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42 results on '"Jiang, Guang-Bin"'

32. Association Between the Aldehyde Dehydrogenase‐2rs671 G>A Polymorphism and Head and Neck Cancer Susceptibility: A Meta‐Analysis in East Asians

Author

Du, Xin‐Ya, Wen, Li, Hu, Yuan‐Yuan, Deng, Sheng‐Qiong, Xie, Long‐Chuan, Jiang, Guang‐Bin, Yang, Gong‐Li, and Niu, Yu‐Ming

Abstract

Aldehyde dehydrogenase‐2 (ALDH2) plays an important role in the alcohol detoxification and acetaldehyde metabolism. Published studies have demonstrated some inconsistent associations between ALDH2rs671 G>A polymorphism and head and neck cancer (HNC) risk. A meta‐analysis was performed to provide pooled data on the association between the ALDH2rs671 G>A polymorphism and HNC risk. Electronic databases were searched to identify relevant studies. Odds ratios and 95% confidence intervals (CIs) were used to examine the pooled effect size of each genetic model. In addition, heterogeneity test, accumulative analysis, sensitivity analysis, and publication bias were conducted to test the statistical power. Thirteen publications (14 independent case–control studies) involving 10,939 subjects were selected. The stratified analysis indicated that both light/moderated drinking (e.g., GA vs. GG: OR = 1.47, 95% CI = 1.16 to 1.86, p< 0.01, I2= 81.1%) and heavy drinking would increase HNC risk with rs671 G>A mutation (e.g., GA vs. GG: OR = 2.30, 95% CI = 1.11 to 4.77, p= 0.03, I2= 81.9%). In summary, this meta‐analysis suggested that the ALDH2rs671 G>A polymorphism may play an important synergistic effect in the pathogenesis of HNC development in East Asians.

Published
2021
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41. Synthesis, Characterization, In Vitro Cytotoxicity, and Apoptosis-Inducing Properties of Ruthenium(II) Complexes.

Author

Xu, Li, Zhong, Nan-Jing, Xie, Yang-Yin, Huang, Hong-Liang, Jiang, Guang-Bin, and Liu, Yun-Jun

Subjects
CHEMICAL synthesis, CELL-mediated cytotoxicity, APOPTOSIS, METAL complexes, RUTHENIUM, ELECTROSPRAY ionization mass spectrometry
Abstract

Two new Ru(II) complexes, [Ru(bpy)2(FAMP)](ClO4)21 and 2, are synthesized and characterized by elemental analysis, electrospray mass spectrometry, and 1H nuclear magnetic resonance. The in vitro cytotoxicities and apoptosis-inducing properties of these complexes are extensively studied. Complexes 1 and 2 exhibit potent antiproliferative activities against a panel of human cancer cell lines. The cell cycle analysis shows that complexes 1 and 2 exhibit effective cell growth inhibition by triggering G0/G1 phase arrest and inducing apoptosis by mitochondrial dysfunction. The in vitro DNA binding properties of the two complexes are investigated by different spectrophotometric methods and viscosity measurements. [ABSTRACT FROM AUTHOR]

Published
2014
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42. Association between Interleukin-1β Gene -511C>T/+3954C>T Polymorphisms and Aggressive Periodontitis Susceptibility: Evidence from a Meta-Analysis.

Author

Hu YY, Liu JH, Jiang GB, Yuan RX, Niu YM, and Shen M

Subjects
Genetic Association Studies, Humans, Odds Ratio, PubMed, Aggressive Periodontitis genetics, Genetic Predisposition to Disease genetics, Interleukin-1beta genetics, Polymorphism, Single Nucleotide genetics
Abstract

Background: Interleukin-1β (IL-1β) is an important inflammatory cytokine. The associations between IL-1β gene -511C>T/+3954C>T polymorphisms and aggressive periodontitis (AgP) susceptibility have been conflicting. We therefore conducted a meta-analysis to investigate the association of IL-1β genetic polymorphisms with susceptibility to AgP., Material and Methods: PubMed and Embase electronic databases were searched for relevant studies. Odds ratios (ORs) with 95% confidence interval (CIs) were used to assess the association between IL-1β polymorphisms and AgP risk. Heterogeneity, publication bias, and sensitivity analysis were performed to guarantee the statistical power., Results: Twenty published studies involving 965 patients and 1234 control subjects were included. No significant association between IL-1β polymorphisms and AgP was found. For -511C>T (T vs. C: OR=0.966, 95%CI=0.696-1.341, P=0.869; CT vs. CC: OR=0.936, 95%CI=0.761-1.151; TT vs. CC: OR=0.892, 95%CI=0.464-1.715, P=0.719; CT+TT vs. CC: OR=1.026, 95%CI=0.795-1.323; TT vs. CC+CT: OR=0.864, 95%CI=0.436-1.713). For +3954C>T (T vs. C: OR=1.069, 95%CI=0.901-1.268; CT vs. CC: OR=0.921, 95%CI=0.699-1.212; TT vs. CC: OR=1.064, 95%CI=0.747-1.515; CT+TT vs. CC: OR=0.990, 95%CI=0.764-1.283; TT vs. CC+CT: OR=1.229, 95%CI=0.919-1.643). Subgroup analyses were conducted with HWE, ethnicity, and study design, and no significant association was detected., Conclusions: These results demonstrate that IL-1β -511C>T and +3954C>T polymorphisms are not the risk factors for developing AgP.

Published
2015
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