, Sung, Jae Sook, Chen, Chung-Hsing, Hsiao, Chin-Fu, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda, Liu, Jia, Zhu, Bin, Berndt, Sonja I., Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Wang, Wen-Chang, Xu, Jun, Guan, Peng, Tan, Wen, Yu, Chong-Jen, Yang, Gong, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Park, In Kyu, Xu, Ping, He, Qincheng, Wang, Chih-Liang, Hung, Hsiao-Han, Vermeulen, Roel C. H., Cheng, Iona, Wu, Junjie, Lim, Wei-Yen, Tsai, Fang-Yu, Chan, John K. C., Li, Jihua, Chen, Hongyan, Lin, Hsien-Chih, Jin, Li, Liu, Jie, Sawada, Norie, Yamaji, Taiki, Wyatt, Kathleen, Li, Shengchao A., Ma, Hongxia, Zhu, Meng, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Chao, Ann, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chen, Chih-Yi, Chen, Chien-Jen, Yang, Pan-Chyr, Yu, Jinming, Stevens, Victoria L., Fraumeni, Jr, Joseph F., Chatterjee, Nilanjan, Gorlova, Olga Y., Hsiung, Chao Agnes, Amos, Christopher I., Shen, Hongbing, Chanock, Stephen J., Rothman, Nathaniel, Kohno, Takashi, and Lan, Qing

Published
2023
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9. Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies

Author

Liu, Qian, Zhang, Jing, Guo, Chenchen, Wang, Mengcheng, Wang, Chenfei, Yan, Yilv, Sun, Liangdong, Wang, Di, Zhang, Lele, Yu, Huansha, Hou, Likun, Wu, Chunyan, Zhu, Yuming, Jiang, Gening, Zhu, Hongwen, Zhou, Yanting, Fang, Shanhua, Zhang, Tengfei, Hu, Liang, Li, Junqiang, Liu, Yansheng, Zhang, Hui, Zhang, Bing, Ding, Li, Robles, Ana I., Rodriguez, Henry, Gao, Daming, Ji, Hongbin, Zhou, Hu, and Zhang, Peng

Published
2024
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10. Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II–III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study

Author

Xia, Haoran, Zhang, Han, Ruan, Zheng, Zhang, Huibiao, Sun, Liangdong, Chen, Hezhong, Zhou, Yongxin, Zhang, Lele, Bian, Dongliang, Zhu, Xinsheng, Zhang, Jing, Sun, Fenghuan, Yu, Huansha, Song, Nan, Liu, Xiaogang, Zhu, Yuming, Zhang, Haiping, He, Wenxin, Chen, Jian, Yang, Jie, Chen, Guohan, Xie, Shiliang, Tang, Dongfang, Zhang, Xiaomiao, Duan, Liang, Zhao, Deping, Li, Qinchuan, Zhang, Peng, and Jiang, Gening

Published
2024
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20. Safety and effectiveness of neoadjuvant PD-1 inhibitor (toripalimab) plus chemotherapy in stage II–III NSCLC (LungMate 002): an open-label, single-arm, phase 2 trial

Author

Zhu, Xinsheng, Sun, Liangdong, Song, Nan, He, Wenxin, Xie, Boxiong, Hu, Junjie, Zhang, Jing, Yang, Jie, Dai, Jie, Bian, Dongliang, Xia, Haoran, Sun, Fenghuan, Xiong, Anwen, Luo, Jie, Zhang, Lele, Yu, Huansha, Liu, Ming, Liu, Hongcheng, Wang, Haifeng, Zhang, Haiping, Chen, Chang, Wu, Chunyan, Duan, Liang, Zhu, Yuming, Zhang, Peng, and Jiang, Gening

Published
2022
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24. Germline Predisposition and Copy Number Alteration in Pre-stage Lung Adenocarcinomas Presenting as Ground-Glass Nodules

Author

Ren, Yijiu, Huang, Shujun, Dai, Chenyang, Xie, Dong, Zheng, Larry, Xie, Huikang, Zheng, Hui, She, Yunlang, Zhou, Fangyu, Wang, Yue, Li, Pengpeng, Fei, Ke, Jiang, Gening, Zhang, Yang, Su, Bo, Sweet-Cordero, E Alejandro, Le Tran, Nhan, Yang, Yanan, Patel, Jai N, Rolfo, Christian, Rocco, Gaetano, Cardona, Andrés Felipe, Tuzi, Alessandro, Suter, Matteo B, Yang, Ping, Xu, Wayne, and Chen, Chang

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Lung, Genetics, Cancer, Lung Cancer, Human Genome, lung cancer, ground-glass nodule, whole-exome sequencing, copy number variation, driver mutations, Clinical sciences, Oncology and carcinogenesis
Abstract

Objective: Synchronous multiple ground-glass nodules (SM-GGNs) are a distinct entity of lung cancer which has been emerging increasingly in recent years in China. The oncogenesis molecular mechanisms of SM-GGNs remain elusive. Methods: We investigated single nucleotide variations (SNV), insertions and deletions (INDEL), somatic copy number variations (CNV), and germline mutations of 69 SM-GGN samples collected from 31 patients, using target sequencing (TRS) and whole exome sequencing (WES). Results: In the entire cohort, many known driver mutations were found, including EGFR (21.7%), BRAF (14.5%), and KRAS (6%). However, only one out of the 31 patients had the same somatic missense or truncated events within SM-GGNs, indicating the independent origins for almost all of these SM-GGNs. Many germline mutations with a low frequency in the Chinese population, and genes harboring both germline and somatic variations, were discovered in these pre-stage GGNs. These GGNs also bore large segments of copy number gains and/or losses. The CNV segment number tended to be positively correlated with the germline mutations (r = 0.57). The CNV sizes were correlated with the somatic mutations (r = 0.55). A moderate correlation (r = 0.54) was also shown between the somatic and germline mutations. Conclusion: Our data suggests that the precancerous unstable CNVs with potentially predisposing genetic backgrounds may foster the onset of driver mutations and the development of independent SM-GGNs during the local stimulation of mutagens.

Published
2019

26. Prognostic and predictive value of the newly proposed grading system of invasive pulmonary adenocarcinoma in Chinese patients: a retrospective multicohort study

Author

Hou, Likun, Wang, Tingting, Chen, Donglai, She, Yunlang, Deng, Jiajun, Yang, Minglei, Zhang, Yu, Zhao, Mengmeng, Zhong, Yifan, Ma, Minjie, Zhao, Guofang, Chen, Yongbing, Xie, Dong, Zhu, Yuming, Chen, Qiankun, Wu, Chunyan, Chen, Chang, Jiang, Gening, Sun, Xiwen, Jiang, Tao, Jin, Feng, Zhang, Yunzeng, Yu, Bentong, Jiang, Lei, Song, Yongxiang, Chen, Cheng, Qu, Wendong, Zhao, Lilan, and Pan, Xiaojie

Published
2022
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29. Machine Learning-Assisted Prognostic Model Reveals EMT-Mediated Chemoresistance Overcome by TGF-β Inhibition in Lung Squamous Cell Carcinoma

Author

Sun, Liangdong, primary, Wang, Jue, additional, Yu, Huansha, additional, Zhu, Xinsheng, additional, Zhang, Jing, additional, Hu, Junjie, additional, Yan, Yilv, additional, Zhang, Xun, additional, Zhu, Yuming, additional, Jiang, Gening, additional, Ding, Ming, additional, Zhang, Peng, additional, and Zhang, Lele, additional

Published
2024
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38. MAIT cells are associated with responsiveness to neoadjuvant immunotherapy in COPD‐associated NSCLC.

Author

Yin, Yanze, Zeng, Ao, Abuduwayiti, Abudumijiti, Xu, Zhilong, Chen, Keyi, Wang, Chao, Fang, Xinyun, Wang, Jiarui, Jiang, Gening, and Dai, Jie

Subjects
CHRONIC obstructive pulmonary disease, NON-small-cell lung carcinoma, IMMUNOTHERAPY, BIOMARKERS
Abstract

Background: Patients with non‐small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD) experience worse clinical outcomes but respond better to immunotherapy than patients with NSCLC without COPD. Mucosal‐associated invariant T (MAIT) cells, a versatile population of innate immune T lymphocytes, have a crucial function in the response to infection and tumors. This study investigated the distribution of MAIT cells in COPD‐associated NSCLC and their involvement in the immune response. Methods: Flow cytometry, immunohistochemistry, and immunofluorescence were performed on tissue samples of patients with NSCLC, with or without COPD, treated with or without anti‐programmed death 1 (PD1) immunotherapy. MAIT cells were stimulated with 5‐OP‐RU using a mouse subcutaneous tumor model. Results: Tumors contained significantly more MAIT cells than paraneoplastic tissues, and CD8+ MAIT cells accounted for more than 90% of these cells. Patients with NSCLC and COPD had higher CD8+ MAIT cell counts than those with NSCLC without COPD. Additionally, patients with NSCLC and COPD displayed reduced expression of the activation marker, CD69, and functional markers, granzyme B (GZMB) and interferon γ (IFNγ), and higher expression of the immune exhaustion marker, PD1. Among patients who received immunotherapy, the proportion with a complete or partial response was higher in those with COPD than in those without COPD. In patients with NSCLC and COPD, the major pathologic response (MPR) group had higher MAIT levels than those in the no major pathologic response (NPR) group. In the mouse subcutaneous tumor model stimulation of MAIT cells using 5‐OP‐RU enhanced the antitumor effects of anti‐PD1. Conclusions: In patients with NSCLC and COPD, response to immunotherapy is associated with accumulation of CD8+ MAIT cells showing immune exhaustion. These findings may contribute to innovative approaches for immunotherapy targeting CD8+ MAIT cells. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Uniportal Posterior Mediastinal Surgery

Author

Hernandez-Arenas, Luis Angel, Yang, Yang, Yu-Ming, Zhu, Jiang, Gening, Gonzalez-Rivas, Diego, Gonzalez-Rivas, Diego, editor, Ng, Calvin Sze Hang, editor, Rocco, Gaetano, editor, and D’Amico, Thomas A., editor

Published
2019
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